کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10110437 | 1619010 | 2018 | 19 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Current EU research activities on combined exposure to multiple chemicals
ترجمه فارسی عنوان
فعالیت های پژوهشی فعلی اتحادیه اروپا در مورد ترکیب مواد شیمیایی چندگانه
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کلمات کلیدی
EQSDArTToxicokineticHBMDEBPNECBiological quality elementIPSCMRAEDCMOAEBTRDTCMEPPBTKEffect-based toolsIPRAMixture risk assessmentCRAAOPPECMECMCRCAGTTCBMDMSFDWFDmcrA - MCAAsMRI - smriThreshold of toxicological concern - آستانه نگرانی سمیcumulative risk assessment - ارزیابی خطر تجمعیEnvironmental quality standard - استاندارد کیفیت محیط زیستIndependent action - اقدام مستقلQSAR - بزرگسال Dynamic Energy Budget - بودجه انرژی پویاHuman biomonitoring - بیومونیتوری انسانیMode of action - حالت عملWater Framework Directive - دستورالعمل چارچوب آبMarine Strategy Framework Directive - دستورالعمل چهارچوب استراتژیک دریاییQuantitative Structure Activity Relationship - رابطه فعالیت ساختاری کمیInduced pluripotent stem cells - سلول های بنیادی پرتوان القاییDevelopmental and reproductive toxicity - سمیت توسعه و باروریendocrine disrupting chemical - شیمیایی خرابکار غدد درون ریزConcentration addition - علاوه بر تمرکزPredicted No Effect Concentration - غلظت بدون اثر پیش بینی شدهLoE - لئوadverse outcome pathway - مسیر ناخوشایندNAM - نامAdverse outcome - نتیجه منفیIATA - یاتا
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
شیمی زیست محیطی
چکیده انگلیسی
Humans and wildlife are exposed to an intractably large number of different combinations of chemicals via food, water, air, consumer products, and other media and sources. This raises concerns about their impact on public and environmental health. The risk assessment of chemicals for regulatory purposes mainly relies on the assessment of individual chemicals. If exposure to multiple chemicals is considered in a legislative framework, it is usually limited to chemicals falling within this framework and co-exposure to chemicals that are covered by a different regulatory framework is often neglected. Methodologies and guidance for assessing risks from combined exposure to multiple chemicals have been developed for different regulatory sectors, however, a harmonised, consistent approach for performing mixture risk assessments and management across different regulatory sectors is lacking. At the time of this publication, several EU research projects are running, funded by the current European Research and Innovation Programme Horizon 2020 or the Seventh Framework Programme. They aim at addressing knowledge gaps and developing methodologies to better assess chemical mixtures, by generating and making available internal and external exposure data, developing models for exposure assessment, developing tools for in silico and in vitro effect assessment to be applied in a tiered framework and for grouping of chemicals, as well as developing joint epidemiological-toxicological approaches for mixture risk assessment and for prioritising mixtures of concern. The projects EDC-MixRisk, EuroMix, EUToxRisk, HBM4EU and SOLUTIONS have started an exchange between the consortia, European Commission Services and EU Agencies, in order to identify where new methodologies have become available and where remaining gaps need to be further addressed. This paper maps how the different projects contribute to the data needs and assessment methodologies and identifies remaining challenges to be further addressed for the assessment of chemical mixtures.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environment International - Volume 120, November 2018, Pages 544-562
Journal: Environment International - Volume 120, November 2018, Pages 544-562
نویسندگان
Stephanie K. Bopp, Robert Barouki, Werner Brack, Silvia Dalla Costa, Jean-Lou C.M. Dorne, Paula E. Drakvik, Michael Faust, Tuomo K. Karjalainen, Stylianos Kephalopoulos, Jacob van Klaveren, Marike Kolossa-Gehring, Andreas Kortenkamp, Erik Lebret,