Modulation of GABAergic synaptic transmission by terminal nicotinic acetylcholine receptors in the central autonomic nucleus of the neonatal rat spinal cord Fulltext Access 13 Pages 2006
Synthesis and biological evaluation of modified acridines: the effect of N- and O- substituent in the nitrogenated ring on antitumor activity Fulltext Access 13 Pages 2006
Synthesis and antiproliferative activities of diversely substituted glycosyl-isoindigo derivatives Fulltext Access 13 Pages 2006
A systematic comparison of intracellular cyclic AMP and calcium signalling highlights complexities in human VPAC/PAC receptor pharmacology Fulltext Access 13 Pages 2006
Enhancing effects of nicotine and impairing effects of scopolamine on distinct aspects of performance in computerized attention and working memory tasks in marmoset monkeys Fulltext Access 13 Pages 2006
The in vivo properties of pagoclone in rat are most likely mediated by 5′-hydroxy pagoclone Fulltext Access 13 Pages 2006
Effects of some neurosteroids injected into some brain areas of WAG/Rij rats, an animal model of generalized absence epilepsy Fulltext Access 13 Pages 2006
Unique patterns of FOS, phospho-CREB and BrdU immunoreactivity in the female rat brain following chronic stress and citalopram treatment Fulltext Access 13 Pages 2006
Suppression of post-hypoxic-ischemic EEG transients with dizocilpine is associated with partial striatal protection in the preterm fetal sheep Fulltext Access 13 Pages 2006
Chronic administration of dehydroepiandrosterone sulfate (DHEAS) primes for facilitated induction of long-term potentiation via sigma 1 (σ1) receptor: Optical imaging study in rat hippocampal slices Fulltext Access 13 Pages 2006
Acetylcholinesterase inhibitors used in treatment of Alzheimer's disease prevent glutamate neurotoxicity via nicotinic acetylcholine receptors and phosphatidylinositol 3-kinase cascade Fulltext Access 13 Pages 2006
Subunit selectivity of topiramate modulation of heteromeric GABAA receptors Fulltext Access 13 Pages 2006
Partial lesion of the serotonergic system by a single dose of MDMA results in behavioural disinhibition and enhances acute MDMA-induced social behaviour on the social interaction test Fulltext Access 13 Pages 2006
Stereoselective effects of the novel anticonvulsant lacosamide against 4-AP induced epileptiform activity in rat visual cortex in vitro Fulltext Access 13 Pages 2006
Structure of daunomycin complexed to d-TGATCA by two-dimensional nuclear magnetic resonance spectroscopy Fulltext Access 13 Pages 2006
Arylmethyl substituted derivatives of Fosmidomycin: Synthesis and antimalarial activity Fulltext Access 13 Pages 2006
Linear and nonlinear QSAR study of N-hydroxy-2-[(phenylsulfonyl)amino]acetamide derivatives as matrix metalloproteinase inhibitors Fulltext Access 14 Pages 2006
Structure–activity relationships and enzyme inhibition of pantothenamide-type pantothenate kinase inhibitors Fulltext Access 14 Pages 2006
Design, synthesis, and biological evaluation of combretastatin nitrogen-containing derivatives as inhibitors of tubulin assembly and vascular disrupting agents Fulltext Access 14 Pages 2006
Design, synthesis, and biological testing of potential heme-coordinating nitric oxide synthase inhibitors Fulltext Access 14 Pages 2006
New insights about HERG blockade obtained from protein modeling, potential energy mapping, and docking studies Fulltext Access 14 Pages 2006
Conformationally restrained carbazolone-containing α,γ-diketo acids as inhibitors of HIV integrase Fulltext Access 14 Pages 2006
Recent developments in the identification of novel oxazolidinone antibacterial agents Fulltext Access 14 Pages 2006
Antagonists of the myelin-associated glycoprotein: A new class of tetrasaccharide mimics Fulltext Access 14 Pages 2006
Three-dimensional quantitative structure–activity relationship studies on diverse structural classes of HIV-1 integrase inhibitors using CoMFA and CoMSIA Fulltext Access 14 Pages 2006
Computational approaches for predicting CYP-related metabolism properties in the screening of new drugs Fulltext Access 14 Pages 2006
Understanding the antitumor activity of novel tricyclicpiperazinyl derivatives as farnesyltransferase inhibitors using CoMFA and CoMSIA Fulltext Access 14 Pages 2006
Synthesis, stereochemistry, and antimicrobial evaluation of substituted piperidin-4-one oxime ethers Fulltext Access 14 Pages 2006
Synthesis of phenanthridinium–bis-nucleobase conjugates, interactions with poly U, nucleotides and in vitro antitumour activity of mono- and bis-nucleobase conjugates Fulltext Access 14 Pages 2006
Glycosides and amino acyl esters of carbohydrates as potent inhibitors of angiotensin converting enzyme Fulltext Access 14 Pages 2006
Synthesis of bicyclic dioxetanes bearing a 2-hydroxy-1,1â²-binaphthyl-5-yl moiety active toward intramolecular charge-transfer-induced chemiluminescent decomposition Fulltext Access 14 Pages 2006
Synthesis of the bifunctional BINOL ligands and their applications in the asymmetric additions to carbonyl compounds Fulltext Access 14 Pages 2006
Total synthesis, elucidation of absolute stereochemistry, and adjuvant activity of trihydroxy fatty acids Fulltext Access 14 Pages 2006
A facile synthesis of fused aromatic spiroacetals based on the 3,4,3â²,4â²-tetrahydro-2,2â²-spirobis(2H-1-benzopyran) skeleton Fulltext Access 14 Pages 2006
The allenic Alder-ene reaction: constitutional group selectivity and its application to the synthesis of ovalicin Fulltext Access 14 Pages 2006
Application of modified Pictet-Spengler reaction for the synthesis of thiazolo- and pyrazolo-quinolines Fulltext Access 14 Pages 2006
1,3,4-Oxadiazole formation as traceless release in solid phase organic synthesis Fulltext Access 14 Pages 2006
Synthesis of chiral C/N-functionalized morpholine alcohols: study of their catalytic ability as ligand in asymmetric diethylzinc addition to aldehyde Fulltext Access 14 Pages 2006
Solid-phase synthesis of positively charged deoxynucleic guanidine (DNG) oligonucleotide incorporating 7-deazaguanine bases Fulltext Access 14 Pages 2006
Effect of alkyl groups on the cellular hydrolysis of stavudine phosphoramidates Fulltext Access 14 Pages 2006
Modeling of farnesyltransferase inhibition by some thiol and non-thiol peptidomimetic inhibitors using genetic neural networks and RDF approaches Fulltext Access 14 Pages 2006
Indazole N-oxide derivatives as antiprotozoal agents: Synthesis, biological evaluation and mechanism of action studies Fulltext Access 14 Pages 2006
Novel potent and selective calcium-release-activated calcium (CRAC) channel inhibitors. Part 2: Synthesis and inhibitory activity of aryl-3-trifluoromethylpyrazoles Fulltext Access 14 Pages 2006
Optimized design and synthesis of chemical dimerizer substrates for detection of glycosynthase activity via chemical complementation Fulltext Access 14 Pages 2006
Hydrophilically enhanced 3-carboranyl thymidine analogues (3CTAs) for boron neutron capture therapy (BNCT) of cancer Fulltext Access 14 Pages 2006
2-Pyridin-2-yl-1H-indole derivatives: Synthesis, estrogen receptor binding affinity, and photophysical properties Fulltext Access 14 Pages 2006
Direct crystallographic observation of an acyl-enzyme intermediate in the elastase-catalyzed hydrolysis of a peptidyl ester substrate: Exploiting the “glass transition” in protein dynamics Fulltext Access 14 Pages 2006
Synthesis with good enantiomeric excess of both enantiomers of α-ketols and acetolactates by two thiamin diphosphate-dependent decarboxylases Fulltext Access 14 Pages 2006
Investigations into the parallel kinetic resolution of 2-phenylpropanoyl chloride using quasi-enantiomeric oxazolidinones Fulltext Access 14 Pages 2006
α-Vinylic amino acids: occurrence, asymmetric synthesis, and biochemical mechanisms Fulltext Access 14 Pages 2006
A credit-card library approach for disrupting protein–protein interactions Fulltext Access 14 Pages 2006
Asymmetric synthesis of chiral bisoxazolines and their use as ligands in metal catalysis Fulltext Access 14 Pages 2006
Synthesis of ethyl and t-butyl (3R,5S)-dihydroxy-6-benzyloxy hexanoates via diastereo- and enantioselective microbial reduction Fulltext Access 14 Pages 2006
Metal-Binding Properties of Human Centrin-2 Determined by Micro-Electrospray Ionization Mass Spectrometry and UV Spectroscopy Fulltext Access 14 Pages 2006
Isotope-Labeled Cross-Linkers and Fourier Transform Ion Cyclotron Resonance Mass Spectrometry for Structural Analysis of a Protein/Peptide Complex Fulltext Access 14 Pages 2006
Prediction of Collective Characteristics for Ion Ensembles in Quadrupole Ion Traps Without Trajectory Simulations Fulltext Access 14 Pages 2006
A High-Performance Liquid Chromatography-Tandem Mass Spectrometry Method for Quantitation of Nitrogen-Containing Intracellular Metabolites Fulltext Access 14 Pages 2006
Electrospray Ionization and Triple Quadrupole Tandem Mass Spectrometry Study of Some Biologically Relevant Homo- and Heterodimeric Cadmium Thiolate Conjugates Fulltext Access 14 Pages 2006
Nanoencapsulation I. Methods for preparation of drug-loaded polymeric nanoparticles Fulltext Access 14 Pages 2006
Molecular dynamics of a biophysical model for β2-adrenergic and G protein-coupled receptor activation Fulltext Access 14 Pages 2006
The prediction of the wild-type telomerase RNA pseudoknot structure and the pivotal role of the bulge in its formation Fulltext Access 14 Pages 2006
Automatic atom type and bond type perception in molecular mechanical calculations Fulltext Access 14 Pages 2006
Synthesis of three classes of rhodacyanine dyes and evaluation of their in vitro and in vivo antimalarial activity Fulltext Access 14 Pages 2006
Evaluation of glycolamide esters of indomethacin as potential cyclooxygenase-2 (COX-2) inhibitors Fulltext Access 14 Pages 2006
Synthesis of new class dipeptide analogues with improved permeability and antithrombotic activity Fulltext Access 14 Pages 2006
Synthesis and anticancer evaluation of bis(benzimidazoles), bis(benzoxazoles), and benzothiazoles Fulltext Access 14 Pages 2006
Synthesis, SAR studies, and pharmacological evaluation of 3-anilino-4-(3-indolyl) maleimides with conformationally restricted structure as orally bioavailable PKCβ-selective inhibitors Fulltext Access 14 Pages 2006
Diversity-oriented chemical modification of heparin: Identification of charge-reduced N-acyl heparin derivatives having increased selectivity for heparin-binding proteins Fulltext Access 14 Pages 2006
Design, synthesis, and preliminary SAR study of 3- and 6-side-chain-extended tetrahydro-pyran analogues of cis- and trans-(6-benzhydryl-tetrahydropyran-3-yl)-benzylamine Fulltext Access 14 Pages 2006
Synthesis and biological evaluation of purine derivatives incorporating metal chelating ligands as HIV integrase inhibitors Fulltext Access 14 Pages 2006
Ligands with a 3,3-diphenylpentane skeleton for nuclear vitamin D and androgen receptors: Dual activities and metabolic activation Fulltext Access 14 Pages 2006
Synthesis and evaluation of acridine- and acridone-based anti-herpes agents with topoisomerase activity Fulltext Access 14 Pages 2006
Arylisothiocyanato selective androgen receptor modulators (SARMs) for prostate cancer Fulltext Access 14 Pages 2006
Synthesis, dihydrofolate reductase inhibition, antitumor testing, and molecular modeling study of some new 4(3H)-quinazolinone analogs Fulltext Access 14 Pages 2006
Automatic extraction of structural alerts for predicting chromosome aberrations of organic compounds Fulltext Access 14 Pages 2006
Synthesis and biological evaluation of novel pyrrolopyrrolizinones as anticancer agents Fulltext Access 14 Pages 2006
Serotype-selective, small-molecule inhibitors of the zinc endopeptidase of botulinum neurotoxin serotype A Fulltext Access 14 Pages 2006
Quantitative structure–activity relationships for small non-peptide antagonists of CXCR2: Indirect 3D approach using the frontal polygon method Fulltext Access 14 Pages 2006
Synthesis and structure–activity studies of schweinfurthin B analogs: Evidence for the importance of a D-ring hydrogen bond donor in expression of differential cytotoxicity Fulltext Access 14 Pages 2006
Theoretical study of structure, pKa, lipophilicity, solubility, absorption, and polar surface area of some centrally acting antihypertensives Fulltext Access 14 Pages 2006
1-Benzyl-1,2,3,4-tetrahydroisoquinoline-6,7-diols as novel affinity and photoaffinity probes for β-adrenoceptor subtypes Fulltext Access 14 Pages 2006
3D QSAR study of hypolipidemic asarones by comparative molecular surface analysis Fulltext Access 14 Pages 2006
3D-QSAR studies on tripeptide aldehyde inhibitors of proteasome using CoMFA and CoMSIA methods Fulltext Access 14 Pages 2006
Polyamine conjugates of meso-tritolylporphyrin and protoporphyrin IX: Potential agents for photodynamic therapy of cancers Fulltext Access 14 Pages 2006
On the active site for hydrolysis of aryl amides and choline esters by human cholinesterases Fulltext Access 14 Pages 2006
The discovery of glycine and related amino acid-based factor Xa inhibitors Fulltext Access 14 Pages 2006