A scarlet pimpernel for the resolution of inflammation? The role of supra-therapeutic doses of cobalamin, in the treatment of systemic inflammatory response syndrome (SIRS), sepsis, severe sepsis, and septic or traumatic shock Fulltext Access 19 Pages 2006
Influence of the anabolic-androgenic steroid nandrolone on cannabinoid dependence Fulltext Access 19 Pages 2006
Molecular graphics approach to bacterial AcrB protein–β-lactam antibiotic molecular recognition in drug efflux mechanism Fulltext Access 20 Pages 2006
Modelling, synthesis and biological evaluation of novel glucuronide-based probes of Vibrio cholerae sialidase Fulltext Access 20 Pages 2006
Tricyclic pharmacophore-based molecules as novel integrin αvβ3 antagonists. Part 1: Design and synthesis of a lead compound exhibiting αvβ3/αIIbβ3 dual antagonistic activity Fulltext Access 20 Pages 2006
Tricyclic pharmacophore-based molecules as novel integrin αvβ3 antagonists. Part III: Synthesis of potent antagonists with αvβ3/αIIbβ3 dual activity and improved water solubility Fulltext Access 20 Pages 2006
The purines: Potent and versatile small molecule inhibitors and modulators of key biological targets Fulltext Access 20 Pages 2006
Synthetic study of hetisine-type aconite alkaloids. Part 3: Total synthesis of (±)-nominine Fulltext Access 20 Pages 2006
Substituted 2-phenyl-benzimidazole derivatives: novel compounds that suppress key markers of allergy Fulltext Access 20 Pages 2006
Synthesis and SAR study of acridine, 2-methylquinoline and 2-phenylquinazoline analogues as anti-prion agents Fulltext Access 20 Pages 2006
α-(3,7-Dioxa-r-1-azabicyclo[3.3.0]oct-c-5-ylmethoxy)-diazines. Part 1: Synthesis and stereochemistry. Extension to s-triazine series Fulltext Access 20 Pages 2006
Synthetic ventures inspired by biosynthetic hypotheses: the evolution of a method for the oxidative amidation of phenols Fulltext Access 20 Pages 2006
Xenobiotic-Metabolizing Enzymes Involved in Activation and Detoxification of Carcinogenic Polycyclic Aromatic Hydrocarbons Fulltext Access 20 Pages 2006
Active dimer of Epratuzumab provides insight into the complex nature of an antibody aggregate Fulltext Access 20 Pages 2006
Physiologically based pharmacokinetic modelling 2: Predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions Fulltext Access 20 Pages 2006
A Risk-Based Approach to Establish Stability Testing Conditions for Tropical Countries Fulltext Access 20 Pages 2006
Recent advances in the Stevens rearrangement of ammonium ylides. Application to the synthesis of alkaloid natural products Fulltext Access 20 Pages 2006
Nuclear Receptor-Mediated Transcriptional Regulation in Phase I, II, and III Xenobiotic Metabolizing Systems Fulltext Access 21 Pages 2006
QSAR modeling of mono- and bis-quaternary ammonium salts that act as antagonists at neuronal nicotinic acetylcholine receptors mediating dopamine release Fulltext Access 21 Pages 2006
A new class of small molecule RNA polymerase inhibitors with activity against Rifampicin-resistant Staphylococcus aureus 1 Fulltext Access 21 Pages 2006
Use of monoterpenes, 3-carene and 2-carene, as synthons in the stereoselective synthesis of 2,2-dimethyl-1,3-disubstituted cyclopropanes Fulltext Access 21 Pages 2006
Deficiencies in estrogen-mediated regulation of cerebrovascular homeostasis may contribute to an increased risk of cerebral aneurysm pathogenesis and rupture in menopausal and postmenopausal women Fulltext Access 21 Pages 2006
Syntheses of glucose-containing E5564 analogues and their LPS-antagonistic activities Fulltext Access 21 Pages 2006
Structure–activity studies of cyclic ketone inhibitors of the serine protease plasmin: Design, synthesis, and biological activity Fulltext Access 21 Pages 2006
Preparation of chiral bipyridine bis-N-oxides by oxidative dimerization of chiral pyridine N-oxides Fulltext Access 21 Pages 2006
Stereoselective additions to the exocyclic CC bond of some α-alkylidene-(+)-camphor derivatives Fulltext Access 21 Pages 2006
Practical preparation of N-(1-alkynyl)sulfonamides and their synthetic utility in titanium alkoxide-mediated coupling reactions Fulltext Access 21 Pages 2006
Structural and thermodynamic studies of simple aldose reductase–inhibitor complexes Fulltext Access 21 Pages 2006
Formamides derived from N-methyl amino acids serve as new chiral organocatalysts in the enantioselective reduction of aromatic ketimines with trichlorosilane Fulltext Access 21 Pages 2006
Structure-activity relationship of for-l-Met l-Leu-l-Phe-OMe analogues in human neutrophils Fulltext Access 21 Pages 2006
Fluorine-substituted dihydrobicyclomycins: Synthesis and biochemical and biological properties Fulltext Access 21 Pages 2006
Reactivity of unsaturated sultones synthesized from unsaturated alcohols by ring-closing metathesis. Application to the racemic synthesis of the originally proposed structure of mycothiazole Fulltext Access 21 Pages 2006
Design and synthesis of an orally active matrix metalloproteinase inhibitor Fulltext Access 21 Pages 2006
Transporters as a determinant of drug clearance and tissue distribution Fulltext Access 22 Pages 2006
Design, synthesis, and biological activity of novel factor Xa inhibitors: Improving metabolic stability by S1 and S4 ligand modification Fulltext Access 22 Pages 2006
Tricyclic pharmacophore-based molecules as novel integrin αvβ3 antagonists. Part 2: Synthesis of potent αvβ3/αIIbβ3 dual antagonists Fulltext Access 22 Pages 2006
Synthesis, biological evaluation, and pharmacokinetic study of prolyl-1-piperazinylacetic acid and prolyl-4-piperidinylacetic acid derivatives as VLA-4 antagonists Fulltext Access 22 Pages 2006
Effects of steric bulk and stereochemistry on the rates of diketopiperazine formation from N-aminoacyl-2,2-dimethylthiazolidine-4-carboxamides (Dmt dipeptide amides)-a model for a new prodrug linker system Fulltext Access 22 Pages 2006
Qualitative analysis of the relation between DNA microarray data and behavioral models of regulation networks Fulltext Access 22 Pages 2006
Toward the control of Leptosphaeria maculans: Design, syntheses, biological activity, and metabolism of potential detoxification inhibitors of the crucifer phytoalexin brassinin Fulltext Access 22 Pages 2006
Isoflavones made simple – Genistein’s agonist activity for the beta-type estrogen receptor mediates their health benefits Fulltext Access 22 Pages 2006
Tailoring structure–function and targeting properties of ceramides by site-specific cationization Fulltext Access 22 Pages 2006
Synthetic study of hetisine-type aconite alkaloids. Part 2: Preparation of hexacyclic compound lacking the C-ring of the hetisan skeleton Fulltext Access 22 Pages 2006
Predicting antitrichomonal activity: A computational screening using atom-based bilinear indices and experimental proofs Fulltext Access 23 Pages 2006
Recent advances in the synthetic applications of the oxazaborolidine-mediated asymmetric reduction Fulltext Access 23 Pages 2006
Engineering d-amino acid containing novel protease inhibitors using catalytic site architecture Fulltext Access 23 Pages 2006
Targeting the α-folate receptor with cyclopenta[g]quinazoline-based inhibitors of thymidylate synthase Fulltext Access 23 Pages 2006
Tetrahedron report number 768Synthesis of 2â²,3â²-didehydro-2â²,3â²-dideoxynucleosides having variations at either or both of the 2â²- and 3â²-positions Fulltext Access 23 Pages 2006
Synthesis and preliminary evaluation of new 1- and 3-[1-(2-hydroxy-3-phenoxypropyl)]xanthines from 2-amino-2-oxazolines as potential A1 and A2A adenosine receptor antagonists Fulltext Access 23 Pages 2006
The dialectics of cancer: A theory of the initiation and development of cancer through errors in RNAi Fulltext Access 24 Pages 2006
Tetrahedron report number XXXBiocatalysis as a profound tool in the preparation of highly enantiopure β-amino acids Fulltext Access 24 Pages 2006
Systemic therapy for gynecological neoplasms: Ovary, cervix and endometrium Fulltext Access 24 Pages 2006
Network topology and the evolution of dynamics in an artificial genetic regulatory network model created by whole genome duplication and divergence Fulltext Access 24 Pages 2006
Role of the PH domain in regulating in vitro autophosphorylation events required for reconstitution of PDK1 catalytic activity Fulltext Access 24 Pages 2006
Tricyclic pharmacophore-based molecules as novel integrin αvβ3 antagonists. Part IV: Preliminary control of αvβ3 selectivity by meta-oriented substitution Fulltext Access 24 Pages 2006
Synthesis and biological activity of tricyclic aryloimidazo-, pyrimido-, and diazepinopurinediones Fulltext Access 24 Pages 2006
Analytical techniques for quantification of amorphous/crystalline phases in pharmaceutical solids Fulltext Access 25 Pages 2006
Transition metal catalyzed oxidative functionalization of carbon-hydrogen bonds Fulltext Access 25 Pages 2006
A highly convergent synthesis of an N-linked glycopeptide presenting the H-type 2 human blood group determinant Fulltext Access 25 Pages 2006
A unified synthetic strategy toward oroidin-derived alkaloids premised on a biosynthetic proposal Fulltext Access 25 Pages 2006
Design and synthesis of novel amino-substituted xanthenones and benzo[b]xanthenones: Evaluation of their antiproliferative activity and their ability to overcome multidrug resistance toward MES-SA/D × 5 cells Fulltext Access 25 Pages 2006
Recent approaches to the construction of 1-azaspiro[4.5]decanes and related 1-azaspirocycles Fulltext Access 26 Pages 2006
α- and β-Glucosidase inhibitors: chemical structure and biological activity Fulltext Access 26 Pages 2006
Synthesis, conformational characteristics and anti-influenza virus A activity of some 2-adamantylsubstituted azacycles Fulltext Access 26 Pages 2006
Recent advances in the chemistry of macroline, sarpagine and ajmaline-related indole alkaloids Fulltext Access 27 Pages 2006
The domino chemistry approach to molecular complexity: high-yielding bis-hetero intramolecular Diels–Alder reactions with ketone components Fulltext Access 27 Pages 2006
Basics and Applications of Solid-State Kinetics: A Pharmaceutical Perspective* Fulltext Access 27 Pages 2006
Design, synthesis, and evaluation of cyclic amide/imide-bearing hydroxamic acid derivatives as class-selective histone deacetylase (HDAC) inhibitors Fulltext Access 27 Pages 2006
Enantioselective α-heterofunctionalisation of carbonyl compounds: organocatalysis is the simplest approach Fulltext Access 28 Pages 2006
Search for α-glucosidase inhibitors: New N-substituted valienamine and conduramine F-1 derivatives Fulltext Access 28 Pages 2006