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Daneshyari Drug Discovery Journas Latest Articles

Drug Discovery Research Articles

Diastereoselective approach to 11-aryl steroid skeletons through a cobalt(I)-mediated [2+2+2] cyclization of allenediynes
Fulltext Access 12 Pages 2006
Synthetic studies on the CDEF ring system of lactonamycin
Fulltext Access 12 Pages 2006
Stereochemistry of substituted isoxazolidines derived from N-methyl C-diethoxyphosphorylated nitrone
Fulltext Access 12 Pages 2006
Asymmetric oxidation of enol phosphates to α-hydroxy ketones by (salen)manganese(III) complex. Effects of the substitution pattern of enol phosphates on the stereochemistry of oxygen transfer
Fulltext Access 12 Pages 2006
Chemo-, regio- and stereoselective 1,3-dipolar cycloaddition of C-aryl-N-phenylnitrones over 3,5-bis(arylidene)-1-methylpiperidin-4-ones: synthesis of highly substituted novel spiro-isoxazolidines
Fulltext Access 12 Pages 2006
A practical one-pot procedure for the synthesis of pyrazino[2′,3′:4,5]thieno[3,2-d]pyrimidinones by a tandem aza-Wittig/heterocumulene-mediated annulation strategy
Fulltext Access 12 Pages 2006
A palladium-catalyzed tandem cyclization-cross-coupling reaction using indolylborate as a transfer agent
Fulltext Access 12 Pages 2006
Chemical synthesis of ComX pheromone and related peptides containing isoprenoidal tryptophan residues
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A synthesis of optically active α-quaternary α-amino acids and esters by assembling three components, ketones, (R)-chloromethyl p-tolyl sulfoxide, and sodium azide, via sulfinyloxiranes
Fulltext Access 12 Pages 2006
1,4-Addition of arylboronic acids to β-aryl-α,β-unsaturated ketones and esters catalyzed by a rhodium(I)-chiraphos complex for catalytic and enantioselective synthesis of selective endothelin A receptor antagonists
Fulltext Access 12 Pages 2006
Photo- and electroluminescent properties of cyano-substituted styryl derivatives and synthesis of CN-PPV model compounds containing an alkoxy spacer for OLEDs
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A ketal-tethered RCM strategy toward the synthesis of spiroketal related natural products
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Asymmetric synthesis of phosphonic acid analogues for acylcarnitine
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Palladium-catalyzed substitution reactions of 4-allylimidazole derivatives
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Diastereoselective synthesis of γ-hydroxy α,β-epoxyesters and their conversion into β-hydroxy α-sulfenyl γ-butyrolactones
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Palladium-mediated fragmentation of meta photocycloadducts using carbon based electrophiles. Part 1
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Synthesis, biology, and modeling of a C-4 carbonyl C,D-seco-taxoid
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Studies towards the biomimetic synthesis of pyridomacrolidin
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Facile stereoselective synthesis of cis- and trans-3-alkoxyazetidin-2-ones
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Synthesis of β-aryl ketones by tetraphosphine/palladium catalysed Heck reactions of 2- or 3-substituted allylic alcohols with aryl bromides
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Synthesis of arylboronates via Cp*RuCl-catalyzed cycloaddition of alkynylboronates
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Fluorescence study on the nyctinasty of Phyllanthus urinaria L. using novel fluorescence-labeled probe compounds
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Synthesis of the novel conjugated ω,ω′-diaryl/heteroaryl hexatriene system with the central double bond in a heteroaromatic ring: photochemical transformations of 2,3-divinylfuran derivatives
Fulltext Access 12 Pages 2006
Graphical contents list
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Phosphoramidites and solid supports based on N-substituted 2,4-dihydroxybutyramides: universal reagents for synthesis of modified oligonucleotides
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First stereoselective synthesis of potassium aeschynomate and its no-natural stereomers
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Asymmetric alkylation of diarylmethane derivatives
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Kinetic models of phosphorylation cycles: A systematic approach using the rapid-equilibrium approximation for protein–protein interactions
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Early development of visual recognition
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Keynote review: Allosterism in membrane receptors
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Interpretable gene expression classifier with an accurate and compact fuzzy rule base for microarray data analysis
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Graphical contents list
Fulltext Access 12 Pages 2006
Graphical contents list
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When language breaks into pieces A conflict between communication through isolated signals and language
Fulltext Access 12 Pages 2006
The role of log-normal dynamics in the evolution of biochemical pathways
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Some introductory formalizations on the affine Hilbert spaces model of the origin of life: I. On quantum mechanical measurement and the origin of the genetic code: A general physical framework theory
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A platform for evolving intelligently interactive adversaries
Fulltext Access 12 Pages 2006
Membrane computing: Brief introduction, recent results and applications
Fulltext Access 12 Pages 2006
'Push-Pull' and spirobicyclic structures by reacting N-methyl cyclic ketene-N,X (X=S, O)-acetals with isocyanates and isothiocyanates
Fulltext Access 13 Pages 2006
Glycosyldisulfides from dynamic combinatorial libraries as O-glycoside mimetics for plant and endogenous lectins: Their reactivities in solid-phase and cell assays and conformational analysis by molecular dynamics simulations
Fulltext Access 13 Pages 2006
One-step three-component coupling of aromatic organozinc reagents, secondary amines, and aromatic aldehydes into functionalized diarylmethylamines
Fulltext Access 13 Pages 2006
Efficient route to benzo[4,5]imidazo[2,1-a]phthalazines
Fulltext Access 13 Pages 2006
Aminophosphine oxides in a pyridine series. Studies on the cleavage of pyridine-2- and pyridine-4-yl-(N-benzylamino)-methyldiphenylphosphine oxides in acidic solutions
Fulltext Access 13 Pages 2006
A [3,3]-sigmatropic process catalysed by acetate. The decarboxylative Claisen rearrangement
Fulltext Access 13 Pages 2006
Graphical contents list
Fulltext Access 13 Pages 2006
Graphical contents list
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Graphical contents list
Fulltext Access 13 Pages 2006
Efficient synthesis of small molecule macroarrays: optimization of the macroarray synthesis platform and examination of microwave and conventional heating methods
Fulltext Access 13 Pages 2006
Asymmetric transfer hydrogenation of α,β-unsaturated, α-tosyloxy and α-substituted ketones
Fulltext Access 13 Pages 2006
Graphical contents list
Fulltext Access 13 Pages 2006
Synthesis of chromanes by sequential '[3+3]-cyclization/Williamson' reactions of 1,3-bis(trimethylsilyloxy)-7-chlorohepta-1,3-dienes
Fulltext Access 13 Pages 2006
Convenient synthesis of highly optically active 2,3,4,6-tetrasubstituted tetrahydropyrans via Prins cyclization reaction (PCR) of optically active homoallylic alcohols with aldehydes
Fulltext Access 13 Pages 2006
The reaction of tetralones with nitriles: a simple approach to the synthesis of new substituted benzo[h]quinazolines, benzo[f]quinazolines and dibenzo[a,i]phenanthridines
Fulltext Access 13 Pages 2006
Synthesis of cicerfuran, an antifungal benzofuran, and some related analogues
Fulltext Access 13 Pages 2006
Enantioselective microbial hydrolysis of dissymmetrical cyclic carbonates with disubstitution
Fulltext Access 13 Pages 2006
Synthesis and structure of 8-hydroxy-6-methoxy-3,7-dimethylisochromane and its analogues
Fulltext Access 13 Pages 2006
Synthesis and fluoride-induced chemiluminescent decomposition of bicyclic dioxetanes substituted with a 2-hydroxynaphthyl group
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An in-depth analysis of the effect of substituents on imines in cycloaddition reactions with nitrosoalkenes
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Synthesis and DNA binding studies of bis-intercalators with a novel spiro-cyclic linker
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Domino intramolecular enyne metathesis/cross metathesis approach to the xanthanolides. Enantioselective synthesis of (+)-8-epi-xanthatin
Fulltext Access 13 Pages 2006
Graphical contents list
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Asymmetric aziridine synthesis by aza-Darzens reaction of N-diphenylphosphinylimines with chiral enolates. Part 1: Formation of cis-aziridines
Fulltext Access 13 Pages 2006
Pentamethylcyclopentadienide in organic synthesis: nucleophilic addition of lithium pentamethylcyclopentadienide to carbonyl compounds and carbon-carbon bond cleavage of the adducts yielding the parent carbonyl compounds
Fulltext Access 13 Pages 2006
Coupling and cycloaddition of ynamides: homo- and Negishi coupling of tosylynamides and intramolecular [4+2] cycloaddition of N-(o-ethynyl)phenyl ynamides and arylynamides
Fulltext Access 13 Pages 2006
Design, synthesis and in vitro antimalarial activity of spiroperoxides
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Quantitative proteome analysis using D-labeled N-ethylmaleimide and 13C-labeled iodoacetanilide by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
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Therapeutic strategies for the treatment of stroke
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Keynote review: Chromatin control and cancer-drug discovery: realizing the promise
Fulltext Access 13 Pages 2006
I want a new drug: G-protein-coupled receptors in drug development
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The role of neuroinflammation in neuropathic pain: mechanisms and therapeutic targets
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Computational analysis of plant RNA Pol-II promoters
Fulltext Access 13 Pages 2006
Synthesis and biological evaluation of benzopyran analogues bearing class III antiarrhythmic pharmacophores
Fulltext Access 13 Pages 2006
MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 6: Exploration of aromatic substituents
Fulltext Access 13 Pages 2006
Discovery of diphenyl amine based sodium channel blockers, effective against hNav1.2
Fulltext Access 13 Pages 2006
Enantioselective synthesis of non-proteinogenic 2-arylallyl-α-amino acids via Pd/In catalytic cascades
Fulltext Access 13 Pages 2006
Novel platinum(II) and palladium(II) complexes with cyclin-dependent kinase inhibitors: Synthesis, characterization and antitumour activity
Fulltext Access 13 Pages 2006
Synthesis and comparative molecular field analysis (CoMFA) of argentatin B derivatives as growth inhibitors of human cancer cell lines
Fulltext Access 13 Pages 2006
Novel vitamin D3 antipsoriatic antedrugs: 16-En-22-oxa-1α,25-(OH)2D3 analogs
Fulltext Access 13 Pages 2006
Identification of a buried pocket for potent and selective inhibition of Chk1: Prediction and verification
Fulltext Access 13 Pages 2006
Discovery of potent and selective PARP-1 and PARP-2 inhibitors: SBDD analysis via a combination of X-ray structural study and homology modeling
Fulltext Access 13 Pages 2006
Synthesis and pharmacology of pyrido[2,3-d]pyrimidinediones bearing polar substituents as adenosine receptor antagonists
Fulltext Access 13 Pages 2006
Synthesis and study of the cancer cell growth inhibitory properties of α-, γ-tocopheryl and γ-tocotrienyl 2-phenylselenyl succinates
Fulltext Access 13 Pages 2006
3D-QSAR analysis of antimalarial farnesyltransferase inhibitors based on a 2,5-diaminobenzophenone scaffold
Fulltext Access 13 Pages 2006
α,α-Difluoro-α-phenylsulfanylmethyl carbanion equivalent: a novel gem-difluoromethylenation of carbonyl compounds
Fulltext Access 13 Pages 2006
Structure of pyrimidinocyclophanes in solution by NMR
Fulltext Access 13 Pages 2006
Directing effects of tethered alkenes in nickel-catalyzed coupling reactions of 1,6-enynes and aldehydes
Fulltext Access 13 Pages 2006
An efficient Negishi cross-coupling reaction catalyzed by nickel(II) and diethyl phosphite
Fulltext Access 13 Pages 2006
Microwave-assisted tandem Wittig-intramolecular Diels-Alder cycloaddition. Product distribution and stereochemical assignment
Fulltext Access 13 Pages 2006
Synthesis and biological activity of mycalolide analogs
Fulltext Access 13 Pages 2006
The application of vinylogous iminium salt derivatives to an efficient synthesis of the pyrrole containing alkaloids Rigidin and Rigidin E
Fulltext Access 13 Pages 2006
One pot synthesis using supported reagents system KSCN/SiO2-RNH3OAc/Al2O3: synthesis of 2-aminothiazoles and N-allylthioureas
Fulltext Access 13 Pages 2006
Studies directed toward the synthesis of the scabrosins: validation of a tandem enyne metathesis approach
Fulltext Access 13 Pages 2006
Synthesis, properties, and hepatic metabolism of strongly fluorescent fluorodipyrrinones
Fulltext Access 13 Pages 2006
New macrobicyclic triphosphazides and triphosphazenes formed by self-assembly of tripodal triazides with triphosphanes
Fulltext Access 13 Pages 2006
Solvent effect on the sensitized photooxygenation of cyclic and acyclic α-diimines
Fulltext Access 13 Pages 2006
A comparative mechanistic analysis of the stereoselectivity trends observed in the oxidation of chiral oxazolidinone-functionalized enecarbamates by singlet oxygen, ozone, and triazolinedione
Fulltext Access 13 Pages 2006
First-principle predictions of basicity of organic amines and phosphines in acetonitrile
Fulltext Access 13 Pages 2006
Synthesis of N,N,N′,N′-tetrasubstituted 1,3-bis(4-aminophenyl)azulenes and their application to a hole-injecting material in organic electroluminescent devices
Fulltext Access 13 Pages 2006
Intercalating nucleic acids (INAs) containing insertions of 6H-indolo[2,3-b]quinoxaline
Fulltext Access 13 Pages 2006
Reduction of substituted 1,10-phenanthrolines as a route to rigid chiral benzimidazolylidenes
Fulltext Access 13 Pages 2006
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