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Daneshyari Drug Discovery Journas Latest Articles

Drug Discovery Research Articles

Biological evaluation of a technetium-99m-labeled integrated tropane-BAT and its piperidine congener as potential dopamine transporter imaging agents
Fulltext Access 9 Pages 2006
Effect of cationized gelatins on the paracellular transport of drugs through caco-2 cell monolayers
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Hyperthermia-Induced Antitumor Activity of Thermosensitive Polymer Modified Temperature-Sensitive Liposomes
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Télomères et télomérase, de nouvelles cibles pour la chimiothérapie anticancéreuse
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John R. Vane, « pharmacologue de l'endothélium vasculaire », 1927-2004
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Sources cellulaires des espèces réactives de l'oxygène et de l'azote
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Allégations de santé des aliments : une perspective communautaire
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Prise en charge thérapeutique de la migraine
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Update in the management of head and neck cancer
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Initial evaluation of 227Th-p-benzyl-DOTA-rituximab for low-dose rate α-particle radioimmunotherapy
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Induction of apoptosis in human tumor cells after exposure to Auger electrons: comparison with γ-ray exposure
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Evaluation of novel cationic 99mTc(I)-tricarbonyl complexes as potential radiotracers for myocardial perfusion imaging
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Synthesis and biological evaluation of potent αvβ3-integrin receptor antagonists
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Polymorphism on Leflunomide: Stability and Crystal Structures
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Preparation of cyclotron-produced 186Re and comparison with reactor-produced 186Re and generator-produced 188Re for the labeling of bombesin
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Reproducibility of intraperitoneal 2-deoxy-2-[18F]-fluoro-d-glucose cerebral uptake in rodents through time
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PET Imaging of the AT1 receptor with [11C]KR31173
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Molecular imaging of alkylguanine-DNA alkyltransferase: further evaluation of radioiodinated derivatives of O6-benzylguanine
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Radiochemical synthesis and tissue distribution of p-[18F]DMPPF, a new 5-HT1A ligand for PET, in rats
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99mTc-labeled annexin V fragments: a potential SPECT radiopharmaceutical for imaging cell death
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Synthesis and biological evaluation of a nonsteroidal bromine-76-labeled androgen receptor ligand 3-[76Br]bromo-hydroxyflutamide
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The serotonin transporter in rhesus monkey brain: comparison of DASB and citalopram binding sites
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Double-stabilized neurotensin analogues as potential radiopharmaceuticals for NTR-positive tumors
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In vitro and in vivo evaluation of novel ligands for radioimmunotherapy
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Biodistribution and catabolism of 18F-labeled N-ε-fructoselysine as a model of Amadori products
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Plaques of Alzheimer’s disease originate from cysts of Borrelia burgdorferi, the Lyme disease spirochete
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ε-Glycation, APP and Aβ in ageing and Alzheimer disease: A hypothesis
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Second-hand exposure to aerosolized intravenous anesthetics propofol and fentanyl may cause sensitization and subsequent opiate addiction among anesthesiologists and surgeons
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An integrative model of developing tinnitus based on recent neurobiological findings
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Cell hydration as the primary factor in carcinogenesis: A unifying concept
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Interactive dualism as a partial solution to the mind–brain problem for psychiatry
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Human balance, the evolution of bipedalism and dysequilibrium syndrome
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Rapid recycling of cholesterol: The joint biologic role of C-reactive protein and serum amyloid A
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Theoretical considerations on the pathophysiology of normal pressure hydrocephalus (NPH) and NPH-related dementia
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Cell brain: Insight into hepatocarcinogenesis
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Yawning: Unsuspected avenue for a better understanding of arousal and interoception
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Is systemic hypertension only a sign of chronic sodium chloride intoxication?
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Pathophysiological factors underlying heatstroke
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In silico identification and biochemical characterization of novel inhibitors of NQO1
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Rapid recovery from major depression using magnesium treatment
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A model linking biology, behavior and psychiatric diagnoses in perpetrators of domestic violence
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Neuronal information coding by oscillation phase prediction error: Implications for consciousness and control of voluntary function
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Popperian epidemiology and the logic of bi-conditional modus tollens arguments for refutational analysis of randomised controlled trials
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A life cycle for Borrelia spirochetes?
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From genes to brain oscillations: Is the visual pathway the epigenetic clue to schizophrenia?
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A mathematical model for the proliferation of bacteria in the urinary bladder due to enlarged prostate
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Sporadic amyotrophic lateral sclerosis as an infectious disease: A possible role of cyanobacteria?
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Crystal structure and physical properties of two polymorphs of ropivacaine HCl
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Electromigration of ions across the skin: Determination and prediction of transport numbers
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Effects of citronellal, a monoterpenoid in Zanthoxyli Fructus, on the intestinal absorption of digoxin in vitro and in vivo
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The use of alkanethiol self-assembled monolayers on 316L stainless steel for coronary artery stent nanomedicine applications: an oxidative and in vitro stability study
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Investigation of Silver Binding to Polyamidoamine (PAMAM) Dendrimers by ESI Tandem Mass Spectrometry
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Identification of Specific Protein Carbonylation Sites in Model Oxidations of Human Serum Albumin
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Electronic Sputtering Produced by Fission Fragments on Condensed CO and CO2
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De Novo Peptide Sequencing Using Exhaustive Enumeration of Peptide Composition
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Novel Linear Ion Trap Mass Analyzer Composed of Four Planar Electrodes
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Mass Spectrometric Separation and Quantitation of Overlapping Isotopologues. H2O/HOD/D2O and H2Se/HDSe/D2Se Mixtures
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Distonoid Ions
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Influence of the Matrix on Analyte Fragmentation in Atmospheric Pressure MALDI
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Expanded Use of a Battery-Powered Two-Electrode Emitter Cell for Electrospray Mass Spectrometry
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Ion Trap Collision-Induced Dissociation of Human Hemoglobin α-Chain Cations
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Investigation of Gas Phase Ion Structure for Proline-Containing b2 Ion
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Interaction of hemoglobin and copper nanoparticles: implications in hemoglobinopathy
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Novel Ion Mobility Setup Combined with Collision Cell and Time-of-Flight Mass Spectrometer
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Mobile microscopic sensors for high resolution in vivo diagnostics
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Label-free direct electronic detection of biomolecules with amorphous silicon nanostructures
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Nano hemostat solution: immediate hemostasis at the nanoscale
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Homology modelling and protein structure based functional analysis of five cucumovirus coat proteins
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Three-dimensional models of histamine H3 receptor antagonist complexes and their pharmacophore
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Wavelet neural network modeling in QSPR for prediction of solubility of 25 anthraquinone dyes at different temperatures and pressures in supercritical carbon dioxide
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Evaluation of a neural networks QSAR method based on ligand representation using substituent descriptors: Application to HIV-1 protease inhibitors
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Computation of through-space NMR shielding effects by functional groups common to peptides
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A reactivity index study to rationalize the effect of dopants on Brönsted and Lewis acidity occurring in MeAlPOs
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Techniques for visualization of carbohydrate molecules
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Structural and dynamical properties of different protonated states of mutant HIV-1 protease complexed with the saquinavir inhibitor studied by molecular dynamics simulations
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Lipase-catalyzed resolution of β-hydroxy selenides
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Lipase-mediated resolution of 3-hydroxy-4-trityloxybutanenitrile: synthesis of 2-amino alcohols, oxazolidinones and GABOB
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An improved synthesis of deuterated Schöllkopf’s bis-lactim ether and its use for the asymmetric synthesis of (R)-[α-2H]-phenylalanine methyl esters
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Crystallisation induced asymmetric transformation (CIAT) in the synthesis of furoylalanines and furylcarbinols
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Resolution of 1-arylalkylamines with 3-O-hydrogen phthalate glucofuranose derivatives: role of steric bulk in a family of resolving agents
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An extension of the 'Bip method': induced axial chirality in a series of dipeptides based on Bip/β2,2-HBip combined with Ala/β3-HAla
Fulltext Access 9 Pages 2006
A practical improvement of crystallization-induced asymmetric transformation of allene-1,3-dicarboxylates
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On the stability of the π-allyl intermediate in molybdenum-catalyzed asymmetric alkylations
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Direct synthesis of methyl 2-diazo-4-aryl-3-butenoates and their application to the enantioselective synthesis of 4-aryl-4-(1-naphthyl)-2-butenoates
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New total synthesis of (+)-ambrein
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Synthesis of polymer-supported chiral lithium amide bases and application in asymmetric deprotonation of prochiral cyclic ketones
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Addition of titanium ester enolates to aldimines containing a chiral α-methylbenzylamine moiety: synthesis of chiral syn-β-amino esters
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Lipase mediated enantiomer and diastereomer separation of 2,2′-[1,2- and 1,3-phenylenebis(oxy)]dicyclohexanols
Fulltext Access 9 Pages 2006
Modelling NifH2 protein of Clostridium pasteurianum reveals clues about its physiological function
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A solution to the stereochemical problems posed by amaryllidaceae constituents using a highly syn-selective arylcuprate conjugate addition to γ-amino and γ-carbamato-α,β-enoates
Fulltext Access 9 Pages 2006
Aziridin-2-yl methanols as organocatalysts in Diels–Alder reactions and Friedel–Crafts alkylations of N-methyl-pyrrole and N-methyl-indole
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Lipase catalyzed enantioselective desymmetrization of a prochiral pentane-1,3,5-triol derivative
Fulltext Access 9 Pages 2006
Preparation of novel N-sulfonylated (S,S)-2,3-diaminosuccinate-type chiral auxiliaries and application to an asymmetric 1,3-dipolar cycloaddition reaction of nitrile oxides to allyl alcohol
Fulltext Access 9 Pages 2006
ESI-FTICR Mass Spectrometric Study of Alcohol Complexation Properties of Mono- and Diphosphonate-Bridged Cavitands
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Monitoring the Zinc Affinity of the Metallo-β-Lactamase CphA by Automated nanoESI-MS
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Factors Affecting Primary Ionization in Dopant-Assisted Atmospheric Pressure Photoionization (DA-APPI) for LC/MS
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Activation Processes and Polyethylene Formation on a Phillips Model Catalyst Studied by Laser Ablation, Laser Desorption, and Static Secondary Ion Mass Spectrometry
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Characterization of Specific Noncovalent Complexes between Guanidinium Derivatives and Single-Stranded DNA by MALDI
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Enhanced MALDI Ionization Efficiency at the Metal-Matrix Interface: Practical and Mechanistic Consequences of Sample Thickness and Preparation Method
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Comparative Studies of 193-nm Photodissociation and TOF-TOFMS Analysis of Bradykinin Analogues: The Effects of Charge Site(s) and Fragmentation Timescales
Fulltext Access 9 Pages 2006
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