کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5509346 | 1538511 | 2017 | 24 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Hepatic stellate cell interferes with NK cell regulation of fibrogenesis via curcumin induced senescence of hepatic stellate cell
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کلمات کلیدی
CMAIFN-γα-SMAγ-H2AXDAPISA-β-galCCl4HSCsNKG2DGAPDHULBP2HMGA1High Mobility Group A1RAE13,4-DCIFBSDMEMPBSMajor histocompatibilty complex3,4-dichloroisocoumarin - 3،4-dichloroisocoumarin4′, 6-diamidino-2-phenylindole - 4 '، 6-دیامیدینو-2-فنیلینولDMSO - DMSODulbecco's modified Eagle Medium - Eagle Medium اصلاح شده Dulbeccosenescence-associated β-galactosidase - β-گالاکتوزیداز وابسته به پیریα-smooth muscle actin - اکتین عضله آلفا صافinterferon-gamma - اینترفرون گاماDimethylsulfoxide - دیمتیل سولفواکسیدfetal bovine serum - سرم جنین گاوNK cell - سلول NKHepatic stellate cell - سلول ستاره ای کبدیNatural killer cell - سلول قاتل طبیعیHepatic stellate cells - سلولهای ستارهای کبدیPVR - ضبط و پخشHepatic fibrosis - فیبروز کبدیHepatic fibrogenesis - فیبروژنز کبدیMHC - مجموعه سازگاری بافتی اصلیPhosphate-buffered saline - محلول نمک فسفات با خاصیت بافریMica - میکاSenescence - پیریCarbon tetrachloride - کربن تتراکلریدConcanamycin A - کنکنامایسین AGranule exocytosis - گرازول اگزوسیتوزGlyceraldehyde phosphate dehydrogenase - گلیسرالیدید فسفات دهیدروژنازpoliovirus receptor - گیرنده پولیوویروس
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Hepatic fibrosis, a common scarring response to various forms of chronic liver injury, is a precursor to cirrhosis and liver cancer. During liver fibrosis, hepatic stellate cells (HSCs) initially activate and proliferate, which are responsible for the secretion of extracellular matrix components. However, these cells eventually senesce and are cleared by natural killer (NK) cells. Our previous researches have shown that the natural product curcumin could promote the senescence of activated HSC. In this study, we investigated how NK cells target senescent HSC and assessed the effect of this process on liver fibrosis. We found that senescent HSC induced by curcumin are susceptible to NK cells killing, due to the increased expression of NK cell activating ligand major histocompatibility complex class I chain-related genes A (MICA) and UL16-binding proteins 2 (ULBP2), but not Poliovirus Receptor (PVR). Further studies displayed that the interaction between NK cells and senescent LX2 cells stimulated granule exocytosis. Moreover, the inhibition of granule exocytosis weakened the cytotoxicity of NK cells and promoted the accumulation of senescent LX2 cells. Therefore, these aggregated data indicated that NK cells mediated clearance of senescent LX2 cells and granule exocytosis could play a protective role in the improvement of liver fibrosis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cellular Signalling - Volume 33, May 2017, Pages 79-85
Journal: Cellular Signalling - Volume 33, May 2017, Pages 79-85
نویسندگان
Huanhuan Jin, Yan Jia, Zhen Yao, Jingjing Huang, Meng Hao, Shunyu Yao, Naqi Lian, Feng Zhang, Chenxi Zhang, Xingran Chen, Mianli Bian, Jiangjuan Shao, Li Wu, Anping Chen, Shizhong Zheng,