Liquid phase migration in the extrusion and squeezing of microcrystalline cellulose pastes Fulltext Access 13 Pages 2006
Polymeric Systems for Amorphous Î9-Tetrahydrocannabinol Produced by a Hot-melt Method. Part II: Effect of Oxidation Mechanisms and Chemical Interactions on Stability Fulltext Access 13 Pages 2006
Simultaneous Quantification of Carbamazepine Crystal Forms in Ternary Mixtures (I, III, and IV) by Diffuse Reflectance FTIR Spectroscopy (DRIFTS) and Multivariate Calibration Fulltext Access 13 Pages 2006
Effect of Pressure on Molecular and Ionic Motions in Ultraviscous Acetaminophen-Aspirin Mixture Fulltext Access 13 Pages 2006
Flurbiprofen Loaded Biodegradable Nanoparticles for Ophtalmic Administration Fulltext Access 13 Pages 2006
Influence of Solid Phase and Formulation Processing on Stability of Abbott-232 Tablet Formulations Fulltext Access 13 Pages 2006
Polyion Complex Micelles Composed of All-TranS Retinoic Acid and Poly (Ethylene Glycol)-Grafted-Chitosan Fulltext Access 13 Pages 2006
A Process Analytical Technology approach to near-infrared process control of pharmaceutical powder blending. Part III: Quantitative near-infrared calibration for prediction of blend homogeneity and characterization of powder mixing kinetics Fulltext Access 13 Pages 2006
Phase solubility and inclusion complex of itraconazole with β-cyclodextrin using supercritical carbon dioxide Fulltext Access 13 Pages 2006
The binding interaction of synthetic ozonide antimalarials with natural and modified β-cyclodextrins Fulltext Access 13 Pages 2006
Characterization of Temperature-Induced Phase Transitions in Five Polymorphic Forms of Sulfathiazole by Terahertz Pulsed Spectroscopy and Differential Scanning Calorimetry Fulltext Access 13 Pages 2006
Antiplasmodial activity of ferrocenyl chalcones: Investigations into the role of ferrocene Fulltext Access 13 Pages 2006
Genetic Variation and Haplotype Structure of the ABC Transporter Gene ABCG2 in a Japanese Population Fulltext Access 13 Pages 2006
Human Carboxylesterase Isozymes: Catalytic Properties and Rational Drug Design Fulltext Access 13 Pages 2006
Identification of an achiral analogue of J-113397 as potent nociceptin/orphanin FQ receptor antagonist Fulltext Access 13 Pages 2006
Stochastic entropy QSAR for the in silico discovery of anticancer compounds: Prediction, synthesis, and in vitro assay of new purine carbanucleosides Fulltext Access 13 Pages 2006
Activity-guided isolation of cytotoxic constituents from the bark of Aglaia crassinervia collected in Indonesia Fulltext Access 13 Pages 2006
Pharmacokinetics and Therapeutic Effects of Oltipraz after Consecutive or Intermittent Oral Administration in Rats with Liver Cirrhosis Induced by Dimethylnitrosamine Fulltext Access 13 Pages 2006
Reductions of (1R,3R,4R)-3-([1,2,4]triazolo[4,3-x]azin-3-yl)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-ones and their analogues Fulltext Access 13 Pages 2006
The pharmacognosy of Humulus lupulus L. (hops) with an emphasis on estrogenic properties Fulltext Access 13 Pages 2006
The inflammatory consequences of psychologic stress: Relationship to insulin resistance, obesity, atherosclerosis and diabetes mellitus, type II Fulltext Access 13 Pages 2006
A tale of two cannabinoids: The therapeutic rationale for combining tetrahydrocannabinol and cannabidiol Fulltext Access 13 Pages 2006
Characterization of supersaturated lidocaine/polyacrylate pressure sensitive adhesive systems: Thermal analysis and FT-IR Fulltext Access 13 Pages 2006
DNA Acts as a Nucleation Site for Transient Cavitation in the Ultrasonic Nebulizer Fulltext Access 13 Pages 2006
Process Simulation in the Pharmaceutical Industry: A Review of Some Basic Physical Models Fulltext Access 13 Pages 2006
Development of a Respirable, Sustained Release Microcarrier for 5-Fluorouracil I: In Vitro Assessment of Liposomes, Microspheres, and Lipid Coated Nanoparticles Fulltext Access 13 Pages 2006
Antibody Response to Aggregated Human Interferon Alpha2b in Wild-type and Transgenic Immune Tolerant Mice Depends on Type and Level of Aggregation Fulltext Access 13 Pages 2006
Ligand design and synthesis of new imidazo[5,1-b]quinazoline derivatives as α1-adrenoceptor agonists and antagonists Fulltext Access 13 Pages 2006
Biophysical Comparability of the Same Protein From Different Manufacturers: A Case Study Using Epoetin Alfa From Epogen® and Eprex® Fulltext Access 13 Pages 2006
An Automated Parallel Crystallisation Search for Predicted Crystal Structures and Packing Motifs of Carbamazepine Fulltext Access 13 Pages 2006
Gelatin-Methotrexate Conjugate Microspheres as a Potential Drug Delivery System Fulltext Access 13 Pages 2006
Preclinical Assessment of the Feasibility of Applying Controlled Release Oral Drug Delivery to a Lead Series of Atypical Antipsychotics Fulltext Access 13 Pages 2006
Synthesis and chemical stability of a disulfide bond in a model cyclic pentapeptide: Cyclo(1,4)âCysâGlyâPheâCysâGlyâOH Fulltext Access 13 Pages 2006
Evaluation of Solution Oxygenation Requirements for Azonitrile-Based Oxidative Forced Degradation Studies of Pharmaceutical Compounds Fulltext Access 13 Pages 2006
Impact of Freeze-Drying on Ionization of Sulfonephthalein Probe Molecules in Trehalose-Citrate Systems Fulltext Access 13 Pages 2006
Polymeric systems for amorphous Î9-tetrahydrocannabinol produced by a hot-melt method. Part I: Chemical and thermal stability during processing Fulltext Access 13 Pages 2006
An Analytical Strategy for Quaternary Ammonium Neuromuscular Blocking Agents in a Forensic Setting Using LC-MS/MS on a Tandem Quadrupole/Time-of-Flight Instrument Fulltext Access 13 Pages 2006
Synthesis and transformations of new dihydro-β-campholenolactone derivatives Fulltext Access 13 Pages 2006
Silver(I)-promoted asymmetric halomethoxylation of chiral α,β-unsaturated carboxylic acid derivatives: enantioselective synthesis of N-protected syn-β-methoxy-α-amino acids Fulltext Access 13 Pages 2006
New chiral NiII complexes of Schiff’s bases of glycine and alanine for efficient asymmetric synthesis of α-amino acids Fulltext Access 13 Pages 2006
Novel enantiopure non-C2-symmetric NCN-pincer palladium complexes with l-proline chiral auxiliaries: mer η3-N,C,N versus square planar η4-N,C,N,O coordination Fulltext Access 13 Pages 2006
Chemoenzymatic synthesis of enantiomerically enriched α-chiral 3-oxy-propionaldehydes by lipase-catalyzed kinetic resolution and desymmetrization Fulltext Access 13 Pages 2006
Synthesis of amino acid derived imidazolidinium salts as new NHC precatalysts Fulltext Access 13 Pages 2006
Application of a Linear Ion Trap/Orbitrap Mass Spectrometer in Metabolite Characterization Studies: Examination of the Human Liver Microsomal Metabolism of the Non-Tricyclic Anti-Depressant Nefazodone Using Data-Dependent Accurate Mass Measurements Fulltext Access 13 Pages 2006
Design Considerations for High Speed Quantitative Mass Spectrometry with MALDI Ionization Fulltext Access 13 Pages 2006
Collision-Induced Dissociation Pathways of Anabolic Steroids by Electrospray Ionization Tandem Mass Spectrometry Fulltext Access 13 Pages 2006
Determination of Peptide and Protein Ion Charge States by Fourier Transformation of Isotope-Resolved Mass Spectra Fulltext Access 13 Pages 2006
Ion Trajectory Simulation for Electrode Configurations with Arbitrary Geometries Fulltext Access 13 Pages 2006
DNA Stability in the Gas Versus Solution Phases: A Systematic Study of Thirty-One Duplexes with Varying Length, Sequence, and Charge Level Fulltext Access 13 Pages 2006
On the Risk of False Positive Identification Using Multiple Ion Monitoring in Qualitative Mass Spectrometry: Large-Scale Intercomparisons with a Comprehensive Mass Spectral Library Fulltext Access 13 Pages 2006
Adaptations of nanoscale viruses and other protein cages for medical applications Fulltext Access 13 Pages 2006
Nanoencapsulation II. Biomedical applications and current status of peptide and protein nanoparticulate delivery systems Fulltext Access 13 Pages 2006
Quantitative structure–pharmacokinetic relationships for drug clearance by using statistical learning methods Fulltext Access 13 Pages 2006
Classification and comparison of ligand-binding sites derived from grid-mapped knowledge-based potentials Fulltext Access 13 Pages 2006
Computational prediction of homodimerization of the A3 adenosine receptor Fulltext Access 13 Pages 2006
Bayesian-regularized genetic neural networks applied to the modeling of non-peptide antagonists for the human luteinizing hormone-releasing hormone receptor Fulltext Access 13 Pages 2006
β-Hairpins with native-like and non-native hydrogen bonding patterns could form during the refolding of staphylococcal nuclease Fulltext Access 13 Pages 2006
A putative bioactive conformation for the altered peptide ligand of myelin basic protein and inhibitor of experimental autoimmune encephalomyelitis [Arg91, Ala96] MBP87–99 Fulltext Access 13 Pages 2006
Synthesis and cytotoxic activities of β-carboline amino acid ester conjugates Fulltext Access 13 Pages 2006
6-Substituted 6H-dibenzo[c,h][2,6]naphthyridin-5-ones: Reversed lactam analogues of ARC-111 with potent topoisomerase I-targeting activity and cytotoxicity Fulltext Access 13 Pages 2006
Synthesis and TNF-α inducing activities of mycoloyl-arabinan motif of mycobacterial cell wall components Fulltext Access 13 Pages 2006
Design, synthesis, and biological activity of N6-substituted-4′-thioadenosines at the human A3 adenosine receptor Fulltext Access 13 Pages 2006
Time-dependent inhibitors of trypanothione reductase: Analogues of the spermidine alkaloid lunarine and related natural products Fulltext Access 13 Pages 2006
Chemotactic peptides: fMLF-OMe analogues incorporating proline–methionine chimeras as N-terminal residue Fulltext Access 13 Pages 2006
An unusual functional group interaction and its potential to reproduce steric and electrostatic features of the transition states of peptidolysis Fulltext Access 13 Pages 2006
5-Alkylated thiazolidinones as follicle-stimulating hormone (FSH) receptor agonists Fulltext Access 13 Pages 2006
Glycosidation of lupane-type triterpenoids as potent in vitro cytotoxic agents Fulltext Access 13 Pages 2006
Identification of 4-amino-2-cyclohexylaminoquinazolines as metabolically stable melanin-concentrating hormone receptor 1 antagonists Fulltext Access 13 Pages 2006
Dose-dependent antithrombotic activity of an orally active tissue factor/factor VIIa inhibitor without concomitant enhancement of bleeding propensity Fulltext Access 13 Pages 2006
A new structural theme in C2-symmetric HIV-1 protease inhibitors: ortho-Substituted P1/P1′ side chains Fulltext Access 13 Pages 2006
Iron(II) triggered conformational changes in Escherichia coli fur upon DNA binding: a study using molecular modeling Fulltext Access 13 Pages 2006
Arylamine based cathepsin K inhibitors: Investigating P3 heterocyclic substituents Fulltext Access 13 Pages 2006
Synthesis, X-ray crystal structural study, antiviral and cytostatic evaluations of the novel unsaturated acyclic and epoxide nucleoside analogues Fulltext Access 13 Pages 2006
Novel diphenyl ethers: Design, docking studies, synthesis and inhibition of enoyl ACP reductase of Plasmodium falciparum and Escherichia coli Fulltext Access 13 Pages 2006
Synthesis and evaluation of α-hydroxymethylated conjugated nitroalkenes for their anticancer activity: Inhibition of cell proliferation by targeting microtubules Fulltext Access 13 Pages 2006
Synthesis and evaluation of novel 8,5-fused bicyclic peptidomimetic compounds as interleukin-1β converting enzyme (ICE) inhibitors Fulltext Access 13 Pages 2006
Delivery of 2-5A cargo into living cells using the Tat cell penetrating peptide: 2-5A-tat Fulltext Access 13 Pages 2006
Discovery of substituted 4-anilino-2-(2-pyridyl)pyrimidines as a new series of apoptosis inducers using a cell- and caspase-based high throughput screening assay. Part 1: Structure–activity relationships of the 4-anilino group Fulltext Access 13 Pages 2006
Parallel synthesis of 5-cyano-6-aryl-2-thiouracil derivatives as inhibitors for hepatitis C viral NS5B RNA-dependent RNA polymerase Fulltext Access 13 Pages 2006
A semiempirical study of acetylcholine hydrolysis catalyzed by Drosophila melanogaster acetylcholinesterase Fulltext Access 13 Pages 2006
Artificial ribonucleases: From combinatorial libraries to efficient catalysts of RNA cleavage Fulltext Access 13 Pages 2006