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Daneshyari Drug Discovery Journas Latest Articles

Drug Discovery Research Articles

Enantio-differential approach to identify the target cell for glucosyl jasmonate-type leaf-closing factor, by using fluorescence-labeled probe compounds
Fulltext Access 9 Pages 2006
The Ugi reaction with 2-substituted cyclic imines. Synthesis of substituted proline and homoproline derivatives
Fulltext Access 9 Pages 2006
Three different fluorescent responses to transition metal ions using receptors based on 1,2-bis- and 1,2,4,5-tetrakis-(8-hydroxyquinolinoxymethyl)benzene
Fulltext Access 9 Pages 2006
α-Aminoisobutyric acid modified protected analogues of β-amyloid residue 17-20: a change from sheet to helix
Fulltext Access 9 Pages 2006
Acid-catalyzed rearrangement of 1-benzyl-2-methyl-3-piperidone to 1-benzyl-2-acetylpyrrolidine
Fulltext Access 9 Pages 2006
Sequential addition reaction of lithium acetylides and Grignard reagents to thioiminium salts from thiolactams leading to 2,2-disubstituted cyclic amines
Fulltext Access 9 Pages 2006
Asymmetric syntheses of N-substituted α-amino esters via dynamic kinetic resolution of α-haloacyl diacetone-d-glucose
Fulltext Access 9 Pages 2006
Synthesis of a hydrophilic and non-ionic anthracene derivative, the N,N′-di-(2,3-dihydroxypropyl)-9,10-anthracenedipropanamide as a chemical trap for singlet molecular oxygen detection in biological systems
Fulltext Access 9 Pages 2006
Dark singlet oxygenation of organic substrates in single-phase and multiphase microemulsion systems
Fulltext Access 9 Pages 2006
Reactions of urocanic acid (UCA) methyl esters with singlet oxygen and 4-methyl-1,2,4-triazoline-3,5-dione (MTAD)
Fulltext Access 9 Pages 2006
Reaction of (1,3-dioxo-2,3-dihydro-1H-inden-2-ylidene)propanedinitrile with N-arylisoindolines
Fulltext Access 9 Pages 2006
A novel tert-butoxycarbonylation reagent: 1-tert-butoxy-2-tert-butoxycarbonyl-1,2-dihydroisoquinoline (BBDI)
Fulltext Access 9 Pages 2006
Graphical contents list
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A free radical Mannich type reaction: selective α-CH aminomethylation of ethers by Ti(III)/t-BuOOH system under aqueous acidic conditions
Fulltext Access 9 Pages 2006
A homologous series of eunicellin-based diterpenes from Acalycigorgia sp. characterised by tandem mass spectrometry
Fulltext Access 9 Pages 2006
Studies toward the construction of substituted piperidine-2-ones and pyridine-2-ones from Baylis-Hillman adducts: discovery of a facile synthesis of 5-methyl-4-oxo-6-aryl-3-aza-bicyclo[3.1.0]hexane-1-carboxylates
Fulltext Access 9 Pages 2006
First synthesis of polyoxin M
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Palladium-catalyzed carbon dioxide elimination-fixation reaction of 6-methoxycarbonyloxy-2,4-hexadien-1-ols
Fulltext Access 9 Pages 2006
Design and synthesis of fluconazole/bile acid conjugate using click reaction
Fulltext Access 9 Pages 2006
Synthesis, in vitro antiproliferative activities, and Chk1 inhibitory properties of dipyrrolo[3,4-a:3,4-c]carbazole-triones
Fulltext Access 9 Pages 2006
Synthesis and conformational analysis of naphth[1′,2′:5,6][1,3]oxazino[3,2-c][1,3]benzoxazine and naphth[1′,2′:5,6][1,3]oxazino[3,4-c][1,3]benzoxazine derivatives
Fulltext Access 9 Pages 2006
Foldamer-based pyridine-fullerene tweezer receptors for enhanced binding of zinc porphyrin
Fulltext Access 9 Pages 2006
Remote stereocontrol by the sulfinyl group: Mukaiyama aldol reactions of (S)-2-[2-(p-tolylsulfinyl)phenyl]acetaldehyde in the asymmetric synthesis of β-hydroxyacids and 1,3-diols
Fulltext Access 9 Pages 2006
5,6-Bis(dimethylamino)acenaphthylene as an activated alkene and 'proton sponge' in halogenation reactions
Fulltext Access 9 Pages 2006
Musk or violet? Design, synthesis and odor of seco-derivates of a musky carotol lead
Fulltext Access 9 Pages 2006
Synthesis of glutamic acid and glutamine peptides possessing a trifluoromethyl ketone group as SARS-CoV 3CL protease inhibitors
Fulltext Access 9 Pages 2006
Synthesis and some transformations of new 9-furylnaphtho[2,3-b]furan derivatives
Fulltext Access 9 Pages 2006
Graphical contents list
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Preparation of functionalized tertiary thiols and nitrosothiols
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Facile and catalytic degradation method of DDT using Pd/C-Et3N system under ambient pressure and temperature
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Chiral ligand-controlled asymmetric conjugate amination of enoates with lithium mesitylmethyl(trimethylsilyl)amide
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Reaction between glutaric anhydride and N-benzylidenebenzylamine, and further transformations to new substituted piperidin-2-ones
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Cobalt-mediated solid phase synthesis of 3-O-alkynylbenzyl galactosides and their evaluation as galectin inhibitors
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Regioselectivity in acylation of oligosaccharides catalyzed by the metalloprotease thermolysin
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An efficient solid-phase synthesis of 2-alkyl-4,6-diaminopyrimidines and 2,4,6-triaminopyrimidines
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A new approach towards 2-amino-1-aryloxy-3-methoxypropanes from 1-arylmethyl-2-(bromomethyl)aziridines
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Study on the reactions of ethyl 4,4,4-trifluoro-3-oxobutanoate with arylidenemalononitriles
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Graphical contents list
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Synthesis of dihydrodehydrodiconiferyl alcohol and derivatives through intramolecular C-H insertion
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New dioxadiaza-, trioxadiaza- and hexaaza-macrocycles containing dibenzofuran units
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Photodegradation of some 14,15-bisnorlabdene-13-ones, derived from larixol. Synthesis of drimanic dienes with functional groups at C-6
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Synthesis of aminimides derived from oleic acid: a new family of drag-reducing surfactants
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Synthesis of enantiopure bis-aziridines, bis-epoxides, and aziridino-epoxides from d-mannitol
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Sodium dithionite initiated regio- and stereoselective radical addition of polyfluoroalkyl iodide with norbornene analogs
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Self-assembly of aromatic sulfonamide–amide hybridized molecules: formation of 2D layers and 3D microporous networks in the solid state
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Catalytic enantioselective [2+2]-cycloaddition reaction of 2-methoxycarbonyl-2-cyclopenten-1-one by chiral copper catalyst
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Synthesis of 6- to 10-membered ring (E)-hydroxyiminohydroazaazoniabenzocycloalkenes derivative from cyclization of 2-nitromethylene-1-(ω-phenylalkyl)imidazolidine or 2-nitromethylene-1-(ω-phenylalkyl)hexahydropyrimidine in trifluoromethanesulfonic acid
Fulltext Access 9 Pages 2006
An efficient synthesis of (E)-α,β-unsaturated ketones and esters with total stereoselectivity by using chromium dichloride
Fulltext Access 9 Pages 2006
Enantioselective total and formal syntheses of paroxetine (PAXIL) via phosphine-catalyzed enone α-arylation using arylbismuth(V) reagents: a regiochemical complement to Heck arylation
Fulltext Access 9 Pages 2006
Longipedlactones A-I, nine novel triterpene dilactones possessing a unique skeleton from Kadsura longipedunculata
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Synthesis, antitumor and anti-HIV activities of benzodithiazine-dioxides
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Synthesis and evaluation of azaindole-α-alkyloxyphenylpropionic acid analogues as PPARα/γ agonists
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Synthesis of functionalised 2-aryl-5-nitro-1H-indoles and their activity as bacterial NorA efflux pump inhibitors
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Improved synthesis of 2′-amino-2′-deoxyguanosine and its phosphoramidite
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Anti-tubercular agents. Part 3. Benzothiadiazine as a novel scaffold for anti-Mycobacterium activity
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Polymeric grape-seed procyanidins, but not monomeric catechins and oligomeric procyanidins, impair degranulation and membrane ruffling in RBL-2H3 cells
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Design, synthesis, and pharmacological evaluation of new neuroactive pyrazolo[3,4-b]pyrrolo[3,4-d]pyridine derivatives with in vivo hypnotic and analgesic profile
Fulltext Access 9 Pages 2006
Phenazine-1-carboxamides: Structure–cytotoxicity relationships for 9-substituents and changes in the H-bonding pattern of the cationic side chain
Fulltext Access 9 Pages 2006
Development and optimization of a useful assay for determining Hsp90’s inherent ATPase activity
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Microwave-assisted synthesis of antimicrobial dihydropyridines and tetrahydropyrimidin-2-ones: Novel compounds against aspergillosis
Fulltext Access 9 Pages 2006
3D QSAR on a library of heterocyclic diamidine derivatives with antiparasitic activity
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Site-specific recombination of asymmetric lox sites mediated by a heterotetrameric Cre recombinase complex
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Mechanism of the Class I KDPG aldolase
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Three-dimensional quantitative structure–activity relationship (3 D-QSAR) and docking studies on (benzothiazole-2-yl) acetonitrile derivatives as c-Jun N-terminal kinase-3 (JNK3) inhibitors
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Steric interactions and the activity of fentanyl analogs at the μ-opioid receptor
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Selection of a 2-azabicyclo[2.2.2]octane-based α4β1 integrin antagonist as an inhaled anti-asthmatic agent
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New derivatives of xanthenone-4-acetic acid: Synthesis, pharmacological profile and effect on TNF-α and NO production by human immune cells
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Studies on quinones. Part 41: Synthesis and cytotoxicity of isoquinoline-containing polycyclic quinones
Fulltext Access 9 Pages 2006
Cytoprotective effect of caffeic acid phenethyl ester (CAPE) and catechol ring-fluorinated CAPE derivatives against menadione-induced oxidative stress in human endothelial cells
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Novel antibiotics: C-2 symmetrical macrocycles inhibiting Holliday junction DNA binding by E. coli RuvC
Fulltext Access 9 Pages 2006
Graphical contents list
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Homology model of RSK2 N-terminal kinase domain, structure-based identification of novel RSK2 inhibitors, and preliminary common pharmacophore
Fulltext Access 9 Pages 2006
Influence of rhamnose substituents on the potency of SL0101, an inhibitor of the Ser/Thr kinase, RSK
Fulltext Access 9 Pages 2006
Efficient microwave enhanced regioselective synthesis of a series of benzimidazolyl/triazolyl spiro [indole-thiazolidinones] as potent antifungal agents and crystal structure of spiro[3H-indole-3,2′-thiazolidine]-3′(1,2,4-triazol-3-yl)-2,4′(1H)-dione
Fulltext Access 9 Pages 2006
Synthesis and anti-HIV activity of new alkenyldiarylmethane (ADAM) non-nucleoside reverse transcriptase inhibitors (NNRTIs) incorporating benzoxazolone and benzisoxazole rings
Fulltext Access 9 Pages 2006
Synthesis and characterization of novel hydrazide–hydrazones and the study of their structure–antituberculosis activity
Fulltext Access 9 Pages 2006
Synthesis and biological properties of new α-methylene-γ-butyrolactones and α,β-unsaturated δ-lactones
Fulltext Access 9 Pages 2006
Antibacterial and antifungal activity of acyclic and macrocyclic uracil derivatives with quaternized nitrogen atoms in spacers
Fulltext Access 9 Pages 2006
Synthesis and in vitro activity of a series 1β-methylcarbapenem derivatives
Fulltext Access 9 Pages 2006
Design and evaluation of “3 + 1” mixed ligand oxorhenium and oxotechnetium complexes bearing a nitroaromatic group with potential application in nuclear medicine oncology
Fulltext Access 9 Pages 2006
In vitro mutagenicity of anti-inflammatory parsalmide analogues PA7, PA10, and PA31 triggered by biotransformation into hydroxy derivatives
Fulltext Access 9 Pages 2006
Adenosine receptor modelling. A1/A2a selectivity
Fulltext Access 9 Pages 2006
Synthesis and antiproliferative activity of benzo[d]isothiazole hydrazones
Fulltext Access 9 Pages 2006
Cytotoxic 5-aryl-1-(4-nitrophenyl)-3-oxo-1,4-pentadienes mounted on alicyclic scaffolds
Fulltext Access 9 Pages 2006
Design, synthesis and antiproliferative activity of some new azapyranoxanthenone aminoderivatives
Fulltext Access 9 Pages 2006
Synthesis and evaluation of 7-amino-2-(2(3)-furyl)-5-phenylethylamino-oxazolo[5,4-d]pyrimidines as potential A2A adenosine receptor antagonists for positron emission tomography (PET)
Fulltext Access 9 Pages 2006
In vivo antitumor, in vitro antibacterial activity and alkylating properties of phosphorohydrazine derivatives of coumarin and chromone
Fulltext Access 9 Pages 2006
Synthesis, characterization, antimicrobial and single crystal X-ray crystallographic studies of some new sulfonyl, 4-chloro phenoxy benzene and dibenzoazepine substituted benzamides
Fulltext Access 9 Pages 2006
Graphical contents list
Fulltext Access 9 Pages 2006
Nitrofurylsemicarbazone Rhenium and Ruthenium Complexes as Anti-trypanosomal Agents
Fulltext Access 9 Pages 2006
Synthesis, structure, toxicological and pharmacological investigations of 4-hydroxycoumarin derivatives
Fulltext Access 9 Pages 2006
Syntheses and odor of “bulky group”-modified sandalwood odorants: isophorono-β-santalol analogues
Fulltext Access 9 Pages 2006
Air to fat and blood to fat distribution of volatile organic compounds and drugs: Linear free energy analyses
Fulltext Access 9 Pages 2006
Structural modifications of benzanilide derivatives, effective potassium channel openers. X.
Fulltext Access 9 Pages 2006
Antihelminthic activity of some newly synthesized 5(6)-(un)substituted-1H-benzimidazol-2-ylthioacetylpiperazine derivatives
Fulltext Access 9 Pages 2006
Synthesis, crystal structure and anticancer activity of novel derivatives of ethyl 1-(4-oxo-8-aryl-4,6,7,8-tetrahydroimidazo[2,1-c][1,2,4]triazin-3-yl)formate
Fulltext Access 9 Pages 2006
Air to brain, blood to brain and plasma to brain distribution of volatile organic compounds: linear free energy analyses
Fulltext Access 9 Pages 2006
Synthesis and structure–activity relationships of retro bis-aminopyrrolidine urea (rAPU) derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1). Part 2
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Quantitative structure–activity analysis of 5-arylidene-2,4-thiazolidinediones as aldose reductase inhibitors
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Identification of phosphodiesterase-1 and 5 dual inhibitors by a ligand-based virtual screening optimized for lead evolution
Fulltext Access 9 Pages 2006
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