Keywords: آستانه نگرانی سمی; Food; Flavoring; Complex mixtures; Toxicology; Botanicals; Threshold of toxicological concern; GRAS;
مقالات ISI آستانه نگرانی سمی (ترجمه نشده)
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در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
Keywords: آستانه نگرانی سمی; ADI; Acceptable Daily Intake; BMD; Benchmark dose; BQ; Benchmark Quotient; CMR; carcinogenic, mutagenic, or toxic to reproduction; CEC; contaminants of emerging concern; DNEL; Derived No Effect Level; GLV; guideline value; LO(A)EL; Lowest Observed (Advers
Keywords: آستانه نگرانی سمی; AO; adverse outcome; AOP; adverse outcome pathway; BMD; benchmark dose modelling; BQE; biological quality element; CA; concentration addition; CAG; cumulative assessment group; CMEP; chemical monitoring and emerging pollutants; CRA; cumulative risk assess
Keywords: آستانه نگرانی سمی; Risk prioritization; FCM; Structure assessment; Semi-quantification; Exposure assessment; Hazard assessment; ADI; applicability domain index; CMR; carcinogenicity, mutagenicity, reproductive toxicity; EDA; effect directed analysis; FCM; food contact mater
Chemical characterisation of aerosols emitted by electronic cigarettes using thermal desorption-gas chromatography-time of flight mass spectrometry
Keywords: آستانه نگرانی سمی; Electronic cigarette; Aerosol; Thermal desorption; Threshold of toxicological concern; Non-targeted; Untargeted;
Keywords: آستانه نگرانی سمی; Botanicals; Dietary supplements; Human safety assessment; In silico; Threshold of toxicological concern; UHPLC-HRMS;
Keywords: آستانه نگرانی سمی; Threshold of Toxicological Concern; TTC; Cosmetics; Cheminformatics; Cramer classification;
Keywords: آستانه نگرانی سمی; 3-chlorotyrosine (PubChem CID: 110992); Sodium hypochlorite (PubChem CID: 23665760); Ethyl chloroformate (PubChem CID: 10928); Dichloromethane (PubChem CID: 6344); Pyridine (PubChem CID: 1049); Sodium sulphate (PubChem CID: 24436); Phenol (PubChem CID: 99
Keywords: آستانه نگرانی سمی; Raspberry ketone; 4-(4-hydroxyphenyl)-2-butanone; Food supplement; Weight loss; Threshold of toxicological concern; Margin of safety; Toxicity; Flavouring; Novel food; Natural;
Keywords: آستانه نگرانی سمی; Pesticide; Non-relevant metabolite; Regulation; Drinking water; Groundwater; Threshold of toxicological concern; TTC;
Keywords: آستانه نگرانی سمی; ADI; Acceptable Daily Intake; D; Decimal (1/10) homeopathic potency, Decimal Hahnemannian dilution; FSD; First Safe Dilution; GHP; German Homeopathic Pharmacopoeia; HMA; Heads of Medicines Agencies; HMPWG; Homeopathic Medicinal Products Working Group of H
Keywords: آستانه نگرانی سمی; Mixture toxicity; Threshold of toxicological concern; Exposure assessment; Pharmaceuticals; Drinking water;
Keywords: آستانه نگرانی سمی; RIFM; Research Institute for Fragrance Materials; SAM; skin absorption model; QSAR; Quantitative Structure-Activity Relationship; EC; European Commission; EFSA; European Food Safety Authority; EDETOX; Evaluations and Predictions of Dermal Absorption of
Keywords: آستانه نگرانی سمی; Bisphenol A; Endocrine disruptors; Food contact materials; Migration; Risk assessment; Threshold of toxicological concern
Utilizing Threshold of Toxicological Concern (TTC) with high throughput exposure predictions (HTE) as a risk-based prioritization approach for thousands of chemicals
Keywords: آستانه نگرانی سمی; AOPs; Adverse Outcome Pathways; FSANZ; Food Standards Australia New Zealand; HTE; High Throughput Exposure; HTS; high throughput screening; ILSI; International Life Sciences Institute; HESI; Health and Environmental Sciences Institute; RISK21; Risk Assess
Derivation of an inhalation TTC for the workplace based on DNEL values reported under REACH
Keywords: آستانه نگرانی سمی; TTC; Threshold of toxicological concern; Inhalation toxicity; Risk assessment; Reach; Alternative methods;
A strategy for systemic toxicity assessment based on non-animal approaches: The Cosmetics Europe Long Range Science Strategy programme
Keywords: آستانه نگرانی سمی; ADME; absorption, distribution, metabolism, elimination; AOP; adverse outcome pathway; EFSA; European Food and Safety Agency; EURL ECVAM; European Union Reference Laboratory for Alternatives to Animal Testing; FDA; US Food and Drug Administration; IATA; I
Finding synergies for 3Rs - Toxicokinetics and read-across: Report from an EPAA partners' Forum
Keywords: آستانه نگرانی سمی; Physiologically-based kinetic (PBK) modelling; Hazard and risk assessment; Weight-of-evidence (WoE); Threshold of toxicological concern (TTC); In vitro to in vivo extrapolation (IVIVE); Integrated approach for testing and assessment (IATA); Absorption; Di
The potential implications of reclaimed wastewater reuse for irrigation on the agricultural environment: The knowns and unknowns of the fate of antibiotics and antibiotic resistant bacteria and resistance genes - A review
Keywords: آستانه نگرانی سمی; Antibiotics; Accumulation; Human health risks; Antibiotic-resistance genes; Uptake; Reclaimed wastewater irrigation; APCI; atmospheric pressure chemical ionization; ARB; antibiotic resistant bacteria; ARGs; antibiotic resistance genes; CytcOx; cytochrome
Linking existing in vitro dermal absorption data to physicochemical properties: Contribution to the design of a weight-of-evidence approach for the safety evaluation of cosmetic ingredients with low dermal bioavailability
Keywords: آستانه نگرانی سمی; In silico prediction; Dermal absorption; Modelling; Bioavailability; Risk assessment; Cosmetic ingredient; Physicochemical properties; Safety evaluation; A; daily amount of product exposed to per kg body weight; CDK; Chemistry Development Kit; DA; dermal
Risk evaluation of the Alternaria mycotoxin tenuazonic acid in foods for adults and infants and subsequent risk management
Keywords: آستانه نگرانی سمی; Tenuazonic acid; Alternaria; Risk assessment; Threshold of toxicological concern; Infant food; Sorghum; MilletTenuazonic Acid (PubChem CID: 54678599)
Inhalation threshold of toxicological concern (TTC) - Structural alerts discriminate high from low repeated-dose inhalation toxicity
Keywords: آستانه نگرانی سمی; Structural alert; Repeated-dose toxicity; Inhalation toxicity; Threshold of toxicological concern; Mode of action; Alternative method;
Inhalation TTC values: A new integrative grouping approach considering structural, toxicological and mechanistic features
Keywords: آستانه نگرانی سمی; TTC; Threshold of toxicological concern; Inhalation exposure; Repeated dose; Grouping; Local effects; Toxicity
Aligning the 3Rs with new paradigms in the safety assessment of chemicals
Keywords: آستانه نگرانی سمی; 3Rs; replacement, refinement and reduction of animals in research; AOP; adverse outcome pathway; EURL-ECVAM; European Union Reference Laboratory for Alternatives to Animal Testing; ICCVAM; Interagency Coordinating Committee on the Validation of Alternativ
Examining the feasibility of mixture risk assessment: A case study using a tiered approach with data of 67 pesticides from the Joint FAO/WHO Meeting on Pesticide Residues (JMPR)
Keywords: آستانه نگرانی سمی; Mixture toxicology; Mixture risk assessment; Dose addition; Hazard index; Pesticide; JMPR; ADI; acceptable daily intake; AL; acceptable level; CAG; cumulative assessment group; EL; exposure level; GAP; good agricultural practice; GEMS; Global Environment
Comparison of Cramer classification between Toxtree, the OECD QSAR Toolbox and expert judgment
Keywords: آستانه نگرانی سمی; RIFM; Research Institute for Fragrance Materials, Inc.; TTC; Threshold of Toxicological Concern; TT; Toxtree; TB; OECD QSAR Toolbox; SCCS; Scientific Committee on Consumer Safety; SCHER; Scientific Committee on Health and Environmental Risks; SCENIHR; Sci
Utilizing relative potency factors (RPF) and threshold of toxicological concern (TTC) concepts to assess hazard and human risk assessment profiles of environmental metabolites: A case study
Keywords: آستانه نگرانی سمی; Metabolites; Groundwater; Risk assessment; Hazard; Agrochemical; Pesticide; Plant protection products; Relative potency; Threshold of toxicological concern; TTC;
Reevaluation of the Munro dataset to derive more specific TTC thresholds
Keywords: آستانه نگرانی سمی; TTC; Threshold of toxicological concern; Risk assessment; Reevaluation; In silico; Threshold; Health limit value;
Exposure assessment of Malondialdehyde, 4-Hydroxy-2-(E)-Nonenal and 4-Hydroxy-2-(E)-Hexenal through specific foods available in Belgium
Keywords: آستانه نگرانی سمی; BNFCS; Belgian National Food Consumption Survey; BSTFA N; O-bis(trimethylsilyl) trifluoroacetamide; GC-MS; gas chromatography-mass spectrometry; HHE; 4-Hydroxy-2-(E)-Hexenal; HNE; 4-Hydroxy-2-(E)-Nonenal; HPLC; high pressure liquid chromatography; LOD;
Trigger values for investigation of hormonal activity in drinking water and its sources using CALUX bioassays
Keywords: آستانه نگرانی سمی; ADI; Acceptable Daily Intake; ADME; Absorption, Distribution, Metabolism, Excretion; AR; Androgen Receptor; BQ; Benchmark Quotient; DEX; Dexamethasone; DHT; Dihydrotestosterone; DMSO; Dimethylsulfoxide; E1; Estrone; E2; 17β-Estradiol; EE2; 17α-Ethinyles
Potentially mutagenic impurities: Analysis of structural classes and carcinogenic potencies of chemical intermediates in pharmaceutical syntheses supports alternative methods to the default TTC for calculating safe levels of impurities
Keywords: آستانه نگرانی سمی; Mutagenic impurities; Threshold of toxicological concern; Potency of synthetic intermediates; Chemical-specific acceptable daily intakes; Class-specific acceptable daily intakes;
International experience in addressing combined exposures: Increasing the efficiency of assessment
Keywords: آستانه نگرانی سمی; Combined exposure; Exposure assessment; Framework analysis; Predictive methodology; Tiered approach; Threshold of toxicological concern
The Assessment of Impurities for Genotoxic Potential and Subsequent Control in Drug Substance and Drug Product
Keywords: آستانه نگرانی سمی; genotoxic impurities; analytical chemistry; toxicology; regulatory science; in silico modeling; stability; degradation; control strategy; risk assessment; threshold of toxicological concern;
Guiding principles for the implementation of non-animal safety assessment approaches for cosmetics: Skin sensitisation
Keywords: آستانه نگرانی سمی; ACD; allergic contact dermatitis; AEL; acceptable exposure level; APC; antigen presenting cells; CEL; consumer exposure level; CIR; cosmetic ingredient review; COLIPA; the European Cosmetics Association; DC; dendritic cells; DPRA; direct peptide reactivit
Correlation of chemical structure with reproductive and developmental toxicity as it relates to the use of the threshold of toxicological concern
Keywords: آستانه نگرانی سمی; Threshold of toxicological concern; Developmental toxicity; Reproductive toxicity; Cramer Class; Chemical structure;
Improved in silico prediction of carcinogenic potency (TD50) and the risk specific dose (RSD) adjusted Threshold of Toxicological Concern (TTC) for genotoxic chemicals and pharmaceutical impurities
Keywords: آستانه نگرانی سمی; TTC; Threshold of toxicological concern; Genotoxic; Mutagenic; Impurities; QSAR; SAR; TD50; Pharmaceuticals; Food contact substances; RSD; Carcinogenicity;
Improvement of the Cramer classification for oral exposure using the database TTC RepDose - A strategy description
Keywords: آستانه نگرانی سمی; TTC concept; Threshold of toxicological concern; Oral exposure; Refinement; Risk assessment; RepDose; Database; Toxicology; Cramer classification; Structure activity relationship; SAR;
Assessment strategies and decision criteria for pesticides with endocrine disrupting properties relevant to humans
Keywords: آستانه نگرانی سمی; ADI; acceptable daily intake; BfR; Bundesinstitut für Risikobewertung (German Federal Institute for Risk Assessment); CMR; carcinogenic, mutagenic, or reprotoxic; DES; diethylstilbestrol; DIT; developmental immunotoxicity; DNT; developmental neurotoxicit
Exposure-driven risk assessment: Applying exposure-based waiving of toxicity tests under REACH
Keywords: آستانه نگرانی سمی; AF; assessment factor; AI; active ingredient; BW; body weight; CoNTC; concentration of no toxicological concern; CSA; chemical safety assessment; CSR; chemical safety report; DNEL; derived no-effect level; DMEL; derived minimal effect level; EBW; exposure
Report from the EPAA workshop: In vitro ADME in safety testing used by EPAA industry sectors
Keywords: آستانه نگرانی سمی; ADME; absorption, distribution, metabolism, and excretion; ADI; Acceptable Daily Intake; Colipa; the European Cosmetic Toiletry and Perfumery Association; CYPs; cytochrome P450s; DNEL; Derived No Effect Level; DG; Directorate General; ECHA; EU Chemicals A
TTC-based risk assessment of tetrachlorobutadienes and pentachlorobutadienes - The in vitro genotoxic contaminants in ground and drinking water
Keywords: آستانه نگرانی سمی; Drinking water contaminants; Micropollutants; In vitro genotoxicity; Threshold of toxicological concern; Polychlorinated butadienes; Pentachlorinated butadienes; Tetrachlorinated butadienes; Hexachlorobutadiene;
In silico approaches to predicting cancer potency for risk assessment of genotoxic impurities in drug substances
Keywords: آستانه نگرانی سمی; Genotoxic; Impurities; In silico; Carcinogenicity; Threshold of toxicological concern; Pharmaceutical; TD50; Cancer potency;
Application of the “threshold of toxicological concern” to derive tolerable concentrations of “non-relevant metabolites” formed from plant protection products in ground and drinking water
Keywords: آستانه نگرانی سمی; Plant protection products; Environmental degradation; Drinking water; Toxicity testing strategies; Threshold of toxicological concern; Tolerable concentration limits
Evaluation of inhalation TTC values with the database RepDose
Keywords: آستانه نگرانی سمی; Risk assessment; TTC concept; Threshold of toxicological concern; Inhalation toxicityLO(A)EL, lowest observed (adverse) effect level; NO(A)EL, no observed (adverse) effect level; N(L)OEC, no (lowest) observed effect concentration
The influence of thresholds on the risk assessment of carcinogens in food
Keywords: آستانه نگرانی سمی; Regulatory toxicology; Tolerable daily intakes; Margin of exposure; Threshold of toxicological concern;
Assurance of compliance within the production chain of food contact materials by good manufacturing practice and documentation - Part 2: Implementation by the compliance box; call for guidelines
Keywords: آستانه نگرانی سمی; BfR; Bundesinstitut für Risikobewertung; CB; compliance box; CD; compliance declaration; CMR; carcinogenic, mutagenic or reprotoxic; DRF; stimulant D reduction factor; FCDec; food contact declaration; FCDoc; food contact documentation; FCM; food contact
Exposure based waiving: The application of the toxicological threshold of concern (TTC) to inhalation exposure for aerosol ingredients in consumer products
Keywords: آستانه نگرانی سمی; TTC; threshold of toxicological concern; EBW; exposure based waiving; REACH TGD; Registration Evaluation and Authorisation of Chemicals Technical Guidance Document; NOAEL; no observed adverse effect level; NOAEC; no observed adverse effect concentration;
Application of the threshold of toxicological concern approach for the safety evaluation of calendula flower (Calendula officinalis) petals and extracts used in cosmetic and personal care products
Keywords: آستانه نگرانی سمی; CF; calendula flower (Calendula officinalis); CFE; Calendula officinalis extracts; GRAS; generally recognized to be Safe; TTC; threshold of toxicological concern; FDA; food and drug administration; FEMA; flavors and extracts manufacturers association; EME
The Dermal Sensitisation Threshold—A TTC approach for allergic contact dermatitis
Keywords: آستانه نگرانی سمی; Threshold; Threshold of toxicological concern; TTC; Contact sensitisation; Allergic contact dermatitis
An impact analysis of the application of the threshold of toxicological concern concept to pharmaceuticals
Keywords: آستانه نگرانی سمی; Threshold of toxicological concern; Genotoxic impurity; Ames test; Salmonella test; Mutagen; Pharmaceutical; Impact analysis; Ionizing radiation; Carcinogen; Active pharmaceutical ingredient; API; BEIR VII; UNSCEAR