Enantioselective organocatalytic epoxidation using hypervalent iodine reagents Fulltext Access 12 Pages 2006
Rh-catalyzed alkene oxidation: a highly efficient and selective process for preparing N-alkoxysulfonyl aziridines Fulltext Access 12 Pages 2006
One-pot cyclization of dilithiated nitriles with isothiocyanates and epibromohydrin. Synthesis of 2-cyano-1-(hydroxymethyl)cyclopropanes and 2-cyanomethylidene-4-(hydroxymethyl)thiazolidines Fulltext Access 12 Pages 2006
Synthesis of racemic and enantiomeric 3-pyrrolidinyl derivatives of nucleobases Fulltext Access 12 Pages 2006
Total synthesis of new indolo[2,3-a]quinolizine alkaloids sempervirine type, potential pharmaceuticals Fulltext Access 12 Pages 2006
A sequential reaction process to assemble polysubstituted indolizidines, quinolizidines and quinolizidine analogues Fulltext Access 12 Pages 2006
Photoreactions of 1,2,4,5-benzenetetracarbonitrile with arylethenes-photo- olefin dimerization-aromatic substitution reactions Fulltext Access 12 Pages 2006
Synthesis and in vitro cytotoxicity of 1,2,3,4-tetrahydroisoquinoline derivatives Fulltext Access 12 Pages 2006
Synthesis and cancer antiproliferative activity of new histone deacetylase inhibitors: hydrophilic hydroxamates and 2-aminobenzamide-containing derivatives Fulltext Access 12 Pages 2006
Novel derivatives of methyl and ethyl 2-(4-oxo-8-aryl-2H-3,4,6,7-tetrahydroimidazo[2,1-c][1,2,4]triazin-3-yl)acetates from biologically active 1-aryl-2-hydrazinoimidazolines: Synthesis, crystal structure and antiproliferative activity Fulltext Access 12 Pages 2006
Interaction of novel condensed triazine derivatives with central and peripheral type benzodiazepine receptors: synthesis, in vitro pharmacology and modelling Fulltext Access 12 Pages 2006
Asymmetric phase-transfer catalysis of homo- and heterochiral quaternary ammonium salts: development and application of conformationally flexible chiral phase-transfer catalysts Fulltext Access 12 Pages 2006
Two- and three-dimensional quantitative structure–activity relationships for a series of purine nucleoside phosphorylase inhibitors Fulltext Access 12 Pages 2006
Anti-tumor and proapoptotic effect of novel synthetic benzophenone analogues in Ehrlich ascites tumor cells Fulltext Access 12 Pages 2006
Synthesis and antiandrogenic activity of some new 3-substituted androstano[17,16-c]-5′-aryl-pyrazoline and their derivatives Fulltext Access 12 Pages 2006
Design, synthesis, and SAR analysis of cytotoxic sinapyl alcohol derivatives Fulltext Access 12 Pages 2006
Structure–activity relationship study of homoallylamines and related derivatives acting as antifungal agents Fulltext Access 12 Pages 2006
Solid phase synthesis and antiprotozoal evaluation of di- and trisubstituted 5′-carboxamidoadenosine analogues Fulltext Access 12 Pages 2006
Direct observation (NMR) of the efficacy of glucagon receptor antagonists in murine liver expressing the human glucagon receptor Fulltext Access 12 Pages 2006
2,2â²-Isopropylidenebis[(4S,5R)-4,5-di(2-naphthyl)-2-oxazoline] ligand for asymmetric cyclization-carbonylation of meso-2-alkyl-2-propargylcyclohexane-1,3-diols Fulltext Access 12 Pages 2006
A short approach to chaetomellic anhydride A from 2,2-dichloropalmitic acid: elucidation of the mechanism governing the functional rearrangement of the chlorinated pyrrolidin-2-one intermediate Fulltext Access 12 Pages 2006
Coupling and fast decarboxylation of aryloxyl radicals of 4-hydroxycinnamic acids with formation of stable p-quinomethanes Fulltext Access 12 Pages 2006
Synthesis of α-diazo-β-hydroxyesters through a one-pot protocol by phase-transfer catalysis: application to enantioselective aldol-type reaction and diastereoselective synthesis of α-amino-β-hydroxyester derivatives Fulltext Access 12 Pages 2006
Highly enantioselective fluorination reactions of β-ketoesters and β-ketophosphonates catalyzed by chiral palladium complexes Fulltext Access 12 Pages 2006
Bulky diarylammonium arenesulfonates as mild and extremely active dehydrative ester condensation catalysts Fulltext Access 12 Pages 2006
Effect of additives on the proline-catalyzed ketone-aldehyde aldol reactions Fulltext Access 12 Pages 2006
Understanding the structure–activity and structure–selectivity correlation of cyclic guanine derivatives as phosphodiesterase-5 inhibitors by molecular docking, CoMFA and CoMSIA analyses Fulltext Access 12 Pages 2006
Highly selective substitutions in 2,3-dichloropyrazine. A novel general approach to aloisines Fulltext Access 12 Pages 2006
Improvement and simplification of synthesis of 3-aryloxy-1,2-epoxypropanes using solvent-free conditions and microwave irradiations. Relation with medium effects and reaction mechanism Fulltext Access 12 Pages 2006
Generation of ketyl radical anions by photoinduced electron transfer (PET) between ketones and amines. Synthetic applications Fulltext Access 12 Pages 2006
Solvent induced folding of conformationally bistable helical imide triads Fulltext Access 12 Pages 2006
Shaping the cavity of calixarene architecture for molecular recognition: synthesis and conformational properties of new azocalix[4]arenes Fulltext Access 12 Pages 2006
Enantioselective synthesis of aurisides A and B, cytotoxic macrolide glycosides of marine origin Fulltext Access 12 Pages 2006
XY-ZH compounds as potential 1,3-dipoles. Part 63: Silver catalysed azomethine ylide cycloaddition-the synthesis of spiro homoserine lactone analogues Fulltext Access 12 Pages 2006
Arenediazonium o-benzenedisulfonimides as efficient reagents for Heck-type arylation reactions Fulltext Access 12 Pages 2006
Preparation of 3-hydroxyoxindoles with dimethyldioxirane and their use for the synthesis of natural products Fulltext Access 12 Pages 2006
Atom transfer radical cyclization reactions (ATRC): synthetic applications Fulltext Access 12 Pages 2006
The synthesis of one enantiomer of the α-methyl-trans-cyclopropane unit of mycolic acids Fulltext Access 12 Pages 2006
Potential Inhibitors of Chemokine Function: Analysis of Noncovalent Complexes of CC Chemokine and Small Polyanionic Molecules by ESI FT-ICR Mass Spectrometry Fulltext Access 12 Pages 2006
Syntheses of l-glucosamine donors for 1,2-trans-glycosylation reactions Fulltext Access 12 Pages 2006
Enantioselective synthesis of chiral 1,2-diamines by the catalytic ring opening of azabenzonorbornadienes: application in the preparation of new chiral ligands Fulltext Access 12 Pages 2006
Rational approach to the selection of conditions for diastereomeric resolution of chiral amines by diacid resolving agents Fulltext Access 12 Pages 2006
Small organic molecule catalyzed enantioselective direct aldol reaction in water Fulltext Access 12 Pages 2006
Chiral linker. Part 4: Diastereoselective addition of RZnX to α-keto esters using m-hydrobenzoin derived chiral auxiliaries in solution and on solid support and their application in the stereoselective synthesis of frontalin Fulltext Access 12 Pages 2006
A Novel Approach for Identification and Characterization of Glycoproteins Using a Hybrid Linear Ion Trap/FT-ICR Mass Spectrometer Fulltext Access 12 Pages 2006
On the Distributions of Ion/Neutral Molecule Clusters in Electrospray and Laser Spray—A Cluster Division Model for the Electrospray Process Fulltext Access 12 Pages 2006
Analysis of Native Milk Oligosaccharides Directly from Thin-Layer Chromatography Plates by Matrix-Assisted Laser Desorption/Ionization Orthogonal-Time-of-Flight Mass Spectrometry with a Glycerol Matrix Fulltext Access 12 Pages 2006
Characterization of Cardiolipin as the Sodiated Ions by Positive-Ion Electrospray Ionization with Multiple Stage Quadrupole Ion-Trap Mass Spectrometry Fulltext Access 12 Pages 2006
Evaluation of Binding of Perylene Diimide and Benzannulated Perylene Diimide Ligands to DNA by Electrospray Ionization Mass Spectrometry Fulltext Access 12 Pages 2006
Analysis of Protein-Protein Interaction Surfaces Using a Combination of Efficient Lysine Acetylation and nanoLC-MALDI-MS/MS Applied to the E9:Im9 Bacteriotoxin—Immunity Protein Complex Fulltext Access 12 Pages 2006
Mechanisms for the Selective Gas-Phase Fragmentation Reactions of Methionine Side Chain Fixed Charge Sulfonium Ion Containing Peptides Fulltext Access 12 Pages 2006
Tandem Mass Spectrometric Analysis of a Complex Triterpene Saponin Mixture of Chenopodium quinoa Fulltext Access 12 Pages 2006
Toward Building a Database of Bifunctional Probes for the MS3D Investigation of Nucleic Acids Structures Fulltext Access 12 Pages 2006
Identification and Characterization of EX1 Kinetics in H/D Exchange Mass Spectrometry by Peak Width Analysis Fulltext Access 12 Pages 2006
Molecular dynamics simulations to aid the rational design of organic friction modifiers Fulltext Access 12 Pages 2006
Homology modeling of human sialidase enzymes NEU1, NEU3 and NEU4 based on the crystal structure of NEU2: Hints for the design of selective NEU3 inhibitors Fulltext Access 12 Pages 2006
Synthesis and activity of a new class of pathway-selective estrogen receptor ligands: Hydroxybenzoyl-3,4-dihydroquinoxalin-2(1H)-ones Fulltext Access 12 Pages 2006
Synthesis and biological evaluation of new non-imidazole H3-receptor antagonists of the 2-aminobenzimidazole series Fulltext Access 12 Pages 2006
Structure–intrinsic activity relationship studies in the group of 1-imido/amido substituted 4-(4-arylpiperazin-1-yl)cyclohexane derivatives; new, potent 5-HT1A receptor agents with anxiolytic- like activity Fulltext Access 12 Pages 2006
Analogs of 1α,25-dihydroxyvitamin D3 with high potency in induction of osteoclastogenesis and prevention of dendritic cell differentiation: Synthesis and biological evaluation of 2-substituted 19-norvitamin D analogs Fulltext Access 12 Pages 2006
4,5-Diaryl-1H-pyrrole-2-carboxylates as combretastatin A-4/lamellarin T hybrids: Synthesis and evaluation as anti-mitotic and cytotoxic agents Fulltext Access 12 Pages 2006
Synthesis of 7-amino-3a,4-dihydro-3H-[1]benzopyrano[4,3-c]isoxazole derivatives displaying combined α2-adrenoceptor antagonistic and 5-HT reuptake inhibiting activities Fulltext Access 12 Pages 2006
Anti-inflammatory profile of some synthesized heterocyclic pyridone and pyridine derivatives fused with steroidal structure Fulltext Access 12 Pages 2006
Efficient approach to acyloxymethyl esters of nalidixic acid and in vitro evaluation as intra-ocular prodrugs Fulltext Access 12 Pages 2006
QSAR studies about cytotoxicity of benzophenazines with dual inhibition toward both topoisomerases I and II: 3D-MoRSE descriptors and statistical considerations about variable selection Fulltext Access 12 Pages 2006
Stereoselective allyl transfer to chiral α-methoxycarbaldehydes: A model study related to the C-9/C-15 fragment of geldanamycin Fulltext Access 12 Pages 2006
Targeting integrins: Insights into structure and activity of cyclic RGD pentapeptide mimics containing azabicycloalkane amino acids Fulltext Access 12 Pages 2006
Novel boronated derivatives of 5,10,15,20-tetraphenylporphyrin: Synthesis and toxicity for drug-resistant tumor cells Fulltext Access 12 Pages 2006
Novel properties of malarial S-adenosylmethionine decarboxylase as revealed by structural modelling Fulltext Access 12 Pages 2006
Synthesis and anticonvulsant activity of a class of 2-amino 3-hydroxypropanamide and 2-aminoacetamide derivatives Fulltext Access 12 Pages 2006
Drug Guru: A computer software program for drug design using medicinal chemistry rules Fulltext Access 12 Pages 2006
Development of new CoMFA and CoMSIA 3D-QSAR models for anti-inflammatory phthalimide-containing TNFα modulators Fulltext Access 12 Pages 2006
Synthesis and biological evaluation of 4-morpholino-2-phenylquinazolines and related derivatives as novel PI3 kinase p110α inhibitors Fulltext Access 12 Pages 2006
Design and synthesis of 3,4-methylenedioxy-6-nitrophenoxyacetylhydrazone derivatives obtained from natural safrole: New lead-agents with analgesic and antipyretic properties Fulltext Access 12 Pages 2006
Synthesis and biological evaluation of a novel class of rofecoxib analogues as dual inhibitors of cyclooxygenases (COXs) and lipoxygenases (LOXs) Fulltext Access 12 Pages 2006
Synthesis, antimycobacterial and antitumor activities of new (1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)methyl N,N-disubstituted dithiocarbamate/O-alkyldithiocarbonate derivatives Fulltext Access 12 Pages 2006
Design, synthesis, and biological evaluation of (E)-3-(4-methanesulfonylphenyl)-2-(aryl)acrylic acids as dual inhibitors of cyclooxygenases and lipoxygenases Fulltext Access 12 Pages 2006
Determinants of substrate specificity in KdcA, a thiamin diphosphate-dependent decarboxylase Fulltext Access 12 Pages 2006
Enantiomeric impurities in chiral synthons, catalysts, and auxiliaries: Part 3 Fulltext Access 12 Pages 2006