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Daneshyari Drug Discovery Journas Latest Articles

Drug Discovery Research Articles

1,7-Electrocyclization reactions of stabilized α,β:γ,δ-unsaturated azomethine ylides
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Thermal cyclization of 1,2-dialkynylimidazoles to imidazo[1,2-a]pyridines
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Preparation of trifluoromethylated ynamines and their reactions with some electrophilic reagents
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Explicit and implicit solvation of radical ions: the cycloreversion of CPD dimers
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Synthesis of novel poly(ethylene glycol) supported benzazepines: the crucial role of PEG on the selectivity of an intramolecular Heck reaction
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Synthesis of conjugated 2 and 2,5-(ethenyl) and (ethynyl)phenylethynyl thiophenes: fluorescence properties
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Unusual anomeric rearrangement of para-nitrobenzoylxanthate d-glycosides: a new direct stereoselective access to α-thioglycosides from pyranose sugars
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Enantioselective homoallyl-cyclopropanation of dibenzylideneacetone by modified allylindium halide reagents-rapid access to enantioenriched 1-styryl-norcarene
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Use of a highly effective intramolecular Pauson-Khand cyclisation for the formal total synthesis of (±)-α- and β-cedrene by preparation of cedrone
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Enantioselective cyanocarbonation of ketones with chiral base
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Vinyl bis-sulfone methodology in thiosugars: selective access to chiral thiovinyl sulfones and PSE oxathianes
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Dimerization of (+)-myrmicarin 215B. A potential biomimetic approach to complex myrmicarin alkaloids
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Synthesis of some multi-β-substituted cationic porphyrins and studies on their interaction with DNA
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Synthesis of vinylpyrroles, vinylfurans and vinylindoles via a Brønsted acid catalyzed highly regio- and stereoselective cis-hydroarylation of ynamides
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Conformationally controlled (entropy effects), stereoselective vibrational quenching of singlet oxygen in the oxidative cleavage of oxazolidinone-functionalized enecarbamates through solvent and temperature variations
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Selenocyclisations of homoallylic sulfonamides: stereoselective methods for the elaboration of substituted pyrrolidines, pyrrolines and derivatives
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Spontaneous Nef reaction of 3-aryl-2-(diethoxyphosphoryl)-4-nitroalkanoic acids
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Synthesis of calix[4]arene(amido)monocrowns and their photoresponsive derivatives
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Mechanistic studies of amination of ketenimines: change of rate-determining step by N-substituents through electronic effects
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Use of Stille-type cross-coupling as a route to oligopyridylimines
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Reactivity and regioselectivity in the synthesis of spiroindoles via indole o-quinodimethanes. An experimental and computational study
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Chiral discrimination of ibuprofen isomers in β-cyclodextrin inclusion complexes: experimental (NMR) and theoretical (MD, MM/GBSA) studies
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Synthesis of bridged nicotinates having [n](2,5)pyridinophane skeletons (n=8-14)
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Stereoselective synthesis of 2-hydroxymorpholines and aminodiols via a three-component boro-Mannich reaction
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10b-Substituted hexahydropyrrolo-isoquinolines: studies on diastereoselective formation of a quaternary carbon stereocenter via N-acyliminium ion cyclization
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A microwave-enhanced, solventless Mannich condensation of terminal alkynes and secondary amines with para-formaldehyde on cuprous iodide doped alumina
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Annulated 1,2,3,4-tetrahydro-β-carbolines by intramolecular Mannich-type amino- and amidoalkylations of N(9)-(ω-nitroalkyl)-3,4-dihydro-β-carbolines
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Cyanoesterification of norbornenes catalyzed by palladium: facile synthetic methodology to introduce cyano and ester functionalities via direct carbon-carbon bond cleavage of cyanoformates
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Intermolecular cycloaddition of nonstabilized azomethine ylides generated from 1,3-thiazolidine-4-carboxylic acids: synthesis of 5,7a-dihydro-1H,3H-pyrrolo[1,2-c]thiazoles
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Synthesis of cesium selective pyridyl azocalix[n]arenes
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The total synthesis of pamamycin-607. Part 2: Synthesis of the C6-C18 domain
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A concise synthesis of novel naphtho[a]carbazoles and benzo[c]carbazoles
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Ab initio study of molecular structures and excited states in anthocyanidins
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Phosphines catalyzed nucleophilic addition of azoles to allenes: synthesis of allylazoles and indolizines
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Synthesis of chiral allenes from ynamides through a highly stereoselective Saucy-Marbet rearrangement
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Metabotropic glutamate receptor targets for neuropsychiatric disorders
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Cyclization and rearrangement products from coupling reactions between terminal o-alkynylphenols or o-ethynyl(hydroxymethyl)benzene and 6-halopurines
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Derivatives of arylhydrazonic acids. Part 3: Stereochemical rearrangement of Z-oxanilo-N1-dialkyl-N2-arylamidrazones
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Synthesis of 5-aryl-2-oxopyrrole derivatives as synthons for highly substituted pyrroles
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Conformationally restricted triplex-forming oligonucleotides (TFOs). Binding properties of α-l-LNA and introduction of the N7-glycosylated LNA-guanosine
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The effect of boronic acid-positioning in an optical glucose-sensing ensemble
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Synthesis of protected derivatives and short peptides of antAib, a novel Cα-tetrasubstituted α-amino acid of the Ac5c type possessing a fused anthracene fluorophore
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Organocatalyzed route to enantioenriched pipecolic esters: decarboxylation of an aminomalonate hemiester
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An approach to triquinane synthesis using the Pauson-Khand reaction
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3-Nitrochromene derivatives as 2π components in 1,3-dipolar cycloadditions of azomethine ylides
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Tautomeric equilibria in the reaction products of asymmetric 1,3-diamines with β-dicarbonyl compounds
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Efficient catalytic asymmetric synthesis of α-substituted phenyloxyacetyloxy and aroyloxy phosphonates
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5-Phenylthio-1,3-oxazinan-4-ones via hetero Diels-Alder reactions: synthesis of (R)- and (S)-Duloxetines and Fluoxetines
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π-Allyl palladium approach toward the diazabicyclo[3.2.1]octane core of the naphthyridinomycin alkaloids
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Mechanisms of perinatal brain damage and protective possibilities
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Oncology exploration: charting cancer medicinal chemistry space
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Status of text-mining techniques applied to biomedical text
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Molecular flexibility in protein–DNA interactions
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Molecular solutions to the binary integer programming problem based on DNA computation
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Signal processing properties of fast spiking interneurons
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Compensation effect of the MAPK cascade on formation of phospho-protein gradients
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Prediction of regulatory pathways using mRNA expression and protein interaction data: Application to identification of galactose regulatory pathway
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Studies on the chemistry of thienoanellated O,N- and S,N-containing heterocycles. Part 30: Synthesis and pharmacological properties of thieno[2,3-b][1,4]thiazines with potential vasopressin receptor antagonistic activity
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Synthesis and characterization of selective dopamine D2 receptor antagonists
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Constructing plasma protein binding model based on a combination of cluster analysis and 4D-fingerprint molecular similarity analyses
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Synthetic utility of glycosyl triazoles in carbohydrate chemistry
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Surveying approaches to the formation of carbon-carbon bonds between a pyran and an adjacent ring
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Transformations of lignans. Part 11: Oxidation of diphyllin with hypervalent iodine reagents and reductive reactions of a resulting 1-methoxy-1-aryl-4-oxonaphthalene lactone
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Efficient synthesis and structural analysis of new dioxopiperazine isoquinolines
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A new convergent and stereoselective synthesis of 2,5-disubstituted N-acylpyrrolidines
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Aromatic homolytic substitution using solid phase synthesis
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Graphical contents list
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Molecular receptors for monosaccharides: di(pyridyl)naphthyridine and di(quinolyl)naphthyridine
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Reactions of some anellated 2-aminothiophenes with electron poor acetylenes
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New diterpenes of the pseudopterane class from two closely related Pseudopterogorgia species: isolation, structural elucidation, and biological evaluation
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Synthesis and reactivity of trans-2-aryl-3-chloroazetidines
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Radical dearomatization of benzene leading to phenanthridine and phenanthridinone derivatives related to (±)-pancratistatin
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Efficient synthesis of carbopeptoid oligomers: insight into mimicry of β-peptide
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Novel 5-(2-hydroxyphenyl)-3-substituted-2,3-dihydro-1,3,4-oxadiazole-2-thione derivatives: Promising anticancer agents
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Microwave-assisted regioselective synthesis of natural 6-prenylpolyhydroxyisoflavones and their hydrates with hypervalent iodine reagents
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Process research on arylnaphthalene lignan aza-analogues: a new palladium-catalyzed benzannulation of α,β-bisbenzylidenesuccinic acid derivatives
Fulltext Access 11 Pages 2006
Generation and electrophilic substitution reactions of 3-lithio-2-methyleneaziridines
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Structure, intramolecular flexibility, and complexation of aza crown ethers to anions H2PO4− and HSO4− in nonprotic solvents
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Homonuclear Diels-Alder dimerization of 5-ethenyl-2-phenylsulfanyl-1H-imidazoles and its application to synthesis of 12,12′-dimethylageliferin
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Stereochemically pure α-trifluoromethyl-malic hydroxamates: synthesis and evaluation as inhibitors of matrix metalloproteinases
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Studies on the reduction of the nitro group in 3-aryl-2-methylene-4-nitro-alkanoates afforded by the Baylis-Hillman adducts: synthesis of 4-aryl-3-methylene-2-pyrrolidinones and 3-(1-alkoxycarbonyl-vinyl)-1H-indole-2-carboxylates
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The enolate anions of chlorophylls a and b as ambident nucleophiles in oxidations with (−)- or (+)-(10-camphorsulfonyl)oxaziridine. Synthesis of 132(S/R)-hydroxychlorophylls a and b
Fulltext Access 11 Pages 2006
Selenium-containing heterocycles from isoselenocyanates: synthesis of 2-methylidene-1,3-selenazolidine derivatives
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Synthesis and ring transformations of 1-amino-1,2,3,9a-tetrahydroimidazo[1,2-a]indol-2(9H)-ones
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Synthesis of thiol-modified peptide nucleic acids designed for post-assembly conjugation reactions
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