Keywords: AIM2; absent in melanoma-2; ASC; apoptosis-associated speck-like protein containing a CARD; ATP; adenosine triphosphate; CAPS; cryopyrin-associated periodic syndromes; CARD; caspase recruitment domain; DAMP; danger-associated molecular pattern; DNA; deoxy
مقالات ISI (ترجمه نشده)
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Keywords: CD39; M1/M2 microglia; Motoneuron; Oligodendrocyte; P2X7; P2Y12; ALS; amyotrophic lateral sclerosis; BBG; Brilliant Blue G; BDNF; brain-derived neurotrophic factor; BzATP; 2â²-3â²-O-(benzoyl-benzoyl) ATP; fALS; familial ALS; FUS; fused in sarcoma; HuR
Keywords: ABCB1; adenosine triphosphate-binding cassette transporter 1; ASC; apoptosis-associated Speck-like protein containing Caspase recruitment domain; ATP; adenosine triphosphate; Bcl-2; B-cell lymphoma 2; BD; Behcetʼs disease; Ca2+; calcium; Caspase; cystein
Keywords: 5-HIAA; 5 hydroxyindoleacetic acid; 5-HT; serotonin; 5-HTT; 5-HT transporter; ACTH; adrenocorticotropic hormone; AIAQ; anger irritability and assault questionnaire; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; BCG; bacille Calmette-Gueri
Keywords: P2X7; Pulmonary tuberculosis; Meta-analysis
Keywords: Inflammasome; PULMONARY TB; polymorphisms; NLRP3; CTSB; P2X7; CARD8
Keywords: Chrysophanol; P2X7; Depression; Inflammation
Association of P2X7 gene common polymorphisms with pulmonary tuberculosis in Lur population of Iran
Keywords: Pulmonary tuberculosis; Immunogenetics; P2X7; Population genetics;
Emerging role of the P2X7-NLRP3-IL1β pathway in mood disorders
Keywords: P2X7; NLRP3; Microglia; Mood disorders; Depression; Neuroinflammation; Neuropsychiatry; Neuroimmunology;
A P2X7 receptor antagonist reverses behavioural alterations, microglial activation and neuroendocrine dysregulation in an unpredictable chronic mild stress (UCMS) model of depression in mice
Keywords: P2X7; Neuroinflammation; Unpredictable chronic mild stress (UCMS); Major depressive disorder (MDD); Neuroendocrine HPA axis; Neurogenesis; Antidepressant pharmacotherapy; Treatment resistance; Microglia; Radioimmunoassay (RIA);
Mapping Txnip: Key connexions in progression of diabetic nephropathy
Keywords: ARRB; arrestin beta; ARRDC; arrestin domain containing protein; ASK-1; apoptosis signal-regulating kinase-1; Cys; cysteine; ECM; extracellular matrix; FOXO; forkhead box protein; Gly; glycine; IL-1β; interleukin-1 β; JNK; c-Jun-N-terminal kinase; MAPK;
The role of polycyclic frameworks in modulating P2X7 receptor function
Keywords: P2X7; Polycyclic; Structure-activity relationships; Isoquinoline; Cyanoguanidine;
The P2X7 receptor: A main player in inflammation
Keywords: P2X7; ATP; Inflammation; Pathogens; Immune response;
Suppression of CD36 attenuates adipogenesis with a reduction of P2X7 expression in 3T3-L1 cells
Keywords: CD36; Adipogenesis; ATP; P2X7;
Acetylcholine-induced ex vivo ATP release from the human nasal mucosa
Keywords: Ach; acetylcholine; M3AchR; M3 acetylcholine receptor; PLC; phospholipase C; PIP2; phosphatidylinositol bisphosphate; DAG; diacylglycerol; IP3; inositol triphosphate; IP3R; inositol triphosphate receptor; P2X7; purinergic P2X7 receptor; Human nasal mucosa
Genetic polymorphisms of the P2X7 gene associated with susceptibility to and prognosis of pulmonary tuberculosis
Keywords: Tuberculosis; Susceptibility; Prognosis; Gene; P2X7; Polymorphism;
Evaluation of P2X7 receptor expression in peripheral lymphocytes and immune profile from patients with indeterminate form of Chagas disease
Keywords: Chagas disease; Lymphocytes; P2X7; Cytokines;
Effects of P2X7 receptor antagonists on hypoxia-induced neonatal seizures in mice
Keywords: Neonatal seizures; Hypoxia; Purinergic receptors; P2X7; Inflammation;
Repression of acetaminophen-induced hepatotoxicity by a combination of celastrol and brilliant blue G
Keywords: NLRP3; NF-κB; P2X7; Liver inflammation;
PYK2 mediates BzATP-induced extracellular matrix proteins synthesis
Keywords: PYK2; BzATP; P2X7; Mechanical stimuli; Extracellular matrix proteins;
The role of the P2X7 receptor on bone loss in a mouse model of inflammation-mediated osteoporosis
Keywords: P2X7; BMD; IMO; Inflammation; Osteoporosis; Microarchitecture;
Preclinical characterization of substituted 6,7-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one P2X7 receptor antagonists
Keywords: P2X7; 6,7-Dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one; Autoradiography; Depression; CNS;
The evolution of P2X7 antagonists with a focus on CNS indications
Keywords: Purinergic; P2X7; Neuroinflammation; IL-1β; Heterocyclic; Heteroaromatic; Brain penetrant
Immuno-Pharmacological Targeting of Virus-Containing Compartments in HIV-1-Infected Macrophages
Keywords: HIV (human immunodeficiency virus); macrophages; VCC (virus-containing compartment); ATP; microvesicles; P2X7
Molecular mechanisms of LL-37-induced receptor activation: An overview
Keywords: AMP; antimicrobial peptide; APD; antimicrobial peptide database; IFN; interferon; DC; dendritic cell; NK-cells; natural killer cells; GPCR; G protein-coupled receptor; RTK; receptor tyrosine kinase; LGIC; ligand-gated ion channel; TLR; toll-like receptor;
Psychological Stress Activates the Inflammasome via Release of Adenosine Triphosphate and Stimulation of the Purinergic Type 2X7 Receptor
Keywords: ATP; Depression; IL-1β; NLRP3 inflammasome; P2X7; Stress;
Evaluation of the expression and function of the P2X7 receptor and ART1 in human regulatory T-cell subsets
Keywords: ART1; ADP-ribosyltransferases 1; ART2; ADP-ribosyltransferases 2; ART5; ADP-ribosyltransferases 5; ATP; adenosine tri-phosphate; CFSE; carboxyfluorescein succinimidyl ester; H2O2; hydrogen peroxide; iTreg; inducible regulatory T cells; NAD; nicotinamide a
Effects of perinatal exposure to lead (Pb) on purine receptor expression in the brain and gliosis in rats tolerant to morphine analgesia
Keywords: Lead (Pb); Purine receptors expression; P2X4; P2X7; A1; Iba1; GFAP; Morphine tolerance; Astrocytosis; Neurodegeneration;
Novel methyl substituted 1-(5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanones are P2X7 antagonists
Keywords: P2X7; 5,6-Dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanones; Depression; CNS;
Purinergic signaling in the immune system
Keywords: Extracellular ATP; Purinergic receptors; P2X4; P2X7; Innate immunity
Blockage of P2X7 attenuates acute lung injury in mice by inhibiting NLRP3 inflammasome
Keywords: Acute lung injury; P2X7; Inflammasome; IL-1β; Neutrophils
Low-intensity pulsed ultrasound-induced ATP increases bone formation via the P2X7 receptor in osteoblast-like MC3T3-E1 cells
Keywords: Low-intensity pulsed ultrasound; Adenosine triphosphate; P2X7; Osteogenesis;
A novel radioligand for the ATP-gated ion channel P2X7: [3H] JNJ-54232334
Keywords: P2X7; Radioligand binding; Depression; Autoradiography; Receptor occupancy; JNJ-54232334; JNJ-54140515;
Oxaliplatin evokes P2X7-dependent glutamate release in the cerebral cortex: A pain mechanism mediated by Pannexin 1
Keywords: Chemotherapy-induced neuropathy; Oxaliplatin; P2X7; Pannexin 1; Synaptosome;
Effect of GLT-1 modulator and P2X7 antagonists alone and in combination in the kindling model of epilepsy in rats
Keywords: GLT-1; P2X7; Ceftriaxone; Brilliant Blue G; Pentylenetetrazole;
Overexpression of tissue-nonspecific alkaline phosphatase increases the expression of neurogenic differentiation markers in the human SH-SY5Y neuroblastoma cell line
Keywords: 36B4; ribosomal protein, large, P0; AADC; aromatic l-amino acid decarboxylase; AD; Alzheimer's disease; ALPL/TNAP/Akp2; tissue-nonspecific alkaline phosphatase; AT; annealing temperature; ATP; adenosine triphosphate; ADP; adenosine diphosphate; AMP; adeno
Understanding the roles of the P2X7 receptor in solid tumour progression and therapeutic perspectives
Keywords: P2X7; Extracellular ATP; Cancer; Biomarker; Pharmacological target
Cathelicidin peptide LL-37 increases UVB-triggered inflammasome activation: Possible implications for rosacea
Keywords: Rosacea; Cathelicidin LL-37; UVB; Inflammasome; Angiogenesis; P2X7
P2X7 receptors mediate resistance to toxin-induced cell lysis
Keywords: HEK; human embryonic kidney 293 cells; HMC-1; human mast cell line 1; P2X7R; P2X7 receptor; RT; room temperature; SLO; streptolysin O; P2X7; Plasmalemma; Blebbing; Calcium; Lysis; Annexin;
Involvement of RVM-expressed P2X7 receptor in bone cancer pain: Mechanism of descending facilitation
Keywords: Bone cancer pain; Descending facilitation; P2X7; RVM;
Pharmacological blockage and P2X7 deletion hinder aversive memories: Reversion in an enriched environment
Keywords: ANOVA; analysis of variance; BBG; Brilliant Blue G; EE; enriched environment; FC; fear-conditioning; KO; knockout; LTM; long-term memory; LTP; long-term potentiation; MWM; Morris water maze; NE; non-enriched environment; P2X7R; P2X7 receptor; RM; repeated
Chronic stress induces prolonged suppression of the P2X7 receptor within multiple regions of the hippocampus: A cumulative threshold spectra analysis
Keywords: Stress; Rat; Purines; P2X7; Hippocampus; ATP;
P2X7 receptor activation regulates microglial cell death during oxygen-glucose deprivation
Keywords: Microglia; Stroke; P2X7; Cell death; ATP; OGD;
High glucose concentration impairs ATP outflow and immunoglobulin production by human peripheral B lymphocytes: Involvement of P2X7 receptor
Keywords: PBL; peripheral blood lymphocytes; SAC; crude extract of Staphylococus aureus Cowan I; FITC; fluorescein isothiocyanate; PE; phycoerythrin; PPADS; pyridoxal 5-phosphate 6-azophenyl-2â²,4â²-disulfonic acid; PPNDS; pyridoxal-5â²-phosphate-6-2â²-naphthyl
Ketamine, magnesium and major depression – From pharmacology to pathophysiology and back
Keywords: Major depression; Ketamine; Magnesium; Synaptogenesis; NMDA; NR2b; CP-AMPA; mTOR; CaMKII; P2X7; Aldosterone; Slow wave sleep; Stress
Protection from asthma in a high-risk birth cohort by attenuated P2X7 function
Keywords: Asthma; allergy; children; P2X7; ATPCOAST, Childhood Origins of Asthma; DC, Dendritic cell; HBS, HEPES-buffered saline; HRV, Human rhinovirus; LOF, Loss of function; MFI, Median fluorescence intensity; OR, Odds ratio; P2RX7, P2X7 receptor gene
Feasibility study of B16 melanoma therapy using oxidized ATP to target purinergic receptor P2X7
Keywords: Oxidized ATP; Purinergic receptor; P2X7; Inhibition; Tumor growth
P2X7 receptor blockade prevents ATP excitotoxicity in neurons and reduces brain damage after ischemia
Keywords: Excitotoxicity; Ischemia; Neuronal damage; P2X7;
Extracellular NAD+: a danger signal hindering regulatory T cells
Keywords: ATP; NAD; P2X7; Danger signals; Tregs; ADPR; adenosine diphosphate ribose; APC; antigen presenting cell; ART; mono-ADP-ribosyl transferase; ATP; adenosine triphosphate; cADPR; cyclic ADP-ribose; DC; dendritic cell; NAD+; nicotinamide adenine dinucleotide;