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Daneshyari Drug Discovery Journas Latest Articles

Drug Discovery Research Articles

Cyclic chlorophosphites as scaffolds for the one-pot synthesis of α-aminophosphonates under solvent-free conditions
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Synthesis of new chiral PNAs bearing a dipeptide-mimic monomer with two lysine-derived stereogenic centres
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Meyers' bicyclic lactam formation under mild and highly stereoselective conditions
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A criterion to demarcate the dual Diels-Alder and σ-complex behaviour of aromatic and heteroaromatic superelectrophiles
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Copper(II) tetrafluoroborate as a novel and highly efficient catalyst for acetal formation
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Synthesis of peptides and oligosaccharides by using a recyclable fluorous tag
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Synthesis of the C42–C52 part of ciguatoxin CTX3C
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Nucleophilic difluoromethylation of carbonyl compounds using TMSCF2SO2Ph and Mg0-mediated desulfonylation
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Synthesis of fused bicyclic pyridines with microwave-assisted intramolecular hetero-Diels-Alder cycloaddition of acetylenic pyrimidines
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4-Acetoxy-2,2-dimethylbutanoate: a useful carbohydrate protecting group for the selective formation of β-(1→3)-d-glucans
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2′-Methyl taxanes: synthesis and NMR configurational assignment
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Novel organic catalysts for the direct enantioselective α-oxidation of carbonyl compounds
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Amino acid catalyzed direct enantioselective formation of carbohydrates: one-step de novo synthesis of ketoses
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Développement d'une solution de chlorhydrate d'oxybutynine pour instillation vésicale : de la formulation au contrôle qualité
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A convenient solid phase synthesis of S-palmitoyl transmembrane peptides
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Super fast cobalt carbonyl-mediated synthesis of ureas
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Suzuki coupling for protein modification
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Chemo-enzymatic short-step total synthesis of symbioramide
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Reaction of allylic and benzylic alcohols and esters with PPh3/I2: one-pot synthesis of β,γ-unsaturated compounds
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Enforcing aggregation in a dipeptide conjugate
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Synthesis of substituted dihydrobenzothiopyrans and dihydrobenzopyrans by cation-mediated cyclisation reactions
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First total synthesis of 7(S),17(S)-Resolvin D5, a potent anti-inflammatory docosanoid
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Enhancement of the catalytic hydrodechlorination of tetrachloroethylene in methanol at mild conditions by water addition
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Remarkable rate acceleration of water-promoted nucleophilic substitution of Baylis-Hillman acetate: a facile and highly efficient synthesis of N-substituted imidazole
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First total synthesis of yanuthones: novel farnesylated epoxycyclohexenoid marine natural products
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Evaluation of chitosan succinate and chitosan phthalate as enteric coating polymers for diclofenac sodium tablets
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Purification of cyclotron-produced 203Pb for labeling Herceptin
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Radiosynthesis, in vitro cellular uptake and in vivo biodistribution of 3′-O-(3-benzenesulfonylfuroxan-4-yl)-5-[125I]iodo-2′-deoxyuridine, a nucleoside-based nitric oxide donor
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Gene manipulation to enhance MIBG-targeted radionuclide therapy
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A simple method for stem cell labeling with fluorine 18
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An improved 99mTc-aprotinin kit formulation: quality control analysis of radiotracer stability and cold kit shelf life
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Preferred stereoselective brain uptake of d-serine - a modulator of glutamatergic neurotransmission
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Therapeutic vaccines for substance dependence
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Imidazenil: An antagonist of the sedative but not the anticonvulsant action of diazepam
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Structural organization of proteocubosome carriers involving medium- and large-size proteins
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Real-time detection and efficacy of antisense oligonucleotides delivered by PAMAM dendrimers in living cells
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Ktenate nanoparticles (bdellosomes): a novel strategy for delivering drugs to parasites or tumours
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Evaluation of the flowability of surface-modified preparations by the measurement of the inter-particle adhesive force
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A stereodivergent cascade imine → azomethine ylide → 1,3-dipolar cycloadditive approach to α-chiral pyrrolidines
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Attachment, uptake and transport of nanoparticles coated with an internalin A fragment in Caco-2 cell monolayers
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Self-assembly of some amphipathic dendrons
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The use of precursor polymers to prepare new excipients
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Delivery of liposomes generated from proliposomes using air-jet, ultrasonic, and vibrating-mesh nebulisers
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γ-scintigraphic evaluation of enteric-coated capsules containing chitosan-brilliant blue gel beads as hydrophilic model for colon drug delivery
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Preparation and characterization of bFGF and BSA-loaded microspheres
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Vehicle and enhancer effects on transdermal permeation of estradiol from gel formulations: evaluation in vitro
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Evaluation of bioadhesive performance of chitosan derivatives as films for buccal application
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Qualité rédactionnelle des ordonnances. Résultats d'une enquête menée auprès des médecins généralistes lorrains
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Thème de la séance académique du 1er décembre 2004
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Allocution du Ministre de la santé
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Mercaptoacetic acid based expeditious synthesis of polyfunctionalised 1,3-thiazines
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The effects of added ammonium chloride in the reductive amination of some carbonyl compounds over Ru and Pd catalysts
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Enhanced activity of α-chymotrypsin in organic media using designed molecular staples
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Bi(III) Catalysed O-acylative cleavage of 2,5-dimethyltetrahydrofuran: a substrate dependent borderline mechanism
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Structure and absolute stereochemistry of novel C15-halogenated acetogenins from the anaspidean mollusc Aplysia dactylomela
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Chiral amidophosphane-copper-catalyzed asymmetric conjugate addition of dialkylzinc reagents to nitroalkenes
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Shimalactone A, a novel polyketide, from marine-derived fungus Emericella variecolor GF10
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Structural and stereochemical revision of isocyanide and isothiocyanate amphilectenes from the Caribbean marine sponge Cribochalina sp.
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Use of isopropyl alcohol as a solvent in Ti(O-i-Pr)4-catalyzed Knöevenagel reactions
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A novel access to highly functionalised β-lactams by regio- and stereoselective 1,3-dipolar cycloaddition reaction
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Dimeric azaphilones from the xylariaceous ascomycete Hypoxylon rutilum
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DMF promoted xylosylation of terpenols
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A formal total synthesis of (±)-9-isocyanoneopupukeanane
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Palladium-catalyzed homocoupling of aryl halides in the presence of fluoride
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Design and synthesis of anti-barnacle active fluorescence-labeled probe compounds and direct observation of the target region in barnacle cypris larvae for dimethyl-isocyanoalkyl compounds
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Ionic liquid promoted palladium-catalyzed Suzuki cross-couplings of N-contained heterocyclic chlorides with naphthaleneboronic acids
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Stereoselective synthesis of tetrazole CB92834, a potent retinoid compound
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Graphical contents list
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The first synthesis of pyridinium N-benzoylguanidines by bismuth- and mercury-promoted guanylation of N-iminopyridinium ylide with thioureas
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Surprising fenchone induced cyclization: synthesis of the new chiral diol biphenyl-2,2′-sulfone-3,3′-bisfenchol (BISFOL)
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Dramatic catalyst evolution in the asymmetric addition of diethylzinc to benzaldehyde
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Domino allylation and cyclization of ortho-alkynylbenzaldehydes with allyltrimethylsilane catalyzed by Pd(II)-Cu(II) bimetallic systems
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Metal catalyzed multicomponent syntheses of secondary propargylamides and oxazoles from silylimines, acid chlorides, and alkynes
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Calculated NMR as a tool for structural elucidation of jungianol and mutisianthol
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A high-swelling reagent scaffold suitable for use in aqueous and organic solvents
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A novel phthalocyanine with two axial fullerene substituents
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Picolinyl group as an efficient alcohol protecting group: cleavage with Zn(OAc)2·2H2O under a neutral condition
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Synthesis and spectral characterization of bisnaphthylmethyl and trinaphthylmethyl cations
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Theoretical design of singlet localized σ-diradicals: C(MH2)3C (M = Si, Ge, Sn, Pb)
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Direct observation of a target cell of the leaf-closing factor by using novel fluorescence-labeled phyllanthurinolactone
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Synthesis of 3-alkenyl-2-arylchromones and 2,3-dialkenylchromones via acid-catalysed retro-Michael ring opening of 3-acylchroman-4-ones
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Synthesis and structural and electronic properties of the octaethylporphyrin-dihexylbithiophene-fullerene derivatives (OEP-DHBTh-C60) connected with diacetylene linkage
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Modified porphyrinoids from carbazates and hydrazones and the first crystal structure of a di-iminoporphodimethene
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Chemoselective deprotection and functional group interconversion of ring-fused 2N,3O-oxazolidinones of N-acetyl-d-glucosamine
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Efficient fluoride-mediated synthesis of 5-alkyl amino- and ether-substituted pyrazoles
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Catalytic properties of several supported Pd(II) complexes for Suzuki coupling reactions
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A direct transformation of O-silyl groups into O-trichloroacetates. A novel synthetic approach to protein kinase C ligands: 1-oleoyl-2-acetyl- and 1-hexadecyl-2-acetyl-sn-glycerols
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A mild and efficient method for halogenation of 3,5-dimethyl pyrazoles by ultrasound irradiation using N-halosuccinimides
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Polystyrene-supported triphenylarsines: useful ligands in palladium-catalyzed aryl halide homocoupling reactions and a catalyst for alkene epoxidation using hydrogen peroxide
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Regioselective construction of polysubstituted pyridine ring from Baylis-Hillman adducts via sequential introduction of tosylamide, Michael reaction, aldol condensation, and elimination of TsH
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New tetrakis(4-aminophenyl)ethenes: synthesis and electrochemical investigations
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Geranylgeraniol formation in Croton stellatopilosus proceeds via successive monodephosphorylations of geranylgeranyl diphosphate
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Elongation of β-hydroxyenones by cross-metathesis
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A novel solid-phase synthesis of cyclic guanidines
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Direct aldol and tandem Mannich reactions in room temperature ammonia solutions
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Indium(III) triflate catalyzed tandem azidation/1,3-dipolar cycloaddition reaction of ω,ω-dialkoxyalkyne derivatives with trimethylsilyl azide
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Synthesis and characterization of low generation halogenated linear poly(arylpropargyl)ether (PAPE) branches via selective palladium catalyzed coupling reactions
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Additions of functionalized α-substituted allylboronates to aldehydes under the novel Lewis and Brønsted acid catalyzed manifolds
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Water-soluble N-oxyl compounds-mediated electrooxidation of alcohols in water: a prominent access to a totally closed system
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New triterpenoid saponins from the roots of Platycodon grandiflorum
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