دانلود مقالات ISI درباره Tetrahydrobiopterin + ترجمه فارسی

The tetrahydrobiopterin radical interacting with high- and low-spin heme in neuronal nitric oxide synthase - A new indicator of the extent of NOS coupling

Keywords: arg; arginine; BH4; tetrahydrobiopterin; CW; continuous wave; ED-EPR; echo-detected EPR; ENDOR; electron nuclear double resonance; EPR; electron paramagnetic resonance, also known as ESR or electron spin resonance; HYSCORE; hyperfine sublevel correlation

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Targeting the nNOS/peroxynitrite/calpain system to confer neuroprotection and aid functional recovery in a mouse model of TBI

Keywords: BH4; tetrahydrobiopterin; CCI; controlled cortical impact; FeTPPS; 5,10,15,20-tetrakis(4-sulfonatophenyl) porphyrinato iron (III); HgCl2; mercuric chloride; GSNO; S-nitrosoglutathione; MBP; myelin basic protein; NeuN; neuronal nuclear protein; 7-NI; 7-nit

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

Updated, web-based nutrition management guideline for PKU: An evidence and consensus based approach

Keywords: ACMG; American College of Medical Genetics; AGREE II; Appraisal of Guidelines for Research and Evaluation; BH4; tetrahydrobiopterin; BMD; bone mineral disease; DRI; dietary reference intake; DXA; dual x-ray absorptiometry; EF; executive function; FFM; fat

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

Rat aorta as a pharmacological tool for in vitro and in vivo studies

Keywords: BH4; tetrahydrobiopterin; cGMP; cyclic guanine monophosphate; COX; cyclooxygenase; cNOS; constitutive NOS; DAG; diacylglycerol; DMEM; Dulbecco's modified eagle's medium; eNOS; endothelial NOS; EDHF; endothelium dependent hyperpolarization factor; EGTA; et

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2016 سفارش ترجمه

Effect of asymmetric dimethylarginine (ADMA) on heart failure development

Keywords: Nitric oxide; Asymmetric dimethylarginine; Dimethylarginine dimethylaminohydrolase-1; Heart failure; CHF; chronic Heart failure; ADMA; Asymmetric dimethylarginine; BH4; tetrahydrobiopterin; DDAH1; dimethylarginine dimethylaminohydrolase 1; PRMT1; type 1 p

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2016 سفارش ترجمه

Photoinactivation of tyrosinase sensitized by folic acid photoproducts

Keywords: A; absorbance of the reactant at the excitation wavelength; Aemi; absorbance of the system at emission wavelengths; Aexc; absorbance of the system at excitation; qn,pa,V; absorbed photon flux density; Bip; biopterin; Cap; 6-carboxypterin; IFcorr; correcte

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

Individualized long-term outcomes in blood phenylalanine concentrations and dietary phenylalanine tolerance in 11 patients with primary phenylalanine hydroxylase (PAH) deficiency treated with Sapropterin-dihydrochloride

Keywords: Tetrahydrobiopterin; Cofactor; Medical nutrition therapy; Pharmacologic therapy; Outcome;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Minimally invasive 13C-breath test to examine phenylalanine metabolism in children with phenylketonuria

Keywords: 13C-PBT; phenylalanine breath test; APE; atom percent excess; BH4; tetrahydrobiopterin; F13CO2; rate of 1-13C-phenylalanine tracer oxidation; HPA; hyperphenylalaninemia; Phe; phenylalanine; PKU; phenylketonuria; PAH; phenylalanine hydroxylase; Phenylketon

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Long-term safety and efficacy of sapropterin: The PKUDOS registry experience

Keywords: AE; adverse event; PKU; phenylketonuria; Phe; phenylalanine; BH4; tetrahydrobiopterin; PKUDOS; phenylketonuria demographics, outcomes and safety; PAH; phenylalanine hydroxylase; Phenylketonuria; Phenylalanine; Sapropterin;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Gender specific generation of nitroxyl (HNO) from rat endothelium

Keywords: ACh; acetylcholine; AS; Angeli's salt; BH4; tetrahydrobiopterin; DEA/NO; diethylamine NONOate; EC; endothelial cell; eNOS; endothelial nitric oxide synthase; GSH; glutathione; HNO; nitroxyl; l-NAME; NG-nitro-l-arginine methyl ester; NO; nitric oxide radic

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Molecular and enzymatic characterization of two enzymes BmPCD and BmDHPR involving in the regeneration pathway of tetrahydrobiopterin from the silkworm Bombyx mori

Keywords: Bombyx mori; Tetrahydrobiopterin; Regeneration pathway; Pterin-4a-carbinolamine dehydratase; Dihydropteridine reductase

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Characterization of cerebral microvasculature in transgenic mice with endothelium targeted over-expression of GTP-cyclohydrolase I

Keywords: Tetrahydrobiopterin; Endothelial nitric oxide synthase; GTP-cyclohydrolase I; Cerebral microvessel;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Tetrahydrobiopterin reverse left ventricular hypertrophy and diastolic dysfunction through the PI3K/p-Akt pathway in spontaneously hypertensive rats

Keywords: Tetrahydrobiopterin; Hypertrophy; Diastolic dysfunction; Phosphorylated Akt; Cardiac oxidation;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Liposomal tetrahydrobiopterin preserves eNOS coupling in the post-ischemic heart conferring in vivo cardioprotection

Keywords: Tetrahydrobiopterin; Ischemia/reperfusion; Myocardial BH4 content; NOS activity; Oxidative stress; Myocardial protection;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

A requirement for Gch1 and tetrahydrobiopterin in embryonic development

Keywords: GCH; Development; Embryo; Heart; Tetrahydrobiopterin;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Regulation of iNOS function and cellular redox state by macrophage Gch1 reveals specific requirements for tetrahydrobiopterin in NRF2 activation

Keywords: As3MT; arsenic(III)-methyltransferase; BH4; tetrahydrobiopterin; [Fe(DETC)2]; colloid iron (II) diethyldithiocarbamate; GTPCH; GTP cyclohydrolase 1; 2-HE; 2-hydroxyethidium; iNOS; inducible nitric oxide synthase; ROS; reactive oxygen species.; Tetrahydrob

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Oxidized LDL and NO synthesis-Biomarkers of endothelial dysfunction and ageing

Keywords: LDL; low-density lipoprotein; oxLDL; oxidized low-density lipoprotein; LOX-1; lectin-like oxidized LDL receptor-1; FFA; free fatty acids; ApoB-100; apolipoprotein B-100; H2O2; hydrogen peroxide; SOD; superoxide dismutase; ROS; reactive oxygen species; O2â

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

Tetrahydrobiopterin (BH4) responsiveness in neonates with hyperphenylalaninemia: A semi-mechanistically-based, nonlinear mixed-effect modeling

Keywords: BH4; tetrahydrobiopterin; CI; confidence interval; CV; coefficient of variation; DHPR; dihydropteridine reductase; GTPCH; guanosine triphosphate cyclohydrolase I; HPA; hyperphenylalaninemia; K-PD; kinetic pharmacodynamic; PAH; phenylalanine hydroxylase; P

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2015 سفارش ترجمه

Sapropterin Is Safe and Effective in Patients less than 4-Years-Old with BH4-Responsive Phenylalanine Hydroxylase Deficiency

Keywords: BH4; Tetrahydrobiopterin; PAH; Phenylalanine hydroxylase; Phe; Phenylalanine;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2014 سفارش ترجمه

A functional polymorphism of the GTP cyclohydrolase 1 gene predicts attention performance

Keywords: BH4; tetrahydrobiopterin; CPT-IP; continuous performance test-identical pairs version; GCH1; GTP cyclohydrolase 1; SNP; single-nucleotide polymorphism; Attention/vigilance; Continuous performance test; GTP cyclohydrolase 1; SNP; Tetrahydrobiopterin;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2014 سفارش ترجمه

Współwystępowanie dwóch rzadkich chorób genetycznych: fenyloketonurii oraz zespołu Pradera i Williego. Opis przypadku

Keywords: fenyloketonuria; zespół Pradera i Williego; hydroksylaza fenyloalaniny; tetrahydrobiopteryna; Phenylketonuria; Prader-Willi Syndrome; Phenylalanine hydroxylase; Tetrahydrobiopterin;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

Research ArticleLiver sinusoidal endothelial dysfunction after LPS administration: A role for inducible-nitric oxide synthase

Keywords: LPS; lipopolysaccharide; MOF; multi-organ failure; iNOS; inducible nitric oxide synthase; eNOS; endothelial NOS; ICG; indocyanine green; ED; endothelial dysfunction; DHE; dihydroethidium; PPP; portal perfusion pressure; BH4; tetrahydrobiopterin; Sepsis; 1

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Does vitamin C enhance nitric oxide bioavailability in a tetrahydrobiopterin-dependent manner? In vitro, in vivo and clinical studies

Keywords: Tetrahydrobiopterin; Dihydrobiopterin; Ascorbate; Nitric oxide bioavailability;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Sapropterin dihydrochloride use in pregnant women with phenylketonuria: An interim report of the PKU MOMS sub-registry

Keywords: AE; adverse event; Apgar; Appearance, Pulse, Grimace, Activity, Respiration; BH4; tetrahydrobiopterin; BMI; Body Mass Index; CDC; Centers for Disease Control and Prevention; ID; identification; LMP; last menstrual period; OFC; occipitofrontal circumferenc

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Anxiety- and depression-like phenotype of hph-1 mice deficient in tetrahydrobiopterin

Keywords: BH4; tetrahydrobiopterin; NO; nitric oxide; NOS; nitric oxide synthase; GTP-CH1; guanosine triphosphate cyclohydrolase 1; DRD; DOPA-responsive dystonia; hph-1; hyperphenylalaninemia 1; WT; wild-type; hph; homozygous hph-1; DOPAC; deuterium-labelled 3,4-di

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

α-Synuclein and mitochondrial bioenergetics regulate tetrahydrobiopterin levels in a human dopaminergic model of Parkinson disease

Keywords: PD; Parkinson disease; SNPc; substantia nigra pars compacta; α-syn; α-synuclein; GTPCH; GTP cyclohydrolase I; MPTP; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; MPP+; 1-methyl-4-phenylpyridinium; NOS; nitric oxide synthase; DAT; dopamine transporter; B

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2014 سفارش ترجمه

White matter integrity and executive abilities following treatment with tetrahydrobiopterin (BH4) in individuals with phenylketonuria

Keywords: Phenylketonuria; Tetrahydrobiopterin; Sapropterin; White matter; Diffusion tensor imaging; Executive;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Chronic hypoxia inhibits tetrahydrobiopterin-induced NO production in rat lungs

Keywords: Hypoxia; Pulmonary hypertension; NO synthase; Tetrahydrobiopterin;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Mechanism of action of salsolinol on tyrosine hydroxylase

Keywords: AADC; aromatic amino acid decarboxylase; BH4; tetrahydrobiopterin; DA; dopamine; KM; Michaelis constant; l-DOPA; l-dihydroxylphenylalanine; IC50; concentration of inhibitor producing 50% inhibition; OC; ovalbumin coated; PKA; protein kinase A; SAL; salsol

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Tyrosine metabolism during interferon-alpha administration: Association with fatigue and CSF dopamine concentrations

Keywords: Interferon-alpha; Dopamine synthesis; Tyrosine metabolism; Tetrahydrobiopterin; Depression; Fatigue;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Tetrahydrobiopterin therapy vs phenylalanine-restricted diet: Impact on growth in PKU

Keywords: Tetrahydrobiopterin; Phenylketonuria; Growth;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Dopamine but not l-dopa stimulates neural glutathione metabolism. Potential implications for Parkinson's and other dopamine deficiency states

Keywords: l-dopa; l-3,4-dihydroxyphenylalanine; AADC; aromatic l-amino acid decarboxylase; BH4; tetrahydrobiopterin; ROS; reactive oxygen species; GSH; reduced glutathione; GSSG; glutathione disulphide; FBS; foetal bovine serum; DOPAC; 3,4-dihydroxyphenylacetic aci

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Electrochemically driven biocatalysis of the oxygenase domain of neuronal nitric oxide synthase in indium tin oxide nanoparticles/polyvinyl alcohol nanocomposite

Keywords: Nitric oxide synthase; Tetrahydrobiopterin; Nω-hydroxy-l-arginine; Indium tin oxide nanoparticles; Biocatalysis

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Modulation of NO and ROS production by AdiNOS transduced vascular cells through supplementation with L-Arg and BH4: Implications for gene therapy of restenosis

Keywords: Nitric oxide; Restenosis; Gene therapy; L-Arg; Tetrahydrobiopterin; Smooth muscle cells; Inducible nitric oxide synthase

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

The regulation of vascular tetrahydrobiopterin bioavailability

Keywords: Tetrahydrobiopterin; GTP cyclohydrolase 1; Nitric oxide synthase; Endothelial

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2013 سفارش ترجمه

START, a double blind, placebo-controlled pharmacogenetic test of responsiveness to sapropterin dihydrochloride in phenylketonuria patients

Keywords: Medication therapy management; Pharmacogenetics; Phenylketonuria; PKU; Tetrahydrobiopterin; Sapropterin dihydrochloride

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Assessment of tetrahydrobiopterin (BH4)-responsiveness and spontaneous phenylalanine reduction in a phenylalanine hydroxylase deficiency population

Keywords: Phenylketonuria; PKU; BH4-responsiveness; Tetrahydrobiopterin; Phe; PAH;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Direct detection of tetrahydrobiopterin (BH4) and dopamine in rat brain using liquid chromatography coupled electrospray tandem mass spectrometry

Keywords: Tetrahydrobiopterin; Dopamine; Rat brain; Tandem mass spectrometry;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Functional evidence for nitric oxide production by skeletal-muscle mitochondria from lipopolysaccharide-treated mice

Keywords: BH4; tetrahydrobiopterin; CcO; cytochrome c oxidase; FCCP; carbonylcyanide p-(trifluoromethoxy) phenylhydrazone; L-NMMA; NG-monomethyl-L-arginine; LPS; lipopolysaccharide; mtNOS; mitochondrial NOS; NO; nitric oxide; NOS; NO synthase; Mitochondrial NOS (mt

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Quantification of phenylalanine hydroxylase activity by isotope-dilution liquid chromatography–electrospray ionization tandem mass spectrometry

Keywords: LC–ESI-MSMS, liquid chromatography electrospray ionization tandem mass spectrometry; Phe, phenylalanine; Tyr, tyrosine; PAH, phenylalanine hydroxylase; PKU, phenylketonuria; BH4, tetrahydrobiopterinPhenylketonuria; Tetrahydrobiopterin; Hyperphenylalaninem

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Advanced glycation end products-mediated hypertrophy is negatively regulated by tetrahydrobiopterin in renal tubular cells

Keywords: Advanced glycation end products; GTP cyclohydrolase I; Hypertrophy; Inducible nitric oxide synthase; Nitric oxide; Tetrahydrobiopterin;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Tetrahydrobiopterin ameliorates hepatic ischemia-reperfusion Injury by coupling with eNOS in mice

Keywords: Tetrahydrobiopterin; Hepatic ischemia-reperfusion injury; Endothelial nitric oxide synthase; Nitric oxide

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Preconditioning the hyperlipidemic myocardium: Fact or fantasy?

Keywords: I/R; ischemia-reperfusion; FWOP; first window of protection; SWOP; second window of protection; TWOP; third window of protection; BH4; tetrahydrobiopterin; eNOS; endothelial nitric oxide synthase; TNF-α; tumor necrosis factor-α; MAPK; mitogen-activate

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Brassica juncea nitric oxide synthase like activity is stimulated by PKC activators and calcium suggesting modulation by PKC-like kinase

Keywords: BjNOSla; l-NAME; NBT; Nitric oxide; Nitric oxide synthase; Phosphorylation; Protein kinase-C; 1,2-DG6; 1,2-dihexanoylglycerol; 4αPDD; 4α-phorbol 12,13-didecanoate; BH4; tetrahydrobiopterin; BjNOSla; Brassica juncea nitric oxide synthase like activity; C

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Allosteric regulation of phenylalanine hydroxylase

Keywords: Phenylalanine hydroxylase; Allostery; Regulation; Phosphorylation; Tetrahydrobiopterin

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Recommendations for the use of sapropterin in phenylketonuria

Keywords: Phenylketonuria; Tetrahydrobiopterin; Sapropterin;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Antioxidant effects of resveratrol and other stilbene derivatives on oxidative stress and NO bioavailability: Potential benefits to cardiovascular diseases

Keywords: Cardiovascular disease; Endothelial dysfunction; Nitric oxide; Oxidative stress; Resveratrol; ADMA; asymmetric dimethyl-arginine; ASL; argininosuccinate lyase; ASS; argininosuccinate synthase; BH4; tetrahydrobiopterin; CAT; cationic transporters of amino

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Simultaneous quantification of tetrahydrobiopterin, dihydrobiopterin, and biopterin by liquid chromatography coupled electrospray tandem mass spectrometry

Keywords: Tetrahydrobiopterin; Dihydrobiopterin; Biopterin; HUVECs; Tandem mass spectrometry

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Engineering of l-tyrosine oxidation in Escherichia coli and microbial production of hydroxytyrosol

Keywords: Tyrosine hydroxylase; Tetrahydrobiopterin; Tetrahydromonapterin; Dopa decarboxylase; Hydroxytyrosol; Microbial production

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Intramolecular hydrogen bonding: A potential strategy for more bioavailable inhibitors of neuronal nitric oxide synthase

Keywords: CNS; central nervous system; NO; nitric oxide; nNOS; neuronal nitric oxide synthase; eNOS; endothelial nitric oxide synthase; iNOS; inducible nitric oxide synthase; BBB; blood-brain barrier; H-bond; hydrogen bond; l-NNA; l-N-nitroarginine; H4B; tetrahyd

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه