دانلود مقالات ISI درباره Tetrahydrobiopterin + ترجمه فارسی

Redox modification of cell signaling in the cardiovascular system

Keywords: AngII; angiotensin II; ASK1; apoptosis signal-regulating kinase 1; BDNF; brain-derived neurotrophic factor; BH4; tetrahydrobiopterin; CaMKII; Ca2+/calmodulin-dependent protein kinase II; cGMP; cyclic guanosine monophosphate; ETC; electron transport chain;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Cardiovascular effects and molecular targets of resveratrol

Keywords: 4-HNE; 4-hydroxy-2-nonenal; ADMA; asymmetric dimethylarginine; AMPK; AMP-activated protein kinase; ApoE; apolipoprotein E; ARE; antioxidant response element; BH4; tetrahydrobiopterin; Cav-1; caveolin-1; COX-1; cyclooxygenase 1; CREB; cAMP response element

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Splicing of phenylalanine hydroxylase (PAH) exon 11 is vulnerable: Molecular pathology of mutations in PAH exon 11

Keywords: Phenylketonuria; Tetrahydrobiopterin; Hyperphenylalaninemia; Pseudoexon; Exomic splicing enhancer; mRNA splicing;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Intramolecular hydrogen bonding: A potential strategy for more bioavailable inhibitors of neuronal nitric oxide synthase

Keywords: CNS; central nervous system; NO; nitric oxide; nNOS; neuronal nitric oxide synthase; eNOS; endothelial nitric oxide synthase; iNOS; inducible nitric oxide synthase; BBB; blood-brain barrier; H-bond; hydrogen bond; l-NNA; l-N-nitroarginine; H4B; tetrahyd

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Ascorbate stimulates endothelial nitric oxide synthase enzyme activity by rapid modulation of its phosphorylation status

Keywords: AMPK; AMP-activated protein kinase; BH4; tetrahydrobiopterin; DMEM; Dulbecco's modified Eagle's medium; DMSO; dimethyl sulfoxide; eNOS; endothelial nitric oxide synthase; FBS; fetal bovine serum; HA-tag; hemagglutinin tag; Hepes; 4-(2-hydroxyethyl)-1-pipe

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Is targeting eNOS a key mechanistic insight of cardiovascular defensive potentials of statins?

Keywords: AFCAPS/TexCAPS; Air Force/Texas Coronary Atherosclerosis Prevention Study; ARMYDA; Atorvastatin for Reduction of MYocardial Damage during Angioplasty; ASCOT-LLA; The Anglo-Scandinavian Cardiac Outcomes Trial- Lipid-Lowering Arm; AURORA; A Study to Evaluat

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Nitric oxide - A versatile key player in cochlear function and hearing disorders

Keywords: ABR; auditory brainstem response; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; ATP; adenosine triphosphate; DAF; 4,5-diaminofluorescein diacetate; dB; decibel; eNOS; endothelial nitric oxide synthase; EP; endocochlear potential; FAD; flavi

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Research ReportModulatory effects of acupuncture on murine depression-like behavior following chronic systemic inflammation

Keywords: 3-OHKYN; 3-hydroxykynurenine; 5-HIAA; 5-hydroxyindole-3-acetic acid; 5-HT; 5-hydroxytryptamine, serotonin; ANOVA; analysis of variance; BCG; Bacillus Calmette-Guérin; BH4; tetrahydrobiopterin; CFU; colony forming unit; CNS; central nerve system; DA; dopa

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

Arg375 tunes tetrahydrobiopterin functions and modulates catalysis by inducible nitric oxide synthase

Keywords: NO; Single turn over; Arg375; Nitric oxide synthase; Tetrahydrobiopterin; Midpoint potential

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2012 سفارش ترجمه

Which Neuroprotective Agents are Ready for Bench to Bedside Translation in the Newborn Infant?

Keywords: 7-NI; 7-nitroindazole; AA; Ascorbic acid; BH4; Tetrahydrobiopterin; DHA; Dehydroascorbic acid; eNOS; Endothelial nitric oxide synthase; Epo; Erythropoietin; FDA; US Food and Drug Administration; NAC; N-acetylcysteine; iNOS; Inducible nitric oxide synthase

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2012 سفارش ترجمه

ReviewCytokine effects on the basal ganglia and dopamine function: The subcortical source of inflammatory malaise

Keywords: Inflammatory cytokines; Interferon-alpha; Inflammation; Dopamine; Tetrahydrobiopterin; Kynurenine; Oxidative stress; Basal ganglia; Fatigue; Depression;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2012 سفارش ترجمه

Effect of tetrahydrobiopterin on Phe/Tyr ratios and variation in Phe levels in tetrahydrobiopterin responsive PKU patients

Keywords: Phenylketonuria (PKU); Tetrahydrobiopterin; Phenylalanine; Tyrosine; Phenylalanine/tyrosine ratio;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2011 سفارش ترجمه

The 48-hour tetrahydrobiopterin loading test in patients with phenylketonuria: Evaluation of protocol and influence of baseline phenylalanine concentration

Keywords: BH4, Tetrahydrobiopterin; BLT, BH4-loading test; Phe, Phenylalanine; PAH, Phenylalanine-hydroxylase; PKU, PhenylketonuriaPhenylketonuria; PKU; Tetrahydrobiopterin; BH4; Sapropterin; Phenylalanine

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2011 سفارش ترجمه

Targeting endothelial and myocardial dysfunction with tetrahydrobiopterin

Keywords: Tetrahydrobiopterin; Sapropterin; eNOS-uncoupling; Endothelial dysfunction; Myocardial dysfunction; Ventricular remodeling and heart failure

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Optimized loading test to evaluate responsiveness to tetrahydrobiopterin (BH4) in Brazilian patients with phenylalanine hydroxylase deficiency

Keywords: Inborn errors of metabolism; Hyperphenylalaninemia; Phenylketonuria; Phenylalanine; Tetrahydrobiopterin

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Bi-modal dose-dependent cardiac response to tetrahydrobiopterin in pressure-overload induced hypertrophy and heart failure

Keywords: Nitric oxide synthase; Tetrahydrobiopterin; NOS-uncoupling; Oxidative stress; Pressure-overload; Mouse models

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Phenylalanine hydroxylase deficiency: Molecular epidemiology and predictable BH4-responsiveness in South Portugal PKU patients

Keywords: Phenylketonuria; Hyperphenylalaninemia; Tetrahydrobiopterin; Genotype; Phenotype

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Up to date knowledge on different treatment strategies for phenylketonuria

Keywords: Phenylketonuria; Tetrahydrobiopterin; Sapropterin; Phenylalanine ammonia lyase; Gene therapy

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Structural insights into the dual substrate specificities of mammalian and Dictyostelium dihydropteridine reductases toward two stereoisomers of quinonoid dihydrobiopterin

Keywords: Dihydropteridine reductase; Quinonoid (6R)-d-threo-dihydrobiopterin; Tetrahydrobiopterin; Crystal structure; Dictyostelium discoideum

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Tetrahydrobiopterin analogues with NO-dependent pulmonary vasodilator properties

Keywords: Tetrahydrobiopterin; Pulmonary artery; Nitric oxide; Pulmonary hypertension; Nitric oxide synthase

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Pulmonary hypertension in the newborn GTP cyclohydrolase I-deficient mouse

Keywords: Tetrahydrobiopterin; Pulmonary hypertension; Endothelial dysfunction; Free radicals

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency

Keywords: Tetrahydrobiopterin; eNOS uncoupling; Superoxide; Dihydrofolate reductase; hph-1; Methotrexate; Free radicals;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Reduction of Radiation-Induced Vascular Nitrosative Stress by the Vitamin E Analog γ-Tocotrienol: Evidence of a Role for Tetrahydrobiopterin

Keywords: Radiation; Oxidative stress; Nitric oxide synthase; Tetrahydrobiopterin; Vitamin E; Endothelial cells;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Disorders of BH4 metabolism and the treatment of patients with 6-pyruvoyl-tetrahydropterin synthase deficiency in Taiwan

Keywords: Hyperphenylalaninemia; 6-pyruvoyl-tetrahydropterin synthase; Tetrahydrobiopterin; BH4; Treatment; OutcomeAR, aldose reductase; BH4, tetrahydrobiopterin; CR, carbonyl reductase; DHPR, dihydropteridine reductase; GTP, guanosine triphosphate; GTPCH, guanosin

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

NAD(P)H oxidase and eNOS play differential roles in cytomegalovirus infection-induced microvascular dysfunction

Keywords: ACh; acetylcholine; BH4; tetrahydrobiopterin; CMV; cytomegalovirus; eNOS; endothelial nitric oxide synthase; gp91phox−/−; gp91phox knockout mice; HC; high-cholesterol diet; L-NNA; NG-nitro-l-arginine; mCMV; murine CMV; ND; normal diet; O2•−; super

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

DIESEL particulate exposed macrophages alter endothelial cell expression of eNOS, iNOS, MCP1, and glutathione synthesis genes

Keywords: PM2.5; particulate matter; DEP; diesel exhaust particulate; eNOS; endothelial nitric oxide synthase; iNOS; inducible nitric oxide synthase; Mcp1; monocyte chemoattractant protein 1; ROS; reactive oxygen species; NO; nitric oxide; ONOO−; peroxynitrite; B

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Endothelial nitric oxide synthase uncoupling as a key mediator of melanocyte malignant transformation associated with sustained stress conditions

Keywords: PMA; phorbol 12-myristate 13-acetate; BH4; tetrahydrobiopterin; BH2; dihydrobiopterin; DAHP; 2,4-diamino-6-hydroxypyrimidine; L-NAME; l-NG-nitroarginine methyl ester; ROS; reactive oxygen species; NOS; nitric oxide synthase; DAF-2DA; diaminofluorescein-2-

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Membrane transport of sepiapterin and dihydrobiopterin by equilibrative nucleoside transporters: A plausible gateway for the salvage pathway of Tetrahydrobiopterin biosynthesis

Keywords: Tetrahydrobiopterin; Supplement; Sepiapterin; Dihydrobiopterin; Equilibrative nucleoside transporter; Tetrahydrobiopterin; Salvage pathway; BH4-responsive PKU; Endothelial cell; NO-synthesis

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Pathogenetic role of eNOS uncoupling in cardiopulmonary disorders

Keywords: eNOS uncoupling; Superoxide; Tetrahydrobiopterin; eNOS modulators; Cardioprotection; Free radicals;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2011 سفارش ترجمه

Endothelial nitric oxide synthase in the vascular wall: Mechanisms regulating its expression and enzymatic function

Keywords: eNOS; Nitric oxide; Tetrahydrobiopterin; Atherosclerosis

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2011 سفارش ترجمه

Cognitive functions in patients with phenylketonuria in long-term treatment with tetrahydrobiopterin

Keywords: Phenylketonuria; Tetrahydrobiopterin; Long-term treatment; Cognitive functions; Motor functions

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2010 سفارش ترجمه

An enzymatic method to distinguish tetrahydrobiopterin from oxidized biopterins using UDP-glucose:tetrahydrobiopterin glucosyltransferase

Keywords: Tetrahydrobiopterin; Pteridine glycosyltransferase; HPLC;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2010 سفارش ترجمه

Introduction of sapropterin dihydrochloride as standard of care in patients with phenylketonuria

Keywords: Phenylketonuria; Sapropterin dihydrochloride; Tetrahydrobiopterin

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2010 سفارش ترجمه

Long-chain polyunsaturated fatty acid status in phenylketonuric patients treated with tetrahydrobiopterin

Keywords: Phenylketonuria; Mild hyperphenylalaninemia; Tetrahydrobiopterin; BH4-therapy; Long-chain polyunsaturated fatty acid; Docosahexaenoic acid; Arachidonic acid; n-6 PUFA; n-3 PUFA; Essential fatty acids

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2010 سفارش ترجمه

Improvement of impaired endothelial function by tetrahydrobiopterin in stroke-prone spontaneously hypertensive rats

Keywords: Tetrahydrobiopterin; Endothelial function; Acetylcholine; Sodium nitroprusside; Nitric oxide; (Stroke-prone spontaneously hypertensive rat)

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Reactive oxygen and nitrogen species regulate inducible nitric oxide synthase function shifting the balance of nitric oxide and superoxide production

Keywords: Inducible nitric oxide synthase; Nitric oxide; Superoxide; Peroxynitrite; Hydroxyl radical; Hydrogen peroxide; Dose-dependent; Uncoupling; Tetrahydrobiopterin; Monomerization

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Tetrahydrobiopterin as a Novel Therapeutic Intervention for Autism

Keywords: Tetrahydrobiopterin; autism spectrum disorder; monoamine neurotransmitters; nitric oxide; treatment;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Reactive oxygen species production and MAPK activation are implicated in tetrahydrobiopterin-induced SH-SY5Y cell death

Keywords: BH4; Dopaminergic neuron; MAPK; Reactive oxygen species; SH-SY5Y; Tetrahydrobiopterin;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2009 سفارش ترجمه

Identification of proteins interacting with GTP cyclohydrolase I

Keywords: GTP cyclohydrolase I; Proteomic; Interacting proteins; Tetrahydrobiopterin; Nitric oxide synthase; Aromatic amino acid hydroxylase;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2009 سفارش ترجمه

l-Arginine and tetrahydrobiopterin protects against ischemia/reperfusion-induced endothelial dysfunction in patients with type 2 diabetes mellitus and coronary artery disease

Keywords: l-Arginine; Tetrahydrobiopterin; Ischemia–reperfusion injury; Type 2 diabetes

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2009 سفارش ترجمه

Optimizing the use of sapropterin (BH4) in the management of phenylketonuria

Keywords: Phenylketonuria; Sapropterin; Tetrahydrobiopterin; Phe; Kuvan; Hyperphenylalaninemia;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2009 سفارش ترجمه

Human C-reactive protein induces endothelial dysfunction and uncoupling of eNOS in vivo

Keywords: CRP; Vasoreactivity; Endothelial nitric oxide synthase; Tetrahydrobiopterin; NADPH oxidase

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2009 سفارش ترجمه

Differential regulation of human tyrosine hydroxylase isoforms 1 and 2 in situ: Isoform 2 is not phosphorylated at Ser35

Keywords: TH; tyrosine hydroxylase; Ser; serine; hTH; human TH; BH4; tetrahydrobiopterin; ERK; extracellular signal-regulated protein kinase; CaMKII; calcium/calmodulin-dependent protein kinase II; DMEM; Dulbecco's Modified Eagle Medium; Tyrosine hydroxylase; Human

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2009 سفارش ترجمه

Melanogenesis inhibition by tetrahydropterines

Keywords: Tetrahydropterines; Tetrahydrobiopterin; Tyrosinase; Oxidation mechanism; Inactivation

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2009 سفارش ترجمه

In vivo regulation of phenylalanine hydroxylase in the genetic mutant hph-1 mouse model

Keywords: Phenylalanine hydroxylase; Hph-1 mouse model; Hyperphenylalaninemia; GTP cyclohydrolase 1; Tetrahydrobiopterin; Pediatric metabolic disease; Phenylketonuria (PKU); Catecholamine; Dopamine; Serotonin

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2009 سفارش ترجمه

Adverse ventricular remodeling and exacerbated NOS uncoupling from pressure-overload in mice lacking the β3-adrenoreceptor

Keywords: β3-adrenoreceptor; Hypertrophy; NOS uncoupling; Oxidative stress; Pressure-overload; Tetrahydrobiopterin;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2009 سفارش ترجمه

Putative antinociceptive action of nitric oxide in the caudal part of the spinal trigeminal nucleus during chronic carrageenan-induced arthritis in the rat temporomandibular joint

Keywords: AD; articular disc; AC; anaesthetic control; BH4; tetrahydrobiopterin; CaM; calmodulin; CFA; complete Freund's adjuvant; cGMP; cyclic guanosine monophosphate; CIA; carrageenan-induced arthritis; CNS; central nervous system; Cuf; cuneate fascicle; DAB; 3,3

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2009 سفارش ترجمه

A case of 6-pyruvoyl-tetrahydropterin synthase deficiency demonstrates a more significant correlation of l-Dopa dosage with serum prolactin levels than CSF homovanillic acid levels

Keywords: BH4, tetrahydrobiopterin; 5-HTP, 5-hydroxytryptophan; HVA, homovanillic acid; l-Dopa, l-3,4-dihydroxyphenylalanine; PTPS, 6-pyruvoyl-tetrahydropterin synthase6-Pyruvoyl-tetrahydropterin synthase deficiency; Prolactin; Tetrahydrobiopterin; Homovanillic aci

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2008 سفارش ترجمه

Autosomal recessive GTP cyclohydrolase I deficiency without hyperphenylalaninemia: Evidence of a phenotypic continuum between dominant and recessive forms

Keywords: GTP cyclohydrolase I; GCH1; Tetrahydrobiopterin; BH4; Hyperphenylalaninemia; Neurotransmitters; Dopa-responsive dystonia; Extrapyramidal movements; Oculogyric crises; Limb spasticity

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2008 سفارش ترجمه

2,4-Diamino-6-hydroxypyrimidine (DAHP) suppresses cytokine-induced VCAM-1 expression on the cell surface of human umbilical vein endothelial cells in a BH4-independent manner

Keywords: 2,4-Diamino-6-hydroxypyrymidine; VCAM-1; Tetrahydrobiopterin; NF-κB; HUVEC; GTP cyclohydrolase I; Sepiapterin

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2008 سفارش ترجمه