Parallel regulation by olanzapine of the patterns of expression of 5-HT2A and D3 receptors in rat central nervous system and blood cells Fulltext Access 10 Pages 2006
Neuropeptide Y and corticotropin-releasing factor bi-directionally modulate inhibitory synaptic transmission in the bed nucleus of the stria terminalis Fulltext Access 10 Pages 2006
Regulation of m1 muscarinic receptors and nNOS mRNA levels by autoantibodies from schizophrenic patients Fulltext Access 10 Pages 2006
The human Ca2+-activated K+ channel, IK, can be blocked by the tricyclic antihistamine promethazine Fulltext Access 10 Pages 2006
CYP2B6 is expressed in African Green monkey brain and is induced by chronic nicotine treatment Fulltext Access 10 Pages 2006
mGlu1 and mGlu5 receptor antagonists lack anticonvulsant efficacy in rodent models of difficult-to-treat partial epilepsy Fulltext Access 10 Pages 2006
Enhancement of AP-1 DNA-binding activity during amphetamine- and phencyclidine-mediated behaviour in rats Fulltext Access 10 Pages 2006
Disinhibition of spinal responses to primary afferent input by antagonism at GABA receptors in urethane-anaesthetised rats is dependent on NMDA and metabotropic glutamate receptors Fulltext Access 10 Pages 2006
Diclofenac, a non-steroidal anti-inflammatory drug, suppresses apoptosis induced by endoplasmic reticulum stresses by inhibiting caspase signaling Fulltext Access 10 Pages 2006
Glycine release in the substantia nigra: Interaction with glutamate and GABA Fulltext Access 10 Pages 2006
Modulation of Δ9-THC-induced increase of cortical and hippocampal acetylcholine release by μ opioid and D1 dopamine receptors Fulltext Access 10 Pages 2006
Depolarization and Ca2+ downregulate CB1 receptors and CB1-mediated signaling in cerebellar granule neurons Fulltext Access 10 Pages 2006
Novel neuroprotective effects of the aqueous extracts from Verbena officinalis Linn Fulltext Access 10 Pages 2006
Antinociceptive activity of chemical congeners of improgan: Optimization of side chain length leads to the discovery of a new, potent, non-opioid analgesic Fulltext Access 10 Pages 2006
Activation of metabotropic glutamate receptors induces propagating network oscillations in the intact cerebral cortex of the newborn mouse Fulltext Access 10 Pages 2006
Quantitative mapping shows that serotonin rather than dopamine receptor mRNA expressions are affected after repeated intermittent administration of MDMA in rat brain Fulltext Access 10 Pages 2006
4-Aminopyridine, a Kv channel antagonist, prevents apoptosis of rat cerebellar granule neurons Fulltext Access 10 Pages 2006
HU0622: A small molecule promoting GAP-43 activation and neurotrophic effects Fulltext Access 10 Pages 2006
Effect of extracellular pH on recombinant α1β2γ2 and α1β2 GABAA receptors Fulltext Access 10 Pages 2006
Mid- to late gestational morphine exposure does not alter the rewarding properties of morphine in adult male rats Fulltext Access 10 Pages 2006
Elevated T-maze evaluation of anxiety and memory effects of NMDA/glycine-B site ligands injected into the dorsal periaqueductal gray matter and the superior colliculus of rats Fulltext Access 10 Pages 2006
The acrylamide (S)-1 differentially affects Kv7 (KCNQ) potassium channels Fulltext Access 10 Pages 2006
Effects of non-competitive AMPA receptor antagonists injected into some brain areas of WAG/Rij rats, an animal model of generalized absence epilepsy Fulltext Access 10 Pages 2006
The role of group I metabotropic glutamate receptors in acquisition and expression of contextual and auditory fear conditioning in rats – a comparison Fulltext Access 10 Pages 2006
Ethanol effects on electrophysiological properties of astrocytes in striatal brain slices Fulltext Access 10 Pages 2006
Central cholinergic modulation of blood pressure short-term variability Fulltext Access 10 Pages 2006
Herbal melanin modulates tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6) and vascular endothelial growth factor (VEGF) production Fulltext Access 10 Pages 2006
Region-specific effects of STW 5 (Iberogast®) and its components in gastric fundus, corpus and antrum Fulltext Access 10 Pages 2006
STW 5 (Iberogast®) and its individual herbal components modulate intestinal electrophysiology of mice Fulltext Access 10 Pages 2006
Antidepressant-like activity of a Kampo (Japanese herbal) medicine, Koso-san (Xiang-Su-San), and its mode of action via the hypothalamic–pituitary–adrenal axis Fulltext Access 10 Pages 2006
Improvement of accessory symptoms of hypertension by TSUMURA Orengedokuto Extract, a four herbal drugs containing Kampo-Medicine Granules for ethical use: A double-blind, placebo-controlled study Fulltext Access 10 Pages 2006
The cannabinoid receptor antagonist SR-141716A induces penile erection in male rats: Involvement of paraventricular glutamic acid and nitric oxide Fulltext Access 10 Pages 2006
Galanin receptor-1 knockout mice exhibit spontaneous epilepsy, abnormal EEGs and altered inhibition in the hippocampus Fulltext Access 10 Pages 2006
1-Methyl-1,2,3,4-tetrahydroisoquinoline enhances the anticonvulsant action of carbamazepine and valproate in the mouse maximal electroshock seizure model Fulltext Access 10 Pages 2006
Expression of opioid receptors and c-fos in CB1 knockout mice exposed to neuropathic pain Fulltext Access 10 Pages 2006
A pharmacological investigation of the role of GLUK5-containing receptors in kainate-driven hippocampal gamma band oscillations Fulltext Access 10 Pages 2006
No cancer in cancers: Evolutionary trade-off between successful viviparity and tumor escape from the adaptive immune system Fulltext Access 10 Pages 2006
Effects of repeated tianeptine treatment on CRF mRNA expression in non-stressed and chronic mild stress-exposed rats Fulltext Access 10 Pages 2006
Antihyperalgesic effects of local injections of anandamide, ibuprofen, rofecoxib and their combinations in a model of neuropathic pain Fulltext Access 10 Pages 2006
Fos immunolabelling evidence for brain regions involved in the Pavlovian degraded contingency effect and in its disruption by atropine Fulltext Access 10 Pages 2006
An AMPA glutamatergic receptor activation-nitric oxide synthesis step signals transsynaptic apoptosis in limbic cortex Fulltext Access 10 Pages 2006
L-type calcium channel ligands block nicotine-induced signaling to CREB by inhibiting nicotinic receptors Fulltext Access 10 Pages 2006
Mechanism of β-bungarotoxin in facilitating spontaneous transmitter release at neuromuscular synapse Fulltext Access 10 Pages 2006
Aversive stimulus properties of the 5-HT2C receptor agonist WAY 161503 in rats Fulltext Access 10 Pages 2006
Null mutation of the α4 nicotinic receptor subunit increases the propensity of muscarinic-mediated neuronal bursting in mouse hippocampal slices Fulltext Access 10 Pages 2006
Participation of α-melanocyte stimulating hormone in ethanol-induced anxiolysis and withdrawal anxiety in rats Fulltext Access 10 Pages 2006
κ-Opioid receptor modulation of accumbal dopamine concentration during operant ethanol self-administration Fulltext Access 10 Pages 2006
Construction of Several Human-derived Stable Cell Lines Displaying Distinct Profiles of CYP3A4 Induction Fulltext Access 10 Pages 2006
In vivo tumor targeting of tumor necrosis factor-α-loaded stealth nanoparticles: Effect of MePEG molecular weight and particle size Fulltext Access 10 Pages 2006
Spray freezing into liquid versus spray-freeze drying: Influence of atomization on protein aggregation and biological activity Fulltext Access 10 Pages 2006
Novel transmucosal absorption enhancers obtained by aminoalkylation of chitosan Fulltext Access 10 Pages 2006
Electrostatic characterisation of inhaled powders: Effect of contact surface and relative humidity Fulltext Access 10 Pages 2006
Review of global regulations concerning biowaivers for immediate release solid oral dosage forms Fulltext Access 10 Pages 2006
Formulation of poorly water-soluble drugs for oral administration: Physicochemical and physiological issues and the lipid formulation classification system Fulltext Access 10 Pages 2006
Biliary secretion of rosuvastatin and bile acids in humans during the absorption phase Fulltext Access 10 Pages 2006
Distinct effects of sucrose and trehalose on protein stability during supercritical fluid drying and freeze-drying Fulltext Access 10 Pages 2006
The effect of solvent polarity on the accumulation of leachables from pharmaceutical product containers Fulltext Access 10 Pages 2006
Prediction of the pharmacokinetics of succinylated human serum albumin in man from in vivo disposition data in animals and in vitro liver slice incubations Fulltext Access 10 Pages 2006
Assessment of Induction of Cytochrome P450 by NO-1886 (Ibrolipim), a Lipoprotein Lipase-Promoting Agent, in Primary Cultures of Human Hepatocytes and in Female Rat Liver Fulltext Access 10 Pages 2006
Transformation of vesicular into cubic nanoparticles by autoclaving of aqueous monoolein/poloxamer dispersions Fulltext Access 10 Pages 2006
Induction of Human P-Glycoprotein in Caco-2 cells: Development of a Highly Sensitive Assay System for P-Glycoprotein-Mediated Drug Transport Fulltext Access 10 Pages 2006
Metabolic and Non-Metabolic Factors Determining Troglitazone Hepatotoxicity: A Review Fulltext Access 10 Pages 2006
Novel Genetic Variations and Haplotypes of Hepatocyte Nuclear Factor 4α(HNF4A) Pound in Japanese Type II Diabetic Patients Fulltext Access 10 Pages 2006
In vivo Evaluation of Coumarin and Nicotine as Probe Drugs to Predict the Metabolic Capacity of CYP2A6 Due to Genetic Polymorphism in Thais Fulltext Access 10 Pages 2006
Evaluation of Human CYP1A2 and CYP3A4 mRNA Expression in Hepatocytes from Chimeric Mice with Humanized Liver Fulltext Access 10 Pages 2006
Fluoroalkyl derivatives of dihydrotetrabenazine as positron emission tomography imaging agents targeting vesicular monoamine transporters Fulltext Access 10 Pages 2006
Synthesis and in vivo evaluation of [O-methyl-11C](2R,4R)-4-hydroxy-2-[2-[2-[2-(3-methoxy)phenyl]ethyl]phenoxy]ethyl-1-methylpyrrolidine as a 5-HT2A receptor PET ligand Fulltext Access 10 Pages 2006
Multidrug resistance mediated by ABC transporters in osteosarcoma cell lines: mRNA analysis and functional radiotracer studies Fulltext Access 10 Pages 2006
The lethal effect of bis-type azridinylnaphthoquinone derivative on oral cancer cells (OEC-M1) associated with anti-apoptotic protein bcl-2 Fulltext Access 10 Pages 2006
Synthesis and structure–activity relationships of novel indirubin derivatives as potent anti-proliferative agents with CDK2 inhibitory activities Fulltext Access 10 Pages 2006
Acidity constants in methanol/water mixtures of polycarboxylic acids used in drug salt preparations: Potentiometric determination of aqueous pKa values of quetiapine formulated as hemifumarate Fulltext Access 10 Pages 2006
A method for extracting muscle information from serum creatine kinase measurements – Its potential value in the monitoring and management of inflammatory muscle disease Fulltext Access 10 Pages 2006
α-Thiolamines such as cysteine and cysteamine act as effective transglycating agents due to formation of irreversible thiazolidine derivatives Fulltext Access 10 Pages 2006
A nutritional supplement formula for influenza A (H5N1) infection in humans Fulltext Access 10 Pages 2006
Is there a causal relationship between the receipt of blood transfusions and the development of chronic lung disease of prematurity? Fulltext Access 10 Pages 2006
Chromosomal fragility, structural rearrangements and mobile element activity may reflect dynamic epigenetic mechanisms of importance in neurobehavioural genetics Fulltext Access 10 Pages 2006
Cancer cachexia demonstrates the energetic impact of gluconeogenesis in human metabolism Fulltext Access 10 Pages 2006
Bronchial epilepsy or broncho-pulmonary hyper-excitability as a model of asthma pathogenesis Fulltext Access 10 Pages 2006
Is there an emerging endosymbiotic relationship between mycobacteria and the human host based on horizontal transfer of genetic sequences? Fulltext Access 10 Pages 2006
The functional evaluation of human peptide/histidine transporter 1 (hPHT1) in transiently transfected COS-7 cells Fulltext Access 10 Pages 2006
Solid lipid nanoparticles of mitoxantrone for local injection against breast cancer and its lymph node metastases Fulltext Access 10 Pages 2006
Stabilization of solid dispersions of nimodipine and polyethylene glycol 2000 Fulltext Access 10 Pages 2006
Boosting support vector regression in QSAR studies of bioactivities of chemical compounds Fulltext Access 10 Pages 2006
A comparison of morphology and surface energy characteristics of sulfathiazole polymorphs based upon single particle studies Fulltext Access 10 Pages 2006
Bioavailability of seocalcitol: II: Development and characterisation of self-microemulsifying drug delivery systems (SMEDDS) for oral administration containing medium and long chain triglycerides Fulltext Access 10 Pages 2006
Influences of excipients on in vitro release and in vivo performance of tetanus toxoid loaded polymer particles Fulltext Access 10 Pages 2006
Doxorubicin encapsulation and diffusional release from stable, polymeric, hydrogel nanoparticles Fulltext Access 10 Pages 2006
Cyclodextrins in the production of large porous particles: Development of dry powders for the sustained release of insulin to the lungs Fulltext Access 10 Pages 2006
Evaluation of the in vitro activity and in vivo bioavailability of realgar nanoparticles prepared by cryo-grinding Fulltext Access 10 Pages 2006
In situ gelling, bioadhesive nasal inserts for extended drug delivery: In vitro characterization of a new nasal dosage form Fulltext Access 10 Pages 2006