Synthesis and in vitro antitumor activity of novel series 2-benzylthio-4-chlorobenzenesulfonamide derivatives Fulltext Access 10 Pages 2006
Pyrazolyl conjugates of bombesin: a new tridentate ligand framework for the stabilization of fac-[M(CO)3]+ moiety Fulltext Access 10 Pages 2006
Synthesis and biological evaluation of a fluorine-18-labeled nonsteroidal androgen receptor antagonist, N-(3-[18F]fluoro-4-nitronaphthyl)-cis-5-norbornene-endo-2,3-dicarboxylic imide Fulltext Access 10 Pages 2006
Synthesis and evaluation of benzothiophene derivatives as ligands for imaging β-amyloid plaques in Alzheimer's disease Fulltext Access 10 Pages 2006
Radiosynthesis and biodistribution of a histamine H3 receptor antagonist 4-[3-(4-piperidin-1-yl-but-1-ynyl)-[11C]benzyl]-morpholine: evaluation of a potential PET ligand Fulltext Access 10 Pages 2006
Chiral dimethylamine flutamide derivatives—modeling, synthesis, androgen receptor affinities and carbon-11 labeling Fulltext Access 10 Pages 2006
Nicotinic α4β2 receptor imaging agents: Part II. Synthesis and biological evaluation of 2-[18F]fluoro-3-[2-((S)-3-pyrrolinyl)methoxy]pyridine (18F-nifene) in rodents and imaging by PET in nonhuman primate Fulltext Access 10 Pages 2006
Synthesis and receptor binding studies of 3-substituted piperazine derivatives Fulltext Access 10 Pages 2006
Polar, functionalized guanine-O6 derivatives resistant to repair by O6-alkylguanine–DNA alkyltransferase: implications for the design of DNA-modifying drugs Fulltext Access 10 Pages 2006
Synthesis of 3-substituted-2-oxoindole analogues and their evaluation as kinase inhibitors, anticancer and antiangiogenic agents Fulltext Access 10 Pages 2006
Intelligent thermoresponsive polymeric micelles for targeted drug delivery Fulltext Access 10 Pages 2006
Pharmaceutical and immunological evaluation of human papillomavirus viruslike particle as an antigen carrier Fulltext Access 10 Pages 2006
Synthesis of new hexahydro- and octahydropyrido[1,2-c]pyrimidine derivatives with an arylpiperazine moiety as ligands for 5-HT1A and 5-HT2A receptors. Part 4 Fulltext Access 10 Pages 2006
Synthesis, antibacterial activity and QSAR studies of 1,2-disubstituted-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolines Fulltext Access 10 Pages 2006
Relative bioavailability estimation of carbamazepine crystal forms using an artificial stomach-duodenum model Fulltext Access 10 Pages 2006
Three-dimensional maximum a posteriori (MAP) imaging with radiopharmaceuticals labeled with three Cu radionuclides Fulltext Access 10 Pages 2006
Les agents de régénération (ou RGTAs) : une nouvelle approche thérapeutique Fulltext Access 10 Pages 2006
Nano-biocapteurs pour la recherche et les diagnostics des maladies inflammatoires et du cancer Fulltext Access 10 Pages 2006
Recent advances in the use of antigen-specific T cells for the treatment of cancer Fulltext Access 10 Pages 2006
Carbopol-mediated paracellular transport enhancement in Calu-3 cell layers Fulltext Access 10 Pages 2006
Brain SPECT imaging and whole-body biodistribution with [123I]ADAM - a serotonin transporter radiotracer in healthy human subjects Fulltext Access 10 Pages 2006
Evaluation of 99mTc-MAG3-annexin V: influence of the chelate on in vitro and in vivo properties in mice Fulltext Access 10 Pages 2006
Antiepidermal growth factor variant III scFv fragment: effect of radioiodination method on tumor targeting and normal tissue clearance Fulltext Access 10 Pages 2006
Polymer-peptide conjugates for angiogenesis targeted tumor radiotherapy Fulltext Access 10 Pages 2006
99mTc Complexes with activated ester functions; ligands comprising a 3,4-diamino-benzoate backbone Fulltext Access 10 Pages 2006
Comparative in vitro and in vivo evaluation of two 64Cu-labeled bombesin analogs in a mouse model of human prostate adenocarcinoma Fulltext Access 10 Pages 2006
Dual optical and nuclear imaging in human melanoma xenografts using a single targeted imaging probe Fulltext Access 10 Pages 2006
Lipid and Electroosmosis Enhanced Transdermal Delivery of Insulin by Electroporation Fulltext Access 10 Pages 2006
Microenvironmental pH Modulation Based Release Enhancement of a Weakly Basic Drug from Hydrophilic Matrices* Fulltext Access 10 Pages 2006
A data base for partition of volatile organic compounds and drugs from blood/plasma/serum to brain, and an LFER analysis of the data Fulltext Access 10 Pages 2006
Solubilization and dissolution of tamoxifenâhydroxybutenyl cyclodextrin complexes Fulltext Access 10 Pages 2006
Involvement of intracellular Ca2+ dynamics in cytoprotective action by amino acids and cytotoxicity by sodium laurate, an absorption enhancer Fulltext Access 10 Pages 2006
Increase of doxorubicin sensitivity for folate receptor positive cells when given as the prodrug Nâ(phenylacetyl) doxorubicin in combination with folateâconjugated PGA Fulltext Access 10 Pages 2006
Effect of cyclodextrins on α-chymotrypsin stability and loading in PLGA microspheres upon S/O/W encapsulation Fulltext Access 10 Pages 2006
Enhanced permeation of diazepam through artificial membranes from supersaturated solutions Fulltext Access 10 Pages 2006
In vitro percutaneous absorption and in vivo protoporphyrin IX accumulation in skin and tumors after topical 5-aminolevulinic acid application with enhancement using an erbium:YAG laser Fulltext Access 10 Pages 2006
Microscopic image analysis techniques for the morphological characterization of pharmaceutical particles: Influence of process variables Fulltext Access 10 Pages 2006
Differentiation and Quantitative Determination of Surface and Hydrate Water in Lyophilized Mannitol Using NIR Spectroscopy Fulltext Access 10 Pages 2006
Predicting the behavior of novel sugar carriers for dry powder inhaler formulations via the use of a cohesive-adhesive force balance approach Fulltext Access 10 Pages 2006
Equilibrium versus kinetic measurements of aqueous solubility, and the ability of compounds to supersaturate in solution-a validation study Fulltext Access 10 Pages 2006
Evaluation of a vaporizing device (Volcano®) for the pulmonary administration of tetrahydrocannabinol Fulltext Access 10 Pages 2006
Crystallization of sucrose glass under ambient conditions: Evaluation of crystallization rate and unusual melting behavior of resultant crystals Fulltext Access 10 Pages 2006
Pharmacokinetic studies of green tea catechins in maternal plasma and fetuses in rats Fulltext Access 10 Pages 2006
Investigation of Targeting Mechanism of New Dextran-Peptide-Methotrexate Conjugates Using Biodistribution Study in Matrix-Metalloproteinase-Overexpressing Tumor Xenograft Model Fulltext Access 10 Pages 2006
The use of colloid probe microscopy to predict aerosolization performance in dry powder inhalers: AFM and in vitro correlation Fulltext Access 10 Pages 2006
3D-QSAR CoMFA study on indenopyrazole derivatives as cyclin dependent kinase 4 (CDK4) and cyclin dependent kinase 2 (CDK2) inhibitors Fulltext Access 10 Pages 2006
Synthesis and antitumor activity of cis-dichloroplatinum(II) complexes of 1-(2-aminophenyl)-1,2,3,4-tetrahydroisoquinolines Fulltext Access 10 Pages 2006
Synthesis, characterization and in vitro biological activity studies of Cu–M (M = Cu2+, Co2+, Ni2+, Mn2+, Zn2+) bimetallic complexes Fulltext Access 10 Pages 2006
Structure-based pharmacophore of COX-2 selective inhibitors and identification of original lead compounds from 3D database searching method Fulltext Access 10 Pages 2006
Synthesis and biological activity of some new 5′-O-acyl tiazofurin derivatives Fulltext Access 10 Pages 2006
In Vivo Evaluation of a Nasal Insulin Delivery System Based on Thiolated Chitosan Fulltext Access 10 Pages 2006
New potent 5-nitrofuryl derivatives as inhibitors of Trypanosoma cruzi growth. 3D-QSAR (CoMFA) studies Fulltext Access 10 Pages 2006
Pharmacophore-based virtual screening: The discovery of novel methionyl-tRNA synthetase inhibitors Fulltext Access 10 Pages 2006
Dose-Independent Pharmacokinetics of Metformin in Rats: Hepatic and Gastrointestinal First-Pass Effects Fulltext Access 10 Pages 2006
Understanding processing-induced phase transformations in erythromycin-PEG 6000 solid dispersions Fulltext Access 10 Pages 2006
Prediction of Plasma Protein Binding Displacement and its Implications for Quantitative Assessment of Metabolic Drug-Drug Interactions from In Vitro Data Fulltext Access 10 Pages 2006
Double asymmetric induction in 1,3-dipolar cycloaddition of five-membered cyclic nitrones to 2-(5H)-furanones Fulltext Access 11 Pages 2006
Enantiomeric synthesis of carbocyclic d-4′-C-methylribonucleosides as potential antiviral agents Fulltext Access 11 Pages 2006
3-Aza-6,8-dioxabicyclo[3.2.1]octanes as new enantiopure heteroatom-rich tropane-like ligands of human dopamine transporter Fulltext Access 11 Pages 2006
Asymmetric synthesis of anti-diastereoisomers of β-heterocycle substituted (S)-α-aminobutyric acids Fulltext Access 11 Pages 2006
Towards the development of oxadiazinanones as chiral auxiliaries: synthesis and application of N3-haloacetyloxadiazinanones Fulltext Access 11 Pages 2006
Sugar amino acids at the anomeric position of carbohydrates: synthesis of spirocyclic amino acids of 6-deoxy-l-lyxofuranose Fulltext Access 11 Pages 2006
Asymmetric synthesis of α-mercapto-β-amino acid derivatives: application to the synthesis of polysubstituted thiomorpholines Fulltext Access 11 Pages 2006
Bisoxazoline ligands with an axial-unfixed biaryl backbone: the effects of the biaryl backbone and the substituent at oxazoline ring on Cu-catalyzed asymmetric cyclopropanation Fulltext Access 11 Pages 2006
Inhibition of cancer cell growth by cyclin dependent kinase 4 inhibitors synthesized based on the structure of fascaplysin Fulltext Access 11 Pages 2006
Total chemical synthesis of the B1 domain of protein L from Peptostreptococcus magnus Fulltext Access 11 Pages 2006
Effect of kosmotropicity of ionic liquids on the enzyme stability in aqueous solutions Fulltext Access 11 Pages 2006
Bioactivity of glycogen phosphorylase inhibitors that bind to the purine nucleoside site Fulltext Access 11 Pages 2006
Novel chemo-enzymatic oligomers of cinnamic acids as direct and indirect inhibitors of coagulation proteinases Fulltext Access 11 Pages 2006
Substituent activity relationship studies on new azolo benzoxazepinyl oxazolidinones Fulltext Access 11 Pages 2006
Synthesis and hydrolytic behavior of two novel tripartate codrugs of naltrexone and 6β-naltrexol with hydroxybupropion as potential alcohol abuse and smoking cessation agents Fulltext Access 11 Pages 2006
Thrombomodulin induction in cultured human endothelial cells by 9-cis-locked retinoic acid analogues Fulltext Access 11 Pages 2006
Nonsteroidal antiinflammatory agents—part 2 antiinflammatory, analgesic and antipyretic activity of some substituted 3-pyrazolin-5-ones and 1,2,4,5,6,7-3H-hexahydroindazol-3-ones Fulltext Access 11 Pages 2006
Anticancer thiopyrano[2,3-d][1,3]thiazol-2-ones with norbornane moiety. Synthesis, cytotoxicity, physico-chemical properties, and computational studies Fulltext Access 11 Pages 2006
Synthesis and structure–activity relationship studies of 4,11-diaminonaphtho[2,3-f]indole-5,10-diones Fulltext Access 11 Pages 2006
Immobilized methyltrioxo rhenium (MTO)/H2O2 systems for the oxidation of lignin and lignin model compounds Fulltext Access 11 Pages 2006
Synthesis and biological evaluation of acyclic triaryl (Z)-olefins possessing a 3,5-di-tert-butyl-4-hydroxyphenyl pharmacophore: Dual inhibitors of cyclooxygenases and lipoxygenases Fulltext Access 11 Pages 2006
2D Autocorrelation modeling of the negative inotropic activity of calcium entry blockers using Bayesian-regularized genetic neural networks Fulltext Access 11 Pages 2006
Synthesis of docosahexaenoic acid derivatives designed as novel PPARγ agonists and antidiabetic agents Fulltext Access 11 Pages 2006
Non-stochastic quadratic fingerprints and LDA-based QSAR models in hit and lead generation through virtual screening: theoretical and experimental assessment of a promising method for the discovery of new antimalarial compounds Fulltext Access 11 Pages 2006
Novel 5,7-disubstituted 6-amino-5H-pyrrolo[3,2-b]pyrazine-2,3-dicarbonitriles, the promising protein kinase inhibitors with antiproliferative activity Fulltext Access 11 Pages 2006
Solid-phase synthesis and pharmacological evaluation of a library of peptidomimetics as potential farnesyltransferase inhibitors: an approach to new lead compounds Fulltext Access 11 Pages 2006
Optimization of a pharmacophore model for 5-HT4 agonists using CoMFA and receptor based alignment Fulltext Access 11 Pages 2006
Synthesis and binding studies of epibatidine analogues as ligands for the nicotinic acetylcholine receptors Fulltext Access 11 Pages 2006
In silico modelling of the interaction of flavonoids with human P-glycoprotein nucleotide-binding domain Fulltext Access 11 Pages 2006
Heterocyclic system containing bridgehead nitrogen atom: synthesis and pharmacological activities of some substituted 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles Fulltext Access 11 Pages 2006