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Daneshyari Drug Discovery Journas Latest Articles

Drug Discovery Research Articles

Dendritic cells in Asthma: A target for novel therapeutics?
Fulltext Access 9 Pages 2006
β-Isocupreidine-hexafluoroisopropyl acrylate method for asymmetric Baylis-Hillman reactions
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Direct asymmetric organocatalytic de novo synthesis of carbohydrates
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Chiral N-heterocyclic carbenes as asymmetric acylation catalysts
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Diastereoselective addition of diethyl difluoromethylphosphonate to enantiopure sulfinimines: synthesis of α,α-difluoro-β-aminophosphonates, phosphonic acids, and phosphonamidic acids
Fulltext Access 9 Pages 2006
Reactivity of imidazolidin-4-one derivatives of primaquine: implications for prodrug design
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Pd(II)-catalyzed acetalization of terminal olefins with electron-withdrawing groups in supercritical carbon dioxide: selective control and mechanism
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Nucleophilic epoxidation of γ-alkoxy dienyl sulfoxide derivatives
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Influence of N-amino protecting group on aldolase-catalyzed aldol additions of dihydroxyacetone phosphate to amino aldehydes
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Azidosubstituted arylboronic acids: synthesis and Suzuki-Miyaura cross-coupling reactions
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RNAi-based treatment of HIV/AIDS: Current status and perspectives
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New approaches to reduce the burden of RSV infection
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Novel metal-free Lewis acid catalysis by phosphonium salts through hypervalent interaction
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Countering core and co-morbid symptoms of affective disorders: Complementary multi-target strategies
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Modern analytical technologies for the detection of drug abuse and doping
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Glycomics – a new target for pharmaceuticals
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Determination of inflammatory biomarkers by immunoaffinity capillary electrophoresis
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Prediction of failure load using micro-finite element analysis models: Toward in vivo strength assessment
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Proteomics in antitumor research
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In silico target fishing: Predicting biological targets from chemical structure
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Chemical diversity and biological activity
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Integration of virtual and physical screening
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Hit and lead identification: Integrated technology-based approaches
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5-Alkynyl-2′-deoxyuridines, containing bulky aryl groups: evaluation of structure-anti-HSV-1 activity relationship
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Graphical contents list
Fulltext Access 9 Pages 2006
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The synthesis and electronic absorption spectra of 3-phenyl-3(4-pyrrolidino-2-substituted phenyl)-3H-naphtho[2,1-b]pyrans: further exploration of the ortho substituent effect
Fulltext Access 9 Pages 2006
Graphical contents list
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Efficient esterification of carboxylic acids and phosphonic acids with trialkyl orthoacetate in ionic liquid
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Microarrays meet the Voltaire challenge: Drug discovery on a chip?
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Graphical contents list
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Origin of the stereo- and regioselectivities in the Diels-Alder reactions of azaphospholes: a DFT investigation
Fulltext Access 9 Pages 2006
Facile synthesis of 3,3-di(heteroaryl)indolin-2-one derivatives catalyzed by ceric ammonium nitrate (CAN) under ultrasound irradiation
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The synthesis of bis(oligophenyleneethynylenes): novel potential nonlinear optical materials
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Application of tri- and tetrasubstituted alkene dipeptide mimetics to conformational studies of cyclic RGD peptides
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Dipolar cycloadditions of imidazoline 3-oxides with N-arylmaleimides. Synthesis and diethylamine induced ring-opening of exo and endo hexahydro-7-oxa-2,5,6a-triaza-cyclopenta[a]pentalene-1,3-diones
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Guanosine and fullerene derived de-aggregation of a new phthalocyanine-linked cytidine derivative
Fulltext Access 9 Pages 2006
Supramolecular complexation studies of [60]fullerene with calix[4]naphthalenes-a reinvestigation
Fulltext Access 9 Pages 2006
Synthesis and photophysics of porphyrin-fullerene donor-acceptor dyads with conformationally flexible linkers
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Strategies to optimize the validity of disease models in the drug discovery process
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Targeting N-type and T-type calcium channels for the treatment of pain
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The promise of a virtual lab in drug discovery
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Inhibitors of the Maillard reaction and AGE breakers as therapeutics for multiple diseases
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Creating more effective antidepressants: clues from the clinic
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Screening in a spirit haunted world
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Progress and problems in the exploration of therapeutic targets
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Towards the discovery of drug-like RNA ligands?
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In search of sustainability: process R&D in light of current pharmaceutical industry challenges
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Mouse models of hypertension
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The cryptome: a subset of the proteome, comprising cryptic peptides with distinct bioactivities
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Dynamical properties of model gene networks and implications for the inverse problem
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The Paton individual-based model legacy
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Formal agent-based modelling of intracellular chemical interactions
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Information processing in brain microtubules
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Modeling feature-based attention as an active top-down inference process
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Multisynaptic activity in a pyramidal neuron model and neural code
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Self-organization versus Watchmaker: Molecular motors and protein translocation
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Chemogenomics: structuring the drug discovery process to gene families
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Target, chemical and bioactivity databases – integration is key
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Models of myocardial ischemia
Fulltext Access 9 Pages 2006
Cellular and animal models of cystic fibrosis, tools for drug discovery
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Animal models of depression
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Animal models of multiple sclerosis
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Mouse models of amyotrophic lateral sclerosis
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Mechanisms of congenital cytomegalovirus-induced deafness
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New aspects of p38 mitogen activated protein kinase (MAPK) biology in lung inflammation
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Screening the receptorome: an efficient approach for drug discovery and target validation
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MRI-guided immunotherapy development for multiple sclerosis in a primate
Fulltext Access 9 Pages 2006
Disease, destination, dose and delivery aspects of ciclosporin: the state of the art
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G-protein-coupled receptor heterodimers: pharmacology, function and relevance to drug discovery
Fulltext Access 9 Pages 2006
SAGE and related approaches for cancer target identification
Fulltext Access 9 Pages 2006
Is the mycobacterial cell wall a hopeless drug target for latent tuberculosis?
Fulltext Access 9 Pages 2006
Graphical contents list
Fulltext Access 10 Pages 2006
The generalized flux-minimization method and its application to metabolic networks affected by enzyme deficiencies
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Metabolomic networks in plants: Transitions from pattern recognition to biological interpretation
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Systems analysis of a quorum sensing network: Design constraints imposed by the functional requirements, network topology and kinetic constants
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Towards building the silicon cell: A modular approach
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Graphical contents list
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An analysis of the class of gene regulatory functions implied by a biochemical model
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Biological significance of autoregulation through steady state analysis of genetic networks
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Oscillations and waves in the models of interactive neural populations
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'Catch and release' cascades: a resin-mediated three-component cascade approach to small molecules
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Neural coding for the retrieval of multiple memory patterns
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Graphical contents list
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Cancer: A Systems Biology disease
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GINsim: A software suite for the qualitative modelling, simulation and analysis of regulatory networks
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Small-world connectivity, motif composition, and complexity of fractal neuronal connections
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Complexity and non-commutativity of learning operations on graphs
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