The synthesis and kinetic evaluation of aryl α-aminophosphonates as novel inhibitors of T. cruzi trans-sialidase Fulltext Access 26 Pages 2018
The development of piperidinones as potent MDM2-P53 protein-protein interaction inhibitors for cancer therapy Fulltext Access 26 Pages 2018
Synthesis and anti-tumor activity of EF24 analogues as IKKβ inhibitors Fulltext Access 26 Pages 2018
Development of novel β-carboline-based hydroxamate derivatives as HDAC inhibitors with antiproliferative and antimetastatic activities in human cancer cells Fulltext Access 26 Pages 2018
Nitrite exerts antioxidant effects, inhibits the mTOR pathway and reverses hypertension-induced cardiac hypertrophy Fulltext Access 26 Pages 2018
Attenuation of oxidative damage by targeting mitochondrial complex I in neonatal hypoxic-ischemic brain injury Fulltext Access 26 Pages 2018
Inhibitory effects and structural insights for a novel series of coumarin-based compounds that selectively target human CA IX and CA XII carbonic anhydrases Fulltext Access 26 Pages 2018
Role of GPx3 in PPARγ-induced protection against COPD-associated oxidative stress Fulltext Access 26 Pages 2018
N-acetylcysteine ethyl ester as GSH enhancer in human primary endothelial cells: A comparative study with other drugs Fulltext Access 26 Pages 2018
Total wrist access for angiography and interventions: Procedural success and access site crossover in a high volume transradial center Fulltext Access 26 Pages 2018
Cholesterol crystals increase vascular permeability by inactivating SHP2 and disrupting adherens junctions Fulltext Access 26 Pages 2018
The chemical reactivity of (-)-epicatechin quinone mainly resides in its B-ring Fulltext Access 26 Pages 2018
Ferritin iron regulators, PCBP1 and NCOA4, respond to cellular iron status in developing red cells Fulltext Access 26 Pages 2018
Orbital atherectomy for the treatment of small (2.5Â mm) severely calcified coronary lesions: ORBIT II sub-analysis Fulltext Access 26 Pages 2018
Postprocedural high-sensitivity troponin T and prognosis in patients with non-ST-segment elevation myocardial infarction treated with early percutaneous coronary intervention Fulltext Access 26 Pages 2018
Switch to Ticagrelor in critical limb ischemia antiplatelet study (STT-CLIPS) Fulltext Access 26 Pages 2018
Discovery of 1,8-acridinedione derivatives as novel GCN5 inhibitors via high throughput screening Fulltext Access 26 Pages 2018
Oxidative stress induces p38MAPK-dependent senescence in the feto-maternal interface cells Fulltext Access 26 Pages 2018
Design, synthesis, structure-activity relationships study and X-ray crystallography of 3-substituted-indolin-2-one-5-carboxamide derivatives as PAK4 inhibitors Fulltext Access 26 Pages 2018
Structure-activity relationships of β-hairpin mimics as modulators of amyloid β-peptide aggregation Fulltext Access 26 Pages 2018
Recent advances in the search for novel 5-lipoxygenase inhibitors for the treatment of asthma Fulltext Access 26 Pages 2018
Novel Mannich bases of α- and γ-mangostins: Synthesis and evaluation of antioxidant and membrane-protective activity Fulltext Access 26 Pages 2018
Recent progress of the development of dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes mellitus Fulltext Access 26 Pages 2018
Antiproliferative efficacy of curcumin mimics through microtubule destabilization Fulltext Access 26 Pages 2018
Synthesis and structure-activity relationship study of arylsulfonamides as novel potent H5N1 inhibitors Fulltext Access 26 Pages 2018
Design, synthesis, anti-lung cancer activity, and chemosensitization of tumor-selective MCACs based on ROS-mediated JNK pathway activation and NF-κB pathway inhibition Fulltext Access 26 Pages 2018
Design, synthesis and biological evaluation of piperazinyl-β-carbolinederivatives as anti-leishmanial agents Fulltext Access 26 Pages 2018
Discovery of [1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives as novel, potent and selective c-Met kinase inhibitors: Synthesis, SAR study, and biological activity Fulltext Access 26 Pages 2018
Engineering a novel protease-based Exendin-4 derivative for type 2 antidiabetic therapeutics Fulltext Access 26 Pages 2018
Synthesis and pharmacological evaluation of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline derivatives as sigma-2 receptor ligands Fulltext Access 26 Pages 2018
Synthesis, β-hematin inhibition studies and antimalarial evaluation of new dehydroxy isoquine derivatives against Plasmodium berghei: A promising antimalarial agent Fulltext Access 26 Pages 2018
An overview on crystal structures of InhA protein: Apo-form, in complex with its natural ligands and inhibitors Fulltext Access 26 Pages 2018
Acetylation of TIP60 at K104 is essential for metabolic stress-induced apoptosis in cells of hepatocellular cancer Fulltext Access 27 Pages 2018
Expression of β1integrin in normal epithelium, oral submucous fibrosis and oral squamous cell carcinoma Fulltext Access 27 Pages 2018
Effects of miR-200a and FH535 combined with taxol on proliferation and invasion of gastric cancer Fulltext Access 27 Pages 2018
High-expressed CKS2 is associated with hepatocellular carcinoma cell proliferation through down-regulating PTEN Fulltext Access 27 Pages 2018
Analysis of the proliferative activity in lung adenocarcinomas with specific driver mutations Fulltext Access 27 Pages 2018
Clinical value of survivin and its underlying mechanism in ovarian cancer: A bioinformatics study based on GEO and TCGA data mining Fulltext Access 27 Pages 2018
K-ras mutation promotes ionizing radiation-induced invasion and migration of lung cancer in part via the Cathepsin L/CUX1 pathway Fulltext Access 27 Pages 2018
microRNA-mediated regulation of splicing factors SRSF1, SRSF2 and hnRNP A1 in context of their alternatively spliced 3â²UTRs Fulltext Access 27 Pages 2018
Inhibition of miR-361-5p suppressed pulmonary artery smooth muscle cell survival and migration by targeting ABCA1 and inhibiting the JAK2/STAT3 pathway Fulltext Access 27 Pages 2018
Capn4 promotes colorectal cancer cell proliferation by increasing MAPK7 through activation of the Wnt/β-Catenin pathway Fulltext Access 27 Pages 2018
Tacripyrimidines, the first tacrine-dihydropyrimidine hybrids, as multi-target-directed ligands for Alzheimer's disease Fulltext Access 27 Pages 2018
Endovascular treatment of iliac and common femoral arteries disease by the transradial access: A prospective, feasibility study Fulltext Access 27 Pages 2018
Observations from a real-time, iFR-FFR “hybrid approach” in patients with severe aortic stenosis and coronary artery disease undergoing TAVI Fulltext Access 27 Pages 2018
Tau localises within mitochondrial sub-compartments and its caspase cleavage affects ER-mitochondria interactions and cellular Ca2+ handling Fulltext Access 27 Pages 2018
LncRNA PRAL is closely related to clinical prognosis of multiple myeloma and the bortezomib sensitivity Fulltext Access 27 Pages 2018
Hepatitis B virus suppresses the secretion of insulin-like growth factor binding protein 1 to facilitate anti-apoptotic IGF-1 effects in HepG2 cells Fulltext Access 27 Pages 2018
Surgical trauma contributes to progression of colon cancer by downregulating CXCL4 and recruiting MDSCs Fulltext Access 27 Pages 2018
Nitrite mediated vasorelaxation in human chorionic plate vessels is enhanced by hypoxia and dependent on the NO-sGC-cGMP pathway Fulltext Access 27 Pages 2018
Assessing the feasibility of intranasal radiotracer administration for in brain PET imaging Fulltext Access 27 Pages 2018
DNA methylation profile at a satellite region is associated with aberrant placentation in cloned calves Fulltext Access 27 Pages 2018
Five threads: How U-shaped thinking weaves together dogs, men, selenium, and prostate cancer risk Fulltext Access 27 Pages 2018
VAOS, a novel vanadyl complexes of alginate saccharides, inducing apoptosis via activation of AKT-dependent ROS production in NSCLC Fulltext Access 27 Pages 2018
Structure-activity relationships for inhibitors of Pseudomonas aeruginosa exoenzyme S ADP-ribosyltransferase activity Fulltext Access 27 Pages 2018
SPARC is down-regulated by DNA methylation and functions as a tumor suppressor in T-cell lymphoma Fulltext Access 27 Pages 2018
Metformin regulates mitochondrial biogenesis and senescence through AMPK mediated H3K79 methylation: Relevance in age-associated vascular dysfunction Fulltext Access 27 Pages 2018
Novel role of apatinib as a multi-target RTK inhibitor in the direct suppression of hepatocellular carcinoma cells Fulltext Access 27 Pages 2018
Ablation of C/EBP homologous protein attenuates renal fibrosis after ureteral obstruction by reducing autophagy and microtubule disruption Fulltext Access 27 Pages 2018
Platelet microparticle delivered microRNA-Let-7a promotes the angiogenic switch Fulltext Access 27 Pages 2018
NF-κB-mediated metabolic remodelling in the inflamed heart in acute viral myocarditis Fulltext Access 27 Pages 2018
Lipid vesicles affect the aggregation of 4-hydroxy-2-nonenal-modified α-synuclein oligomers Fulltext Access 27 Pages 2018
MitoQ protects dopaminergic neurons in a 6-OHDA induced PD model by enhancing Mfn2-dependent mitochondrial fusion via activation of PGC-1α Fulltext Access 27 Pages 2018
CCR6 promotes tumor angiogenesis via the AKT/NF-κB/VEGF pathway in colorectal cancer Fulltext Access 27 Pages 2018
Discovery, optimization and biological evaluation for novel c-Met kinase inhibitors Fulltext Access 27 Pages 2018
Synthesis, biological evaluation and structure-activity relationship studies of hederacolchiside E and its derivatives as potential anti-Alzheimer agents Fulltext Access 27 Pages 2018
Synthesis and biological evaluation of a novel β-D-2â²-deoxy-2â²-α-fluoro-2â²-β-C-(fluoromethyl)uridine phosphoramidate prodrug for the treatment of hepatitis C virus infection Fulltext Access 27 Pages 2018
Design, synthesis and QSAR study of novel isatin analogues inspired Michael acceptor as potential anticancer compounds Fulltext Access 27 Pages 2018
Bysspectin A, an unusual octaketide dimer and the precursor derivatives from the endophytic fungus Byssochlamys spectabilis IMM0002 and their biological activities Fulltext Access 27 Pages 2018
Simple 2(5H)-furanone derivatives with selective cytotoxicity towards non-small cell lung cancer cell line A549 - Synthesis, structure-activity relationship and biological evaluation Fulltext Access 27 Pages 2018
Synthesis and biological evaluation of clovamide analogues as potent anti-neuroinflammatory agents in vitro and in vivo Fulltext Access 27 Pages 2018
Synthesis of pyrazolo[3,4-d]pyrimidin-4(5H)-ones tethered to 1,2,3-triazoles and their evaluation as potential anticancer agents Fulltext Access 27 Pages 2018
Bach2 regulates aberrant activation of B cell in systemic lupus erythematosus and can be negatively regulated by BCR-ABL/PI3K Fulltext Access 27 Pages 2018
Human miR-26a-5p regulates the glutamate transporter SLC1A1 (EAAT3) expression. Relevance in multiple sclerosis Fulltext Access 27 Pages 2018
ChIP-seq analysis reveals alteration of H3K4 trimethylation occupancy in cancer-related genes by cold atmospheric plasma Fulltext Access 27 Pages 2018
The role and mechanism of KCa3.1 channels in human monocyte migration induced by palmitic acid Fulltext Access 27 Pages 2018
Designing aptamers which respond to intracellular oxidative stress and inhibit aggregation of mutant huntingtin Fulltext Access 27 Pages 2018
Analysis of eicosanoid oxidation products in Alzheimer brain by LC-MS with uniformly 13C-labeled internal standards Fulltext Access 27 Pages 2018
Thermal tolerance and thermal sensitivity of heart mitochondria: Mitochondrial integrity and ROS production Fulltext Access 27 Pages 2018
The possible repositioning of an oral anti-arthritic drug, auranofin, for Nrf2-activating therapy: The demonstration of Nrf2-dependent anti-oxidative action using a zebrafish model Fulltext Access 27 Pages 2018
Systems Signatures Reveal Unique Remission-path of Type 2 Diabetes Following Roux-en-Y Gastric Bypass Surgery Fulltext Access 27 Pages 2018
CDK5-mediated phosphorylation of Sirt2 contributes to depressive-like behavior induced by social defeat stress Fulltext Access 27 Pages 2018
Long-range telomere regulation of gene expression: Telomere looping and telomere position effect over long distances (TPE-OLD) Fulltext Access 27 Pages 2018
Mechanical wounding promotes local and long distance response in the halophyte Cakile maritima through the involvement of the ROS and RNS metabolism Fulltext Access 27 Pages 2018
Ectopic overexpression of MCPIP1 impairs adipogenesis by modulating microRNAs Fulltext Access 28 Pages 2018
NO, hydrogen sulfide does not come first during tomato response to high salinity Fulltext Access 28 Pages 2018
Effect of ginger, Paullinia cupana, muira puama and l- citrulline, singly or in combination, on modulation of the inducible nitric oxide- NO-cGMP pathway in rat penile smooth muscle cells Fulltext Access 28 Pages 2018
Discovery and development of sGC stimulators for the treatment of pulmonary hypertension and rare diseases Fulltext Access 28 Pages 2018
TRAIL induces apoptosis but not necroptosis in colorectal and pancreatic cancer cells preferentially via the TRAIL-R2/DR5 receptor Fulltext Access 28 Pages 2018
Platelet factor XI: intracellular localization and mRNA splicing following platelet activation Fulltext Access 28 Pages 2018
Percutaneous angioplasty versus atherectomy for treatment of symptomatic infra-popliteal arterial disease Fulltext Access 28 Pages 2018