Synthesis, cellular uptake and animal toxicity of a tetra(carboranylphenyl)-tetrabenzoporphyrin Fulltext Access 9 Pages 2006
Synthesis of amino acid derived seven-membered lactams by RCM and their evaluation against HIV protease Fulltext Access 9 Pages 2006
Design, synthesis and preliminary evaluation of new cinnamoyl pyrrolidine derivatives as potent gelatinase inhibitors Fulltext Access 9 Pages 2006
Green route for the heterocyclization of 2-mercaptobenzimidazole into β-lactum segment derivatives containing –CONH– bridge with benzimidazole: Screening in vitro antimicrobial activity with various microorganisms Fulltext Access 9 Pages 2006
Probing the physicochemical and structural requirements for glycogen synthase kinase-3α inhibition: 2D-QSAR for 3-anilino-4-phenylmaleimides Fulltext Access 9 Pages 2006
Acetoxy drug: Protein transacetylase catalyzed activation of human platelet nitric oxide synthase by polyphenolic peracetates Fulltext Access 9 Pages 2006
Synthesis of N2-(substituted benzyl)-3-(4-methylphenyl)indazoles as novel anti-angiogenic agents Fulltext Access 9 Pages 2006
Enantiomers of cis-constrained and flexible 2-substituted GABA analogues exert opposite effects at recombinant GABAC receptors Fulltext Access 9 Pages 2006
Anticancer and superoxide scavenging activities of p-alkylaminophenols having various length alkyl chains Fulltext Access 9 Pages 2006
Synthesis, characterization, cytotoxic activities, and DNA-binding properties of the La(III) complex with Naringenin Schiff-base Fulltext Access 9 Pages 2006
Synthesis, enzymatic activity, and X-ray crystallography of an unusual class of amino acids Fulltext Access 9 Pages 2006
Advances in the synthesis and recent therapeutic applications of 1,2,4-thiadiazole heterocycles Fulltext Access 9 Pages 2006
Synthesis and biological evaluation of a series of flavone derivatives as potential radioligands for imaging the multidrug resistance-associated protein 1 (ABCC1/MRP1) Fulltext Access 9 Pages 2006
Substituted phenanthrenes with basic amino side chains: A new series of anti-breast cancer agents Fulltext Access 9 Pages 2006
A combined approach of docking and 3D QSAR study of β-ketoacyl-acyl carrier protein synthase III (FabH) inhibitors Fulltext Access 9 Pages 2006
Stereoselective synthesis and anti-inflammatory activities of 6- and 7-membered dioxacycloalkanes Fulltext Access 9 Pages 2006
Synthesis and in vitro activities of ferrocenic aminohydroxynaphthoquinones against Toxoplasma gondii and Plasmodium falciparum Fulltext Access 9 Pages 2006
Synthesis and biodistribution of [11C]R107474, a new radiolabeled α2-adrenoceptor antagonist Fulltext Access 9 Pages 2006
Synthesis of enantiopure Δ2-isoxazoline derivatives and evaluation of their affinity and efficacy profiles at human β-adrenergic receptor subtypes Fulltext Access 9 Pages 2006
Synthesis and CB1 receptor activities of dimethylheptyl derivatives of 2-arachidonoyl glycerol (2-AG) and 2-arachidonyl glyceryl ether (2-AGE) Fulltext Access 9 Pages 2006
Synthesis of new piperazine–pyridazinone derivatives and their binding affinity toward α1-, α2-adrenergic and 5-HT1A serotoninergic receptors Fulltext Access 9 Pages 2006
New leads of metallo-β-lactamase inhibitors from structure-based pharmacophore design Fulltext Access 9 Pages 2006
Role of small bioorganic molecules in stem cell differentiation to insulin-producing cells Fulltext Access 9 Pages 2006
Synthesis and in vitro binding of N,N-dialkyl-2-phenylindol-3-yl-glyoxylamides for the peripheral benzodiazepine binding sites Fulltext Access 9 Pages 2006
Novel bis(1-acyl-2-pyrazolines) of potential anti-inflammatory and molluscicidal properties Fulltext Access 9 Pages 2006
A novel kind of nitrogen heterocycle compound induces apoptosis of human chronic myelogenous leukemia K562 cells Fulltext Access 9 Pages 2006
Synthesis, docking, and in vitro activity of thiosemicarbazones, aminoacyl-thiosemicarbazides and acyl-thiazolidones against Trypanosoma cruzi Fulltext Access 9 Pages 2006
Synthesis and structure–activity relationships (SARs) of 1,5-diarylpyrazole cannabinoid type-1 (CB1) receptor ligands for potential use in molecular imaging Fulltext Access 9 Pages 2006
Synthesis, anticonvulsant, and anti-inflammatory evaluation of some new benzotriazole and benzofuran-based heterocycles Fulltext Access 9 Pages 2006
The conjugates of uracil–cyclen Zn(II) complexes: Synthesis, characterization, and their interaction with plasmid DNA Fulltext Access 9 Pages 2006
New analogues of butylated hydroxytoluene as anti-inflammatory and antioxidant agents Fulltext Access 9 Pages 2006
A novel QSAR model for predicting induction of apoptosis by 4-aryl-4H-chromenes Fulltext Access 9 Pages 2006
The synthesis of l-carvone and limonene derivatives with increased antiproliferative effect and activation of ERK pathway in prostate cancer cells Fulltext Access 9 Pages 2006
Direct PCR amplification of various modified DNAs having amino acids: Convenient preparation of DNA libraries with high-potential activities for in vitro selection Fulltext Access 9 Pages 2006
A fluorine containing bipyridine cisplatin analog is more effective than cisplatin at inducing apoptosis in cancer cell lines Fulltext Access 9 Pages 2006
Molybdenocene-oligonucleotide binding study at physiological pH using NMR spectroscopy and cyclic voltammetry Fulltext Access 9 Pages 2006
Insecticidal lead identification by screening benzopyrano[4,3-c] pyrazol-3(2H)-ones library constructed from multiple-parallel synthesis under microwave irradiation Fulltext Access 9 Pages 2006
A cationic chalcogenoxanthylium photosensitizer effective in vitro in chemosensitive and multidrug-resistant cells Fulltext Access 9 Pages 2006
Identification of 2-hydroxymethyl-4-[5-(4-methoxyphenyl)-3-trifluoromethyl-pyrazol-1-yl]-N-propionylbenzenesulfonamide sodium as a potential COX-2 inhibitor for oral and parenteral administration Fulltext Access 9 Pages 2006
Synthesis of carbon-11 labeled fluorinated 2-arylbenzothiazoles as novel potential PET cancer imaging agents Fulltext Access 9 Pages 2006
Synthesis and evaluation of a classical 2,4-diamino-5-substituted-furo[2,3-d]pyrimidine and a 2-amino-4-oxo-6-substituted-pyrrolo[2,3-d]pyrimidine as antifolates Fulltext Access 9 Pages 2006
New bisanthraquinone antibiotics and semi-synthetic derivatives with potent activity against clinical Staphylococcus aureus and Enterococcus faecium isolates Fulltext Access 9 Pages 2006
Discovery of novel, highly potent and selective β-hairpin mimetic CXCR4 inhibitors with excellent anti-HIV activity and pharmacokinetic profiles Fulltext Access 9 Pages 2006
Enantioseparation of amino acids by co-extractants with di(2-ethylhexyl)phosphoric acid and tartaric acid derivatives Fulltext Access 9 Pages 2006
Antioxidant and anti-inflammatory activities of N-acetyldopamine dimers from Periostracum Cicadae Fulltext Access 9 Pages 2006
α-1-C-Octyl-1-deoxynojirimycin as a pharmacological chaperone for Gaucher disease Fulltext Access 9 Pages 2006
Hydrogen transfer pathways of the asymmetric reduction of α,β-unsaturated ketone mediated by baker's yeast Fulltext Access 9 Pages 2006
Alkylation reactions of phosphachroman-2,4-diones and 4-hydroxy phosphacoumarins Fulltext Access 9 Pages 2006
3-Amidoquinuclidine derivatives: Synthesis of compounds and inhibition of butyrylcholinesterase Fulltext Access 9 Pages 2006
Synthesis of novel chiral 6,6′-bis(oxazolyl)-1,1′-biphenyls and their application as ligands in copper(I)-catalyzed asymmetric cyclopropanation Fulltext Access 9 Pages 2006
Synthesis and conformational preferences of unnatural tetrapeptides containing l-valine units Fulltext Access 9 Pages 2006
NMR studies of chiral recognition mechanisms: interaction of enantiomers of N-imidazole derivatives with cyclodextrin hosts. Correlation with the CD-EKC studies Fulltext Access 9 Pages 2006
Catalytic asymmetric oxidation of sulfide and styrene derivatives using macroporous resins containing chiral metalloporphyrins (Fe, Ru) Fulltext Access 9 Pages 2006
First stereoselective synthesis of serinol-derived malyngamides and their 1′-epi-isomers Fulltext Access 9 Pages 2006
Discovery of novel inhibitors of the ZipA/FtsZ complex by NMR fragment screening coupled with structure-based design Fulltext Access 9 Pages 2006
Observation of Phenyl-Fused Porphyrinoids During the ESI Mass Spectrometric Analysis of meso-Pentafluorophenyl-Substituted Porphyrin and Corrole Fulltext Access 9 Pages 2006
The Effect of Radical Trap Moieties on Electron Capture Dissociation Spectra of Substance P Fulltext Access 9 Pages 2006
A Systematic and Efficient Method to Estimate the Vibrational Frequencies of Linear Peptide and Protein Ions with Any Amino Acid Sequence for the Calculation of Rice-Ramsperger-Kassel-Marcus Rate Constant Fulltext Access 9 Pages 2006
Peptide Conformation in Gas Phase Probed by Collision-Induced Dissociation and Its Correlation to Conformation in Condensed Phases Fulltext Access 9 Pages 2006
Picolinyl Ester Fragmentation Mechanism Studies with Application to the Identification of Acylcarnitine Acyl Groups Following Transesterification Fulltext Access 9 Pages 2006
Reversed-Phase Liquid Chromatography In-Line with Negative Ionization Electrospray Mass Spectrometry for the Characterization of the Disulfide-Linkages of an Immunoglobulin Gamma Antibody Fulltext Access 9 Pages 2006
Extraction of Local Hydrogen Exchange Data from HDX CAD MS Measurements by Deconvolution of Isotopic Distributions of Fragment Ions Fulltext Access 9 Pages 2006
Application of SIMSTEX to Oligomerization of Insulin Analogs and Mutants Fulltext Access 9 Pages 2006
Bis-imidazoles as molecular probes for peripheral sites of the zinc endopeptidase of botulinum neurotoxin serotype A Fulltext Access 9 Pages 2006
Synthesis and biological evaluation of dimeric cinnamaldehydes as potent antitumor agents Fulltext Access 9 Pages 2006
Synthesis and antitumor activity of 1-substituted-2-methyl-5-nitrobenzimidazoles Fulltext Access 9 Pages 2006
Synthesis, anti-tuberculosis activity, and 3D-QSAR study of ring-substituted-2/4-quinolinecarbaldehyde derivatives Fulltext Access 9 Pages 2006
Non-isosteric C-glycosyl analogues of natural nucleotide diphosphate sugars as glycosyltransferase inhibitors Fulltext Access 9 Pages 2006
Novel curcumin analogs targeting TNF-induced NF-κB activation and proliferation in human leukemic KBM-5 cells Fulltext Access 9 Pages 2006
Characterization of a transglycosylase domain of Streptococcus pneumoniae PBP1b Fulltext Access 9 Pages 2006
Triple helix stabilization by covalently linked DNA–bisbenzimidazole conjugate synthesized by maleimide–thiol coupling chemistry Fulltext Access 9 Pages 2006
Nucleosides with self-complementary hydrogen-bonding motifs: Synthesis and base-pairing studies of two nucleosides containing the imidazo[4,5-d]pyridazine ring system Fulltext Access 9 Pages 2006
A flexible approach for the preparation of substituted benzazepines: Application to the synthesis of tolvaptan Fulltext Access 9 Pages 2006
Crystallographic studies on two bioisosteric analogues, N-acetyl-β-d-glucopyranosylamine and N-trifluoroacetyl-β-d-glucopyranosylamine, potent inhibitors of muscle glycogen phosphorylase Fulltext Access 9 Pages 2006
Synthesis and anti-viral activity of a series of sesquiterpene lactones and analogues in the subgenomic HCV replicon system Fulltext Access 9 Pages 2006
Nanoprobes and nanobiosensors for monitoring and imaging individual living cells Fulltext Access 9 Pages 2006
Chlamydocin analogs bearing carbonyl group as possible ligand toward zinc atom in histone deacetylases Fulltext Access 9 Pages 2006
Reassessing the melatonin pharmacophore—Enantiomeric resolution, pharmacological activity, structure analysis, and molecular modeling of a constrained chiral melatonin analogue Fulltext Access 9 Pages 2006
Spin trapping of C- and O-centered radicals with methyl-, ethyl-, pentyl-, and phenyl-substituted EMPO derivatives Fulltext Access 9 Pages 2006
Crystallographic studies on N-azidoacetyl-β-d-glucopyranosylamine, an inhibitor of glycogen phosphorylase: Comparison with N-acetyl-β-d-glucopyranosylamine Fulltext Access 9 Pages 2006
New 1,2,3,9-tetrahydro-4H-carbazol-4-one derivatives: Analogues of HEAT as ligands for the α1-adrenergic receptor subtypes Fulltext Access 9 Pages 2006
Synthesis and biological evaluation of novel heterocyclic ionone-like derivatives as anti-inflammatory agents Fulltext Access 9 Pages 2006
Structure–activity relationship of natural and synthetic coumarins inhibiting the multidrug transporter P-glycoprotein Fulltext Access 9 Pages 2006
Acenaphtho[1,2-b]pyrrole derivatives as new family of intercalators: Various DNA binding geometry and interesting antitumor capacity Fulltext Access 9 Pages 2006
Comparative molecular field analysis and comparative molecular similarity indices analysis of boron-containing human thymidine kinase 1 substrates Fulltext Access 9 Pages 2006
Molecular modeling of the non-covalent binding of the dietary tomato carotenoids lycopene and lycophyll, and selected oxidative metabolites with 5-lipoxygenase Fulltext Access 9 Pages 2006
Tricyclic etheno analogs of PMEG and PMEDAP: Synthesis and biological activity Fulltext Access 9 Pages 2006