A slow-onset, long-duration indanamine monoamine reuptake inhibitor as a potential maintenance pharmacotherapy for psychostimulant abuse: Effects in laboratory rat models relating to addiction Fulltext Access 11 Pages 2006
Effects of dorsal and ventral hippocampal NMDA stimulation on nucleus accumbens core and shell dopamine release Fulltext Access 11 Pages 2006
Trafficking of presynaptic AMPA receptors mediating neurotransmitter release: Neuronal selectivity and relationships with sensitivity to cyclothiazide Fulltext Access 11 Pages 2006
Use of an inverse agonist radioligand [3H]A-317920 reveals distinct pharmacological profiles of the rat histamine H3 receptor Fulltext Access 11 Pages 2006
Down-regulation of GFRα-1 expression by antisense oligodeoxynucleotide aggravates thermal hyperalgesia in a rat model of neuropathic pain Fulltext Access 11 Pages 2006
Airjet and FG-7142-induced Fos expression differs in rats selectively bred for high and low anxiety-related behavior Fulltext Access 11 Pages 2006
Reinforcing effects of nicotine microinjections into the ventral tegmental area of mice: Dependence on cholinergic nicotinic and dopaminergic D1 receptors Fulltext Access 11 Pages 2006
Strong modulation by RFamide neuropeptides of the ASIC1b/3 heteromer in competition with extracellular calcium Fulltext Access 11 Pages 2006
Dopaminergic control of food choice: Contrasting effects of SKF 38393 and quinpirole on high-palatability food preference in the rat Fulltext Access 11 Pages 2006
Expression of D2 receptor isoforms in cultured neurons reveals equipotent autoreceptor function Fulltext Access 11 Pages 2006
Dopamine D4 receptor signaling in the rat paraventricular hypothalamic nucleus: Evidence of natural coupling involving immediate early gene induction and mitogen activated protein kinase phosphorylation Fulltext Access 11 Pages 2006
Nicotine, but neither the α4β2 ligand RJR2403 nor an α7 nAChR subtype selective agonist, protects against a partial 6-hydroxydopamine lesion of the rat median forebrain bundle Fulltext Access 11 Pages 2006
Protection against MDMA-induced dopaminergic neurotoxicity in mice by methyllycaconitine: Involvement of nicotinic receptors Fulltext Access 11 Pages 2006
The muscle relaxant thiocolchicoside is an antagonist of GABAA receptor function in the central nervous system Fulltext Access 11 Pages 2006
Inhibition of the striatum-enriched phosphodiesterase PDE10A: A novel approach to the treatment of psychosis Fulltext Access 11 Pages 2006
NMDA depresses glutamatergic synaptic transmission in the striatum through the activation of adenosine A1 receptors: Evidence from knockout mice Fulltext Access 11 Pages 2006
The effect of dibutyryl cAMP on tetrodotoxin-sensitive and -resistant voltage-gated sodium currents in rat dorsal root ganglion neurons and the consequences for their sensitivity to lidocaine Fulltext Access 11 Pages 2006
In vitro galantamine-memantine co-application: Mechanism of beneficial action Fulltext Access 11 Pages 2006
Cholinergic receptor-independent dysfunction of mitochondrial respiratory chain enzymes, reduced mitochondrial transmembrane potential and ATP depletion underlie necrotic cell death induced by the organophosphate poison mevinphos Fulltext Access 11 Pages 2006
DNA based customized nutraceutical “gene therapy” utilizing a genoscore: A hypothesized paradigm shift of a novel approach to the diagnosis, stratification, prognosis and treatment of inflammatory processes in the human Fulltext Access 11 Pages 2006
Violence in mental disorders and community sample: An evolutionary model related with dominance in social relationships Fulltext Access 11 Pages 2006
Phototherapy and malignancy: Possible enhancement by iron administration and hyperbaric oxygen Fulltext Access 11 Pages 2006
Tinospora cordifolia induces enzymes of carcinogen/drug metabolism and antioxidant system, and inhibits lipid peroxidation in mice Fulltext Access 11 Pages 2006
Comparative studies for selective deprotection of the N-arylideneamino moiety from heterocyclic amides: kinetic and theoretical studies Fulltext Access 11 Pages 2006
Enantioselective synthesis of homocarbocyclic-2â²-oxo-3â²-azanucleosides Fulltext Access 11 Pages 2006
Synthesis of dinucleotides with 2â²-C to phosphate connections by ring-closing metathesis Fulltext Access 11 Pages 2006
Stereoselective synthesis and functionalization of 4-heterosubstituted β-lactams Fulltext Access 11 Pages 2006
A simple approach for the regioselective synthesis of imidazo[1,2-a]pyrimidiones and pyrimido[1,2-a]pyrimidinones Fulltext Access 11 Pages 2006
Structural and stereochemical aspects of the enantioselective halogenation of 1,3-dicarbonyl compounds catalyzed by Ti(TADDOLato) complexes Fulltext Access 11 Pages 2006
Chiral base-catalyzed aldol reaction of trimethoxysilyl enol ethers: effect of water as an additive on stereoselectivities Fulltext Access 11 Pages 2006
Screening of novel nuclear receptor agonists by a convenient reporter gene assay system using green fluorescent protein derivatives Fulltext Access 11 Pages 2006
Mechanisms involved in the gastro-protective effect of STW 5 (Iberogast®) and its components against ulcers and rebound acidity Fulltext Access 11 Pages 2006
Pharmacological actions of Thespesia populnea relevant to Alzheimer's disease Fulltext Access 11 Pages 2006
Intranasal Mucoadhesive Microemulsions of Clonazepam: Preliminary Studies on Brain Targeting Fulltext Access 11 Pages 2006
Effects of the mGluR8 agonist (S)-3,4-DCPG in the lateral amygdala on acquisition/expression of fear-potentiated startle, synaptic transmission, and plasticity Fulltext Access 11 Pages 2006
Membrane voltage modulates the GABAA receptor gating in cultured rat hippocampal neurons Fulltext Access 11 Pages 2006
Chronic pre-treatment with nicotine enhances nicotine-evoked striatal dopamine release and α6 and β3 nicotinic acetylcholine receptor subunit mRNA in the substantia nigra pars compacta of the rat Fulltext Access 11 Pages 2006
Allosteric positive interaction of thymol with the GABAA receptor in primary cultures of mouse cortical neurons Fulltext Access 11 Pages 2006
Opposing effects of AMPA and 5-HT1A receptor blockade on passive avoidance and object recognition performance: Correlation with AMPA receptor subunit expression in rat hippocampus Fulltext Access 11 Pages 2006
Increased ethanol consumption and preference and decreased ethanol sensitivity in female FAAH knockout mice Fulltext Access 11 Pages 2006
Chronic low-dose administration of nicotine facilitates recovery and synaptic change after focal ischemia in rats Fulltext Access 11 Pages 2006
Role of noradrenergic and GABA-ergic inputs in pedunculopontine tegmentum for regulation of rapid eye movement sleep in rats Fulltext Access 11 Pages 2006
The H current blocker ZD7288 decreases epileptiform hyperexcitability in the rat neocortex by depressing synaptic transmission Fulltext Access 11 Pages 2006
Enhanced antinociceptive effects of morphine in histamine H2 receptor gene knockout mice Fulltext Access 11 Pages 2006
Chronic methylphenidate modulates locomotor activity and sensory evoked responses in the VTA and NAc of freely behaving rats Fulltext Access 11 Pages 2006
Drug permeability across a phospholipid vesicle based barrier: A novel approach for studying passive diffusion Fulltext Access 11 Pages 2006
Effect of pH and ionic strength on the physical stability of adenovirus type 5 Fulltext Access 11 Pages 2006
Preparation, characterization, and drug release in vitro of chitosan-glycyrrhetic acid nanoparticles Fulltext Access 11 Pages 2006
Solubilization of two structurally related anticancer drugs: XK-469 and PPA Fulltext Access 11 Pages 2006
Effect of different surfactants in biorelevant medium on the secretion of a lipophilic compound in lipoproteins using Caco-2 cell culture Fulltext Access 11 Pages 2006
Biowaiver monographs for immediate release solid oral dosage forms: Acetaminophen (paracetamol) Fulltext Access 11 Pages 2006
The distribution pattern of radioactivity across different tissues in quantitative whole-body autoradiography (QWBA) studies Fulltext Access 11 Pages 2006
Characterization of oxalic acid derivatives as new metabolites of metamizol (dipyrone) in incubated hen's egg and human Fulltext Access 11 Pages 2006
In vitro evaluation of N-methyl amide tripeptidomimetics as substrates for the human intestinal di-/tri-peptide transporter hPEPT1 Fulltext Access 11 Pages 2006
Visualization studies of human skin in vitro/in vivo under the influence of an electrical field Fulltext Access 11 Pages 2006
Application of a combined effect compartment and binding model for gastric acid inhibition of AR-HO47108: A potassium competitive acid blocker, and its active metabolite AR-HO47116 in the dog Fulltext Access 11 Pages 2006
Synthesis of radiolabelled 1-trichloromethyl-1,2,3,4-tetrahydro-β-carboline (TaClo), a neurotoxic chloral-derived mammalian alkaloid, and its biodistribution in rats Fulltext Access 11 Pages 2006
Comparison of neurofuzzy logic and neural networks in modelling experimental data of an immediate release tablet formulation Fulltext Access 11 Pages 2006
Mechanistic model of acute autoinhibitory feedback action after administration of SSRIs in rats: Application to escitalopram-induced effects on brain serotonin levels Fulltext Access 11 Pages 2006
Site of drug absorption after oral administration: Assessment of membrane permeability and luminal concentration of drugs in each segment of gastrointestinal tract Fulltext Access 11 Pages 2006
Structural investigations on lipid nanoparticles containing high amounts of lecithin Fulltext Access 11 Pages 2006
Interfacial adsorption of insulin: Conformational changes and reversibility of adsorption Fulltext Access 11 Pages 2006
Diverse Structures of Chimeric CYP-REP7/6-Containing CYP2D6 and a Novel Defective CYP2D6 Haplotype Harboring Single-type *36 and CYP-REP7/6 in Japanese Fulltext Access 11 Pages 2006
Regulation of mRNA Expression of MDR1, MRP1, MRP2 and MRP3 by Prototypical Microsomal Enzyme Inducers in Primary Cultures of Human and Rat Hepatocytes Fulltext Access 11 Pages 2006
Chemoselective hydrazone formation between HYNIC-functionalized peptides and 18F-fluorinated aldehydes Fulltext Access 11 Pages 2006
[11C]SMe-ADAM, an imaging agent for the brain serotonin transporter: synthesis, pharmacological characterization and microPET studies in rats Fulltext Access 11 Pages 2006
Synthesis and radiolabeling of N-[4-[4-(2-[11C]methoxyphenyl)piperazin-1-yl]butyl]benzo[b]thiophene-2-carboxamide - a potential radiotracer for D3 receptor imaging with PET Fulltext Access 11 Pages 2006
A novel 125I-labeled daunorubicin derivative for radionuclide-based cancer therapy Fulltext Access 11 Pages 2006
Reducing renal uptake of 90Y- and 177Lu-labeled alpha-melanocyte stimulating hormone peptide analogues Fulltext Access 11 Pages 2006
Preparation of budesonide/γâcyclodextrin complexes in supercritical fluids with a novel SEDS method Fulltext Access 11 Pages 2006
Structure and Physical Stability of Hydrates and Thermotropic Mesophase of Calcium Benzoate Fulltext Access 11 Pages 2006
Particle Size Limits to Meet USP Content Uniformity Criteria for Tablets and Capsules Fulltext Access 11 Pages 2006
Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Cimetidine* Fulltext Access 11 Pages 2006
Effect of design on the performance of a dry powder inhaler using computational fluid dynamics. Part 2: Air inlet size Fulltext Access 11 Pages 2006
The application of mechanism-based PK/PD modeling in pharmacodynamic-based dose selection of muM17, a surrogate monoclonal antibody for efalizumab Fulltext Access 11 Pages 2006
Effect of Food Intake on the Oral Absorption of Poorly Water-Soluble Drugs: In Vitro Assessment of Drug Dissolution and Permeation Assay System Fulltext Access 11 Pages 2006
Multivariate data analysis as a fast tool in evaluation of solid state phenomena Fulltext Access 11 Pages 2006
Development of a recursive finite difference pharmacokinetic model from an exponential model: Application to a propofol bolus* Fulltext Access 11 Pages 2006
Chemical Kinetics and Aqueous Degradation Pathways of a New Class of Synthetic Ozonide Antimalarials Fulltext Access 11 Pages 2006
Modulating βâlapachone release from polymer millirods through cyclodextrin complexation Fulltext Access 11 Pages 2006
Advances in the production, processing and microPET image quality of technetium-94m Fulltext Access 11 Pages 2006
Level A in vitro-in vivo Correlation (IVIVC) Model with Bayesian Approach to Formulation Series Fulltext Access 11 Pages 2006
Towards an Understanding of the Molecular Mechanism of Solvation of Drug Molecules: A Thermodynamic Approach by Crystal Lattice Energy, Sublimation, and Solubility Exemplified by Hydroxybenzoic Acids Fulltext Access 11 Pages 2006
Hepatic Disposition of the Cytochrome P450 2E1 Marker Chlorzoxazone and its Hydroxylated Metabolite in Isolated Perfused Rat Livers Fulltext Access 11 Pages 2006
A Novel MDR1 G1199T Variant Alters Drug Resistance and Efflux Transport Activity of P-Glycoprotein in Recombinant Hek Cells Fulltext Access 11 Pages 2006
Kinetic Analyses for Species Differences in P-glycoprotein-Mediated Drug Transport Fulltext Access 11 Pages 2006
Determination of drug plasma protein binding by solid phase microextraction Fulltext Access 11 Pages 2006
Pharmacokinetics of Chlorzoxazone in Rats with Diabetes: Induction of CYP2E1 on 6-Hydroxychlorzoxazone Formation Fulltext Access 11 Pages 2006
In-line Measurement of a Drug Substance via Near Infrared Spectroscopy to Ensure a Robust Crystallization Process Fulltext Access 11 Pages 2006
Factors influencing regional differences in intestinal absorption of UK-343,664 in rat: Possible role in dose-dependent pharmacokinetics Fulltext Access 11 Pages 2006