Keywords: Baylis-Hillman; Bromomethyl acrylate; 2-Alkoxycarbonylallyl esters; DNA alkylation; Breast cancer; Pancreatic cancer; Karyorrhexis; γ-H2AX; PARP-1 activation;
مقالات ISI (ترجمه نشده)
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Keywords: AgNPs; silver nanoparticles; cit; citrate; PVP; polyvinylpyrrolidone; AgOAc; silver acetate; Ag+;  silver ions; 8-oxoG; 7,8-dihydro-8-oxoguanine; γ-H2AX; phosphorylated histone 2AX; DSBs; double strand breaks; MN; micronuclei; SPR; surface plasmon reson
Keywords: HPCs; hepatic progenitor cells; mtROS; mitochondrial reactive oxygen species; DEN; diethylnitrosamine; SPCs; stem/progenitor cells; HSCs; hematopoietic stem cells; NSCs; neural stem cells; DMEM; Dulbecco's modified Eagle's medium; FBS; fetal bovine serum;
Keywords: Hydrogenated nanodiamonds (H-NDs); Radiation sensitization; Oxidative stress; γ-H2AX; Senescence;
Keywords: NAFLD; non-alcohol-related fatty liver; DDR; DNA damage response; γ-H2AX; phosphorylated histone H2AX; Q-FISH; quantitative fluorescent in situ hybridization; MCM; minichromosome maintenance protein; PH3; phosphorylated histone 3; MFI; mean fluorescent i
Keywords: γ-H2AX; gamma-H2AX; 8-OH-dG; 8-hydroxyguanosine; ANOVA; analysis of variance; BAL; bronchoalveolar lavage; DSB; DNA double-strand breaks; LDH; lactate dehydrogenase; MNP; microscale and nanoscale particles; NO; nitric oxide; OGG1; 8-oxoguanine DNA glycos
Cytotoxicity and DNA double-strand breaks in human gingival fibroblasts exposed to eluates of dental composites
Keywords: DNA double-strand breaks; γ-H2AX; Multiple components; Elution; Cytotoxicity; Genotoxicity; TEGDMA; Culture medium; DMEM;
DNA and chromosome damage induced by bleomycin in mammalian cells: An update
Keywords: BLM; bleomycin; CAs; chromosomal aberrations; MN; micronucleus; FISH; fluorescent in situ hybridization; mtDNA; mitochondrial DNA; SCEs; sister-chromatid exchanges; ITSs; interstitial telomeric sequences; γ-H2AX; phosphorylated histone H2AX; PNA; peptide
Inhibition of Notch1/Hes1 signaling pathway improves radiosensitivity of colorectal cancer cells
Keywords: Notch1; Colorectal cancer; Radiosensitiviy; γ-H2AX; DNA-PK;
Synthesis, cytotoxic evaluation and target identification of thieno[2,3-d]pyrimidine derivatives with a dithiocarbamate side chain at C2 position
Keywords: Thieno[2,3-d]pyrimidine; Dithiocarbamate; Cytotoxicity; Probe; Target identification; Tubulin; Boc; tert-butyloxycarbonyl; CPT; camptothecin; DMF; N,N-dimethylformamide; DMSO; dimethyl sulphoxide; DSB; DNA double-strand break; EDCI; 1-ethyl-3-(3-dimethyla
Study of γ-H2AX as DNA double strand break biomarker in resident living in high natural radiation area of Mamuju, West Sulawesi
Keywords: γ-H2AX; DNA damage; High background radiation;
Enhanced DNA double-strand break repair of microbeam targeted A549 lung carcinoma cells by adjacent WI38 normal lung fibroblast cells via bi-directional signaling
Keywords: Proton microbeam; Lung cells; γ-H2AX; Radiation induced bystander effect; Rescue effect;
DNA damage and the bystander response in tumor and normal cells exposed to X-rays
Keywords: γ-H2AX; P53; ATM; Cyclins;
The comparative in vitro assessment of e-cigarette and cigarette smoke aerosols using the γH2AX assay and applied dose measurements
Keywords: ACM; aerosol collected mass; ALI; air liquid interface; ATCC; American type culture collection; BEAS-2Bs; human bronchial epithelial cells; BEGM; bronchial epithelial cell growth medium; CRM No 81; CORESTA Recommended Method No 81; E-cigarettes; electroni
Double strand break repair and γ-H2AX formation in erythrocytes of medaka (Oryzias latipes) after γ-irradiation
Keywords: γ-H2AX; Erythrocytes; DNA repair; Fish; Radiation;
Combination of ABT-737 and resveratrol enhances DNA damage and apoptosis in human T-cell acute lymphoblastic leukemia MOLT-4 cells
Keywords: T-ALL; T-cell acute lymphoblastic leukemia; RES; resveratrol; Bcl-2; B-cell lymphoma 2; Bcl-xL; B-cell lymphoma extra-large; Bcl-w; BCL-2-like protein 2; Bax; Bcl-2-associated X protein; Bak; Bcl-2-associated killer; Bad; Bcl-2-associated death promoter;
Chk1 Inhibitor SCH900776 Effectively Potentiates the Cytotoxic Effects of Platinum-Based Chemotherapeutic Drugs in Human Colon Cancer Cells
Keywords: CDDP; cisplatin; Chk1; checkpoint kinase 1; Chk2; checkpoint kinase 2; γ-H2AX; phosphorylated histone H2AX at Ser 139; LA-12; (OC-6-43)-bis(acetato)(1-adamantylamine)amminedichloroplatinum(IV); PARP; poly (ADP-ribose) polymerase; PBS; phosphate-buffered
Immunostaining of UVA-induced DNA damage in erythrocytes of medaka (Oryzias latipes)
Keywords: γ-H2AX; Hd-rR; UVA; Comet assay; DNA;
Hepatic stellate cell interferes with NK cell regulation of fibrogenesis via curcumin induced senescence of hepatic stellate cell
Keywords: Hepatic fibrosis; Natural killer cell; Hepatic stellate cell; Senescence; Granule exocytosis; 3,4-DCI; 3,4-Dichloroisocoumarin; α-SMA; α-Smooth muscle actin; CCl4; Carbon tetrachloride; CMA; Concanamycin A; DAPI; 4â², 6-Diamidino-2-phenylindole; DMEM;
Detection of DNA damage by space radiation in human fibroblasts flown on the International Space Station
Keywords: Space radiation; γ-H2AX; Particle track;
Contrasting cellular damage after Blue-IRIS and Femto-LASIK in cat cornea
Keywords: Refractive correction; Stroma; Refractive index modification; GRIN lens; Photoablation; TUNEL; γ-H2AX;
Myb-like, SWIRM, and MPN domains 1 (MYSM1) deficiency: Genotoxic stress-associated bone marrow failure and developmental aberrations
Keywords: Immunodeficiency; stem cells; hematopoiesis; rare disease; transplantation; BMF; Bone marrow failure; EBV-LCL; Epstein-Barr virus transformed B lymphoblastoid cell line; H2A; Histone 2A; γ-H2AX; Phospho-histone H2AX; HD; Healthy donor; HSCT; Hematopoieti
γ-H2AX responds to DNA damage induced by long-term exposure to combined low-dose-rate neutron and γ-ray radiation
Keywords: Low-dose radiation; 60Co γ-ray; Neutron; γ-H2AX; Ku70; Ku80;
Original ArticleCompromized DNA repair as a basis for identification of cancer radiotherapy patients with extreme radiosensitivity
Keywords: Radiation therapy; Radiosensitivity; Predictive assays; DNA repair; γ-H2AX; Statistical criteria; RT; radiation therapy; RS; radiosensitivity; γ-H2AX; phosphorylated histone H2AX; 53BP1; p53 binding protein 1; DSB; double-strand break; PBL; peripheral b
Epigallocatechin-3-gallate enhances key enzymatic activities of hepatic thioredoxin and glutathione systems in selenium-optimal mice but activates hepatic Nrf2 responses in selenium-deficient mice
Keywords: ALT; alanine aminotransferase; AST; aspartate aminotransferase; BSO; buthionine sulfoximine; CDNB; 1-chloro-2, 4-dinitrobenzene; ECL; enhanced chemiluminescense; EDTA; ethylene diamine tetraacetic acid; EGCG; epigallocatechin-3-gallate; FoxO; Forkhead box
Targeting the replisome with transduced monoclonal antibodies triggers lethal DNA replication stress in cancer cells
Keywords: DDR; DNA damage response; DSB; double-strand break; CRISPR; clustered regularly interspaced short palindromic repeats; CSK; cytoskeletal; DTT; dithiothreitol; EdU; 5-ethynyl-2â²-deoxyuridine; EM-CCD; electron multiplying-charge coupled device; γ-H2AX; p
Contributions of DNA repair and damage response pathways to the non-linear genotoxic responses of alkylating agents
Keywords: AAG; alkyladenine DNA glycosylase; ATM; ataxia telangiectasia mutated; BER; base excision repair; BPD; break point dose; BMD; benchmark dose; BMDL; benchmark dose lower confidence limit; CSBP; computational systems biology pathway; DSB; double strand brea
Duodenal crypt health following exposure to Cr(VI): Micronucleus scoring, γ-H2AX immunostaining, and synchrotron X-ray fluorescence microscopy
Keywords: Hexavalent chromium; Cr(VI); Synchrotron; Duodenum; Carcinogenesis; Mode of action; γ-H2AX;
New mechanism of γ-H2AX generation: Surfactant-induced actin disruption causes deoxyribonuclease I translocation to the nucleus and forms DNA double-strand breaks
Keywords: Nonylphenol polyethoxylates; Deoxyribonuclease I; Actin; DNA double-strand breaks; γ-H2AX; Surfactants;
Targeting pyruvate kinase M2 contributes to radiosensitivity of non-small cell lung cancer cells in vitro and in vivo
Keywords: NSCLC; non-small cell lung cancer; PKM2; pyruvate kinase M2 isoform; pshRNA; the plasmid encoding a short hairpin RNA; IR; ionizing radiation; PEP; phosphoenolpyruvate; 3-MA; 3-methyladenine; Z-VAD; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl keto
Dental composite components induce DNA-damage and altered nuclear morphology in gingiva fibroblasts
Keywords: Dental composites; Monomers; Chromatin; Gingiva fibroblasts; DNA damage; Nuclear morphology; DNA double-strand breaks; γ-H2AX; 53BP1;
X-ray and ultraviolet C irradiation-induced γ-H2AX and p53 formation in normal human periosteal cells in vitro: markers for quality control in cell therapy
Keywords: cell cycle; γ-H2AX; oxidative stress; p53; periosteal cells; quality control;
The autotaxin-LPA2 GPCR axis is modulated by γ-irradiation and facilitates DNA damage repair
Keywords: DNA damage repair; Lysophosphatidic acid; ATX; LPA2; γ-H2AX; NF-κB;
Blockade of metabotropic glutamate receptor 5 protects against DNA damage in a rotenone-induced Parkinson's disease model
Keywords: DHPG; (s)-3,5- dihydroxy-phenylglycine; DMSO; dimethylsulfoxide; ERK; extracellular signal-regulated kinase; MAPK; mitogen-activated protein kinase; mGluR5; metabotropic glutamate receptor 5; MPEP; 2-methyl-6-(phenylethynyl)pyridine; PD; Parkinson's dis
Spatiotemporal kinetics of γ-H2AX protein on charged particles induced DNA damage
Keywords: DNA damage; DNA repair; γ-H2AX; Radiobiological effect;
Evaluation of N-acetyl-cysteine against tetrachlorobenzoquinone-induced genotoxicity and oxidative stress in HepG2 cells
Keywords: DAPI; 4â²,6-diamidino-2-phenylindole dihydrochloride; DCFH-DA; 2â²,7â²-dichlorodihydrofluorescein diacetate; ELISA; enzyme-linked immunosorbent assay; γ-H2AX; phosphorylation of histone H2AX; MN; micronucleus; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-dip
High levels of γ-H2AX foci and cell membrane oxidation in adolescents with type 1 diabetes
Keywords: γ-H2AX; Peripheral lymphocytes; Diabetes; iNOS;
Aldosterone induces fibrosis, oxidative stress and DNA damage in livers of male rats independent of blood pressure changes
Keywords: Hyperaldosteronism; Mineralocorticoid receptor; DNA damage; α-SMA; γ-H2AX; Nrf2;
Formaldehyde-induced histone H3 phosphorylation via JNK and the expression of proto-oncogenes
Keywords: Formaldehyde; Histone H3; Phosphorylation; γ-H2AX; Proto-oncogene; JNK;
Autophagy inhibition switches low-dose camptothecin-induced premature senescence to apoptosis in human colorectal cancer cells
Keywords: CRC; colorectal cancer; CPT; camptothecin; DSBs; double-strand breaks; DDR; DNA damage response; γ-H2AX; phosphorylated histone H2AX; ATM; ataxia telangiectasia mutated; Chk2; check-point kinase; AMPK; AMP-activated protein kinase; TSC2; tuberous scleros
Targeting DNA damage response: Threshold, chromatin landscape and beyond
Keywords: DSBs; double strand breaks; γ-H2AX; phosphorylation of histone variant H2AX in Ser139; SUMO; small ubiquitin modifier; ROS; reactive oxygen species; IR; ionizing radiation; Tip60; Tat-interactive 60; HAT; histone acetyltransferase; HDAC; histone deacetyl
Depletion of ERK2 but not ERK1 abrogates oncogenic Ras-induced senescence
Keywords: OIS; oncogene-induced senescence; MEF; mouse embryonic fibroblast; ERK; extracellular signal-regulated kinase; MEK; mitogen-activated protein kinase kinase; PI3K; phosphatidylinositol 3-kinase; pRb; retinoblastoma tumor suppressor protein; SA-β-Gal; sene
Biological clues to potent DNA-damaging activities in food and flavoring
Keywords: γ-H2AX; phosphorylated histone protein H2AX; 5-FU; fluorouracil; CHO; Chinese hamster ovary; CMV; cytomegalovirus; DMEM; Dulbecco's modified Eagle's medium; DMSO; dimethyl sulfoxide; EGCG; epigallocatechin-3-gallate; FBS; fetal bovine serum; HEPES; 4
Genotoxicity of uranium contamination in embryonic zebrafish cells
Keywords: Uranium; DNA repair; γ-H2AX; Zebrafish; Comet assay; TEM;
Potentials and mechanisms of genotoxicity of six pharmaceuticals frequently detected in freshwater environment
Keywords: Chicken DT40 cell; Genotoxicity; Pharmaceutical; γ-H2AX; Chromosome aberration;
Dual effects of N-acetyl-l-cysteine dependent on NQO1 activity: Suppressive or promotive of 9,10-phenanthrenequinone-induced toxicity
Keywords: BSFGE; biased sinusoidal field gel electrophoresis; DCFH-DA; 6-carboxy-2, 7â²-diclorodihydrofluorescein diacetate, di(acetoxymethyl ester); DCPIP; 2,6-dichlorophenol-indophenol; DSBs; double strand breaks; DTT; dithiothreitol; GSH; glutathione; γ-H2AX;
Use of the γ-H2AX assay to monitor DNA damage and repair in translational cancer research
Keywords: γ-H2AX; Double-strand breaks (DSBs); Translational research; Chemotherapy; Radiation therapy; Radiosensitivity; Biodosimetry; Imaging;
Radical-induced DNA damage by cytotoxic square-planar copper(II) complexes incorporating o-phthalate and 1,10-phenanthroline or 2,2â²-dipyridyl
Keywords: Copper; Anticancer; SOD; CAT; ROS generation; DNA binding; Nuclease; γ-H2AX; Double-strand DNA breaks; Free radicals;
The amount of DNA damage needed to activate the radiation-induced G2 checkpoint varies between single cells
Keywords: Ionizing radiation; G2-arrest; Checkpoint adaptation; Single cells; γ-H2AX; DNA damage;
Expression of γ-H2AX in endometrial carcinomas: An immunohistochemical study with p53
Keywords: Endometrial cancer; Immunohistochemistry; H2AX; p53; γ-H2AX;