Loss of Parkin reduces inflammatory arthritis by inhibiting p53 degradation
Keywords: یوبی کوئیتینه شدن ; Parkin; Arthritis; p53; Ubiquitination;
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Polyglutamine expansion of ataxin-3 alters its degree of ubiquitination and phosphorylation at specific sites
Keywords: یوبی کوئیتینه شدن ; Ataxin-3; Spinocerebellar ataxia type 3; Mass spectrometry; Neurodegeneration; Ubiquitination; Phosphorylation; DUB; deubiquitinating enzyme;; HD; Huntington's disease; HEK; human embryonic kidney;; LC-MS/MS; liquid chromatography tandem mass spectrometry
Subcellular distribution of RAD23B controls XPC degradation and DNA damage repair in response to chemotherapy drugs
Keywords: یوبی کوئیتینه شدن ; DNA damage repair; RAD23B; XPC; Ubiquitination; Compartmentation;
Overview of the membrane-associated RING-CH (MARCH) E3 ligase family
Keywords: یوبی کوئیتینه شدن ; MARCH E3 ligase; MARCH-1; Ubiquitination; MHC-II; GxxxG;
Original ArticleThe E3 ligase HECTD3 promotes esophageal squamous cell carcinoma (ESCC) growth and cell survival through targeting and inhibiting caspase-9 activation
Keywords: یوبی کوئیتینه شدن ; Ubiquitination; ESCC; HECTD3; Caspase-9; ERK;
Role of ubiquitination and proteolysis in the regulation of pro- and anti-apoptotic TNF-R1 signaling
Keywords: یوبی کوئیتینه شدن ; TNF; TNF-receptor 1; Proteolysis; Ubiquitination; Apoptosis; Receptor compartmentalization;
Original ArticleTumor suppressor SPOP ubiquitinates and degrades EglN2 to compromise growth of prostate cancer cells
Keywords: یوبی کوئیتینه شدن ; EglN2; SPOP; Ubiquitination; Prostate cancer; Androgen receptor;
A comprehensive computational study on pathogenic mis-sense mutations spanning the RING2 and REP domains of Parkin protein
Keywords: یوبی کوئیتینه شدن ; Parkin; RING2 domain; Mis-sense mutation; E3 ligase; Interaction energy; Parkinson's disease; Ubiquitination; Protein docking;
Suppressed ubiquitination of Nrf2 by p47phox contributes to Nrf2 activation
Keywords: یوبی کوئیتینه شدن ; Nrf2; p47phox; NADPH oxidase; Keap1; Ubiquitination; Lung inflammation;
Original ArticleA novel HDAC6 inhibitor Tubastatin A: Controls HDAC6-p97/VCP-mediated ubiquitination-autophagy turnover and reverses Temozolomide-induced ER stress-tolerance in GBM cells
Keywords: یوبی کوئیتینه شدن ; Tubastatin A; ER stress-tolerance; HDAC6-p97/VCP; Ubiquitination; Autophagy;
Original ArticleGRP78 inhibition enhances ATF4-induced cell death by the deubiquitination and stabilization of CHOP in human osteosarcoma
Keywords: یوبی کوئیتینه شدن ; Osteosarcoma; ATF4; GRP78; CHOP; Ubiquitination; ATF4; activating transcription factor 4; BTZ; bortezomib; CFDA SE; carboxyfluorescein diacetate succinimidyl ester; CHOP; CCAAT/enhancer-binding protein (C/EBP) homologous protein; CHX; cycloheximide; DDIT3
Sirt1 suppresses Wnt/βCatenin signaling in liver cancer cells by targeting βCatenin in a PKAα-dependent manner
Keywords: یوبی کوئیتینه شدن ; KO; knock-out; KI; knock-in; βTrCP; beta-transducin repeat containing E3 ubiquitin protein ligase; RING; really interesting new gene; S; Ser; T; Thr; A; alanine; R; arginine; mSirt1; mouse Sirt1; mSIRT1-KI; mouse Sirt1 knock-in; mSirt1-LKO; mSirt1-liver
Original ArticleLong noncoding RNA UCA1 promotes tumour metastasis by inducing GRK2 degradation in gastric cancer
Keywords: یوبی کوئیتینه شدن ; lncRNA; UCA1; Gastric cancer; Ubiquitination; Metastasis;
Original ArticleDoxorubicin anti-tumor mechanisms include Hsp60 post-translational modifications leading to the Hsp60/p53 complex dissociation and instauration of replicative senescence
Keywords: یوبی کوئیتینه شدن ; Doxorubicin; Hsp60; Acetylation; Ubiquitination; p53; Replicative senescence; DMSO; dimethylsulfoxide; ELISA; enzyme linked immunosorbent assay; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; GUSB; betaglucuronidase; HDAC; histone deacetylases; H2AX; H2
Centrosomal MCM7 strengthens the Cep68-VHL interaction and excessive MCM7 leads to centrosome splitting resulting from increase in Cep68 ubiquitination and proteasomal degradation
Keywords: یوبی کوئیتینه شدن ; MCM7; Cep68; Centrosome splitting; Proteasomal degradation; Ubiquitination;
E6AP inhibits G-CSFR turnover and functions by promoting its ubiquitin-dependent proteasome degradation
Keywords: یوبی کوئیتینه شدن ; Ubiquitin ligase; Ubiquitination; Proteasome; Cell differentiation; G-CSFR;
Valproic acid downregulates heme oxygenase-1 independently of Nrf2 by increasing ubiquitination and proteasomal degradation
Keywords: یوبی کوئیتینه شدن ; Heme Oxygenase-1; Valproic acid; Ubiquitination; Rhabdomyosarcoma; Nrf2;
Molecular dynamics simulations reveal a new role for a conserved active site asparagine in a ubiquitin-conjugating enzyme
Keywords: یوبی کوئیتینه شدن ; Ubiquitin; E2; Ubc13; Ubiquitination; Molecular dynamics;
PLMD: An updated data resource of protein lysine modifications
Keywords: یوبی کوئیتینه شدن ; Post-translational modification (PTM); Protein lysine modification (PLM); Ubiquitination; Acetylation; PTM crosstalk;
Possible roles of the transcription factor Nrf1 (NFE2L1) in neural homeostasis by regulating the gene expression of deubiquitinating enzymes
Keywords: یوبی کوئیتینه شدن ; Proteostasis; Ubiquitination; Deubiquitination; Neurodegeneration; Gene regulation; ARE; antioxidant response element; CNC; Cap'n'Collar; DUB; deubiquitinating enzyme; Nrf1; NF-E2-related factor 1; NFE2L1; NF-E2-like 1; qRT-PCR; quantitative real time- PC
Survivin does not influence the anti-apoptotic action of XIAP on caspase-9
Keywords: یوبی کوئیتینه شدن ; Apoptosis; Survivin; XIAP; Caspase inhibition; Ubiquitination; Smac;
Transcriptional and post-transcriptional regulation of Cdc20 during the spindle assembly checkpoint in S. cerevisiae
Keywords: یوبی کوئیتینه شدن ; APC/C; the anaphase-promoting complex/cyclosome; SCF; the Skp1-cullin-F-box protein complex; SAC; the spindle assembly checkpoint; MCCs; mitotic checkpoint complexes; Protein degradation; Spindle assembly checkpoint; Cdc20; Post-transcriptional regulation
Suppression of NF-κB signal pathway by NLRC3-like protein in stony coral Acropora aculeus under heat stress
Keywords: یوبی کوئیتینه شدن ; Heat stress; NF-κB pathway; Ubiquitination; Coral; Acropora aculeus;
Stimulation of RNA Polymerase II ubiquitination and degradation by yeast mRNA 3â²-end processing factors is a conserved DNA damage response in eukaryotes
Keywords: یوبی کوئیتینه شدن ; mRNA 3â²-end processing; CFIA; CPF; RNA Polymerase II; Ubiquitination; DNA Repair;
Characterization and function of a β-catenin homolog from Litopenaeus vannamei in WSSV infection
Keywords: یوبی کوئیتینه شدن ; β-catenin; Ubiquitination; Wnt/β-catenin pathway; Litopenaeus vannamei; WSSV;
The E3 ubiquitin ligase MID1/TRIM18 promotes atypical ubiquitination of the BRCA2-associated factor 35, BRAF35
Keywords: یوبی کوئیتینه شدن ; BHC; BRAF-histone deacetylase; BRAF35/HMG20b; BRCA2-associated factor 35; CC; coiled-coil; coREST/RCOR1; REST corepressor 1; E1; UBE1, ubiquitin activating enzyme; E2; UBE2 ubiquitin conjugating enzyme; E3; ubiquitin ligase enzyme; FN3; fibronectin type I
RNF8 identified as a co-activator of estrogen receptor α promotes cell growth in breast cancer
Keywords: یوبی کوئیتینه شدن ; RNF8; Co-activator; Estrogen receptor α; Ubiquitination; Breast cancer;
Deubiquitinases and cancer: A snapshot
Keywords: یوبی کوئیتینه شدن ; Deubiquitinases; Ubiquitination; Cancer; Deubiquitination; DUBs; DUBs inhibitors;
The ubiquitination of serotonin transporter in lymphoblasts derived from fluvoxamine-resistant depression patients
Keywords: یوبی کوئیتینه شدن ; MDD; major depressive disorder; SERT; serotonin transporter; MAGE-D1; melanoma antigen gene-D1; EBV; Epstein-Barr virus; HAM-D; Hamilton depression scale; UPS; ubiquitin-proteasome system; Major depressive disorder; Serotonin transporter; Ubiquitination
Proteolysis targeting peptide (PROTAP) strategy for protein ubiquitination and degradation
Keywords: یوبی کوئیتینه شدن ; Ubiquitination; Proteolysis; Proteasome; PROTAP; Bcl-xL;
Mitochondrial E3 ubiquitin ligase 1: A key enzyme in regulation of mitochondrial dynamics and functions
Keywords: یوبی کوئیتینه شدن ; Mitochondrial E3 ubiquitin ligase 1; Ubiquitination; SUMOylation; Mitochondrial dynamic; Apoptosis; NF-κB;
Heat shock modulates the subcellular localization, stability, and activity of HIPK2
Keywords: یوبی کوئیتینه شدن ; Stress kinase; Heat-shock response; Ubiquitination; Cell death pathway;
Evaluation of dose-dependent effects of the proteasome inhibitor bortezomib in human platelets
Keywords: یوبی کوئیتینه شدن ; Bortezomib (PubChem CID: 387447); Adenosine 5′-diphosphate (PubChem CID: 6022); TRAP-6 (PubChem CID: 9831933)Bortezomib; Platelet; Proteasome; Ubiquitination; Aggregation
The E3 ligase UBR5 regulates gastric cancer cell growth by destabilizing the tumor suppressor GKN1
Keywords: یوبی کوئیتینه شدن ; UBR5; Gastric cancer; GKN1; Ubiquitination;
Enterovirus 71 inhibits cellular type I interferon signaling by inhibiting host RIG-I ubiquitination
Keywords: یوبی کوئیتینه شدن ; Enterovirus 71; Type I interferon; RIG-I; Ubiquitination
The E3 ubiquitin ligase CHIP selectively regulates mutant epidermal growth factor receptor by ubiquitination and degradation
Keywords: یوبی کوئیتینه شدن ; CHIP protein; EGFR protein; Ubiquitination; Adenocarcinoma;
Transcription factor RFX1 is ubiquitinated by E3 ligase STUB1 in systemic lupus erythematosus
Keywords: یوبی کوئیتینه شدن ; Systemic lupus erythematosus (SLE); Transcription factor regulatory factor X 1 (RFX1); STIP1 homology and U-box containing protein 1 (STUB1); Ubiquitination;
Identification of an active-site residue in invertase SUC2 by mass spectrometry-based proteomics and site-directed mutagenesis
Keywords: یوبی کوئیتینه شدن ; Invertase; Ubiquitination; Mass spectrometry; Site-directed mutagenesis; Active-site residue;
Mapping ubiquitination sites of S. cerevisiae Mcm10
Keywords: یوبی کوئیتینه شدن ; DNA replication; Mcm10; PCNA; Ubiquitination; 9-1-1 checkpoint clamp;
E3 ubiquitin ligase CHIP interacts with C-type lectin-like receptor CLEC-2 and promotes its ubiquitin-proteasome degradation
Keywords: یوبی کوئیتینه شدن ; CLEC-2; C-type lectin-like receptor 2; CHIP; C terminus of Hsc70-interacting protein; PMA; phorbol myristate acetate; CHX; cycloheximide; HEK293T; human emborynic kidney 293T; MS; mass spectrometry; FACS; fluorescence-activated cell sorting; ITAM; immunor
On the linkage between the ubiquitin-proteasome system and the mitochondria
Keywords: یوبی کوئیتینه شدن ; Ubiquitin-proteasome system; Mitochondria; Ubiquitination; Protein degradation; Proteasome; Protein–protein interactionSCUD, Saccharomyces cerevisiae ubiquitination database; GO, gene ontology; DUDE, database of ubiquitinating and deubiquitinating eznymes
Original ArticlepVHL mediates K63-linked ubiquitination of IKKβ, leading to IKKβ inactivation
Keywords: یوبی کوئیتینه شدن ; IKKβ; pVHL; Ubiquitination;
The E3 ubiquitin ligase c-Cbl mediates integrin β1 ubiquitination during dilated cardiomyopathy
Keywords: یوبی کوئیتینه شدن ; Dilated cardiomyopathy; Integrin β1; Ubiquitination; C-Cbl; COMP;
USP15 stabilizes the transcription factor Nrf1 in the nucleus, promoting the proteasome gene expression
Keywords: یوبی کوئیتینه شدن ; Ubiquitination; Deubiquitination; Proteasomal degradation; Transcription factor; Gene regulation; ARE; antioxidant response element; CNC; Cap'n'Collar; DUB; deubiquitinating enzyme; ER; endoplasmic reticulum; NHB1; N-terminal homology box 1; Nrf1; NF-
Development of Keap1-interactive small molecules that regulate Nrf2 transcriptional activity
Keywords: یوبی کوئیتینه شدن ; Keap1; Nrf2; Protein-protein interactions; Ubiquitination; Parkinson's disease; Alzheimer's disease; Cancer chemoprevention;
RNF12 promotes p53-dependent cell growth suppression and apoptosis by targeting MDM2 for destruction
Keywords: یوبی کوئیتینه شدن ; RNF12; p53; MDM2; Ubiquitination; Degradation; Apoptosis;
Functions of PARylation in DNA Damage Repair Pathways
Keywords: یوبی کوئیتینه شدن ; Poly ADP-ribosylation; PARPs; DNA damage response; PAR-binding modules; Ubiquitination
F-box proteins: Keeping the epithelial-to-mesenchymal transition (EMT) in check
Keywords: یوبی کوئیتینه شدن ; EMT; Snail; Twist; Zeb; F-box; Ubiquitination; Proteasome; Cancer;
The E3 ubiquitin-ligase SEVEN IN ABSENTIA like 7 mono-ubiquitinates glyceraldehyde-3-phosphate dehydrogenase 1 isoform in vitro and is required for its nuclear localization in Arabidopsis thaliana
Keywords: یوبی کوئیتینه شدن ; SINAL7; GAPC; Interaction; Ubiquitination; Nuclear localization;
E3 ubiquitin ligase NKLAM ubiquitinates STAT1 and positively regulates STAT1-mediated transcriptional activity
Keywords: یوبی کوئیتینه شدن ; NKLAM; natural killer lytic-associated molecule; STAT1; signal transducer and activator of transcription 1; RBR; RING in between RING; JAK1; Janus kinase 1; IFNγ; interferon gamma; IFNGR; interferon gamma receptor; GAS; gamma interferon activation sequen