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Daneshyari Drug Discovery Journas Latest Articles

Drug Discovery Research Articles

Stereoselective synthesis of C1-C5 and C4-C5 linked deoxy disaccharides via a ring closing metathesis protocol
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Synthesis of oligodeoxyribonucleotides containing hydroxymethylphosphonate bonds in the phosphoramidite method and their hybridization properties
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A mild and highly convenient chemoselective alkylation of thiols using Cs2CO3-TBAI
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Symmetrical biodegradable crosslinkers for use in polymeric devices
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An unexpected inversion of enantioselectivity in the proline catalyzed intramolecular Baylis-Hillman reaction
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Amidine derivatives of α-arylglycines from N-(1-aryl-2,2,2-trichloroethyl)amides of arenesulfonic acids and secondary amines
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A sequential RCM/fragmentation protocol towards chiral, stereodefined medium ring sesquiterpenoids. A carvone route to E- and Z-germacrenes
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Synthesis and fluorescence properties of naphthalimide-containing Tröger's bases
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Utilisation of 1,3-dialkylimidazolium-2-carboxylates as CO2-carriers in the presence of Na+ and K+: application in the synthesis of carboxylates, monomethylcarbonate anions and halogen-free ionic liquids
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Convergent syntheses of carbon-13 labeled midazolam and 1′-hydroxymidazolam
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Direct organocatalytic asymmetric α-oxidation of ketones with iodosobenzene and N-sulfonyloxaziridines
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Direct synthesis of hetero-biaryl compounds containing an unprotected NH2 group via Suzuki-Miyaura reaction
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Activation energies for the 1,2-carbon migration of ring-fused cyclopropylchlorocarbenes
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Regioselective and high-yielding bromination of aromatic compounds using hexamethylenetetramine-bromine
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The 'fully protected backbone' approach as a versatile tool for a new solid-phase PNA synthesis strategy
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Synthesis of 1,3-cyclohexadienes by tandem diene-alkyne metathesis: improved procedure
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Synthesis of highly substituted 2,6-anti-configured tetrahydropyrans. First steps towards an efficient access to amphidinol 3 ring system
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Convergent synthesis of the FGHI ring system of yessotoxin: stereoselective construction of the G ring
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Enantioselective conjugate addition of diethylzinc to acyclic enones using a copper phosphino-phenol complex as catalyst
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Palladium charcoal-catalyzed, ligandless Suzuki reaction by using tetraarylborates in water
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Synthesis of 1,3-diaryl benzo[c]thiophenes
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An efficient one-pot synthesis of pyrrolines and tetrahydropyridines from their chloro-precursors via in situ aza-Wittig reaction
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N-Methylpyrrolidin-2-one hydrotribromide (MPHT) a mild reagent for selective bromination of carbonyl compounds: synthesis of substituted 2-bromo-1-naphtols
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syn-π-Face- and endo-selective, inverse electron-demand Diels-Alder reactions of 3,4-di-tert-butylthiophene 1-oxide with electron-rich dienophiles
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De novo synthesis of a galacto-papulacandin moiety via an iterative dihydroxylation strategy
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Improved synthesis of N-alkyl substituted dithieno[3,2-b:2′,3′-d]pyrroles
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Calendar
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Facile Yb(OTf)3 promoted one-pot synthesis of polyhydroquinoline derivatives through Hantzsch reaction
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Stereoselective hydrolysis of sec-mono-alkyl sulfate esters with retention of configuration
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Contrast performance in catalytic ability-new cinchona phase transfer catalysts for asymmetric synthesis of α-amino acids
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Efficient synthesis of halohydroxypyridines by hydroxydeboronation
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A new approach to 3-hydroxyquinoline-2-carboxylic acid
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Halichonadins A-D, new sesquiterpenoids from a sponge Halichondria sp.
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Amine- and phosphine-free palladium(II)-catalyzed homocoupling reaction of terminal alkynes
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5′-Noraristeromycin derivatives isomeric to aristeromycin and 2′-deoxyaristeromycin
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Oxidation of aromatic aldehydes and ketones by H2O2/CH3ReO3 in ionic liquids: a catalytic efficient reaction to achieve dihydric phenols
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One pot synthesis of fused [1,2-a]pyrrole from 1,6-dioxo-2,4-diene and haloalkyl primary amine
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Effect of substituent on the enantioselectivity for lipase-catalyzed kinetic resolution of glycerol derivatives
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Novel C2-symmetric chiral 18-crown-6 derivatives with two aromatic sidearms as chiral NMR discriminating agents
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First chemical study of anaspidean Syphonota geographica: structure of degraded sterols aplykurodinone-1 and -2
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New glycolipid inhibitors of Myt1 kinase
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Easy route to labeled and unlabeled R,R,R-γ-tocopherol by aryl demethylation of α-homologues
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Safe radical azidonation using polystyrene supported diazidoiodate(I)
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Synthesis of an imidazolium-linked cyclophane from histamine
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Conformationally constrained amino acids: enantiodivergent synthesis of all four stereoisomers of 2-(tetrahydrofuran-2-yl)glycine
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Dynamic molecular recognition in the generation of a new crystal-engineering motif: a unique case study of a dicarboxylic acid with a ditopic receptor favouring a polymeric over a dimeric hydrogen-bonded supramolecular complex
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A simple and clean procedure for the synthesis of polyhydroacridine and quinoline derivatives: reaction of Schiff base with 1,3-dicarbonyl compounds in aqueous medium
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Highly enantioselective rhodium-catalyzed conjugate addition of arylboronic acids to enones at room temperature
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An improved synthesis of 3-aminoestrone
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New guanidinium-based carboxylate receptors derived from 5-amino-pyrrole-2-carboxylate: synthesis and first binding studies
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Calendar
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Justiciosides E-G, triterpenoidal glycosides with an unusual skeleton from Justicia betonica
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Clean and efficient microwave-solvent-free conversion of homochiral amines, α-amino alcohols and α-amino acids to their chiral 2-substituted pyrrole derivatives
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Isoaurostatin: total synthesis and structural revision
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Graphical contents list
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A new synthesis of highly functionalized 2H-pyran derivatives
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Corrigendum to “Enantioselective alkylation and protonation of prochiral enolates in the asymmetric synthesis of β-amino acids” [Tetrahedron 59 (2003) 4223]
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Steric effects in the tetracyanoethylene catalysed methanolysis of some cyclohexane epoxides
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Annulation of pyrrole: application to the synthesis of indolizidine alkaloids
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Generation and reactivity of polyanions derived from 1-[1-(benzotriazol-1-yl)alkyl]-1H-benzotriazoles
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On the deprotonation of 3,5-dichloropyridine using lithium bases: in situ infrared spectroscopic studies
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Novel synthesis of o-naphthothiophenequinone derivatives via regioselective Diels-Alder reaction
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Novel tocopheryl compounds XX. 1,3,8-Trioxaphenanthrenes derived from γ-tocopherol
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Calendar
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The deoxygenation of sulfoxide mediated by the Ph3P/Lewis acid combination and the application to the kinetic resolution of racemic phosphines using optically active sulfoxide
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On the non-classical course of Polonowski reactions of N-benzylmorpholine-N-oxide (NBnMO)
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Graphical contents list
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Design of highly active heterogeneous palladium catalysts for the activation of aryl chlorides in Heck reactions
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Reversal of aryl bromide reactivity in Pd-catalysed aryl amination reactions promoted by a hemilabile aminophosphine ligand
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Efficient palladium catalysts for the amination of aryl chlorides: a comparative study on the use of phosphium salts as precursors to bulky, electron-rich phosphines
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Calendar
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A new synthesis of (−)-thioambrox and its 8-epimer
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Laccase-catalyzed carbon-carbon bond formation: oxidative dimerization of salicylic esters by air in aqueous solution
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Aza-Michael addition of chiral hydrazines to alkylidene malonates
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Rearrangement of allylic azide and phenylthio groups of 3′-azido- or 3′-phenylthio-4′,5′-didehydro-5′-deoxyarabinofuranosyluridines
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Synthesis of substituted aryl amidines from aminoacetonitriles
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New chiral bis(diphenylphospholane) ligands: design, synthesis, and application to catalytic enantioselective aldol reaction to ketones
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A simple and efficient procedure for the synthesis of benzimidazoles using air as the oxidant
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The preparation of C-glycosyl amino acids-an examination of olefin cross-metathesis
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Synthesis of (4R,15R,16R,21S)- and (4R,15S,16S,21S)-rollicosin
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A high loading sulfonic acid-functionalized ordered nanoporous silica as an efficient and recyclable catalyst for chemoselective deprotection of tert-butyldimethylsilyl ethers
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Aerobic oxidation with N-hydroxyphthalimide catalysts in ionic liquid
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Regioselectivity of dimerisation of butenolides via captodative stabilised radicaloid intermediates
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Synthesis and photoluminescence study of benz[f]indene derivatives
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Microwave-promoted synthesis of amino-substituted 2-pyridone derivatives via palladium-catalyzed amination reaction
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Perylene-3,4:9,10-bis(dicarboximide) linked to [60]fullerene as a light-harvesting antenna
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Dimethylaluminum methyltellurate, a new reagent for the cleavage of hindered methyl esters under exceptionally mild conditions by a novel mechanism
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Alkane oxygenation with H2O2 catalysed by FeCl3 and 2,2′-bipyridine
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Aerobic oxidation of 1,3,5-triisopropylbenzene using N-hydroxyphthalimide (NHPI) as key catalyst
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Convenient fluorination of nitro and nitrile compounds with Selectfluor
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Synthesis of novel rigid-rod and tripodal azulene chromophores
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Concise synthesis of glyconoamidines as affinity ligands for the purification of β-glucosidase involved in control of some biological events including plant leaf movement
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Synthesis of 3,4-disubstituted 2,5-dihydrofurans starting from the Baylis-Hillman adducts via consecutive radical cyclization, halolactonization, and decarboxylation strategy
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Aspects of investigating scrambling in the synthesis of porphyrins: different analytical methods
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Ultrasonically activated reduction of substituted nitrobenzenes to corresponding N-arylhydroxylamines
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Efficient and eco-friendly process for the synthesis of N-substituted 4-methylene-2-oxazolidinones in ionic liquids
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A convenient and efficient approach to synthesize negletein from baicalin
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Racemization at proline residues during peptide bond formation
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Synthesis of a new class of keto-linked bis heterocycles
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A new approach for the synthesis of 2-substituted indole derivatives via Michael type adducts
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