Short pseudopeptides containing turn scaffolds with high AT2 receptor affinity Fulltext Access 10 Pages 2006
Synthesis and biological evaluation of carboacyclic nucleosides with (Z) and (E)-9-[4,4-bis(hydroxymethyl)]-2-butenyl side chain Fulltext Access 10 Pages 2006
Synthesis of 1-O-monoacyl or 12-O-monoacyl, 1-,12-O-diacyl-, and 11,12-dehydrated excisanin A 7,14-acetonides and their cytotoxic activity Fulltext Access 10 Pages 2006
Carbonic anhydrase inhibitors: Transepithelial transport of thioureido sulfonamide inhibitors of the cancer-associated isozyme IX is dependent on efflux transporters Fulltext Access 10 Pages 2006
Synthesis of new bioactive venlafaxine analogs: Novel thiazolidin-4-ones as antimicrobials Fulltext Access 10 Pages 2006
Effect of cholesterol on DMPC phospholipid membranes and QSAR model construction in membrane-interaction QSAR study through molecular dynamics simulation Fulltext Access 10 Pages 2006
Synthesis and biological evaluation of new dipyrrolo[3,4-a:3,4-c]carbazole-1,3,4,6-tetraones, substituted with various saturated and unsaturated side chains via palladium catalyzed cross-coupling reactions Fulltext Access 10 Pages 2006
N-Thiolated β-lactam antibacterials: Effects of the N-organothio substituent on anti-MRSA activity Fulltext Access 10 Pages 2006
Hydroxyl-terminated peptidomimetic inhibitors of neuronal nitric oxide synthase Fulltext Access 10 Pages 2006
[(S)-γ-(Arylamino)prolyl]thiazolidine compounds as a novel series of potent and stable DPP-IV inhibitors Fulltext Access 10 Pages 2006
Comparative structure–activity relationships of benztropine analogues at the dopamine transporter and histamine H1 receptors Fulltext Access 10 Pages 2006
Synthesis, characterization, and DNA-binding properties of the Ln(III) complexes with 6-hydroxy chromone-3-carbaldehyde-(2′-hydroxy) benzoyl hydrazone Fulltext Access 10 Pages 2006
Novel 2-substituted nitronyl nitroxides as free radical scavengers: Synthesis, biological evaluation and structure–activity relationship Fulltext Access 10 Pages 2006
Synthesis and evaluation of 5,5-diphenylimidazolones as potent human neuropeptide Y5 receptor antagonists Fulltext Access 10 Pages 2006
Antitumor agents 251: Synthesis, cytotoxic evaluation, and structure–activity relationship studies of phenanthrene-based tylophorine derivatives (PBTs) as a new class of antitumor agents Fulltext Access 10 Pages 2006
Structure–activity-relationship studies of conformationally restricted analogs of combretastatin A-4 derived from SU5416 Fulltext Access 10 Pages 2006
Phosphatidylinositol mannosides: Synthesis and adjuvant properties of phosphatidylinositol di- and tetramannosides Fulltext Access 10 Pages 2006
Synthesis and receptor binding studies of halogenated N,N-dialkylel-(2-phenyl-1H-indol-3-yl)glyoxylamides to visualize peripheral benzodiazepine receptors with SPECT or PET Fulltext Access 10 Pages 2006
Synthesis, characterization, and anti-bacterial efficacy of some novel cyclophane amide Fulltext Access 10 Pages 2006
Synthesis and biological evaluation of deoxy salacinols, the role of polar substituents in the side chain on the α-glucosidase inhibitory activity Fulltext Access 10 Pages 2006
DNA binding potential and cytotoxicity of newly designed pyrrolobenzodiazepine dimers linked through a piperazine side-armed-alkane spacer Fulltext Access 10 Pages 2006
Parallel synthesis of 9-aminoacridines and their evaluation against chloroquine-resistant Plasmodium falciparum Fulltext Access 10 Pages 2006
Enaminones 9. Further studies on the anticonvulsant activity and potential type IV phosphodiesterase inhibitory activity of substituted vinylic benzamides Fulltext Access 10 Pages 2006
Parallel synthesis of modular chiral Schiff base ligands and evaluation in the titatium(IV) catalyzed asymmetric trimethylsilylcyanation of aldehydes Fulltext Access 10 Pages 2006
Synthesis of linear and cyclic homo-β-peptides based on a binaphthylic β-amino acid with only axial chirality Fulltext Access 10 Pages 2006
Preparation and biological activity of 6-benzylaminopurine derivatives in plants and human cancer cells Fulltext Access 10 Pages 2006
3D-QSAR study of ring-substituted quinoline class of anti-tuberculosis agents Fulltext Access 10 Pages 2006
Inhibition of O-GlcNAcase by PUGNAc is dependent upon the oxime stereochemistry Fulltext Access 10 Pages 2006
Design, synthesis, and antifungal activity of inhibitors of brassilexin detoxification in the plant pathogenic fungus Leptosphaeria maculans Fulltext Access 10 Pages 2006
Cytotoxic activity of (S)-goniothalamin and analogues against human cancer cells Fulltext Access 10 Pages 2006
Molecular modeling and 3D-QSAR studies of indolomorphinan derivatives as kappa opioid antagonists Fulltext Access 10 Pages 2006
Induction of apoptosis in HeLa cells by 3β-hydroxy-12-oleanen-27-oic acid from the rhizomes of Astilbe chinensis Fulltext Access 10 Pages 2006
Combination of porphyrins and DNA-alkylation agents: Synthesis and tumor cell apoptosis induction Fulltext Access 10 Pages 2006
Synthesis and properties of 2′-O,4′-C-methyleneoxymethylene bridged nucleic acid Fulltext Access 10 Pages 2006
2-Benzyl and 2-phenyl-3-hydroxypropyl pivalates as protein kinase C ligands Fulltext Access 10 Pages 2006
Versatile synthesis and biological evaluation of 1,3-diamino-substituted 1α,25-dihydroxyvitamin D3 analogues Fulltext Access 10 Pages 2006
Synthesis, molecular modelling and enzymatic evaluation of (±)3,5-diphenyl-2-thioxoimidazolidin-4-ones as new potential cyclooxygenase inhibitors Fulltext Access 10 Pages 2006
Dicationic pyridium porphyrins appending different peripheral substituents: Synthesis and studies for their interactions with DNA Fulltext Access 10 Pages 2006
Structure basis for the inhibitory mechanism of a novel DNase γ-specific inhibitor, DR396 Fulltext Access 10 Pages 2006
Tetrahydropyrrolo[3,2-c]azepin-4-ones as a new class of cytotoxic compounds Fulltext Access 10 Pages 2006
The application of a 3D-QSAR (autoMEP/PLS) approach as an efficient pharmacodynamic-driven filtering method for small-sized virtual library: Application to a lead optimization of a human A3 adenosine receptor antagonist Fulltext Access 10 Pages 2006
Structure–activity studies of a novel series of 5,6-fused heteroaromatic ureas as TRPV1 antagonists Fulltext Access 10 Pages 2006
Synthesis, reactions and structure–activity relationships of 1-hydroxyspiro[2.5]cyclooct-4-en-3-ones: Illudin analogs with in vitro cytotoxic activity Fulltext Access 10 Pages 2006
QSAR analysis of antimicrobial and haemolytic effects of cyclic cationic antimicrobial peptides derived from protegrin-1 Fulltext Access 10 Pages 2006
The binding of 3′-N-piperidine-4-carboxyl-3′-deoxy-ara-uridine to ribonuclease A in the crystal Fulltext Access 10 Pages 2006
Biotinylated biphenyl ketone-containing 2,4-dioxobutanoic acids designed as HIV-1 integrase photoaffinity ligands Fulltext Access 10 Pages 2006
Synthesis and SAR studies of a novel series of T-type calcium channel blockers Fulltext Access 10 Pages 2006
Fluorescent intercalator displacement analyses of DNA binding by the peptide-derived natural products netropsin, actinomycin, and bleomycin Fulltext Access 10 Pages 2006
Essential structural profile of a dual functional inhibitor against cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX): Molecular docking and 3D-QSAR analyses on DHDMBF analogues Fulltext Access 10 Pages 2006
Carbonyl- and sulfur-containing analogs of suberoylanilide hydroxamic acid: Potent inhibition of histone deacetylases Fulltext Access 10 Pages 2006
Fragment-based drug discovery of carbonic anhydrase II inhibitors by dynamic combinatorial chemistry utilizing alkene cross metathesis Fulltext Access 10 Pages 2006
High-mannose-type glycan modifications of dihydrofolate reductase using glycan–methotrexate conjugates Fulltext Access 10 Pages 2006
Total syntheses of three copper (II) tetracarboranylphenylporphyrins containing 40 or 80 boron atoms and their biological properties in EMT-6 tumor-bearing mice Fulltext Access 10 Pages 2006
Biochemical and functional characterization of an l-amino acid oxidase isolated from Bothrops pirajai snake venom Fulltext Access 10 Pages 2006
Synthesis of N-substituted 9-azabicyclo[3.3.1]nonan-3α-yl carbamate analogs as σ2 receptor ligands Fulltext Access 10 Pages 2006
Synthesis of dopamine transporter selective 3-diarylmethoxymethyl-8-arylalkyl-8-azabicyclo[3.2.1]octane derivatives Fulltext Access 10 Pages 2006
Inhibition of monoamine oxidase B by analogues of the adenosine A2A receptor antagonist (E)-8-(3-chlorostyryl)caffeine (CSC) Fulltext Access 10 Pages 2006
Synthesis of 2,4,6-trisubstituted pyrimidine and triazine heterocycles as antileishmanial agents Fulltext Access 10 Pages 2006
Synthesis and transdermal permeation-enhancing activity of carbonate and carbamate analogs of Transkarbam 12 Fulltext Access 10 Pages 2006
Synthesis and effects of 3-methylthiopropanoyl thiolesters of lipoic acid, methional metabolite mimics Fulltext Access 10 Pages 2006
Reaction of acrolein with 2â²-deoxyadenosine and 9-ethyladenine-Formation of cyclic adducts Fulltext Access 10 Pages 2006
Synthesis, structure, and hydrolytic reaction of trans-dichlorobis(diethanolamine-N)palladium(II) with N-acetylated L-histidylglycine dipeptide Fulltext Access 10 Pages 2006
Synthesis and differential antiproliferative activity of Biginelli compounds against cancer cell lines: Monastrol, oxo-monastrol and oxygenated analogues Fulltext Access 10 Pages 2006
A convenient route to enantiomerically pure, conjugated dienes from sugar allyltin derivatives Fulltext Access 10 Pages 2006
The preparation of new enantiopure imidazolinium salts and their evaluation as catalysts and shift reagents Fulltext Access 10 Pages 2006
Screening, substrate specificity and stereoselectivity of yeast strains, which reduce sterically hindered isopropyl ketones Fulltext Access 10 Pages 2006
Reversing Dane’s strategy: a new, concise, enantioselective synthesis of the steroid nucleus Fulltext Access 10 Pages 2006
Biocatalytic preparation of optically active 4-(N,N-dimethylamino)pyridines for application in chemical asymmetric catalysis Fulltext Access 10 Pages 2006
A modelling study of a non-concerted hydrolytic cycloaddition reaction by the catalytic antibody H11 Fulltext Access 10 Pages 2006
Synthesis of 26,27-bisnorcastasterone analogs and analysis of conformation–activity relationship for brassinolide-like activity Fulltext Access 10 Pages 2006
The development of 3D-QSAR study and recursive partitioning of heterocyclic quinone derivatives with antifungal activity Fulltext Access 10 Pages 2006
Synthesis of hypermodified adenosine derivatives as selective adenosine A3 receptor ligands Fulltext Access 10 Pages 2006
Synthesis of multisubstituted quinolines from Baylis–Hillman adducts obtained from substituted 2-chloronicotinaldehydes and their antimicrobial activity Fulltext Access 10 Pages 2006
Antioxidant activity of β-blockers: An effect mediated by scavenging reactive oxygen and nitrogen species? Fulltext Access 10 Pages 2006
Novel cyano- and amidino-substituted derivatives of thieno[2,3-b]- and thieno[3,2-b]thiophene-2-carboxanilides and thieno[3′,2′:4,5]thieno- and thieno[2′,3′:4,5]thieno [2,3-c]quinolones: Synthesis, photochemical synthesis, DNA binding, and antitumor evalu Fulltext Access 10 Pages 2006
Synthesis and in vitro evaluation of pseudosaccharinamine derivatives as potential elastase inhibitors Fulltext Access 10 Pages 2006
QSAR models for Daphnia toxicity of pesticides based on combinations of topological parameters of molecular structures Fulltext Access 10 Pages 2006
Synthesis of verbenachalcone congeners and their biological assessment against activation of the NGF-mediated neurite outgrowth of PC12D cells’ activity Fulltext Access 10 Pages 2006
Preparation of N-phenyl-(S)-prolinol-derived P,N-ligands and their application in Pd-catalyzed asymmetric allylic alkylation Fulltext Access 10 Pages 2006
Fluorescein-based amino acids for solid phase synthesis of fluorogenic protease substrates Fulltext Access 10 Pages 2006
Synthesis and appetite suppressant activity of 1-aryloxy-2-substituted aminomethyltetrahydronaphthalenes as conformationally rigid analogues of fluoxetine Fulltext Access 10 Pages 2006
New cytotoxic furoquinones obtained from terpenyl-1,4-naphthoquinones and 1,4-anthracenediones Fulltext Access 10 Pages 2006
Synthesis of novel 5-substituted indirubins as protein kinases inhibitors Fulltext Access 10 Pages 2006
N-Terminal amino acid side-chain cleavage of chemically modified peptides in the gas phase: A mass spectrometry technique for N-terminus identification Fulltext Access 10 Pages 2006
Polycationic lipophilic-core dendrons as penetration enhancers for the oral administration of low molecular weight heparin Fulltext Access 10 Pages 2006
Synthesis, antiplatelet and antithrombotic activities of new 2-substituted benzopyrano[4,3-d]pyrimidin-4-cycloamines and 4-amino/cycloamino-benzopyrano[4,3-d]pyrimidin-5-ones Fulltext Access 10 Pages 2006
Optimizing phenylethylphosphonamidates for the inhibition of prostate-specific membrane antigen Fulltext Access 10 Pages 2006
Structural and functional characterization of human microsomal prostaglandin E synthase-1 by computational modeling and site-directed mutagenesis Fulltext Access 10 Pages 2006
Aponeocarzinostatin-A superior drug carrier exhibiting unusually high endurance against denaturants Fulltext Access 10 Pages 2006