In vitro and in vivo investigation of matrix metalloproteinase expression in metastatic tumor models Fulltext Access 11 Pages 2006
Les anévrysmes intracrâniens et leur traitement endovasculaire par l'utilisation de coils Fulltext Access 11 Pages 2006
Identification, Preparation, and Characterization of Several Polymorphs and Solvates of Terazosin Hydrochloride Fulltext Access 12 Pages 2006
Sublethal mitochondrial stress with an attendant stoichiometric augmentation of reactive oxygen species may precipitate many of the beneficial alterations in cellular physiology produced by caloric restriction, intermittent fasting, exercise and dietary p Fulltext Access 12 Pages 2006
Insular Alzheimer’s disease pathology as a cause of “age-related” autonomic dysfunction and mortality in the non-demented elderly Fulltext Access 12 Pages 2006
Sensory gating deficits, pattern completion, and disturbed fronto-limbic balance, a model for description of hallucinations and delusions in schizophrenia Fulltext Access 12 Pages 2006
A fuzzy theory of cortical computation: Neuropoietic engrams, fuzzy hypercubes, and the nature of consciousness Fulltext Access 12 Pages 2006
Evaluation of Ingredient Concentration in Powders Using Two-Speed Photon Migration Theory and Measurements Fulltext Access 12 Pages 2006
Solid state interactions between the proton pump inhibitor omeprazole and various enteric coating polymers Fulltext Access 12 Pages 2006
The Influence of Actuation Parameters on in Vitro Testing of Nasal Spray Products Fulltext Access 12 Pages 2006
Determination of solubility profiles of eflucimibe polymorphs: Experimental and modeling Fulltext Access 12 Pages 2006
Comparison between dehydration and desolvation kinetics of fluconazole monohydrate and fluconazole ethylacetate solvate using three different methods Fulltext Access 12 Pages 2006
Thermodynamic modeling of activity coefficient and prediction of solubility: Part 2. Semipredictive or semiempirical models Fulltext Access 12 Pages 2006
Catanionic mixtures involving a drug: A rather general concept that can be utilized for prolonged drug release from gels Fulltext Access 12 Pages 2006
Disassembly and reassembly of yeastâderived recombinant human papillomavirus virusâlike particles (HPV VLPs) Fulltext Access 12 Pages 2006
Towards an understanding of the molecular mechanism of solvation of drug molecules: A thermodynamic approach by crystal lattice energy, sublimation, and solubility exemplified by paracetamol, acetanilide, and phenacetin Fulltext Access 12 Pages 2006
Multiscale Modelling Methodology for Virtual Prototyping of Effervescent Tablets Fulltext Access 12 Pages 2006
Stability profiles of drug products extended beyond labeled expiration dates Fulltext Access 12 Pages 2006
Towards an Understanding of the Structurally Based Potential for Mechanically Activated Disordering of Small Molecule Organic Crystals Fulltext Access 12 Pages 2006
Novel Colon-Specific Microspheres With Highly Dispersed Hydroxycamptothecin Cores: Their Preparation, ReleaseBehavior, and Therapeutic Efficiency Against Colonic Cancer Fulltext Access 12 Pages 2006
Aluminum hydroxide adjuvant produced under constant reactant concentration Fulltext Access 12 Pages 2006
Prediction of human drug clearance from animal data: Application of the rule of exponents and 'fu corrected intercept method' (FCIM) Fulltext Access 12 Pages 2006
Neuroanatomical and pharmacological assessment of Fos expression induced in the rat brain by the phosphodiesterase-4 inhibitor 6-(4-pyridylmethyl)-8-(3-nitrophenyl) quinoline Fulltext Access 12 Pages 2006
Anti-diabetic properties of the Canadian lowbush blueberry Vaccinium angustifolium Ait. Fulltext Access 12 Pages 2006
Inhibitory effects of aloe carboxypeptidase fraction on streptozotocin-induced enhancement of vascular permeability in the pancreatic islets Fulltext Access 12 Pages 2006
Caffeine promotes hyperthermia and serotonergic loss following co-administration of the substituted amphetamines, MDMA (“Ecstasy”) and MDA (“Love”) Fulltext Access 12 Pages 2006
Immediate-early gene expression in the central nucleus of the amygdala is not specific for anxiolytic or anxiogenic drugs Fulltext Access 12 Pages 2006
In vitro and in vivo characterization of F-97013-GD, a partial 5-HT1A agonist with antipsychotic- and antiparkinsonian-like properties Fulltext Access 12 Pages 2006
Irt > t schedule controlled behavior in ‘learned-helpless’ rats: Effects from a cannabinoid agonist Fulltext Access 12 Pages 2006
Chronic DHEAS administration facilitates hippocampal long-term potentiation via an amplification of Src-dependent NMDA receptor signaling Fulltext Access 12 Pages 2006
SB-699551-A (3-cyclopentyl-N-[2-(dimethylamino)ethyl]-N-[(4′-{[(2-phenylethyl)amino]methyl}-4-biphenylyl)methyl]propanamide dihydrochloride), a novel 5-ht5A receptor-selective antagonist, enhances 5-HT neuronal function: Evidence for an autoreceptor role Fulltext Access 12 Pages 2006
Alterations in 5-HT2A receptor signaling in male and female transgenic rats over-expressing either Gq or RGS-insensitive Gq protein Fulltext Access 12 Pages 2006
Glutamate receptors in the raphe pallidus mediate brown adipose tissue thermogenesis evoked by activation of dorsomedial hypothalamic neurons Fulltext Access 12 Pages 2006
Grid-Based Molecular Modeling for Pharmaceutical Salt Screening: Case Example of 3,4,6,7,8,9-Hexahydro-2H-pyrimido (1,2-a) Pyrimidinium Acetate Fulltext Access 12 Pages 2006
Induction of UGT1A6 isoform by inflammatory conditions in rat astrocytes Fulltext Access 12 Pages 2006
The neurotoxin 2′-NH2-MPTP degenerates serotonin axons and evokes increases in hippocampal BDNF Fulltext Access 12 Pages 2006
Molecular analysis of the interaction of the pyrazine derivatives RPR119990 and RPR117824 with human AMPA-type glutamate receptor channels Fulltext Access 12 Pages 2006
Differential pharmacological in vitro properties of organic cation transporters and regional distribution in rat brain Fulltext Access 12 Pages 2006
Characterization of proteinase-activated receptor 2 signalling and expression in rat hippocampal neurons and astrocytes Fulltext Access 12 Pages 2006
The novel antidyskinetic drug sarizotan elicits different functional responses at human D2-like dopamine receptors Fulltext Access 12 Pages 2006
Genetic deletion of the striatum-enriched phosphodiesterase PDE10A: Evidence for altered striatal function Fulltext Access 12 Pages 2006
Cross talk between nitric oxide and ERK1/2 signaling pathway in the spinal cord mediates naloxone-precipitated withdrawal in morphine-dependent rats Fulltext Access 12 Pages 2006
Retigabine and flupirtine exert neuroprotective actions in organotypic hippocampal cultures Fulltext Access 12 Pages 2006
QF2004B, a potential antipsychotic butyrophenone derivative with similar pharmacological properties to clozapine Fulltext Access 12 Pages 2006
Tolerance to morphine analgesia: Evidence for stimulus intensity as a key factor and complete reversal by a glycine site-specific NMDA antagonist Fulltext Access 12 Pages 2006
Macrocyclic inhibitors of the malarial aspartic proteases plasmepsin I, II, and IV Fulltext Access 12 Pages 2006
In silico ADME modelling 2: Computational models to predict human serum albumin binding affinity using ant colony systems Fulltext Access 12 Pages 2006
Binding of actinomycin C1 (D) and actinomin to base-modified oligonucleotide duplexes with parallel chain orientation Fulltext Access 12 Pages 2006
Synthesis, labeling, and biological evaluation of halogenated 2-quinolinecarboxamides as potential radioligands for the visualization of peripheral benzodiazepine receptors Fulltext Access 12 Pages 2006
Synthesis, antiviral activity, and pharmacokinetic evaluation of P3 pyridylmethyl analogs of oximinoarylsulfonyl HIV-1 protease inhibitors Fulltext Access 12 Pages 2006
Quantitative 31P NMR detection of oxygen-centered and carbon-centered radical species Fulltext Access 12 Pages 2006
Antisense oligonucleotides: Efficient synthesis of 2′-O-methoxyethyl phosphorothioate oligonucleotides using 4,5-dicyanoimidazole. Are these oligonucleotides comparable to those synthesized using 1H-tetrazole as coupling activator? Fulltext Access 12 Pages 2006
Nonsteroidal progesterone receptor ligands (I): Synthesis and SAR of new tetrahydronaphthofuranone derivatives Fulltext Access 12 Pages 2006
γ-(Monophenyl)phosphono glutamate analogues as mechanism-based inhibitors of γ-glutamyl transpeptidase Fulltext Access 12 Pages 2006
Side-chain and backbone amide bond requirements for glycopeptide stimulation of T-cells obtained in a mouse model for rheumatoid arthritis Fulltext Access 12 Pages 2006
Synthesis and pharmacology of 11-nor-1-methoxy-9-hydroxyhexahydrocannabinols and 11-nor-1-deoxy-9-hydroxyhexahydrocannabinols: New selective ligands for the cannabinoid CB2 receptor Fulltext Access 12 Pages 2006
Discovery of a new chemical lead for a matrix metalloproteinase inhibitor Fulltext Access 12 Pages 2006
Phosphoramidate and phosphate prodrugs of (−)-β-d-(2R,4R)-dioxolane-thymine: Synthesis, anti-HIV activity and stability studies Fulltext Access 12 Pages 2006
Synthesis and in vivo biodistribution of F-18 labeled 3-cis-, 3-trans-, 4-cis-, and 4-trans-fluorocyclohexane derivatives of WAY 100635 Fulltext Access 12 Pages 2006
Antikinetoplastid antimitotic activity and metabolic stability of dinitroaniline sulfonamides and benzamides Fulltext Access 12 Pages 2006
Discovery of heteroaryl sulfonamides as new EP1 receptor selective antagonists Fulltext Access 12 Pages 2006
Synthesis and biological activities of 7-aza rebeccamycin analogues bearing the sugar moiety on the nitrogen of the pyridine ring Fulltext Access 12 Pages 2006
Design, synthesis and molecular modeling study of iminodiacetyl monohydroxamic acid derivatives as MMP inhibitors Fulltext Access 12 Pages 2006
Synthesis of 15,20-triamide analogue with polar substituent on the phenyl ring of arenastatin A, an extremely potent cytotoxic spongean depsipeptide Fulltext Access 12 Pages 2006
Dicationic DNA-targeted antiprotozoal agents: Naphthalene replacement of benzimidazole Fulltext Access 12 Pages 2006
Synthesis of bicyclic molecular scaffolds (BTAa): An investigation towards new selective MMP-12 inhibitors Fulltext Access 12 Pages 2006
Synthesis and activity of a new class of dual acting norepinephrine and serotonin reuptake inhibitors: 3-(1H-indol-1-yl)-3-arylpropan-1-amines Fulltext Access 12 Pages 2006
Binding interaction of quercetin-3-β-galactoside and its synthetic derivatives with SARS-CoV 3CLpro: Structure–activity relationship studies reveal salient pharmacophore features Fulltext Access 12 Pages 2006
Sertaconazole/hydroxypropyl-β-cyclodextrin complexation: Isothermal titration calorimetry and solubility approaches Fulltext Access 12 Pages 2006
Intraluminal drug and formulation behavior and integration in in vitro permeability estimation: A case study with amprenavir Fulltext Access 12 Pages 2006
Carrier-mediated hepatic uptake of a novel nonrenal excretion type uric acid generation inhibitor, Y-700 Fulltext Access 12 Pages 2006
Alteration of the intravenous pharmacokinetics of a synthetic ozonide antimalarial in the presence of a modified cyclodextrin Fulltext Access 12 Pages 2006
Transport of drugs in the kidney by the human organic cation transporter, OCT2 and its genetic variants Fulltext Access 12 Pages 2006
Development, validation and utility of an in vitro technique for assessment of potential clinical drug–drug interactions involving P-glycoprotein Fulltext Access 12 Pages 2006
Can 29 kDa rhGM-CSF expressed by Silkworm pupae bioreactor bring into effect as active cytokine through orally administration? Fulltext Access 12 Pages 2006
Insulin encapsulation in reinforced alginate microspheres prepared by internal gelation Fulltext Access 12 Pages 2006
The potential inhibitory effect of antiparasitic drugs and natural products on P-glycoprotein mediated efflux Fulltext Access 12 Pages 2006
Enhanced bioavailability of a new thiazolidine derivative FPFS-410, an antidiabetic and lipid-lowering drug, after oral administration of its hydroxypropyl-β-cyclodextrin complex to bile duct-cannulated rats Fulltext Access 12 Pages 2006
Contribution of solid-state properties to the aqueous solubility of drugs Fulltext Access 12 Pages 2006
Pharmacokinetics of DA-6034, an agent for inflammatory bowel disease, in rats and dogs: Contribution of intestinal first-pass effect to low bioavailability in rats Fulltext Access 12 Pages 2006
Solid-state chemistry and particle engineering with supercritical fluids in pharmaceutics Fulltext Access 12 Pages 2006
Design and evaluation of a water-soluble bioadhesive patch formulation for cutaneous delivery of 5-aminolevulinic acid to superficial neoplastic lesions Fulltext Access 12 Pages 2006
Le cannabis - données neurobiologiques récentes éclairant les perturbations de la conduite des véhicules Fulltext Access 12 Pages 2006
New approaches to identification of antigenic candidates for future prostate cancer immunotherapy Fulltext Access 12 Pages 2006
Preparation and in vivo evaluation of a novel stabilized linker for 211At labeling of protein Fulltext Access 12 Pages 2006
Synthesis of (4R,15R,16R,21S)- and (4R,15S,16S,21S)-rollicosin, squamostolide, and their inhibitory action with bovine heart mitochondrial complex I Fulltext Access 12 Pages 2006
Synthesis and evaluation of antitubercular activity of imidazo[2,1-b][1,3,4]thiadiazole derivatives Fulltext Access 12 Pages 2006