Keywords: Aβ; amyloid-β; BBB; blood-brain-barrier; CaMKII; calcium calmodulin kinase II; CFC; contextual fear conditioning test; DAG; diacylglycerol; F3; fibronectin type III module; FGFR; fibroblast growth factor receptor; GABAAR; γ-aminobutyric acid A recept
مقالات ISI (ترجمه نشده)
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Keywords: BSA; bovine serum albumin; CL; cardiolipin; Dd; dodecahedron; ECL; enhanced chemiluminescence; FBS; fetal bovine serum; GUV; giant unilamellar vesicle; HAd3; human adenovirus serotype 3; HRP; horseradish peroxidase; HSPG; heparan sulphate proteoglycan; LU
Keywords: ACh; acetylcholine; AChE; acetylcholinesterase; AChEIs; acetylcholinesterase inhibitors; ASD; Autism Spectrum Disorder; BuChE; pseudocholinesterase; EDs; endocrine disruptors; PIP2; phosphatidylinositol (3,4)-bisphosphate; PIP3; phosphatidylinositol (3,4,
Keywords: 3-MP; 3-mercaptopyruvate; 3-MST; 3-mercaptopyruvate sulfurtransferase; AAT; aspartate amino transferase; AE1; anion exchanger-1; AGEs; advanced glycation end products; AKI; acute kidney injury; AMPK; AMP-activated protein kinase; AT1; angiotensin receptor
Keywords: 27-HC; 27-Hydroxycholesterol; 3PO; 3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one; ABCG1; ATP-binding cassette subfamily G1; ACBA1; ATP-binding cassette subfamily A1; ACC1; Acetyl-Co-A carboxylase-1; AKAP4; A-kinase anchoring protein 4; ALDO; Aldolase; AM
Keywords: Lipocalin 2; Fat; MCD; NASH; PIP3; Oxidative stress; Mitochondria;
Keywords: AD; Alzheimer's disease; BBB; blood brain barrier; RAGE; Receptor for Advanced Glycation End products; AGE; advanced glycation end products; IL1β; interleukin 1 beta; Aβ; amyloid beta; TNF â;  tumor necrosis factor alpha; TGFβ; transforming growth
Keywords: Cytokines; Signal transduction; Drug development; Inflammation; Autoimmunity; Therapy; JAK; Janus Kinase; STAT; Signal transducer and activator of transcription; NF-kB; nuclear factor kappa-light-chain-enhancer of activated B cells; MAPK; Mitogen activate
Keywords: Synergy; Ferulic acid; Metformin; Anti-diabetic agents; AMPK, PI-3K; Akt; protein kinase B; AMPK; AMP-activated protein kinase; DM; Diabetes mellitus; G6Pase; glucose-6-phosphatase; IRS; Insulin receptor substrate; LD50; lethal dose 50%; PDK-1; 3-phosphoi
Keywords: ACSL; Acyl-CoA synthetases; ANOVA; analysis of variance; CHP; cumene hydroperoxide; CPT1; carnitine palmitoyltransferase 1; CRAT; carnitine acetyltransferase; DHB; 2,5-dihydroxybenzoic acid; FABP; fatty acid binding protein; FCCP; carbonyl cyanide-4-(trif
Keywords: Sortilin; VLDL-B100; Neurotensin; Surface plasmon resonance; PIP3; phosphatidylinositol (3,4,5)-trisphosphate; diC4-PIP3; dibutanoyl PIP3; hsortilin; human recombinant sortilin; NT; neurotensin; C-term; carboxy terminus; N-term; amino terminus; SPR; surfa
Keywords: (I-R); ischemia-reperfusion injury; IPC; ischemia preconditioning; ROS; reactive oxygen species; RNS; reactive nitrogen species; (ONOOâ); peroxynitrite; PI3K; phosphatidylinositol 3-kinase; PIP3; phosphatidyl-inositol 3,4,5-triphosphate; PIP2; phosp
Keywords: AP1; Activator protein 1; cAMP; Cyclic adenosine monophoshate; CXCR; Cytokine receptors; CRTH2; Chemoattractant receptor-homologous molecule expressed on Th2 cells; DAMPs; Damage-associated molecular pattern; EtBr; Ethidium Bromide; IgE; Immunoglobulin E;
Keywords: Beta cells; Diabetes; Eicosanoids; Fatty aldehyde dehydrogenase; Glutathione peroxidase; Glutathione-S-transferase4-hydroxyalkenals; 4-Hydroxynonenal; Lipid peroxidation; Phospholipase A; 12-HETE (PubChem CID: 5283155); 15-HETE (PubChem CID: 280724); 4-HN
Keywords: AKT; protein kinase B; ATF4; activating transcription factor 4; cAMP; cyclic adenosine monophosphate; CCL5; (C-C motif) ligand 5; CNS; central nervous system; 4EBP1; 4E (elF4E) binding protein; ECM; extracellular matrix; ERK; p44/p42 extracellular signal-
Keywords: AA; arachidonic acid; Cygb; cytoglobin; Cyt c; cytochrome c; DOPA; dioleyl phosphatidic acid (1,2-dioleoyl-sn-glycero-3-phosphate); DOPC; dioleyl phosphatidyl choline (1,2 Dioleoyl-sn-glycero-3-phosphocholine); DTPA; diethylenetriaminepentaacetic acid; DT
Keywords: Membrane; Lipid; Receptor; Membrane properties; Signaling; Host-pathogen; AC; adenylyl cyclase; CaMK; Ca2+-calmodulin-dependent protein kinase; cAMP; cyclic adenosine monophosphate; ChOx; cholesterol oxidase; CREB; cAMP response element-binding protei
Keywords: AA; arachidonic acid; Aβ; fibrillar β-amyloid; ACC; acetyl-CoA carboxylase; Akt; protein kinase B; APP; amyloid precursor protein; ASAH2; neutral ceramidase; BA; benzyl alcohol; BBB; blood-brain-barrier; BMI; body mass index; BPM; bis(monoacylglycero)
Keywords: OS; overall survival; MAPK; mitogen-activated protein kinase; RTKs; receptor tyrosine kinases; PI3K; phosphatidylinositide 3-kinases; GEFs; guanine nucleotide exchange factors; GAPs; GTPase-activating proteins; FTIs; farnesyltransferase inhibitors; mTOR;
Keywords: Lipid rafts; Signal transduction; IGF-I/PI3K/Akt signaling; Fas/CD95; CASMER; Cancer; APL; alkylphospholipid analogue; CASMER; cluster of apoptotic signaling molecule-enriched rafts; DED; death effector domain; DD; death domain; DISC; death-inducing signa
Keywords: AchR; acethylcholine receptor; AP-1; activator protein 1; cAMP; cyclic adenosine monophosphate; cdc42; cell division control protein 42 homolog; cGMP; cyclic guanosine monophosphate; CNS; central nervous system; EF; electric filed; EGFR; epidermal growth
Keywords: Orexin; Hypocretin; Phospholipase; Endocannabinoid; Ion fluxes; 2-AG; 2-arachidonoylglycerol; AA; arachidonic acid; anandamide; N-arachidonoylethanolamine; CNS; central nervous system; cPLA2 and iPLA2; cytosolic (Ca2+-dependent) and intracellular (Ca2+-in
Keywords: DIC; differential interference contrast; HUVECs; human umbilical vein endothelial cells; PIP2; phosphatidylinositol 4,5-bisphosphate; TBS; Tris-buffered saline; DAG; 1,2-diacylglycerol; IP3; inositol 1,4,5-trisphosphate; MβCD; methyl-β-cyclodextrin; PI3
Keywords: Akt; protein kinase B; DHA; docosahexaenoic acid; ERK; extracellular signal-regulated protein kinase; NAPE; N-acylphosphatidylethanolamine; PC; phosphatidylcholine; PDK1; phosphoinositide-dependent kinase-1; PE; phosphatidylethanolamine; PEMT; phosphatidy
Keywords: BM; basement membrane; ECM; extracellular membrane; EMT; epithelial mesenchymal transition; FAK; focal adhesion kinase; MAPK; mitogen-activated protein kinase; LOH; loss of heterozygosity; NCOR1; nuclear receptor co-repressor 1; MMP; matrix metalloprotein
Keywords: ALP; alkylphospholipid; ASK1; apoptosis signal-regulating kinase 1; CT; CTP:phosphocholine cytidylyltransferase; DISC; death-inducing signaling complex; EGF; epidermal growth factor; ER; endoplasmic reticulum; ERK; extracellular-signal-regulated kinase; J
Keywords: AP-1; adaptor protein 1; ASL; airway surface liquid; CCO; cytochrome c oxidase; CF; cystic fibrosis; COX-2; cyclooxygenase 2; Csk; c-src kinase; DMEM; Dulbeccos' minimal essential medium; DMT1; divalent metal ion transporter 1; DUOX; dual oxidase; EGFR;
Keywords: Abl; Abelson leukemia proto-oncogene; ADAP; adhesion and degranulation promoting adapter protein (Fyb, SLAP-130); Asc; apoptosis-associated speck-like protein containing a CARD; BCR; B-cell receptor; C3G; Crk SH3 domain-binding guanine nucleotide exchange
Keywords: AMPK; AMP activated protein kinase; ECM; extracellular matrix; EGFR; epidermal growth factor receptor; EMT; epithelial-mesenchymal transition; ERK; extracellular signal-regulated kinase; FLIP; FLICE inhibitory protein; FAK; focal adhesion kinase; GSK-3;
AKT1 distinctively suppresses MyD88-depenedent and TRIF-dependent Toll-like receptor signaling in a kinase activity-independent manner
Keywords: TLR; Toll-like receptor; TRIF; Toll/IL-1R domain-containing adaptor inducing IFN-β; LPS; lipopolysaccharide; KD; kinase-dead; IRAK; IL-1R-associated kinase; ISG; interferon stimulated gene; PIP3; phosphatidylinositol (3,4,5) trisphosphate; PH; pleckstrin
Targeting AgRP neurons to maintain energy balance: Lessons from animal models
Keywords: ARC; arcuate nucleus; POMC; proopiomelanocortin; GABA; γ-aminobutyric acid; LHA; lateral hypothalamic nucleus; VHA; ventromedial nuclei; PVH; paraventricular; PBN; parabrachial nuclei; MSH; melanocyte-stimulating hormone; CART; amphetamine-stimulating ho
Coordinated regulation of hepatic FoxO1, PGC-1α and SREBP-1c facilitates insulin action and resistance
Keywords: aPKC; atypical protein kinase C; ACC; acetyl-CoA carboxylase; ACPD; 2-acetyl-cyclopentane-1,3-dione; AMPK; AMP-activated protein kinase; Akt; protein kinase B; FAS; fatty acid synthase; FoxO1; forkhead homeobox class O1 protein; G6Pase; glucose-6-phosphat
Re-evaluating the role of FOXOs in cancer
Keywords: RTK; receptor tyrosine kinase; GF; growth factor; PI3K; Phosphatidylinositol-4,5-bisphosphate 3-kinase; PKB; protein kinase B; AKT; RAC-alpha serine/threonine-protein kinase; FOXO; forkhead box O; GFR; growth factor receptor; PDPK1; Phosphoinositide-depen
The beneficial effects of Zn on Akt-mediated insulin and cell survival signaling pathways in diabetes
Keywords: Akt2-KO; Akt2 gene deletion; CHO; Chinese hamster ovary; DM; diabetes mellitus; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; ER; endoplasmic reticulum; GLUT4; glucose transporter type-4; GS; glycogen synthase; GSK-3; glycogen synt
β-Heregulin impairs EGF induced PLC-γ1 signalling in human breast cancer cells
Keywords: ErbB receptors; Breast cancer; EGF; β-Heregulin; Signal transduction; DAG; diacylglycerol; FCS; foetal calf serum; IP3; inositol-1,4,5-trisphosphate; MDA-HER2; MDA-MB-468-HER2; MDA-NEO; MDA-MB-468-NEO; MDA-PM; MDA-MB-468-PM; PI3K; phosphatidyl-inositol-3
KRAS-Mutant non-small cell lung cancer: From biology to therapy
Keywords: BATTLE; Biomarker-Integrated Approaches of Targeted Therapy for Lung Cancer Elimination; BET; bromodomains and extra-terminal domain; CDK; cyclin-dependent kinase; Chk1; checkpoint kinase 1; CI; confidence interval; CUSTOM; Molecular Profiling and Targete
Redox biosensors in a context of multiparameter imaging
Keywords: CaMKII; Ca2+/calmodulinâdependent protein kinase II; CFP; cyan fluorescent protein; cpGFP; circularly permuted green fluorescent protein; cpFP; circularly permuted fluorescent protein; cpYFP; circularly permuted yellow fluorescent protein; CRDR; CellROX
High-fat diet alters PAS kinase regulation by fasting and feeding in liver
Keywords: ACC; acetyl CoA carboxylase; Akt/PKB; protein kinase B; CHREBP; carbohydrate-responsive element-binding protein; CPT1-A; carnitine palmitoyltransferase 1A; DAPI; 4,6-diamidino-2-phenylindole; FAS; fatty acid synthase; FOXO1; forkhead box protein O1; GCK;
The role of insulin signalling in the endocrine stress response in Drosophila melanogaster: A mini-review
Keywords: JH; juvenile hormone; JHE; JH-esterase; DA; dopamine; ALP; alkaline phosphatase; TH; tyrosine hydroxylase; OA; octopamine; TDC; tyrosine decarboxylase; 20E; 20-hydroxyecdysone; E20MO; ecdysone 20-monooxygenase; CA; corpus allatum; IIS; insulin/insulin-lik
Mapping Txnip: Key connexions in progression of diabetic nephropathy
Keywords: ARRB; arrestin beta; ARRDC; arrestin domain containing protein; ASK-1; apoptosis signal-regulating kinase-1; Cys; cysteine; ECM; extracellular matrix; FOXO; forkhead box protein; Gly; glycine; IL-1β; interleukin-1 β; JNK; c-Jun-N-terminal kinase; MAPK;
F2-isoprostanes affect macrophage migration and CSF-1 signalling
Keywords: Akt; Protein Kinase B; BMM; Bone Marrow derived Macrophages; BSA; Bovine Serum Albumin; Chol-IsoP; Cholesterol-Isoprostane; CSF-1; Colony Stimulating Factor-1; CSF-1R; Colony Stimulating Factor-1 Receptor; DAPI 4â²; 6-Diamidino-2-phenylindole; DMSO; Dime
PI3K pathway in prostate cancer: All resistant roads lead to PI3K
Keywords: CRPC; castration-resistant prostate cancer; ADT; androgen deprivation therapy; PI3K; phosphoinositide 3-kinase; AR; androgen receptor; PTEN; phosphatase and tensin homologue deleted on chromosome 10; INPP4B; inositol polyphosphate 4-phosphatase type II; P
The FOXO3-FOXM1 axis: A key cancer drug target and a modulator of cancer drug resistance
Keywords: ABCB1; ATP-binding cassette sub-family B member 1; AML; acute myeloid leukaemia; AMPK; adenosine monophosphate-activated protein kinase; ATM; Ataxia-telangiectasia mutated; AURKA; aurora kinase A; BER; base excision repair; Bim; B-cell lymphoma 2 interact
Ca2+ signaling and Src-kinases-controlled cellular functions
Keywords: Ca2+ channels; Cell signaling; Phosphatases; Receptors; Src-family kinases; A23187; 5-(methylamino)-2-({(2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(1S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl]-1,7-dioxaspiro[5.5]undec-2-yl}methyl)-1,3-benzoxazole-4-carboxyli
Smooth muscle cell-driven vascular diseases and molecular mechanisms of VSMC plasticity
Keywords: Vascular smooth muscle; Vasoproliferative disease; Vascular smooth muscle cell; Phenotype switching; Signalling pathways; AJ; adherens junction; ApoE; apolipoprotein E; BMP; bone morphogenetic protein; CAD; coronary artery diseases; CADASIL; cerebral auto
H. pylori infection increases gastric mucosal COX2 and mTOR expression in chronic gastritis: Implications for cancer progression?
Keywords: H. pylori; Helicobacter pylori; GOD; Oesophago-gastroduodenoscopy; COX2; Cyclooxygenase-2; COX1; Cyclooxygenase-1; mTOR; Mechanistic target of rapamycin; PI3âK; Phosphatidylinositol-3-kinase; PIP3; Phosphatidyl-inositol 3,4,5-triphosphate; ILK; Integrin
Original research articleImmunohistochemical analysis of PTEN, HER2/neu, and ki67 expression in patients with gastric cancer and their association with survival
Keywords: PTEN; phosphatase and tensin homolog; HER2; human epidermal growth factor receptor 2; OS; overall survival; DFS; disease free survival; TNM; tumor-node-metastasis; PIP3; phosphatidylinositol-(3,4,5)-triphosphate; TK; tyrosine kinase; EGFRs; epidermal grow
Targeting energy metabolism of cancer cells: Combined administration of NCL-240 and 2-DG
Keywords: ATP; adenosine triphosphate; HIF1-α; hypoxia inducible factor 1-α; GLUT; glucose transporter; DM-PIT-1; N-[(2-hydroxy-5-nitrophenyl)amino]carbonothioyl-3,5-dimethylbenzamide; PI3K; phosphoinositide 3-kinase; PIP3; phosphatidylinositol-3,4,5-triphosphate
Phosphoinositide 3-kinase γ ties chemoattractant- and adrenergic control of microglial motility
Keywords: Akt; protein kinase Akt/PKB; ATP; Adenosine triphosphate; C5a; complement system component 5a; C5aR; complement system component 5a receptor; cAMP; Cyclic adenosine monophosphate; DAPI; 4â²,6-diamidino-2-phenylindole; HRP; horseradish peroxidase; PIP3; p
Depsidone and xanthones from Garcinia xanthochymus with hypoglycemic activity and the mechanism of promoting glucose uptake in L6 myotubes
Keywords: GLUT4; glucose transporter type 4; PI3K; phosphatidylinositol-3 kinase; PKB/Akt; serine/threonine kinase protein kinase B; AMPK; AMP-activated protein kinase; DM; diabetes mellitus; T2DM; type 2 diabetes mellitus; DMEM; Dulbecco's modified Eagle's med