Evolving visual pigments: Hints from the opsin-based proteins in a phylogenetically old “eyeless” invertebrate Fulltext Access 15 Pages 2006
Microwave-assisted synthesis and transformations of sterically hindered 3-(5-tetrazolyl)pyridines Fulltext Access 15 Pages 2006
The biomimetic synthesis of SNF4435C and SNF4435D, and the total synthesis of the polyene metabolites aureothin, N-acetyl-aureothamine and spectinabilin Fulltext Access 15 Pages 2006
Synthesis and kinetic investigation of the selective acidolysis of para-substituted N-benzyl- or N-phenyl-N-phenylacetyl-α,α-dialkylglycine cyclohexylamides Fulltext Access 15 Pages 2006
Tetrahedron report number 765Recent advances in homogeneous transition metal-catalyzed aerobic alcohol oxidations Fulltext Access 15 Pages 2006
Highly efficient total synthesis of Î12-PGJ2, 15-deoxy-Î12,14-PGJ2, and their analogues Fulltext Access 15 Pages 2006
4-exo-dig and 5-exo-dig Cyclocarbopalladations: an expeditious solution toward molecular complexity? Fulltext Access 15 Pages 2006
On the reactivity of some 2-methyleneindolines with β-nitroenamines, α-nitroalkenes, and 1,2-diaza-1,3-butadienes Fulltext Access 15 Pages 2006
Synthetic study of hetisine-type aconite alkaloids. Part 1: Preparation of tetracyclic intermediate containing the C14-C20 bond Fulltext Access 15 Pages 2006
Cyclization reactions of N-acryloyl-2-aminobenzaldehyde derivatives: formal total synthesis of martinellic acid Fulltext Access 15 Pages 2006
Trading the micro-world of combinatorial complexity for the macro-world of protein interaction domains Fulltext Access 15 Pages 2006
New heterotopic, linked macrocyclic systems derived from selectively protected macrocycles Fulltext Access 15 Pages 2006
Complete settlement of long-standing confusion on the term 'prochirality' in stereochemistry. Proposal of pro-RS-stereogenicity and integrated treatment with prochirality Fulltext Access 15 Pages 2006
Synthetic sulfated glucuronosyl paragloboside (SGPG) and its use for the detection of autoimmune peripheral neuropathies Fulltext Access 15 Pages 2006
Efficient synthesis of 1,4-dihydronaphthalenelignans from 5-methylene-4-substituted-2(5H)-furanones and a concise synthesis of solafuranone Fulltext Access 15 Pages 2006
Aza-Baylis-Hillman reaction of N-tosylated imines with β-substituted α,β-unsaturated esters Fulltext Access 15 Pages 2006
Regioselective functionalisation of nitrobenzene and benzonitrile derivatives via nucleophilic aromatic substitution of hydrogen by phosphorus-stabilized carbanions Fulltext Access 15 Pages 2006
Anodic cyclization reactions: probing the chemistry of N,O-ketene acetal derived radical cations Fulltext Access 15 Pages 2006
Enantiodiscrimination of racemic electrophiles by diketopiperazine enolates: asymmetric synthesis of methyl 2-amino-3-aryl-butanoates and 3-methyl-aspartates Fulltext Access 15 Pages 2006
Stereocontrolled synthesis of thiohydantoin spironucleosides from sugar spiroacetals Fulltext Access 15 Pages 2006
Synthesis and characterization of chiral, bridged resorcinarenes as templates for asymmetric catalysis Fulltext Access 15 Pages 2006
Neuroprotective effect of arundic acid, an astrocyte-modulating agent, in mouse brain against MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) neurotoxicity Fulltext Access 16 Pages 2006
Dynamic Heat Capacity and Relaxation Time of Ultraviscous Melt and Glassy Acetaminophen Fulltext Access 16 Pages 2006
Novel drug discovery and molecular biological methods, via DNA, RNA and protein changes using structure–function transitions: Transitional structural chemogenomics, transitional structural chemoproteomics and novel multi-stranded nucleic acid microarray Fulltext Access 16 Pages 2006
Treatment with valproate after status epilepticus: Effect on neuronal damage, epileptogenesis, and behavioral alterations in rats Fulltext Access 16 Pages 2006
Pharmacokinetics of 5-fluorouracil in the hamster following inhalation delivery of lipid-coated nanoparticles Fulltext Access 16 Pages 2006
Effects of mGlu2 or mGlu3 receptor deletions on mGlu2/3 receptor agonist (LY354740)-induced brain c-Fos expression: Specific roles for mGlu2 in the amygdala and subcortical nuclei, and mGlu3 in the hippocampus Fulltext Access 16 Pages 2006
Toward prevention of alzheimers disease – Potential nutraceutical strategies for suppressing the production of amyloid beta peptides Fulltext Access 16 Pages 2006
Evolutionary neuropathology & congenital mental retardation: Environmental cues predictive of maternal deprivation influence the fetus to minimize cerebral metabolism in order to express bioenergetic thrift Fulltext Access 16 Pages 2006
Preclinical Drug Metabolism and Pharmacokinetic Evaluation of GW844520, A Novel Anti-Malarial Mitochondrial Electron Transport Inhibitor Fulltext Access 16 Pages 2006
MDR1 haplotypes significantly minimize intracellular uptake and transcellular Pâgp substrate transport in recombinant LLCâPK1 cells Fulltext Access 16 Pages 2006
The active components and the pharmacological multi-target principle of STW 5 (Iberogast®) Fulltext Access 16 Pages 2006
1-Aryltetralin privileged structure-based libraries: parallel synthesis of N-aryl and N-biaryl γ-lactam lignans Fulltext Access 16 Pages 2006
Stereoelectronic and solvent effects on the allylic oxyfunctionalization of alkenes with singlet oxygen Fulltext Access 16 Pages 2006
Tetrahedron report number 772Synthetic routes to porphyrins bearing fused rings Fulltext Access 16 Pages 2006
Reaction of vinyl triflates of α-keto esters and imides with secondary amines: synthesis of α,β-diamino carboxylic acid derivatives through aziridinium ions Fulltext Access 16 Pages 2006
Comprehensive synthesis of ER related high-mannose-type sugar chains by convergent strategy Fulltext Access 16 Pages 2006
An efficient and versatile synthesis of all structural types of acylpolyamine spider toxins Fulltext Access 16 Pages 2006
α-(3,7-Dioxa-r-1-azabicyclo[3.3.0]oct-c-5-ylmethoxy)-diazines. Part 2: Functionalisation via directed ortho-metallation and cross-coupling reactions Fulltext Access 16 Pages 2006
Improved synthesis of tocopherol fatty alcohols and analogs: microglial activation modulators Fulltext Access 16 Pages 2006
Recent applications of 2,4,6-trichloro-1,3,5-triazine and its derivatives in organic synthesis Fulltext Access 16 Pages 2006
Scope and selectivity in palladium-catalyzed directed C-H bond halogenation reactions Fulltext Access 16 Pages 2006
Nucleoside 5â²-C-phosphonates: reactivity of the α-hydroxyphosphonate moiety Fulltext Access 16 Pages 2006
Radical cascade cyclizations and platinum(II)-catalyzed cycloisomerizations of ynamides Fulltext Access 16 Pages 2006
14-Membered cyclodepsipeptides with alternating β-hydroxy and α-amino acids by cyclodimerization Fulltext Access 16 Pages 2006
Optimization of sulfonamide derivatives as highly selective EP1 receptor antagonists Fulltext Access 16 Pages 2006
Exploration of acyl sulfonamides as carboxylic acid replacements in protease inhibitors of the hepatitis C virus full-length NS3 Fulltext Access 16 Pages 2006
Affinity prediction on A1 adenosine receptor agonists: The chemometric approach Fulltext Access 16 Pages 2006
Design, synthesis, and biological evaluation of chicoric acid analogs as inhibitors of HIV-1 integrase Fulltext Access 16 Pages 2006
A Staphylococcus aureus lipoteichoic acid (LTA) derived structural variant with two diacylglycerol residues Fulltext Access 16 Pages 2006
Hydrophilic photolabelling of glycopeptides from the murine liver–intestine (LI) cadherin recognition domain Fulltext Access 16 Pages 2006
Enantioselective synthesis of 1-methoxy- and 1-deoxy-2′-methyl-Δ8-tetrahydrocannabinols: New selective ligands for the CB2 receptor Fulltext Access 16 Pages 2006
Synthesis, in vitro pharmacology, and structure–activity relationships of 2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivatives as mGluR2 antagonists Fulltext Access 16 Pages 2006
Potent inhibitors of the hepatitis C virus NS3 protease: Use of a novel P2 cyclopentane-derived template Fulltext Access 16 Pages 2006
In vitro activity of novel dual action MDR anthranilamide modulators with inhibitory activity at CYP-450 Fulltext Access 16 Pages 2006
A platform for designing HIV integrase inhibitors. Part 1: 2-Hydroxy-3-heteroaryl acrylic acid derivatives as novel HIV integrase inhibitor and modeling of hydrophilic and hydrophobic pharmacophores Fulltext Access 16 Pages 2006
Glycosyl bis-porphyrin conjugates: Synthesis and potential application in PDT Fulltext Access 16 Pages 2006
Structure–activity relationship studies of resveratrol and its analogues by the reaction kinetics of low density lipoprotein peroxidation Fulltext Access 16 Pages 2006
Reaction of epichlorohydrin with adenosine, 2â²-deoxyadenosine and calf thymus DNA: Identification of adducts Fulltext Access 16 Pages 2006
Diversification of function in the haloacid dehalogenase enzyme superfamily: The role of the cap domain in hydrolytic phosphoruscarbon bond cleavage Fulltext Access 16 Pages 2006
Vibrational circular dichroism DFT study on bicyclo[3.3.0]octane derivatives Fulltext Access 16 Pages 2006
Catalytic asymmetric transformations with fine-tunable biphenol-based monodentate ligands Fulltext Access 16 Pages 2006
Mass Discrimination During MC-ICPMS Isotopic Ratio Measurements: Investigation by Means of Synthetic Isotopic Mixtures (IRMM-007 Series) and Application to the Calibration of Natural-Like Zinc Materials (Including IRMM-3702 and IRMM-651) Fulltext Access 16 Pages 2006
RNA Fragmentation in MALDI Mass Spectrometry Studied by H/D-Exchange: Mechanisms of General Applicability to Nucleic Acids Fulltext Access 16 Pages 2006
Quantum mechanical description of the interactions between DNA and water Fulltext Access 16 Pages 2006
Docking studies of agonists and antagonists suggest an activation pathway of the A3 adenosine receptor Fulltext Access 16 Pages 2006
A network model of early events in epidermal growth factor receptor signaling that accounts for combinatorial complexity Fulltext Access 16 Pages 2006
Pharmacokinetics and Pharmacodynamics Analysis of Transdermal Iontophoresis of 5-OH-DPAT in Rats: In vitro-in vivo Correlation Fulltext Access 16 Pages 2006
Penetration of Crystalline Powder Particles into Excised Human Skin Membranes and Model Gels from a Supersonic Powder Injector Fulltext Access 16 Pages 2006
Physicochemical and Biopharmaceutical Characterization of endo-2-(8-Methyl-8-azabicyclo[3.2.1]oct-3-yl)-2,3-dihydro-1H-benz[e]isoindol-1-one (CR3124) a Novel Potent 5-HT3 Receptor Antagonist Fulltext Access 16 Pages 2006
Homology modeling of four Y-family, lesion-bypass DNA polymerases: The case that E. coli Pol IV and human Pol κ are orthologs, and E. coli Pol V and human Pol η are orthologs Fulltext Access 16 Pages 2006
Formulation considerations for proteins susceptible to asparagine deamidation and aspartate isomerization Fulltext Access 16 Pages 2006
Physical stability of crystal hydrates and their anhydrates in the presence of excipients Fulltext Access 16 Pages 2006
Spectrométrie de Masse à Plasma couplé par induction (ICP-MS) Potentialités en analyse et en biologie Fulltext Access 16 Pages 2006
Multi-scale keypoints in V1 and beyond: Object segregation, scale selection, saliency maps and face detection Fulltext Access 16 Pages 2006
Permeability assessment of poorly waterâsoluble compounds under solubilizing conditions: The reciprocal permeability approach Fulltext Access 16 Pages 2006
Design, synthesis and activity against Toxoplasma gondii, Plasmodium spp., and Mycobacterium tuberculosis of new 6-fluoroquinolones Fulltext Access 16 Pages 2006
Design, synthesis and early structure–activity relationship of farnesyltransferase inhibitors which mimic both the peptidic and the prenylic substrate Fulltext Access 16 Pages 2006
Synthesis of 3,6-diazabicyclo[3.1.1]heptanes as novel ligands for the opioid receptors Fulltext Access 16 Pages 2006
Synthesis and antimicrobial evaluation of new 2-substituted 5,7-di-tert-butylbenzoxazoles Fulltext Access 16 Pages 2006
Discovering novel chemical inhibitors of human cyclophilin A: Virtual screening, synthesis, and bioassay Fulltext Access 16 Pages 2006
Bicyclic and tricyclic thiophenes as protein tyrosine phosphatase 1B inhibitors Fulltext Access 16 Pages 2006
Preparation of fluorescent tocopherols for use in protein binding and localization with the α-tocopherol transfer protein Fulltext Access 16 Pages 2006