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Daneshyari Drug Discovery Journas Latest Articles

Drug Discovery Research Articles

A quantum chemical study on the mechanism of chiral N-oxides-catalyzed Strecker reaction
Fulltext Access 10 Pages 2006
Palladium catalysed bis- and tris-cyclisations furnishing fused cyclopropyl carbo/heterocycles
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Theoretical design of dendrimeric fractal patterns for the encapsulation of a family of drugs: salicylanilides
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Synthetic studies on Ecteinascidin-743: synthesis of building blocks through Sharpless asymmetric dihydroxylation and aza-Michael reactions
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Synthesis, complexation studies and biological applications of some novel stilbenophanes, indolophanes and bisindolostilbenophanes via McMurry coupling
Fulltext Access 10 Pages 2006
Tandem reduction-olefination of triethyl 2-acyl-2-fluoro-2-phosphonoacetates and a synthetic approach to Cbz-Gly-Ψ[(Z)-CFC]-Gly dipeptide isostere
Fulltext Access 10 Pages 2006
Trapping of carbamic acid species with (trimethylsilyl)diazomethane
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Monoaza[5]helicenes. Part 2: Synthesis, characterisation and theoretical calculations
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Synthesis and absolute configuration of brevione B, an allelochemical isolated from Penicillium sp.
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A structure-activity relationship study of brusatol, an antitumor quassinoid
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A scheme estimating the energy of intramolecular hydrogen bonds in diols
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Synthesis of 4-aminomethyl-tetrahydrofuran-2-carboxylates with 2,4-cis and 2,4-trans relationships
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Stereoselective radical cyclizations of N-(2-halobenzoyl)-cyclic ketene-N,X(X=O, S)-acetals
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Two novel blue pigments with ellagitannin moiety, rosacyanins A1 and A2, isolated from the petals of Rosa hybrida
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Towards new camptothecins. Part 3: Synthesis of 5-methoxycarbonyl camptothecin
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Direct palladium/carboxylic acid-catalyzed allylation of anilines with allylic alcohols in water
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Graphical contents list
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A one-pot access to cycloalkano[1,2-a]indoles through an intramolecular alkyl migration reaction in indolylborates
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Palladium-catalyzed carbonylative cyclization of Baylis-Hillman adducts. An efficient approach for the stereoselective synthesis of 3-alkenyl phthalides
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What are the pKa values of organophosphorus compounds?
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Facile synthesis of substituted 2,3,4,7-tetrahydro-1H-azepines via ring-closing metathesis
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Synthesis of the CD-ring of the anticancer agent streptonigrin: studies of aryl-aryl coupling methodologies
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A consecutive Diels-Alder approach toward a Tet repressor directed combinatorial library
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One-step construction of carbazoles by way of the palladium-catalyzed double N-arylation reaction and its application to the total synthesis of murrastifoline-A
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DABCO catalyzed reaction of various nucleophiles with activated alkynes leading to the formation of alkenoic acid esters, 1,4-dioxane, morpholine, and piperazinone derivatives
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(±)-Diinsininone: made nature's way
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A new mechanism for oxidation of epigallocatechin and production of benzotropolone pigments
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A multicomponent approach to substituted benzenes involving sequential nickel-catalyzed reactions
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Amino acid-peptide-catalyzed enantioselective Morita-Baylis-Hillman reactions
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Preparation of 2-arylindole-4-carboxylic amide derivatives
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Brønsted acid-promoted cyclizations of siloxy alkynes with unactivated arenes, alkenes, and alkynes
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Nickel-catalyzed coupling of terminal allenes, aldehydes, and silanes
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Catalytic asymmetric allylation of aldehydes using the chiral (salen)chromium(III) complexes
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Arene cis-dihydrodiols-useful precursors for the preparation of antimetabolites of the shikimic acid pathway: application to the synthesis of 6,6-difluoroshikimic acid and (6S)-6-fluoroshikimic acid
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Syntheses and Vero toxin-binding activities of carbosilane dendrimers periphery-functionalized with galabiose
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A tandem enyne/ring closing metathesis approach to the synthesis of novel angularly fused dioxa-triquinanes
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C-3 β-lactam carbocation equivalents: versatile synthons for C-3 substituted β-lactams
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The power of singlet oxygen chemistry in biomimetic syntheses
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Synthesis of α-amino tetrahydropyranyl-, tetrahydrothiopyranyl-, 4- and 3-piperidinyl-phosphonic acids via phosphite addition to iminium ions
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The structural and synthetic implications of the biosynthesis of the calycanthaceous alkaloids, the communesins, and nomofungin
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Synthesis of highly-functionalised pyridines via hetero-Diels-Alder methodology: reaction of 3-siloxy-1-aza-1,3-butadienes with electron deficient acetylenes
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Influence of intramolecular hydrogen bonds in the enzyme-catalyzed regioselective acylation of quinic and shikimic acid derivatives
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Asymmetric epoxidation of 6-cyano-2,2-dimethylchromene on Mn(salen) catalyst immobilized in mesoporous materials
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Catalytic asymmetric epoxidation of α,β-unsaturated N-acylpyrroles as monodentate and activated ester equivalent acceptors
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Ti(III)-promoted cyclizations. Application to the synthesis of (E)-endo-bergamoten-12-oic acids. Moth oviposition stimulants isolated from Lycopersicon hirsutum
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Carboxylic fused furans for amino acid fluorescent labelling
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Highly enantioselective hydrogenation of exocyclic double bond of N-tosyloxazolidinones catalyzed by a neutral rhodium complex and its synthetic applications
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Synthesis of 1-deoxyhept-2-ulosyl-glycono-1,5-lactone utilizing α-selective O-glycosidation of 2,6-anhydro-1-deoxy-d-hept-1-enitols
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Synthesis, crystal structures and the preliminary evaluation of the new dibenzotetraaza[14]annulene-based DNA/RNA binding agents
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Introduction of the Aib-Pro unit into peptides by means of the 'azirine/oxazolone method' on solid phase
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Bioactive prenylated xanthones and anthraquinones from Cratoxylum formosum ssp. pruniflorum
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Structural studies and binding properties of pendant diazacoronands-precursors to macrocyclic compounds of planar chirality
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Graphical contents list
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Analogues of cytotoxic squamocin using reliable reactions: new insights into the reactivity and role of the α,β-unsaturated lactone of the annonaceous acetogenins
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The reaction of 4-amino-2-oxazolines with isocyanates and isothiocyanates. Synthesis and X-ray structures of polysubstituted 2-imidazolidinones, 1,3-oxazolidines and 1,3-thiazolidines
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Graphical contents list
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Intrazeolite photooxygenation of chiral alkenes. Control of facial selectivity by confinement and cation-π interactions
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Synthesis and anticancer activity studies of novel 1-(2,3-dihydro-5H-1,4-benzodioxepin-3-yl)uracil and (6′-substituted)-7- or 9-(2,3-dihydro-5H-1,4-benzodioxepin-3-yl)-7H- or 9H-purines
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An efficient one-pot construction of substituted pyrimidinones
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Synthesis and structural study of tetrahydroindazolones
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Cholic acid-based high sensitivity fluorescent sensor for α,ω-dicarboxylate: an intramolecular excimer emission quenched by complexation
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Oligomers of β-amino acid bearing non-planar amides form ordered structures
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Correlation of calculated halonium ion structures with product distributions from fluorine substituted terminal alkenes
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[6+3] Cycloaddition of pentafulvenes with 3-oxidopyrylium betaine: a novel methodology toward the synthesis of 5-8 fused oxabridged cyclooctanoids
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A general approach to crinine-type Amaryllidaceae alkaloids: total syntheses of (±)-haemanthidine, (±)-pretazettine, (±)-tazettine, and (±)-crinamine
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Regio- and stereoselective double alkylation of β-enamino esters with organolithium reagents followed by one-pot reduction: convenient method for the synthesis of tertiary γ-amino alcohols
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Structure revision of HM-3, an aromatic sesquiterpene isolated from the phytopathogenic fungus Helicobasidium mompa. First total syntheses of HM-3 and HM-4
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The effect of polar substituents on the heterocyclic benzoxazoles
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Synthesis of some cyclic indolic peptoids as potential antibacterials
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A concise synthesis of (−)-cytoxazone and (−)-4-epi-cytoxazone using chlorosulfonyl isocyanate
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Stereoselective titanium-mediated aldol reactions of (S)-2-tert-butyldimethylsilyloxy-3-pentanone
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Regioselectivity in alkenyl(aryl)-heteroaryl Suzuki cross-coupling reactions of 2,4-dibromopyridine. A synthetic and mechanistic study
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Enantiodivergent synthesis of muricatacin related lactones from d-xylose based on the latent symmetry concept: preparation of two novel cytotoxic (+)- and (−)-muricatacin 7-oxa analogs
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Stereoselective Diels-Alder reactions of 3-phosphonopropenoyl derivatives of 1,3-oxazolidin-2-ones
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Chirality induction of π-conjugated chains through chiral complexation
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Stereoselective synthesis of fluoroalkenes via (Z)-2-fluoroalkenyliodonium salts
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Regioselectivity in the 1,3-dipolar cycloaddition of adamantylidenefulvene and its modification by inclusion in cyclodextrins' solutions
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Isoxazoline-carbocyclic aminols for nucleoside synthesis through aza-Diels–Alder reactions
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The role of terminal tyrosine residues in the formation of tripeptide nanotubes: a crystallographic insight
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Arylcyanation of alkynes catalyzed by nickel
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Asymmetric total synthesis of enantiopure (−)-methyl jasmonate via catalytic asymmetric intramolecular cyclopropanation of α-diazo-β-keto sulfone
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Monosubstituted thermotropic ferrocenomesogens containing heterocyclic pyrazole
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Synthesis of plakevulin A and structure-activity relationships of its related compounds against DNA polymerases
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Direct synthesis of 4,4-disubstituted N-silyl-1,4-dihydropyridines
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Correct structures of Diels–Alder adducts from the natural cyclolignan thuriferic acid and its 8-epimer
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Backbone extended pyrrolidine PNA (bepPNA): a chiral PNA for selective RNA recognition
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Practical method for the synthesis of (R)-homopipecolinic acid and (R)-homoproline esters from ω-chloroalkanoic acids and available chiral amines
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Synthesis and characterization of novel styryl-substituted oligothienylenevinylenes
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1,3-Dipolar cycloaddition of α-alkoxycarbonylnitrones with vinyl ethers and allyl alcohols in the presence of Eu(fod)3: selective activation of (Z)-isomers of the nitrones
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Carboxylic acid to amide hydrogen bonding. 10-Oxo-semirubins
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Tröger's base scaffold in racemic and chiral fashion as a spacer for bisdistamycin formation. Synthesis and DNA binding study
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Access to a new family of medium ring aromatic lactones
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Synthetic oligorhamnans related to the most common O-chain backbone from phytopathogenic bacteria
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Synthesis and utility of new amine/nucleobase addition products of allenylphosphonates
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Efficient microwave-assisted synthesis of highly functionalized pyrimidine derivatives
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Triadic analysis of substituent effects-gas-phase acidity of para-substituted phenols
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Synthesis of optically active amphiphilic tetrathiafulvalene derivatives
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Further studies on enantioselective synthesis of (+)-anatoxin-a using enyne metathesis: unexpected inversion of chirality via a skeletal rearrangement of 9-azabicyclo[4.2.1]nonene derivative
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Enantioselective syntheses of tremulenediol A and tremulenolide A
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Selective substitutions in the C10-methyl group in erythromycin derivatives
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