Novel non-classical C9-methyl-5-substituted-2,4-diaminopyrrolo[2,3-d]pyrimidines as potential inhibitors of dihydrofolate reductase and as anti-opportunistic agents Fulltext Access 11 Pages 2006
Synthesis and radiosynthesis of [18F]FPhEP, a novel α4β2-selective, epibatidine-based antagonist for PET imaging of nicotinic acetylcholine receptors Fulltext Access 11 Pages 2006
Synthesis and CYP26A1 inhibitory activity of 1-[benzofuran-2-yl-(4-alkyl/aryl-phenyl)-methyl]-1H-triazoles Fulltext Access 11 Pages 2006
Phosphatidylinositol mannosides: Synthesis and suppression of allergic airway disease Fulltext Access 11 Pages 2006
Application of multicomponent reactions to antimalarial drug discovery. Part 2: New antiplasmodial and antitrypanosomal 4-aminoquinoline γ- and δ-lactams via a ‘catch and release’ protocol Fulltext Access 11 Pages 2006
Synthesis and pharmacological studies of new hybrid derivatives of fentanyl active at the μ-opioid receptor and I2–imidazoline binding sites Fulltext Access 11 Pages 2006
Synthesis and in vitro antitumor evaluation of some indeno[1,2-c]pyrazol(in)es substituted with sulfonamide, sulfonylurea(-thiourea) pharmacophores, and some derived thiazole ring systems Fulltext Access 11 Pages 2006
Synthesis and conformational analysis of His-Phe-Arg-Trp-NH2 and analogues with antifungal properties Fulltext Access 11 Pages 2006
Amino- and glycoconjugates of pyrido[4,3,2-kl]acridine. Synthesis, antitumor activity, and DNA binding Fulltext Access 11 Pages 2006
Novel potent neuropeptide Y Y5 receptor antagonists: Synthesis and structure–activity relationships of phenylpiperazine derivatives Fulltext Access 11 Pages 2006
Exploring the limits of benzimidazole DNA-binding oligomers for the hypoxia inducible factor (HIF) site Fulltext Access 11 Pages 2006
Modification at the C9 position of the marine natural product isoaaptamine and the impact on HIV-1, mycobacterial, and tumor cell activity Fulltext Access 11 Pages 2006
Binding of oxalyl derivatives of β-d-glucopyranosylamine to muscle glycogen phosphorylase b Fulltext Access 11 Pages 2006
Synthesis and antitubercular activity of substituted phenylmethyl- and pyridylmethyl amines Fulltext Access 11 Pages 2006
Aryl nucleoside H-phosphonates. Part 15: Synthesis, properties and, anti-HIV activity of aryl nucleoside 5′-α-hydroxyphosphonates Fulltext Access 11 Pages 2006
Synthesis and biological activity of novel 4,4-difluorobenzazepine derivatives as non-peptide antagonists of the arginine vasopressin V1A receptor Fulltext Access 11 Pages 2006
Biomimetic synthesis, antimicrobial, antileishmanial and antimalarial activities of euglobals and their analogues Fulltext Access 11 Pages 2006
Synthesis and biological evaluation of 9-(5′,5′-difluoro-5′-phosphonopentyl)guanine derivatives for PNP-inhibitors Fulltext Access 11 Pages 2006
Structure–activity relationships of a series of tariquidar analogs as multidrug resistance modulators Fulltext Access 11 Pages 2006
Elucidation of sulfadoxine resistance with structural models of the bifunctional Plasmodium falciparum dihydropterin pyrophosphokinase–dihydropteroate synthase Fulltext Access 11 Pages 2006
Neamine derivatives having a nucleobase with a lysine or an arginine as a linker, their synthesis and evaluation as potential inhibitors for HIV TAR–Tat Fulltext Access 11 Pages 2006
α-Peptide/β-sulfonamidopeptide hybrids: Analogs of the chemotactic agent for-Met-Leu-Phe-OMe Fulltext Access 11 Pages 2006
Isoxazole-type derivatives related to combretastatin A-4, synthesis and biological evaluation Fulltext Access 11 Pages 2006
Synthesis, radiosynthesis and in vivo preliminary evaluation of [11C]LBT-999, a selective radioligand for the visualisation of the dopamine transporter with PET Fulltext Access 11 Pages 2006
Synthesis and biological evaluation of N-(7-indazolyl)benzenesulfonamide derivatives as potent cell cycle inhibitors Fulltext Access 11 Pages 2006
Building a successful structural motif into sialylmimetics—cyclohexenephosphonate monoesters as pseudo-sialosides with promising inhibitory properties Fulltext Access 11 Pages 2006
Synthesis of C-6 substituted pyrazolo[1,5-a]pyridines with potent activity against herpesviruses Fulltext Access 11 Pages 2006
Synthesis and DNA cleavage reaction characteristics of enediyne prodrugs activated via an allylic rearrangement by base or UV irradiation Fulltext Access 11 Pages 2006
Synthesis and antimicrobial activity of new (4,4,4-trihalo-3-oxo-but-1-enyl)-carbamic acid ethyl esters, (4,4,4-trihalo-3-hydroxy-butyl)-carbamic acid ethyl esters, and 2-oxo-6-trihalomethyl-[1,3]oxazinane-3-carboxylic acid ethyl esters Fulltext Access 11 Pages 2006
Synthesis and preliminary chemotherapeutic evaluation of the fully C-linked glucuronide of N-(4-hydroxyphenyl)retinamide Fulltext Access 11 Pages 2006
Preparation of antibodies against a novel immunosuppressant, FTY720, and development of an enzyme immunoassay for FTY720 Fulltext Access 11 Pages 2006
β-Nitrostyrene derivatives as potential antibacterial agents: A structure–property–activity relationship study Fulltext Access 11 Pages 2006
Synthesis and anti-inflammatory activity of a series of N-substituted naproxen glycolamides: Nitric oxide-donor naproxen prodrugs Fulltext Access 11 Pages 2006
Synthesis of pyrazole-based hybrid molecules: Search for potent multidrug resistance modulators Fulltext Access 11 Pages 2006
Transformations of bioactive peptides in the presence of sugars—Characterization and stability studies of the adducts generated via the Maillard reaction Fulltext Access 11 Pages 2006
Identification of chemically diverse Chk1 inhibitors by receptor-based virtual screening Fulltext Access 11 Pages 2006
Synthesis and biological evaluation of homoserine lactone derived ureas as antagonists of bacterial quorum sensing Fulltext Access 11 Pages 2006
Novel potent and selective calcium-release-activated calcium (CRAC) channel inhibitors. Part 1: Synthesis and inhibitory activity of 5-(1-methyl-3-trifluoromethyl-1H-pyrazol-5-yl)-2-thiophenecarboxamides Fulltext Access 11 Pages 2006
Molecular docking study and development of an empirical binding free energy model for phosphodiesterase 4 inhibitors Fulltext Access 11 Pages 2006
Atom-based 3D-chiral quadratic indices. Part 2: Prediction of the corticosteroid-binding globulinbinding affinity of the 31 benchmark steroids data set Fulltext Access 11 Pages 2006
Evaluation of fosmidomycin analogs as inhibitors of the Synechocystis sp. PCC6803 1-deoxy-d-xylulose 5-phosphate reductoisomerase Fulltext Access 11 Pages 2006
Synthesis and anti-HIV activity of bi-functional betulinic acid derivatives Fulltext Access 11 Pages 2006
Syntheses and evaluation of fluorinated conformationally restricted analogues of GABA as potential inhibitors of GABA aminotransferase Fulltext Access 11 Pages 2006
Use of a Double Resonance Electron Capture Dissociation Experiment to Probe Fragment Intermediate Lifetimes Fulltext Access 11 Pages 2006
Analyte Response in Laser Ablation Inductively Coupled Plasma Mass Spectrometry Fulltext Access 11 Pages 2006
Electrospray Mass Spectral Fragmentation Study of N,N′-Disubstituted Imidazolium Ionic Liquids Fulltext Access 11 Pages 2006
Mapping Noncovalent Ligand Binding to Stemloop Domains of the HIV-1 Packaging Signal by Tandem Mass Spectrometry Fulltext Access 11 Pages 2006
Identification of the Adduct Between a 4-Aza-3-ene-1,6-diyne and DNA Using Electrospray Ionization Mass Spectrometry Fulltext Access 11 Pages 2006
Divalent Metal Ion-Peptide Interactions Probed by Electron Capture Dissociation of Trications Fulltext Access 11 Pages 2006
Sub Part-Per-Million Mass Accuracy by Using Stepwise-External Calibration in Fourier Transform Ion Cyclotron Resonance Mass Spectrometry Fulltext Access 11 Pages 2006
Isotope Labeling and Theoretical Study of the Formation of a3* Ions from Protonated Tetraglycine Fulltext Access 11 Pages 2006
Characteristics of Photodissociation at 193 nm of Singly Protonated Peptides Generated by Matrix-Assisted Laser Desorption Ionization (MALDI) Fulltext Access 11 Pages 2006
The Influence of Sialylation on Glycan Negative Ion Dissociation and Energetics Fulltext Access 11 Pages 2006
Solvent-Free MALDI-MS: Developmental Improvements in the Reliability and the Potential of MALDI in the Analysis of Synthetic Polymers and Giant Organic Molecules Fulltext Access 11 Pages 2006
Multi-walled carbon nanotube exposure alters protein expression in human keratinocytes Fulltext Access 11 Pages 2006
New technology and clinical applications of nanomedicine: Highlights of the second annual meeting of the American Academy of Nanomedicine (Part I) Fulltext Access 11 Pages 2006
Unveiling hidden features of orphan nuclear receptors: The case of the small heterodimer partner (SHP) Fulltext Access 11 Pages 2006
Molecular dynamics and circular dichroism studies of human and rat C-peptides Fulltext Access 11 Pages 2006
Architecture with GIDEON, a program for design in structural DNA nanotechnology Fulltext Access 11 Pages 2006
A theory of mode of action of azolylalkylquinolines as DNA binding agents using automated flexible ligand docking Fulltext Access 11 Pages 2006
Exploring the potential of complex formation between a mutant DNA and the wild type protein counterpart: A MM and MD simulation approach Fulltext Access 11 Pages 2006
A reactivity index study to monitor the role of solvation on the interaction of the chromophores with amino-functional silanol surface for colorimetric sensors Fulltext Access 11 Pages 2006
A connection rule for α-carbon coarse-grained elastic network models using chemical bond information Fulltext Access 11 Pages 2006
Barnase thermal titration via molecular dynamics simulations: Detection of early denaturation sites Fulltext Access 11 Pages 2006
Nitrile biotransformations for the practical synthesis of highly enantiopure azido carboxylic acids and amides, ‘click’ to functionalized chiral triazoles and chiral β-amino acids Fulltext Access 11 Pages 2006
Design, synthesis, and biological evaluation of substituted 3-alkylthio-4,5-diaryl-4H-1,2,4-triazoles as selective COX-2 inhibitors Fulltext Access 11 Pages 2006
2,4-Diamino-9H-pyrimido[4,5-b]indol-5-ols: Synthesis, in vitro cytotoxic activity, and QSAR investigations Fulltext Access 11 Pages 2006
Synthesis and biological assays of E-ring analogs of camptothecin and homocamptothecin Fulltext Access 11 Pages 2006
Intramolecular asymmetric C–H insertion of N-arylalkyl, N-bis(trimethylsilyl)methyldiazoamides mediated by chiral rhodium(II) catalysts. Synthesis of (R)-β-benzyl-γ-aminobutyric acid Fulltext Access 11 Pages 2006
Highly diastereoselective allylation and reduction of chiral camphor-derived α-ketoamides Fulltext Access 11 Pages 2006
Studies on the structure–enantioselectivity relationships in the catalytic asymmetric intramolecular cyclopropanation reaction of α-diazo-β-keto sulfones possessing a methyl-substituted phenyl group Fulltext Access 11 Pages 2006
Tropos deoxycholic acid-derived biphenylphosphites: synthesis, stereochemical characterization and use as chiral ligands in the copper catalyzed conjugate addition of diethylzinc to acyclic enones Fulltext Access 11 Pages 2006
Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods Fulltext Access 11 Pages 2006
Isolation synthesis and glycosidase inhibition profile of 3-epi-casuarine Fulltext Access 11 Pages 2006
Factors Influencing the Electrospray Intrasource Separation and Selective Ionization of Glycerophospholipids Fulltext Access 11 Pages 2006
Using Tandem Mass Spectrometry to Predict Chemical Transformations of 2-Pyrimidinyloxy-N-Arylbenzyl Amine Derivatives in Solution Fulltext Access 11 Pages 2006
Ions Generated from Uranyl Nitrate Solutions by Electrospray Ionization (ESI) and Detected with Fourier Transform Ion-Cyclotron Resonance (FT-ICR) Mass Spectrometry Fulltext Access 11 Pages 2006
MALDI-TOF and ESI-MS Analysis of Oligosaccharides Labeled with a New Multifunctional Oligosaccharide Tag Fulltext Access 11 Pages 2006
Structural Relationships in Small Molecule Interactions Governing Gas-Phase Enantioselectivity and Zwitterionic Formation Fulltext Access 11 Pages 2006
Influence of Crosslinker Identity and Position on Gas-Phase Dissociation of Lys–Lys Crosslinked Peptides Fulltext Access 11 Pages 2006
Sources of Artefacts in the Electrospray Ionization Mass Spectra of Saturated Diacylglycerophosphocholines: From Condensed Phase Hydrolysis Reactions Through to Gas Phase Intercluster Reactions Fulltext Access 11 Pages 2006
Multiple Neutral Loss Monitoring (MNM): A Multiplexed Method for Post-Translational Modification Screening Fulltext Access 11 Pages 2006
Reassessment of the Structural Composition of the Alkenone Distributions in Natural Environments Using an Improved Method for Double Bond Location Based on GC-MS Analysis of Cyclopropylimines Fulltext Access 11 Pages 2006