An Extended Model Based on the Modified Nernst-Planck Equation for Describing Transdermal Iontophoresis of Weak Electrolytes Fulltext Access 14 Pages 2006
A direct synthesis of 1,7-dioxaspiro[4.5]decanes from the new 3-methylidenepentane-1,5-dianion synthon Fulltext Access 14 Pages 2006
Preclinical evaluation of 2,2,3,3-tetramethylcyclopropanecarbonyl-urea, a novel, second generation to valproic acid, antiepileptic drug Fulltext Access 14 Pages 2006
Midbrain neuronal cultures from parkin mutant mice are resistant to nitric oxide-induced toxicity Fulltext Access 14 Pages 2006
Spirochetal cyst forms in neurodegenerative disorders, … hiding in plain sight Fulltext Access 14 Pages 2006
Madness explained: Why we must reject the Kraepelinian paradigm and replace it with a ‘complaint-orientated’ approach to understanding mental illness Fulltext Access 14 Pages 2006
Self-Assembled Polyelectrolyte Nanocomplexes between Chitosan Derivatives and Insulin Fulltext Access 14 Pages 2006
Crystal structure of carnidazole form II from synchrotron Xâray powder diffraction: Structural comparison with form I, the hydrated form and the low energy conformations in vacuo Fulltext Access 14 Pages 2006
Biophysical characterization of polymeric and liposomal gene delivery systems using empirical phase diagrams Fulltext Access 14 Pages 2006
BSA Degradation Under Acidic Conditions: A Model For Protein Instability During Release From PLGA Delivery Systems Fulltext Access 14 Pages 2006
Microwave-assisted solution phase synthesis of dihydropyrimidine C5 amides and esters Fulltext Access 14 Pages 2006
Influence of Different Polymers on the Crystallization Tendency of Molecularly Dispersed Amorphous Felodipine Fulltext Access 14 Pages 2006
Dehydration of Risedronate Hemi-Pentahydrate: Analytical and Physical Characterization Fulltext Access 14 Pages 2006
Ultra-Fast Absorption of Amorphous Pure Drug Aerosols via Deep Lung Inhalation Fulltext Access 14 Pages 2006
Influence of aggregation on immunogenicity of recombinant human Factor VIII in hemophilia A mice Fulltext Access 14 Pages 2006
A mathematical model to predict the size of the pellets formed in freeze pelletization techniques: Parameters affecting pellet size* Fulltext Access 14 Pages 2006
Regulation of drug transporters by PDZ adaptor proteins and nuclear receptors Fulltext Access 14 Pages 2006
Primary porcine proximal tubular cells as a model for transepithelial drug transport in human kidney Fulltext Access 14 Pages 2006
Synthesis of fullerohelicates and fine tuning of the photoinduced processes by changing the number of addends on the fullerene subunits Fulltext Access 14 Pages 2006
Diastereoselective synthesis of aziridine esters via amino selanyl esters Fulltext Access 14 Pages 2006
Chemical predisposition in synthesis: application to the preparation of the pyrrolidine natural products, plakoridines A and B Fulltext Access 14 Pages 2006
Photoreactions of β-aziridinylacrylonitriles and acrylates with alkenes: the substituent effects on the formation of [3+2] cycloadducts Fulltext Access 14 Pages 2006
Methodology for the synthesis of 1,2-disubstituted arylnaphthalenes from α-tetralones Fulltext Access 14 Pages 2006
Synthesis of 3-(arylmethylene)isoindolin-1-ones from ynamides by Heck-Suzuki-Miyaura domino reactions. Application to the synthesis of lennoxamine Fulltext Access 14 Pages 2006
Ruthenium-catalyzed [2+2] cycloadditions of bicyclic alkenes and ynamides Fulltext Access 14 Pages 2006
Investigating the hydrate conversion propensity of different etoricoxib lots Fulltext Access 14 Pages 2006
Antenna-functionalized dendritic β-diketonates and europium complexes: synthetic approaches to generation growth Fulltext Access 14 Pages 2006
The direct preparation of functionalised cyclopropanes from allylic alcohols or α-hydroxyketones using tandem oxidation processes Fulltext Access 14 Pages 2006
Easy α-alkylation of ketones with alcohols through a hydrogen autotransfer process catalyzed by RuCl2(DMSO)4 Fulltext Access 14 Pages 2006
The synthesis of single enantiomers of meromycolic acids from mycobacterial wax esters Fulltext Access 14 Pages 2006
Synthesis and anti-tubulin evaluation of chromone-based analogues of combretastatins Fulltext Access 14 Pages 2006
Efficient synthesis of 18-40 membered macrocyclic polyoxadiamides and polyoxatetraamides via ring closing metathesis Fulltext Access 14 Pages 2006
Evaluation of novel cationic 99mTc-nitrido complexes as radiopharmaceuticals for heart imaging: improving liver clearance with crown ether groups Fulltext Access 14 Pages 2006
Alkyl-fluorinated thymidine derivatives for imaging cell proliferation: I. The in vitro evaluation of some alkyl-fluorinated thymidine derivatives Fulltext Access 14 Pages 2006
Effect of the MAPK cascade structure, nuclear translocation and regulation of transcription factors on gene expression Fulltext Access 14 Pages 2006
A network model for the control of the differentiation process in Th cells Fulltext Access 14 Pages 2006
A game-theoretic model for punctuated equilibrium: Species invasion and stasis through coevolution Fulltext Access 14 Pages 2006
Design and synthesis of novel imidazoline derivatives with potent antihyperglycemic activity in a rat model of type 2 diabetes Fulltext Access 15 Pages 2006
Modeling of activity of cyclic urea HIV-1 protease inhibitors using regularized-artificial neural networks Fulltext Access 15 Pages 2006
Synthesis of functionalized biphenyl-C-nucleosides and their incorporation into oligodeoxynucleotides Fulltext Access 15 Pages 2006
Effect of functional group polarity on the antimalarial activity of spiro and dispiro-1,2,4-trioxolanes Fulltext Access 15 Pages 2006
Structural basis for androgen receptor agonists and antagonists: Interaction of SPEED 98-listed chemicals and related compounds with the androgen receptor based on an in vitro reporter gene assay and 3D-QSAR Fulltext Access 15 Pages 2006
Design of potent inhibitors for Schistosoma japonica glutathione S-transferase Fulltext Access 15 Pages 2006
Novel 1,3-dicarbonyl compounds having 2(3H)-benzazolonic heterocycles as PPARγ agonists Fulltext Access 15 Pages 2006
Flavonoids and cinnamic acid esters as inhibitors of fungal 17β-hydroxysteroid dehydrogenase: A synthesis, QSAR and modelling study Fulltext Access 15 Pages 2006
Structure–activity relationships in platelet-activating factor. Part 14: Synthesis and biological evaluation of piperazine derivatives with dual anti-PAF and anti-HIV-1 activity Fulltext Access 15 Pages 2006
Regiocontrolled synthesis and HIV inhibitory activity of unsymmetrical binaphthoquinone and trimeric naphthoquinone derivatives of conocurvone Fulltext Access 15 Pages 2006
A new type of ketolide bearing an N-aryl-alkyl acetamide moiety at the C-9 iminoether: Synthesis and structure–activity relationships (2) Fulltext Access 15 Pages 2006
α7 Nicotinic acetylcholine receptor as a target to rescue deficit in hippocampal LTP induction in β-amyloid infused rats Fulltext Access 15 Pages 2006
Underlying mechanism for NMDA receptor antagonism by the anti-inflammatory drug, sulfasalazine, in mouse cortical neurons Fulltext Access 15 Pages 2006
Bicyclic[4.1.0]heptanes as phenyl replacements for melanin concentrating hormone receptor antagonists Fulltext Access 15 Pages 2006
Synthesis and antimalarial activity of chain substituted pivaloyloxymethyl ester analogues of Fosmidomycin and FR900098 Fulltext Access 15 Pages 2006
Synthesis and SAR of indazole-pyridine based protein kinase B/Akt inhibitors Fulltext Access 15 Pages 2006
Salicylaldehyde Schiff bases derived from 2-ferrocenyl-2-amino alcohols. Part 1: New chiral ligands for the titanium-catalyzed enantioselective cyanation of aldehydes Fulltext Access 15 Pages 2006
Kinetic and chemical resolution of different 1-phenyl-2-propanol derivatives Fulltext Access 15 Pages 2006
Iridium-catalyzed cascade decarbonylation/highly enantioselective Pauson–Khand-type cyclization reactions Fulltext Access 15 Pages 2006
Enantiomerically pure α-pinene derivatives from material of 65% enantiomeric purity. Part 2: C2-symmetric N,N′-3-(2α-hydroxy)pinane diimines and diamines Fulltext Access 15 Pages 2006
Catalytic asymmetric hydrogenation of indoles using a rhodium complex with a chiral bisphosphine ligand PhTRAP Fulltext Access 15 Pages 2006
Rigid P-chiral mono and diphosphines. Configurative stability and P-inversion barrier Fulltext Access 15 Pages 2006
Preparation of various enantiomerically pure (benzotriazol-1-yl)- and (benzotriazol-2-yl)-alkan-2-ols Fulltext Access 15 Pages 2006
Synthesis of a 28-mer oligosaccharide core of Mycobacterial lipoarabinomannan (LAM) requires only two n-pentenyl orthoester progenitors Fulltext Access 15 Pages 2006
The influence of drug kinetics in blood on the calculation of oral bioavailability in linear pharmacokinetics: The traditional equation may considerably overestimate the true value Fulltext Access 15 Pages 2006
Multiple uses of tumor necrosis therapy (TNT) for the treatment and imaging of solid tumors: Preclinical considerations and progress Fulltext Access 15 Pages 2006
Nanoscale analysis of protein and peptide absorption: Insulin absorption using complexation and pH-sensitive hydrogels as delivery vehicles Fulltext Access 15 Pages 2006
In vitro cytotoxicity of 211At-labeled trastuzumab in human breast cancer cell lines: effect of specific activity and HER2 receptor heterogeneity on survival fraction Fulltext Access 15 Pages 2006
Electron Capture Dissociation of Peptides Metalated with Alkaline-Earth Metal Ions Fulltext Access 15 Pages 2006
A Process Analytical Technology approach to near-infrared process control of pharmaceutical powder blending. Part I: D-optimal design for characterization of powder mixing and preliminary spectral data evaluation Fulltext Access 15 Pages 2006
A Process Analytical Technology approach to near-infrared process control of pharmaceutical powder blending: Part II: Qualitative near-infrared models for prediction of blend homogeneity Fulltext Access 15 Pages 2006
Novel potent and selective αvβ3/αvβ5 integrin dual antagonists with reduced binding affinity for human serum albumin Fulltext Access 15 Pages 2006
Synthesis, photochemical synthesis, DNA binding and antitumor evaluation of novel cyano- and amidino-substituted derivatives of naphtho-furans, naphtho-thiophenes, thieno-benzofurans, benzo-dithiophenes and their acyclic precursors Fulltext Access 15 Pages 2006
CoMFA and CoMSIA investigations of dopamine D3 receptor ligands leading to the prediction, synthesis, and evaluation of rigidized FAUC 365 analogues Fulltext Access 15 Pages 2006
Stealth PEG-PHDCA niosomes: Effects of Chain Length of PEG and Particle Size on Niosomes Surface Properties, In Vitro Drug Release, Phagocytic Uptake, In Vivo Pharmacokinetics and Antitumor Activity Fulltext Access 15 Pages 2006
Corticosteroid Microparticles Produced by Supercritical-Assisted Atomization: Process Optimization, Product Characterization, and “in Vitro” Performance Fulltext Access 15 Pages 2006
Effect of buffer species on the thermally induced aggregation of interferon-tau Fulltext Access 15 Pages 2006
Manipulation of Beclomethasone-Hydrofluoroalkane Interactions using Biocompatible Macromolecules Fulltext Access 15 Pages 2006
The binding of DNA intercalating and non-intercalating compounds to A-form and protonated form of poly(rC)·poly(rG): Spectroscopic and viscometric study Fulltext Access 15 Pages 2006
Antibodies and antibody-fusion proteins as anti-angiogenic, anti-tumor agents Fulltext Access 15 Pages 2006
Prodrugs of 3-(3,4-dichlorobenzyloxy)-2-amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (MGS0039): A potent and orally active group II mGluR antagonist with antidepressant-like potential Fulltext Access 15 Pages 2006
C19-Steroids as androgen receptor modulators: Design, discovery, and structure-activity relationship of new steroidal androgen receptor antagonists Fulltext Access 15 Pages 2006
Postnatal development of P2 receptors in the murine gastrointestinal tract Fulltext Access 15 Pages 2006