3-Bromo-4-(1H-3-indolyl)-2,5-dihydro-1H-2,5-pyrroledione derivatives as new lead compounds for antibacterially active substances Fulltext Access 16 Pages 2006
QSAR study for a novel series of ortho disubstituted phenoxy analogues of α1-adrenoceptor antagonist WB4101 Fulltext Access 16 Pages 2006
New highly potent GABA uptake inhibitors selective for GAT-1 and GAT-3 derived from (R)- and (S)-proline and homologous pyrrolidine-2-alkanoic acids Fulltext Access 16 Pages 2006
Design and synthesis of novel 7-heterocycle-6-trifluoromethyl-3-oxoquinoxaline-2-carboxylic acids bearing a substituted phenyl group as superior AMPA receptor antagonists with good physicochemical properties Fulltext Access 17 Pages 2006
Pyranocoumarin, a novel anti-TB pharmacophore: Synthesis and biological evaluation against Mycobacterium tuberculosis Fulltext Access 17 Pages 2006
Pyrrolo[2,3-h]quinolinones: A new ring system with potent photoantiproliferative activity Fulltext Access 17 Pages 2006
Tesmilifene may enhance breast cancer chemotherapy by killing a clone of aggressive, multi-drug resistant cells through its action on the p-glycoprotein pump Fulltext Access 17 Pages 2006
An etiologic model proposing that sporadic adult-onset carcinoma is extramedullary hematopoiesis Fulltext Access 17 Pages 2006
Development of a Respirable, Sustained Release Microcarrier for 5-Fluorouracil II: In Vitro and In Vivo Optimization of Lipid Coated Nanoparticles Fulltext Access 17 Pages 2006
Isothiazolidinone heterocycles as inhibitors of protein tyrosine phosphatases: Synthesis and structure–activity relationships of a peptide scaffold Fulltext Access 17 Pages 2006
Discovery of thiochroman and chroman derivatives as pure antiestrogens and their structure–activity relationship Fulltext Access 17 Pages 2006
Nonsteroidal progesterone receptor ligands (II); synthesis and SAR of new tetrahydrobenzindolone derivatives Fulltext Access 17 Pages 2006
Amber force field implementation, molecular modelling study, synthesis and MMP-1/MMP-2 inhibition profile of (R)- and (S)-N-hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3-methylbutanamides Fulltext Access 17 Pages 2006
Polymorphism and Pseudopolymorphism of Salicaine and Salicaine Hydrochloride Crystal Polymorphism of Local Anaesthetic Drugs, Part V Fulltext Access 17 Pages 2006
High-throughput screening of ecdysone agonists using a reporter gene assay followed by 3-D QSAR analysis of the molting hormonal activity Fulltext Access 17 Pages 2006
In situ studies of regional absorption of lobucavir and ganciclovir from rabbit intestine and predictions of doseâlimited absorption and associated variability in humans Fulltext Access 17 Pages 2006
[HP(HNCH2CH2)3N]NO3: an efficient homogeneous and solid-supported promoter for aza and thia-Michael reactions and for Strecker reactions Fulltext Access 17 Pages 2006
A global examination of allometric scaling for predicting human drug clearance and the prediction of large vertical allometry* Fulltext Access 17 Pages 2006
Medicinal chemistry strategies to 5-HT6 receptor ligands as potential cognitive enhancers and antiobesity agents Fulltext Access 17 Pages 2006
Synthesis and biological evaluation of (3,4,5-trimethoxyphenyl)indol-3-ylmethane derivatives as potential antivascular agents Fulltext Access 17 Pages 2006
Synthesis of thienamycin-like 2-iso-oxacephems with optional stereochemistry Fulltext Access 17 Pages 2006
Chiral linker. Part 3: Synthesis and evaluation of aryl substituted m-hydrobenzoins as solid supported open chain chiral auxiliaries for the diastereoselective reduction of α-keto esters Fulltext Access 17 Pages 2006
Synthesis, characterisation and application of enantiomeric isotopomers of Evans’ oxazolidinones Fulltext Access 17 Pages 2006
Development of novel brush-type chiral stationary phases based on terpenoid selectors: HPLC evaluation and theoretical investigation of enantioselective binding interactions Fulltext Access 17 Pages 2006
Inactivation of the phenylpyruvate tautomerase activity of macrophage migration inhibitory factor by 2-oxo-4-phenyl-3-butynoate Fulltext Access 17 Pages 2006
Characterization of benzaldehyde lyase from Pseudomonas fluorescens: A versatile enzyme for asymmetric C–C bond formation Fulltext Access 17 Pages 2006
Evaluation of possible intramolecular [4+2] cycloaddition routes for assembling the central tetracyclic core of the potent marine antiinflammatory agent mangicol A Fulltext Access 17 Pages 2006
New approaches toward the synthesis of (D-homo) steroid skeletons using Mukaiyama reactions Fulltext Access 17 Pages 2006
Structure–activity relationships in platelet-activating factor. Part 13: Synthesis and biological evaluation of piperazine derivatives with dual anti-PAF and anti-HIV-1 or pure antiretroviral activity Fulltext Access 17 Pages 2006
Synthesis and RNA-selective hybridization of α-l-ribo- and β-d-lyxo-configured oligonucleotides Fulltext Access 17 Pages 2006
Discovery of potent, selective 4-fluoroproline-based thrombin inhibitors with improved metabolic stability Fulltext Access 17 Pages 2006
Real light emitter in the bioluminescence of the calcium-activated photoproteins aequorin and obelin: light emission from the singlet-excited state of coelenteramide phenolate anion in a contact ion pair Fulltext Access 17 Pages 2006
Further optimization of sulfonamide analogs as EP1 receptor antagonists: Synthesis and evaluation of bioisosteres for the carboxylic acid group Fulltext Access 17 Pages 2006
Design, synthesis, and evaluation of Leu∗Ala hydroxyethylene-based non-peptide β-secretase (BACE) inhibitors Fulltext Access 17 Pages 2006
Differential targeting and function of α2A and α2C adrenergic receptor subtypes in cultured sympathetic neurons Fulltext Access 17 Pages 2006
Synthesis and structure activity relationships of novel non-peptidic metallo-aminopeptidase inhibitors Fulltext Access 17 Pages 2006
Synthesis and metabolism of naphthyl substituted phosphoramidate derivatives of stavudine Fulltext Access 17 Pages 2006
Stereodivergent synthesis of 1,4-bifunctional compounds by regio- and diastereoselective Pd-catalyzed allylic substitution reaction Fulltext Access 18 Pages 2006
Graphical exploratory data analysis of RNA secondary structure dynamics predicted by the massively parallel genetic algorithm Fulltext Access 18 Pages 2006
New indium-mediated cyclisation reactions of tethered haloenynes in aqueous solvent systems Fulltext Access 18 Pages 2006
Mediastinal node and diaphragmatic targeting after intracavitary injection of avidin/99mTc-blue-biotin-liposome system Fulltext Access 18 Pages 2006
A topological substructural approach for the prediction of P-glycoprotein substrates Fulltext Access 18 Pages 2006
Thermodynamic Stability and Crystal Structures for Polymorphs and Solvates of Formoterol Fumarate Fulltext Access 18 Pages 2006
Changes in purinergic signalling in developing and ageing rat tail artery: Importance for temperature control Fulltext Access 18 Pages 2006
Effects of pH, Temperature, and Sucrose on Benzyl Alcohol-Induced Aggregation of Recombinant Human Granulocyte Colony Stimulating Factor Fulltext Access 18 Pages 2006
A unified synthetic approach to trachylobane-, beyerane-, atisane- and kaurane-type diterpenes Fulltext Access 18 Pages 2006
An ICR Study of Ion-Molecules Reactions Relevant to Titan’s Atmosphere: An Investigation of Binary Hydrocarbon Mixtures up to 1 Micron Fulltext Access 18 Pages 2006
Acetylphosphinate is the most potent mechanism-based substrate-like inhibitor of both the human and Escherichia coli pyruvate dehydrogenase components of the pyruvate dehydrogenase complex Fulltext Access 18 Pages 2006
Potent and selective TF/FVIIa inhibitors containing a neutral P1 ligand Fulltext Access 18 Pages 2006
Design, synthesis, and BK channel-opening activity of hexahydrodibenzazepinone derivatives Fulltext Access 18 Pages 2006
Synthesis and pharmacological characterization of novel inverse agonists acting on the viral-encoded chemokine receptor US28 Fulltext Access 18 Pages 2006
Retinoic acid metabolism blocking agents (RAMBAs) for treatment of cancer and dermatological diseases Fulltext Access 18 Pages 2006
Discovery of imidazolidine-2,4-dione-linked HIV protease inhibitors with activity against lopinavir-resistant mutant HIV Fulltext Access 18 Pages 2006
New derivatives of silybin and 2,3-dehydrosilybin and their cytotoxic and P-glycoprotein modulatory activity Fulltext Access 18 Pages 2006
Tissue-Specific mRNA Expression Profiles of Human Phase I Metabolizing Enzymes Except for Cytochrome P450 and Phase II Metabolizing Enzymes Fulltext Access 18 Pages 2006
Synthesis and biological activities of new 1α,25-dihydroxy-19-norvitamin D3 analogs with modifications in both the A-ring and the side chain Fulltext Access 18 Pages 2006
Object segmentation and recovery via neural oscillators implementing the similarity and prior knowledge gestalt rules Fulltext Access 18 Pages 2006
A hybrid approach for efficient and robust parameter estimation in biochemical pathways Fulltext Access 18 Pages 2006
Benzodiazepine receptor ligands. 8: Synthesis and pharmacological evaluation of new pyrazolo[5,1-c] [1,2,4]benzotriazine 5-oxide 3- and 8-disubstituted: High affinity ligands endowed with inverse-agonist pharmacological efficacy Fulltext Access 18 Pages 2006
1-Iodo-1-selenoalkenes as versatile alkene 1,1-dianion equivalents. Novel connective approach towards the tetrahydropyran subunit of polycavernoside A Fulltext Access 19 Pages 2006
Enantiocontrolled synthesis of the epoxycyclohexenone moieties of scyphostatin, a potent and specific inhibitor of neutral sphingomyelinase Fulltext Access 19 Pages 2006
RuO4-mediated oxidative polycyclization of linear polyenes. A new approach to the synthesis of the bis-THF diol core of antitumour cis-cis adjacent bis-THF annonaceous acetogenins Fulltext Access 19 Pages 2006
Efficient synthesis of indoles using [3,3]-sigmatropic rearrangement of N-trifluoroacetyl enehydrazines Fulltext Access 19 Pages 2006
Intramolecular nucleophilic capture of radical cations by tethered hydroxy functions Fulltext Access 19 Pages 2006
Homochiral lithium amides for the asymmetric synthesis of β-amino acids Fulltext Access 19 Pages 2006
Total synthesis of actinobolin from d-glucose by way of the stereoselective three-component coupling reaction Fulltext Access 19 Pages 2006
Synthesis of substrate analogs of methyltransferases in the vitamin B12 biosynthetic pathway and characterization of their enzymatic products Fulltext Access 19 Pages 2006
The synthesis and biological evaluation of lactose-based sialylmimetics as inhibitors of rotaviral infection Fulltext Access 19 Pages 2006
Structure-based design of isoquinoline-5-sulfonamide inhibitors of protein kinase B Fulltext Access 19 Pages 2006
A generic building block for C- and N-terminal protein-labeling and protein-immobilization Fulltext Access 19 Pages 2006
Conformational structure, dynamics, and solvation energies of small alanine peptides in water and carbon tetrachloride Fulltext Access 19 Pages 2006
Design, synthesis and evaluation of peptidomimetics based on substituted bicyclic 2-pyridones—Targeting virulence of uropathogenic E. coli Fulltext Access 19 Pages 2006
Novel ligands for the human histamine H1 receptor: Synthesis, pharmacology, and comparative molecular field analysis studies of 2-dimethylamino-5-(6)-phenyl-1,2,3,4-tetrahydronaphthalenes Fulltext Access 19 Pages 2006
Down-regulation of microglial activation may represent a practical strategy for combating neurodegenerative disorders Fulltext Access 19 Pages 2006
Synthesis of lipid A monosaccharide analogues containing acidic amino acid: Exploring the structural basis for the endotoxic and antagonistic activities Fulltext Access 19 Pages 2006
Synthesis and biological evaluation of B-ring analogues of (â)-rhazinilam Fulltext Access 19 Pages 2006