Synthesis and evaluation of 99mTc/Re-tricarbonyl complexes of the triphenylphosphonium cation for mitochondrial targeting Fulltext Access 29 Pages 2018
Case report of three EGFR TKI naïve lung adenocarcinoma containing double EGFR mutations (L858R/T790M or Exon 19 Deletion/T790M); Comparing genetic information and histology Fulltext Access 29 Pages 2018
Therapeutic management of peritoneal ascitic sarcomatosis by Ruta graveolens: A study in experimental mice Fulltext Access 29 Pages 2018
Biological function of UCA1 in hepatocellular carcinoma and its clinical significance: Investigation with in vitro and meta-analysis Fulltext Access 29 Pages 2018
The clinical value of HPV E6/E7 and STAT3 mRNA detection in cervical cancer screening Fulltext Access 29 Pages 2018
The effect of neoadjuvant chemotherapy on the correlation of tumor-associated macrophages with CD31 and LYVE-1 Fulltext Access 29 Pages 2018
Synthetic High-Density Lipoprotein-Mediated Targeted Delivery of Liver X Receptors Agonist Promotes Atherosclerosis Regression Fulltext Access 30 Pages 2018
Egr-1 mediated cardiac miR-99 family expression diverges physiological hypertrophy from pathological hypertrophy Fulltext Access 30 Pages 2018
MiR-124 induces autophagy-related cell death in cholangiocarcinoma cells through direct targeting of the EZH2-STAT3 signaling axis Fulltext Access 30 Pages 2018
Lentivirus-mediated CTRP6 silencing ameliorates diet-induced obesity in mice Fulltext Access 30 Pages 2018
Overexpression of miR-182 inhibits ossification of ligamentum flavum cells by targeting NAMPT Fulltext Access 30 Pages 2018
PRP4 kinase induces actin rearrangement and epithelial-mesenchymal transition through modulation of the actin-binding protein cofilin Fulltext Access 30 Pages 2018
Cadherin profiling for therapeutic interventions in Epithelial Mesenchymal Transition (EMT) and tumorigenesis Fulltext Access 30 Pages 2018
Glycyrrhizin ameliorates inflammatory pain by inhibiting microglial activation-mediated inflammatory response via blockage of the HMGB1-TLR4-NF-kB pathway Fulltext Access 30 Pages 2018
Vascular endothelial growth factor aggravates cerebral ischemia and reperfusion-induced blood-brain-barrier disruption through regulating LOC102640519/HOXC13/ZO-1 signaling Fulltext Access 30 Pages 2018
Long-term biodistribution study of HPMA-ran-LMA copolymers in vivo by means of 131I-labeling Fulltext Access 30 Pages 2018
High Expression of TET1 Predicts Poor Survival in Cytogenetically Normal Acute Myeloid Leukemia From Two Cohorts Fulltext Access 30 Pages 2018
Development of urogenital system in the Spix cavy: A model for studies on sexual differentiation Fulltext Access 30 Pages 2018
Discovery and development of next generation sGC stimulators with diverse multidimensional pharmacology and broad therapeutic potential Fulltext Access 30 Pages 2018
The SNP rs4252548 (R112H) which is associated with reduced human height compromises the stability of IL-11 Fulltext Access 30 Pages 2018
Use of liquid isoelectric focusing (OFFGEL) on the discovery of meat tenderness biomarkers Fulltext Access 30 Pages 2018
mTOR in Down syndrome: Role in AÃ and tau neuropathology and transition to Alzheimer disease-like dementia Fulltext Access 30 Pages 2018
Metformin treatment prevents SREBP2-mediated cholesterol uptake and improves lipid homeostasis during oxidative stress-induced atherosclerosis Fulltext Access 30 Pages 2018
Expression of reactive species related genes is associated with patient survival in luminal B breast cancer Fulltext Access 30 Pages 2018
Kinetic and stoichiometric constraints determine the pathway of H2O2 consumption by red blood cells Fulltext Access 30 Pages 2018
ST elevation myocardial infarction in patients with anomalous left main coronary artery: Case series and review of the literature Fulltext Access 30 Pages 2018
Design, synthesis and structure-based optimization of novel isoxazole-containing benzamide derivatives as FtsZ modulators Fulltext Access 30 Pages 2018
Designing dichlorobinaphthoquinone as a prooxidative anticancer agent based on hydrogen peroxide-responsive in situ production of hydroxyl radicals Fulltext Access 30 Pages 2018
The role of E2F1-topoIIβ signaling in regulation of cell cycle exit and neuronal differentiation of human SH-SY5Y cells Fulltext Access 30 Pages 2018
Selenoprotein T is a key player in ER proteostasis, endocrine homeostasis and neuroprotection Fulltext Access 30 Pages 2018
Identification of novel inhibitors of histone acetyltransferase hMOF through high throughput screening Fulltext Access 30 Pages 2018
Nucleoporin35 is a novel microtubule associated protein functioning in oocyte meiotic spindle architecture Fulltext Access 30 Pages 2018
NMDA receptors inhibit axonal outgrowth by inactivating Akt and activating GSK-3β via calcineurin in cultured immature hippocampal neurons Fulltext Access 30 Pages 2018
ADAM17 promotes cell migration and invasion through the integrin β1 pathway in hepatocellular carcinoma Fulltext Access 30 Pages 2018
E4BP4 inhibits AngII-induced apoptosis in H9c2 cardiomyoblasts by activating the PI3K-Akt pathway and promoting calcium uptake Fulltext Access 30 Pages 2018
Dual lumen microcatheters for complex percutaneous coronary interventions Fulltext Access 30 Pages 2018
Novel proctorship effectively teaches interventionists coronary artery chronic total occlusion lesions Fulltext Access 30 Pages 2018
ARHGEF11 affecting the placental insulin signaling pathway in fetal macrosomia of normal glucose tolerance pregnant women Fulltext Access 30 Pages 2018
HPV infection and p16INK4A and TP53 expression in rare cancers of the uterine cervix Fulltext Access 30 Pages 2018
MiR-199a-3p acts as a tumor suppressor in clear cell renal cell carcinoma Fulltext Access 30 Pages 2018
A damaged DNA binding protein 2 mutation disrupting interaction with proliferating-cell nuclear antigen affects DNA repair and confers proliferation advantage Fulltext Access 30 Pages 2018
89Zr for antibody labeling and in vivo studies - A comparison between liquid and solid target production Fulltext Access 30 Pages 2018
Design, synthesis and biological evaluation of 1, 4-dihydro indeno[1,2-c] pyrazole linked oxindole analogues as potential anticancer agents targeting tubulin and inducing p53 dependent apoptosis Fulltext Access 30 Pages 2018
Design and synthesis of novel 1H-tetrazol-5-amine based potent antimicrobial agents: DNA topoisomerase IV and gyrase affinity evaluation supported by molecular docking studies Fulltext Access 30 Pages 2018
Design, synthesis and in vitro evaluation of heterobivalent peptidic radioligands targeting both GRP- and VPAC1-Receptors concomitantly overexpressed on various malignancies - Is the concept feasible? Fulltext Access 30 Pages 2018
Targeting mitochondria: Esters of rhodamine B with triterpenoids are mitocanic triggers of apoptosis Fulltext Access 30 Pages 2018
Discovery of novel 2,4-diarylaminopyrimidine derivatives as potent and selective epidermal growth factor receptor (EGFR) inhibitors against L858R/T790M resistance mutation Fulltext Access 30 Pages 2018
Potholing of the hydrophobic heme oxygenase-1 western region for the search of potent and selective imidazole-based inhibitors Fulltext Access 30 Pages 2018
Efficient synthesis and first regioselective C-6 direct arylation of imidazo[2,1-c][1,2,4]triazine scaffold and their evaluation in H2O2-induced oxidative stress Fulltext Access 30 Pages 2018
Synthesis and bioevaluation and doking study of 1H-pyrrolo[2,3-b]pyridine derivatives bearing aromatic hydrazone moiety as c-Met inhibitors Fulltext Access 30 Pages 2018
Synthesis and biological evaluation of bifendate derivatives bearing 6,7-dihydro-dibenzo[c,e]azepine scaffold as potential P-glycoprotein and tumor metastasis inhibitors Fulltext Access 30 Pages 2018
Rational design of novel TLR4 ligands by in silico screening and their functional and structural characterization in vitro Fulltext Access 30 Pages 2018
Long-lived and short-lived reactive species produced by a cold atmospheric pressure plasma jet for the inactivation of Pseudomonas aeruginosa and Staphylococcus aureus Fulltext Access 30 Pages 2018
Development of potent and proteolytically stable human neuromedin U receptor agonists Fulltext Access 30 Pages 2018
Interaction of glucocorticoids with FXR/FGF19/FGF21-mediated ileum-liver crosstalk Fulltext Access 30 Pages 2018
Depletion of Ubiquilin induces an augmentation in soluble ubiquitinated Drosophila TDP-43 to drive neurotoxicity in the fly Fulltext Access 30 Pages 2018
A new bioluminescent imaging technology for studying oxidative stress in the testis and its impacts on fertility Fulltext Access 30 Pages 2018
Characterization of subventricular zone-derived progenitor cells from mild and late symptomatic YAC128 mouse model of Huntington's disease Fulltext Access 30 Pages 2018
c-Abl phosphorylation of Yin Yang 1's conserved tyrosine 254 in the spacer region modulates its transcriptional activity Fulltext Access 31 Pages 2018
Ethyl pyruvate reduces acute lung damage following trauma and hemorrhagic shock via inhibition of NF-κB and HMGB1 Fulltext Access 31 Pages 2018
Jatrophane diterpenoids from Euphorbia sororia as potent modulators against P-glycoprotein-based multidrug resistance Fulltext Access 31 Pages 2018
Rab and Arf proteins at the crossroad between membrane transport and cytoskeleton dynamics Fulltext Access 31 Pages 2018
Zirconium catalyzed synthesis of 2-arylidene Indan-1,3-diones and evaluation of their inhibitory activity against NS2B-NS3 WNV protease Fulltext Access 31 Pages 2018
A novel tetrahydroisoquinoline (THIQ) analogue induces mitochondria-dependent apoptosis Fulltext Access 31 Pages 2018
Synthesis of 7β-hydroxy-8-ketone opioid derivatives with antagonist activity at mu- and delta-opioid receptors Fulltext Access 31 Pages 2018
Design, synthesis and activity of BBI608 derivatives targeting on stem cells Fulltext Access 31 Pages 2018
MicroRNA-30d/JAG1 axis modulates pulmonary fibrosis through Notch signaling pathway Fulltext Access 31 Pages 2018
YKL-40: A biomarker for early nephropathy in type 2 diabetic patients and its association with inflammatory cytokines Fulltext Access 31 Pages 2018
Piperidinyl-embeded chalcones possessing anti PI3Kδ inhibitory properties exhibit anti-atopic properties in preclinical models Fulltext Access 31 Pages 2018
Discovery of novel quinazolinone derivatives as high potent and selective PI3Kδ and PI3Kδ/γ inhibitors Fulltext Access 31 Pages 2018
TGF-β synergizes with ML264 to block IL-1β-induced matrix degradation mediated by Krüppel-like factor 5 in the nucleus pulposus Fulltext Access 31 Pages 2018
Synthesis and evaluation of 4-cycloheptylphenols as selective Estrogen receptor-β agonists (SERBAs) Fulltext Access 31 Pages 2018
Structure-based drug design: Synthesis and biological evaluation of quinazolin-4-amine derivatives as selective Aurora A kinase inhibitors Fulltext Access 31 Pages 2018
Pyridinium and indole orientation determines the mitochondrial uncoupling and anti-cancer efficiency of F16 Fulltext Access 31 Pages 2018
Synthesis, molecular structure, and metabolic stability of new series of N'-(2-alkylthio-4-chloro-5-methylbenzenesulfonyl)-1-(5-phenyl-1H-pyrazol-1-yl)amidine as potential anti-cancer agents Fulltext Access 31 Pages 2018
Synthesis and biological evaluation of novel 2-arylvinyl-substituted naphtho[2,3-d]imidazolium halide derivatives as potent antitumor agents Fulltext Access 31 Pages 2018
Low galactosylation of IgG associates with higher risk for future diagnosis of rheumatoid arthritis during 10â¯years of follow-up Fulltext Access 31 Pages 2018
VPS33B and VIPAR are essential for epidermal lamellar body biogenesis and function Fulltext Access 31 Pages 2018
GLP-1 receptor agonists and reduction of cardiometabolic risk: Potential underlying mechanisms Fulltext Access 31 Pages 2018
Novel vanillin derivatives: Synthesis, anti-oxidant, DNA and cellular protection properties Fulltext Access 31 Pages 2018
Design, synthesis and biological activity evaluation of novel 4-subtituted 2-naphthamide derivatives as AcrB inhibitors Fulltext Access 31 Pages 2018
Recent advances in the discovery of potent and selective HDAC6 inhibitors Fulltext Access 31 Pages 2018
Orai1 is critical for Notch-driven aggressiveness under hypoxic conditions in triple-negative breast cancers Fulltext Access 31 Pages 2018
A trithiol bifunctional chelate for 72,77As: A matched pair theranostic complex with high in vivo stability Fulltext Access 31 Pages 2018
A new method measuring the interaction of radiotracers with the human P-glycoprotein (P-gp) transporter Fulltext Access 31 Pages 2018
Structure and energetic basis of overrepresented λ light chain in systemic light chain amyloidosis patients Fulltext Access 31 Pages 2018
Design, synthesis and evaluation of novel phenyl propionamide derivatives as non-nucleoside hepatitis B virus inhibitors Fulltext Access 31 Pages 2018
The putative flippase Apt1 is required for intracellular membrane architecture and biosynthesis of polysaccharide and lipids in Cryptococcus neoformans Fulltext Access 31 Pages 2018
HSF1, in association with MORC2, downregulates ArgBP2 via the PRC2 family in gastric cancer cells Fulltext Access 31 Pages 2018
18F-labeled norepinephrine transporter tracer [18F]NS12137: radiosynthesis and preclinical evaluation Fulltext Access 31 Pages 2018
A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design Fulltext Access 31 Pages 2018
Profiling calcium signals of in vitro polarized human effector CD4+ T cells Fulltext Access 31 Pages 2018
Antitumor activity of pyrrolizines and their Cu(II) complexes: Design, synthesis and cytotoxic screening with potential apoptosis-inducing activity Fulltext Access 31 Pages 2018
Discovery and optimization of phthalazinone derivatives as a new class of potent dengue virus inhibitors Fulltext Access 31 Pages 2018
Connexin43 and zonula occludens-1 are targets of Akt in cardiomyocytes that correlate with cardiac contractile dysfunction in Akt deficient hearts Fulltext Access 31 Pages 2018