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Daneshyari Drug Discovery Journas Latest Articles

Drug Discovery Research Articles

Photomediated synthesis of β-alkylketones from cycloalkanes
Fulltext Access 9 Pages 2006
Synthesis of new, BODIPY-based sensors and labels
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Synthesis and properties of N,N′-dialkylimidazolium bis(nonafluorobutane-1-sulfonyl)imides: a new subfamily of ionic liquids
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Regioselective synthesis of polysubstituted benzenes from Baylis-Hillman adducts via [4+2] annulation protocol
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Mg-promoted reductive coupling of aromatic carbonyl compounds with trimethylsilyl chloride and bis(chlorodimethylsilyl) compounds
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Novel crowned-porphyrin ligands. Synthesis and conformational studies
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An effective method for the preparation of mono N-alkyl derivatives of 1,1′-bis(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline)
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Synthesis and X-ray crystallographic analysis of chiral pyridyl substituted carbocyclic molecular clefts
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5-Nitroisocoumarins from tandem Castro-Stephens coupling-6-endo-dig cyclisation of 2-iodo-3-nitrobenzoic acid and arylethynes and ring-closure of methyl 2-alkynyl-3-nitrobenzoates with electrophiles
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Highly stereoselective synthesis of perhydropyrano[2,3-b]pyrans from the new 3-methylidenepentane-1,5-dianion synthon
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Graphical contents list
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New conditions for the synthesis of thiophenes via the Knoevenagel/Gewald reaction sequence. Application to the synthesis of a multitargeted kinase inhibitor
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Facile biomimetic syntheses of the azaspiracid spiroaminal
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A DFT study for the formation of imidazo[1,2-c]pyrimidines through an intramolecular Michael addition
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1H and 13C NMR assignments of the three dicyclopenta-fused pyrene congeners
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Synthesis of 4-(3-hydroxyalkyl)pyrimidines by ring transformation reactions of 2-alkylidenetetrahydrofurans with amidines
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Sesterterpene metabolites from the sponge Hyatella intestinalis
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Screening of ligands in the asymmetric metallocenethiolatocopper(I)-catalyzed allylic substitution with Grignard reagents
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Unexpected formation of N,N-disubstituted formamidines from aromatic amines, formamides and trifluoroacetic anhydride
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N-Acyltrifluoromethanesulfonamides as new chemoselective acylating agents for aliphatic and aromatic amines
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Indirect catalytic epoxidation with hydrogen peroxide electrogenerated in ionic liquids
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Asymmetric epoxidation of cis-alkenes with arabinose-derived ketones: enantioselective synthesis of the side chain of Taxol®
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2-(2-Hydroxyaryl)cinnamic amides: a new class of axially chiral molecules
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Triazolopeptides: chirospecific synthesis and cis/trans prolyl ratios of structural isomers
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Intramolecular electrophilic hydroarylation via Claisen rearrangement: synthesis of chromenes, heterothiochromenes and heterodihydrothiochromenes
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Photochemical substitution of olefins and aromatic compounds with difluoromethyl radicals bearing ester and phosphonate groups
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Reactions of carbanions derived from α-substituted-methyl tolyl sulfones with quinone methides as Michael acceptors
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A new route for the preparation of the 22,23-dioxocholestane side chain from diosgenin and its application to the stereocontrolled construction of the 22R,23S-diol function
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Substituent effects on the 31P NMR chemical shifts of arylphosphorothionates
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Ytterbium-catalyzed dual intermolecular hydrophosphination: synthesis of bis(phosphinyl)dienes and bis(alkenyl)phosphine oxides
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A new approach towards peptidosulfonamides: synthesis of potential inhibitors of bacterial peptidoglycan biosynthesis enzymes MurD and MurE
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Oxidation and ring cleavage reactions of 3-benzhydrylchromones. Generation of triarylmethine cations from methylidenechroman-4-ones and benzopyrano[4,3-c]pyrazoles
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An entry to 7-amino- and to 2-ethoxycarbonyl-5-dethia-5-oxa-cephams from 1,3-alkylidene-l-erythritol
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An efficient synthetic methodology of chiral isoquinuclidines by the enantioselective Diels-Alder reaction of 1,2-dihydropyridines using chiral cationic palladium-phosphinooxazolidine catalyst
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Regioselective hydroxylation of phenols by simultaneous photochemical generation of phenol cation-radical and hydroxyl radical
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Total synthesis of (±)-herbertenediol
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Synthesis and conformational analysis of tetrahydroisoquinoline- and piperidine-fused 1,3,4,2-oxadiazaphosphinanes, new ring systems
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Solid-state tubular assemblies of thiolactones: synthesis and structural characterization
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Friedel-Crafts acylation reaction using carboxylic acids as acylating agents
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Platinum-catalyzed allylation of aminonaphthalenes with allylic acetates
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The methoxycarbonylcarbene insertion into 1,3-dithiolane and 1,3-oxathiolane rings
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Enantioselective oxidation of olefins catalyzed by chiral copper bis(oxazolinyl)pyridine complexes: a reassessment
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Polybrominated diphenyl ethers (BDEs); preparation of reference standards and fluorinated internal analytical standards
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Synthesis of formyl-thienylpyrroles: versatile building blocks for NLO materials
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Graphical contents list
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Oxidative cyclization of N-alkyl-o-methyl-arenesulfonamides to biologically important saccharin derivatives
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Mesitylene based azo-coupled chromogenic tripodal receptors-a visual detection of Ag(I) in aqueous medium
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11,16 Oxetane lactones. Spectroscopic evidences and conformational analysis
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Intramolecular charge transfer dual fluorescent sensors from 4-(dialkylamino)benzanilides with metal binding site within electron acceptor
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Enantioselective total synthesis of both diastereomers of preclavulone-A methyl ester
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An efficient synthesis of highly substituted pyrroles from β-oxodithiocarboxylates
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Synthesis of β-hydroxy sulfones via opening of hydrophilic epoxides with zinc sulfinates in aqueous media
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Synthesis and structural characterisation of novel platinum-based drug candidates with extended functionality by incorporation of bis(diphenylphosphino)ferrocene units as metal chelators
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Two-way enantioselective control in the epoxidation of alkenes with the keto bile acid-Oxone® system
Fulltext Access 9 Pages 2006
Studies on electrophilic addition reaction of 2,3-allenoates with PhSeCl
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Highly efficient and practical phosphoramidite-copper catalysts for amination of aryl iodides and heteroaryl bromides with alkylamines and N(H)-heterocycles
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First synthesis of a steroid containing an unstable 19-nor-androsta-1,5-dien-3-one system
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Synthesis and characterization of porphyrin-ferrocene-fullerene triads
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Synthesis of 7H-indolo[2,3-c]quinolines: study of the Pd-catalyzed intramolecular arylation of 3-(2-bromophenylamino)quinolines under microwave irradiation
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Synthesis of original thiazoloindolo[3,2-c]quinoline and novel 8-N-substituted-11H-indolo[3,2-c]quinoline derivatives from benzotriazoles. Part I
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New axially dissymmetric ligand recoverable with fluorous solvent
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A glycal approach towards an efficient and stereodivergent synthesis of polyhydroxypyrrolidines
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Domino Mukaiyama-Michael reactions in the synthesis of polycyclic systems
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Complementary regioselective esterification of non-reducing oligosaccharides catalyzed by different hydrolases
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Efficient sulfonation of 1-phenylsulfonyl-1H-pyrroles and 1-phenylsulfonyl-1H-indoles using chlorosulfonic acid in acetonitrile
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Effect of ionic liquid organizing ability and amine structure on the rate and mechanism of base induced elimination of 1,1,1-tribromo-2,2-bis(phenyl-substituted)ethanes
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Formation of benzylamines from triazene compounds via a 1,2-proton shift
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New antitumor sesquiterpenoids from Santalum album of Indian origin
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Construction of C-nucleosides diversified by [3+2] cycloaddition from a sugar-based mesoionic ring
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Alternative syntheses of the D2d symmetric 1,3,5,7-tetraiodotricyclo[3.3.0.03,7]octane
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New microviridins from a water bloom of the cyanobacterium Microcystis aeruginosa
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Synthesis and biological evaluation of anthranilamide-based non-peptide mimetics of ω-conotoxin GVIA
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Isotopic labelling of quercetin 3-glucoside
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Nickel-mediated cyclization of enynes under an atmosphere of carbon dioxide
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Nickel-catalyzed multi-component connection reaction of isoprene, aldimines (lactamines), and diphenylzinc
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A new approach for the asymmetric syntheses of 2-epi-deoxoprosopinine and azasugar derivatives
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Enantioselective synthesis of 2-substituted-1,4-diketones from (S)-mandelic acid enolate and α,β-enones
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Effect of a perfluorocyclopentene core unit on the structures and photoluminescence of fluorene- and anthracene-based compounds
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Oxidative cleavage of ribofuranose 5-(α-hydroxyphosphonates): a route to erythrofuranose-based nucleoside phosphonic acids
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Regioselective dehydrogenation of 3,4-dihydropyrimidin-2(1H)-ones mediated by ceric ammonium nitrate
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Enantioselective synthesis and absolute configurations of aculeatins A, B, D, and 6-epi-aculeatin D
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Graphical contents list
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Disproportionation reaction of diarylmethylisopropyl ethers: a versatile access to diarylmethanes from diarylcarbinols speeded up by the use of microwave irradiation
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Synthesis of calixarene-cyclodextrin coupling products
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Hydrogen bonding-mediated self-assembly of anthranilamide-based homodimers through preorganization of the amido and ureido binding sites
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Density functional theory calculations and experimental parameters for mutarotation of 6-deoxy-l-mannopyranosyl hydrazine
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Synthesis of phosphorus dendrimers bearing chromophoric end groups: toward organic blue light-emitting diodes
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Graphical contents list
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Synthesis and separation of the atropisomers of 2-(5-benzo[b]fluorenyl)-2′-hydroxy-1,1′-binaphthyl and related compounds
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Stereoselective synthesis of amino acid-derived β-lactams. Experimental evidence for TADDOL as a memory of chirality enhancer
Fulltext Access 9 Pages 2006
Synthesis of novel 1-methyl-1H-pyridazino[3,4-b]indoles
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Efficient synthesis of enynes by tetraphosphine-palladium-catalysed reaction of vinyl bromides with terminal alkynes
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Reaction of magnesium cyclopropylidene with N-lithio arylamines: a method for generation of α-amino-substituted cyclopropylmagnesiums and a study for their reactivity with electrophiles
Fulltext Access 9 Pages 2006
Further studies on the constituents of the gorgonian octocoral Pseudopterogorgia elisabethae collected in San Andrés and Providencia islands, Colombian Caribbean: isolation of a putative biosynthetic intermediate leading to erogorgiaene
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Studies in stereoselective [2+2]-cycloadditions with dichloroketene
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Regio- and stereochemical aspects in the synthesis of homoallylic alcohols from benzoins and their iodocyclisation to 2,3-diphenyltetrahydrofurans
Fulltext Access 9 Pages 2006
Enantioselective addition of diethylzinc to benzaldehyde catalysed by chiral, bridged resorcinarenes: a stereoselectivity model based on chirality transfer
Fulltext Access 9 Pages 2006
Synthesis of atropoisomeric pyridines via cobalt-catalyzed cocyclotrimerization of diynes with benzonitrile
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Reaction of α,β-unsaturated Fischer carbene complexes with allyl alkoxide
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A short and novel synthesis of carbocyclic nucleosides and 4′-epi-carbocyclic nucleosides from 2-cyclopenten-1-ones
Fulltext Access 9 Pages 2006
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