Building a Virus from Scratch: Assembly of an Infectious Virus Using Purified Components in a Rigorously Defined Biochemical Assay System Fulltext Access 13 Pages 2006
FGFR3 Dimer Stabilization Due to a Single Amino Acid Pathogenic Mutation Fulltext Access 13 Pages 2006
Nuclear Transport of Trimeric Assembly Intermediates Exerts a Morphogenetic Control on the Icosahedral Parvovirus Capsid Fulltext Access 13 Pages 2006
Structure of the Regulatory Subunit of Acetohydroxyacid Synthase Isozyme III from Escherichia coli Fulltext Access 13 Pages 2006
Analysis of the Secondary Structure of Expansion Segment 39 in Ribosomes from Fungi, Plants and Mammals Fulltext Access 13 Pages 2006
Scanning Mutagenesis Studies Reveal Multiple Distinct Regions within the Human Protein Kinase C Alpha Regulatory Domain Important for Phorbol Ester-dependent Activation of the Enzyme Fulltext Access 13 Pages 2006
Glycan Microarray Analysis of the Hemagglutinins from Modern and Pandemic Influenza Viruses Reveals Different Receptor Specificities Fulltext Access 13 Pages 2006
Fold Independent Structural Comparisons of Protein–Ligand Binding Sites for Exploring Functional Relationships Fulltext Access 13 Pages 2006
Cell-specific Regulation of TRBP1 Promoter by NF-Y Transcription Factor in Lymphocytes and Astrocytes Fulltext Access 13 Pages 2006
Unveiling the Molecular Mechanism of a Conjugative Relaxase: The Structure of TrwC Complexed with a 27-mer DNA Comprising the Recognition Hairpin and the Cleavage Site Fulltext Access 13 Pages 2006
Cofilin Cross-bridges Adjacent Actin Protomers and Replaces part of the Longitudinal F-actin Interface Fulltext Access 13 Pages 2006
The Autocrine Motility Factor (AMF) and AMF-receptor Combination Needs Sugar Chain Recognition Ability and Interaction Using the C-terminal Region of AMF Fulltext Access 13 Pages 2006
Prediction of Binding Sites of Peptide Recognition Domains: An Application on Grb2 and SAP SH2 Domains Fulltext Access 13 Pages 2006
Structure of a Putative Lipoate Protein Ligase from Thermoplasma acidophilum and the Mechanism of Target Selection for Post-translational Modification Fulltext Access 13 Pages 2006
Structural Determinants of Rotavirus Subgroup Specificity Mapped by Cryo-electron Microscopy Fulltext Access 13 Pages 2006
Saccharomyces cerevisiae Ste50 Binds the MAPKKK Ste11 Through a Head-to-tail SAM Domain Interaction Fulltext Access 13 Pages 2006
The Oxidation State of DJ-1 Regulates its Chaperone Activity Toward α-Synuclein Fulltext Access 13 Pages 2006
Crystal Structure of Bordetella pertussis BugD Solute Receptor Unveils the Basis of Ligand Binding in a New Family of Periplasmic Binding Proteins Fulltext Access 13 Pages 2006
A Structural Basis for the Role of Nucleotide Specifying Residues in Regulating the Oligomerization of the Rv1625c Adenylyl Cyclase from M. tuberculosis Fulltext Access 13 Pages 2006
Crystal Structure of Full Length Topoisomerase I from Thermotoga maritima Fulltext Access 13 Pages 2006
Identity Elements Required for Enzymatic Formation of N2,N2-dimethylguanosine from N2-monomethylated Derivative and its Possible Role in Avoiding Alternative Conformations in Archaeal tRNA Fulltext Access 13 Pages 2006
A New Solution Structure of ATP Synthase Subunit c from Thermophilic Bacillus PS3, Suggesting a Local Conformational Change for H+-Translocation Fulltext Access 13 Pages 2006
Crystal Structure of Human BACE2 in Complex with a Hydroxyethylamine Transition-state Inhibitor Fulltext Access 13 Pages 2006
Structural Evidence for Adaptive Ligand Binding of Glycolipid Transfer Protein Fulltext Access 13 Pages 2006
Human atrial conduction and arrhythmogenesis correlates with conformational exposure of specific epitopes on the connexin40 carboxyl tail Fulltext Access 13 Pages 2006
Histidine-rich Ca binding protein: a regulator of sarcoplasmic reticulum calcium sequestration and cardiac function Fulltext Access 13 Pages 2006
Class II HDACs mediate CaMK-dependent signaling to NRSF in ventricular myocytes Fulltext Access 13 Pages 2006
Expression of Kir2.1 and Kir6.2 transgenes under the control of the α-MHC promoter in the sinoatrial and atrioventricular nodes in transgenic mice Fulltext Access 13 Pages 2006
Molecular Basis for Nucleotide-binding Specificity: Role of the Exocyclic Amino Group “N2” in Recognition by a Guanylyl-ribonuclease Fulltext Access 13 Pages 2006
Nuclear Sequestration of β-Subunits by Rad and Rem is Controlled by 14-3-3 and Calmodulin and Reveals a Novel Mechanism for Ca2+ Channel Regulation Fulltext Access 13 Pages 2006
Three-dimensional Structure of a Double Apoptosome Formed by the Drosophila Apaf-1 Related Killer Fulltext Access 13 Pages 2006
Roles of N-terminal Pyroglutamate in Maintaining Structural Integrity and pKa Values of Catalytic Histidine Residues in Bullfrog Ribonuclease 3 Fulltext Access 13 Pages 2006
Differential Roles of PKC-θ in the Regulation of Intracellular Calcium Concentration in Primary T Cells Fulltext Access 13 Pages 2006
Intrinsically Disordered Loops Inserted into the Structural Domains of Human Proteins Fulltext Access 13 Pages 2006
Gold Nanocluster Formation using Metallothionein: Mass Spectrometry and Electron Microscopy Fulltext Access 13 Pages 2006
Structural Studies of MFE-1: the 1.9 Å Crystal Structure of the Dehydrogenase Part of Rat Peroxisomal MFE-1 Fulltext Access 13 Pages 2006
Crystal Structure of Penicillin-binding Protein 1a (PBP1a) Reveals a Mutational Hotspot Implicated in β-Lactam Resistance in Streptococcus pneumoniae Fulltext Access 13 Pages 2006
Structural Basis of Syndecan-4 Phosphorylation as a Molecular Switch to Regulate Signaling Fulltext Access 13 Pages 2006
During the Early Phase of HIV-1 DNA Synthesis, Nucleocapsid Protein Directs Hybridization of the TAR Complementary Sequences via the Ends of their Double-stranded Stem Fulltext Access 13 Pages 2006
Individual Metal Ligands Play Distinct Functional Roles in the Zinc Sensor Staphylococcus aureus CzrA Fulltext Access 13 Pages 2006
Solvation-assisted Pressure Tuning of Insulin Fibrillation: From Novel Aggregation Pathways to Biotechnological Applications Fulltext Access 13 Pages 2006
Crystal Structures of Mouse Autocrine Motility Factor in Complex with Carbohydrate Phosphate Inhibitors Provide Insight into Structure–Activity Relationship of the Inhibitors Fulltext Access 13 Pages 2006
Thioredoxin Fusions Increase Folding of Single Chain Fv Antibodies in the Cytoplasm of Escherichia coli: Evidence that Chaperone Activity is the Prime Effect of Thioredoxin Fulltext Access 13 Pages 2006
The Co-chaperone p23 Arrests the Hsp90 ATPase Cycle to Trap Client Proteins Fulltext Access 13 Pages 2006
An Epidemiologically Significant Epitope of a 1998 Human Influenza Virus Neuraminidase Forms a Highly Hydrated Interface in the NA–Antibody Complex Fulltext Access 13 Pages 2006
Structural Basis for Metal Binding Specificity: the N-terminal Cadmium Binding Domain of the P1-type ATPase CadA Fulltext Access 13 Pages 2006
The Component Polypeptide Chains of Bovine Insulin Nucleate or Inhibit Aggregation of the Parent Protein in a Conformation-dependent Manner Fulltext Access 13 Pages 2006
Quantitative Actin Folding Reactions using Yeast CCT Purified via an Internal Tag in the CCT3/γ Subunit Fulltext Access 13 Pages 2006
Solution Structure of the NEAT (NEAr Transporter) Domain from IsdH/HarA: the Human Hemoglobin Receptor in Staphylococcus aureus Fulltext Access 13 Pages 2006
Crystal Structure of Escherichia coliL-Arabinose Isomerase (ECAI), The Putative Target of Biological Tagatose Production Fulltext Access 13 Pages 2006
Interplay Between Ion Binding and Catalysis in the Thioredoxin-coupled Arsenate Reductase Family Fulltext Access 13 Pages 2006
T-rich DNA Single Strands Bind to a Preformed Site on the Bacterial Cold Shock Protein Bs-CspB Fulltext Access 13 Pages 2006
Structural and Kinetic Analysis of Caspase-3 Reveals Role for S5 Binding Site in Substrate Recognition Fulltext Access 13 Pages 2006
Structure of a GDP:AlF4 Complex of the SRP GTPases Ffh and FtsY, and Identification of a Peripheral Nucleotide Interaction Site Fulltext Access 13 Pages 2006
Translocation of a tRNA with an Extended Anticodon Through the Ribosome Fulltext Access 13 Pages 2006
Structural Rearrangements in the Thyroid Hormone Receptor Hinge Domain and Their Putative Role in the Receptor Function Fulltext Access 13 Pages 2006
A Novel Glycoside Hydrolase Family 105: The Structure of Family 105 Unsaturated Rhamnogalacturonyl Hydrolase Complexed with a Disaccharide in Comparison with Family 88 Enzyme Complexed with the Disaccharide Fulltext Access 13 Pages 2006
Specific Recognition of HIV TAR RNA by the dsRNA Binding Domains (dsRBD1–dsRBD2) of PKR Fulltext Access 13 Pages 2006
Monitoring the Diffusion of Single Heterotrimeric G Proteins in Supported Cell-membrane Sheets Reveals their Partitioning into Microdomains Fulltext Access 13 Pages 2006
Evidence that Creation of Invasion Sites Determines the Rate of Strand Transfer Mediated by HIV-1 Reverse Transcriptase Fulltext Access 13 Pages 2006
The Alkali Molten Globule State of Horse Ferricytochrome c: Observation of Cold Denaturation Fulltext Access 13 Pages 2006
Mechanism of Phosphoryl Transfer Catalyzed by Shikimate Kinase from Mycobacterium tuberculosis Fulltext Access 13 Pages 2006
Self-interaction of a SNARE Transmembrane Domain Promotes the Hemifusion-to-fusion Transition Fulltext Access 13 Pages 2006
Crystal Structures of Human NUDT5 Reveal Insights into the Structural Basis of the Substrate Specificity Fulltext Access 13 Pages 2006
Structural Tolerance versus Functional Intolerance to Mutation of Hydrophobic Core Residues Surrounding Cavities in a Parvovirus Capsid Fulltext Access 13 Pages 2006
Characterization of the Functional Domains of Escherichia coli RNase II Fulltext Access 13 Pages 2006
Simulations of the Myosin II Motor Reveal a Nucleotide-state Sensing Element that Controls the Recovery Stroke Fulltext Access 13 Pages 2006
Structural Classification and Prediction of Reentrant Regions in α-Helical Transmembrane Proteins: Application to Complete Genomes Fulltext Access 13 Pages 2006
GuHCl and NaCl-dependent Hydrogen Exchange in MerP Reveals a Well-defined Core with an Unusual Exchange Pattern Fulltext Access 13 Pages 2006
Molecular Structure of a Novel Membrane Protease Specific for a Stomatin Homolog from the Hyperthermophilic Archaeon Pyrococcus horikoshii Fulltext Access 13 Pages 2006
A Rearranging Ligand Enables Allosteric Control of Catalytic Activity in Copper-containing Nitrite Reductase Fulltext Access 13 Pages 2006
The C-terminal TPR Domain of Tom70 Defines a Family of Mitochondrial Protein Import Receptors Found only in Animals and Fungi Fulltext Access 13 Pages 2006
Stimulated Expression of mRNAs in Activated T Cells Depends on a Functional CRM1 Nuclear Export Pathway Fulltext Access 13 Pages 2006
Structural Insights into Enzyme–Substrate Interaction and Characterization of Enzymatic Intermediates of Organic Hydroperoxide Resistance Protein from Xylella fastidiosa Fulltext Access 13 Pages 2006
Structures of Ubiquitin Insertion Mutants Support Site-specific Reflex Response to Insertions Hypothesis Fulltext Access 13 Pages 2006
The First Holocomplex Structure of Ribonucleotide Reductase Gives New Insight into its Mechanism of Action Fulltext Access 13 Pages 2006
Structure–Stability–Activity Relationship in Covalently Cross-linked N-Carbamoyl d-Amino acid Amidohydrolase and N-Acylamino acid Racemase Fulltext Access 13 Pages 2006
Crystal Structures of SnoaL2 and AclR: Two Putative Hydroxylases in the Biosynthesis of Aromatic Polyketide Antibiotics Fulltext Access 13 Pages 2006
The N-terminal 12 Residue Long Peptide of HIV gp41 is the Minimal Peptide Sufficient to Induce Significant T-cell-like Membrane Destabilization in Vitro Fulltext Access 13 Pages 2006
The Exocyclic Amine at the RNase P Cleavage Site Contributes to Substrate Binding and Catalysis Fulltext Access 13 Pages 2006
Transcriptional Response of Candida albicans to Hypoxia: Linkage of Oxygen Sensing and Efg1p-regulatory Networks Fulltext Access 13 Pages 2006
Computational Sampling of a Cryptic Drug Binding Site in a Protein Receptor: Explicit Solvent Molecular Dynamics and Inhibitor Docking to p38 MAP Kinase Fulltext Access 13 Pages 2006
The Structure of an Inverting GH43 β-Xylosidase from Geobacillus stearothermophilus with its Substrate Reveals the Role of the Three Catalytic Residues Fulltext Access 13 Pages 2006
Overexpression of Hepatitis C Virus NS5A Protein Induces Chromosome Instability via Mitotic Cell Cycle Dysregulation Fulltext Access 13 Pages 2006
X-ray Crystal Structures of Rabbit N-acetylglucosaminyltransferase I (GnT I) in Complex with Donor Substrate Analogues Fulltext Access 13 Pages 2006
Human Transcription Factors Contain a High Fraction of Intrinsically Disordered Regions Essential for Transcriptional Regulation Fulltext Access 13 Pages 2006
Evolutionarily Distinct Residues in the Uncoupling Protein UCP1 Are Essential for Its Characteristic Basal Proton Conductance Fulltext Access 13 Pages 2006
Structure of the N-terminal Domain of the FOP (FGFR1OP) Protein and Implications for its Dimerization and Centrosomal Localization Fulltext Access 13 Pages 2006
Insights into Cephamycin Biosynthesis: the Crystal Structure of CmcI from Streptomyces clavuligerus Fulltext Access 13 Pages 2006
Role of Structural and Dynamical Plasticity in Sin3: The Free PAH2 Domain is a Folded Module in mSin3B Fulltext Access 13 Pages 2006
Structural Studies of a Two-domain Chitinase from Streptomyces griseus HUT6037 Fulltext Access 13 Pages 2006