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Daneshyari Drug Discovery Journas Latest Articles

Drug Discovery Research Articles

The Frequency of Candidate Alleles for CYP2D6 Genotyping in the Japanese Population with an Additional Respect to the − 1584C to G Substitution
Fulltext Access 4 Pages 2005
Effect of Isoniazid on the Pharmacodynamics of Cefazolin-Induced Seizures in Rats
Fulltext Access 4 Pages 2005
A Novel Single Nucleotide Polymorphism of the Human Methylenetetrahydrofolate Reductase Gene in Japanese Individuals
Fulltext Access 4 Pages 2005
Effect of physical properties of carrier particles on drug emission from a dry powder inhaler device
Fulltext Access 4 Pages 2005
The influence of formulation variables on stability and microbicidal activity of monoglyceride monocaprin
Fulltext Access 4 Pages 2005
Particle release and surface characteristics of polyvinylchloride perfusional containers after steam sterilization
Fulltext Access 4 Pages 2005
Design and optimization of ocular inserts for prolonged delivery of ciprofloxacin hydrochloride
Fulltext Access 4 Pages 2005
Incorporating protein transduction domains (PTD) within intracellular proteins associated with the 'stemness' phenotype. Novel use of such recombinant 'fusion' proteins to overcome current limitations of applying autologous adult stem cells in regenerativ
Fulltext Access 5 Pages 2005
Maternal heterozygosity for a mitochondrial trifunctional protein mutation as a cause for liver disease in pregnancy
Fulltext Access 5 Pages 2005
Targeting fatty acid synthase-driven lipid rafts: a novel strategy to overcome trastuzumab resistance in breast cancer cells
Fulltext Access 5 Pages 2005
Cancer by negative heterosis: breast and ovarian cancer excess in hybrids of inbred ethnic groups
Fulltext Access 5 Pages 2005
Secondary hyperparathyroidism promotes the acute phase response - a rationale for supplemental Vitamin D in prevention of vascular events in the elderly
Fulltext Access 5 Pages 2005
Evidence-based medicine is rooted in Protestant exegesis
Fulltext Access 5 Pages 2005
Serotonergic hypothesis of sleepwalking
Fulltext Access 5 Pages 2005
Is there a role for long-chain ω3 or oil-rich fish in the treatment of atrial fibrillation?
Fulltext Access 5 Pages 2005
Effect of antibiotics, prebiotics and probiotics in treatment for hepatic encephalopathy
Fulltext Access 5 Pages 2005
The role of fat tissue in the cholesterol lowering and the pleiotropic effects of statins - statins activate the generation of metabolically more capable adipocytes
Fulltext Access 5 Pages 2005
How PEDF prevents angiogenesis: a hypothesized pathway
Fulltext Access 5 Pages 2005
Clinically significant cancer evolves from transient mutated and/or aneuploid neoplasia by cell fusion to form unstable syncytia that give rise to ecologically viable parasite species
Fulltext Access 5 Pages 2005
Antioxidants may increase the probability of developing allergic diseases and asthma
Fulltext Access 5 Pages 2005
Neurodegeneration caused by the translation of nonsense: Does macromolecular misfolding impair the synchrony of gene expression?
Fulltext Access 5 Pages 2005
Protein aggregation as a possible cause for pathology in a subset of familial Unverricht-Lundborg disease
Fulltext Access 5 Pages 2005
Improvement of cervical dystonia: possible role of transcranial magnetic stimulation simulating sensory tricks effect
Fulltext Access 5 Pages 2005
Inflammation may be a bridge connecting hypertension and atherosclerosis
Fulltext Access 5 Pages 2005
Ecstasy (MDMA) mimics the post-orgasmic state: Impairment of sexual drive and function during acute MDMA-effects may be due to increased prolactin secretion
Fulltext Access 5 Pages 2005
Possible involvement of the BDNF-dependent pathway in treatment-emergent suicidality or decreased response to antidepressants
Fulltext Access 5 Pages 2005
Intestinal involvement is not sufficient to explain hypertransaminasemia in celiac disease?
Fulltext Access 5 Pages 2005
Induction of fetal haemoglobin expression in erythroid cells - A model based on iron availability signalling
Fulltext Access 5 Pages 2005
Origin and evolution of viruses: Escaped DNA/RNA sequences as evolutionary accelerators and natural biological weapons
Fulltext Access 5 Pages 2005
Inefficient central nervous system delivery limits the use of ibuprofen in neurodegenerative diseases
Fulltext Access 5 Pages 2005
Osteoblastic proliferative activity of Epimedium brevicornum Maxim.
Fulltext Access 5 Pages 2005
What can we learn from atomic force microscopy adhesion measurements with single drug particles?
Fulltext Access 5 Pages 2005
Selenocarbamates are effective superoxide anion scavengers in vitro
Fulltext Access 5 Pages 2005
Solubilization of poorly soluble lichen metabolites for biological testing on cell lines
Fulltext Access 5 Pages 2005
Table of Contents
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Pharmacology and preclinical pharmacokinetics of peppermint oil
Fulltext Access 5 Pages 2005
Gastrointestinal clinical pharmacology of peppermint oil
Fulltext Access 5 Pages 2005
Screening of Echinops ellenbeckii and Echinops longisetus for biological activities and chemical constituents
Fulltext Access 5 Pages 2005
A study of the antidiarrheal properties of Loeselia mexicana on mice and rats
Fulltext Access 5 Pages 2005
Prokinetic effect of a Kampo medicine, Hange-koboku-to (Banxia-houpo-tang), on patients with functional dyspepsia
Fulltext Access 5 Pages 2005
Antifungal activity of some Brazilian Hypericum species
Fulltext Access 5 Pages 2005
Potent suppressive effect of green tea polyphenols on tobacco-induced mutagenicity
Fulltext Access 5 Pages 2005
Statin, like aspirin, should be given as early as possible in patients with acute coronary syndrome
Fulltext Access 5 Pages 2005
Cimicifuga racemosa extract BNO 1055 inhibits proliferation of the human prostate cancer cell line LNCaP
Fulltext Access 5 Pages 2005
Magnesium as NMDA receptor blocker in the traditional Chinese medicine Danshen
Fulltext Access 5 Pages 2005
Vasodilative effect of perillaldehyde on isolated rat aorta
Fulltext Access 5 Pages 2005
Effects of methyl-eugenol administration on behavioral models related to depression and anxiety, in rats
Fulltext Access 5 Pages 2005
Assessment of estrogenic activity of flavonoids from Mediterranean plants using an in vitro short-term test
Fulltext Access 5 Pages 2005
Antiinflammatory and chronic toxicity study of the leaves of Ageratum conyzoides L. in rats
Fulltext Access 5 Pages 2005
Platelet-activating factor (PAF) receptor-binding antagonist activity of Malaysian medicinal plants
Fulltext Access 5 Pages 2005
Senna and the formation of aberrant crypt foci and tumors in rats treated with azoxymethane
Fulltext Access 5 Pages 2005
Antinociceptive effects of the essential oil of Alpinia zerumbet on mice
Fulltext Access 5 Pages 2005
Acute anti-inflammatory activity of four saponins isolated from ivy: alpha-hederin, hederasaponin-C, hederacolchiside-E and hederacolchiside-F in carrageenan-induced rat paw edema
Fulltext Access 5 Pages 2005
Chromium picolinate may favorably influence the vascular risk associated with smoking by combating cortisol-induced insulin resistance
Fulltext Access 5 Pages 2005
The optimal treatment strategy for chronic hepatitis C
Fulltext Access 5 Pages 2005
Persistence of inflammatory cytokines cause a spectrum of chronic progressive diseases: Implications for therapy
Fulltext Access 5 Pages 2005
Clinical benefits of hydration and volume expansion in a wide range of illnesses may be attributable to reduction of sympatho-vagal ratio
Fulltext Access 5 Pages 2005
Disruption of cholesterol homeostasis in the developing brain as a potential mechanism contributing to the developmental neurotoxicity of ethanol: an hypothesis
Fulltext Access 5 Pages 2005
Pain in patients with chronic fatigue syndrome: Does nitric oxide trigger central sensitisation?
Fulltext Access 5 Pages 2005
Placental defence is considered sufficient to control lipid peroxidation in pregnancy
Fulltext Access 5 Pages 2005
Protective correlates against HIVs may have evolved in human populations in the areas of historic occurrence of primate-to-man transmissions of SIVs ancestral to HIVs: studies in these populations may provide crucial insights for treatment and prevention
Fulltext Access 5 Pages 2005
Are treatment emergent suicidality and decreased response to antidepressants in younger patients due to bipolar disorder being misdiagnosed as unipolar depression?
Fulltext Access 5 Pages 2005
Rationale for the treatment of cancer with sodium selenite
Fulltext Access 5 Pages 2005
Should atherosclerosis be considered a cancer of the vascular wall?
Fulltext Access 5 Pages 2005
Persistent gestational trophoblastic disease is rarely, if ever, derived from non-molar first-trimester miscarriage
Fulltext Access 5 Pages 2005
Active fascial contractility: Fascia may be able to contract in a smooth muscle-like manner and thereby influence musculoskeletal dynamics
Fulltext Access 5 Pages 2005
AMPK activation as a strategy for reversing the endothelial lipotoxicity underlying the increased vascular risk associated with insulin resistance syndrome
Fulltext Access 5 Pages 2005
Motion sickness is linked to nystagmus-related trigeminal brain stem input: a new hypothesis
Fulltext Access 5 Pages 2005
A hypothesis matrix for studying biomechanical factors associated with the initiation and progression of posttraumatic osteoarthritis
Fulltext Access 5 Pages 2005
The chemical reactions in the human stomach and the relationship to metabolic disorders
Fulltext Access 5 Pages 2005
“Starve a fever and feed a cold”: feeding and anorexia may be adaptive behavioral modulators of autonomic and T helper balance
Fulltext Access 5 Pages 2005
Severe blood loss during spinal reconstructive procedures: The potential usefulness of topical hemostatic agents
Fulltext Access 5 Pages 2005
Retrograde regulation due to mitochondrial dysfunction may be an important mechanism for carcinogenesis
Fulltext Access 5 Pages 2005
Lactoferrin-enhanced anoikis: A defense against neonatal necrotizing enterocolitis
Fulltext Access 5 Pages 2005
Differentiation of organ availability by sequential and simultaneous analyses: Intestinal conjugative metabolism impacts on intestinal availability in humans*
Fulltext Access 5 Pages 2005
Carrier-Mediated Uptake of Grepafloxacin, a Fluoroquinolone Antibiotic, by the Isolated Rat Lung Cells
Fulltext Access 5 Pages 2005
Stereoselective Effect of Amiodarone on the Pharmacokinetics of Racemic Carvedilol
Fulltext Access 5 Pages 2005
A novel therapeutic strategy for Ehlers-Danlos syndrome based on nutritional supplements
Fulltext Access 5 Pages 2005
A computational model to predict aortic wall stresses in patients with systolic arterial hypertension
Fulltext Access 5 Pages 2005
“Nanobacterium sanguineum” - Is it a new life-form in search of human ailment or commensal: Overview of its transmissibility and chemical means of intervention
Fulltext Access 5 Pages 2005
Optic neuropathies - Importance of spatial distribution of mitochondria as well as function
Fulltext Access 5 Pages 2005
If 'atypical' neuroleptics did not exist, it wouldn't be necessary to invent them: Perverse incentives in drug development, research, marketing and clinical practice
Fulltext Access 5 Pages 2005
The low-AGE content of low-fat vegan diets could benefit diabetics - though concurrent taurine supplementation may be needed to minimize endogenous AGE production
Fulltext Access 5 Pages 2005
Acid-base balance may influence risk for insulin resistance syndrome by modulating cortisol output
Fulltext Access 5 Pages 2005
Ageing and maintenance of the interstitial fluid traffic: possible roles of initial lymphatics and circadian hormones
Fulltext Access 5 Pages 2005
Inhibition of fatty acid synthase-dependent neoplastic lipogenesis as the mechanism of γ-linolenic acid-induced toxicity to tumor cells: an extension to Nwankwo's hypothesis
Fulltext Access 5 Pages 2005
Antisense oligonucleotides and prevention of tumor growth: a different approach and proposal for a new method
Fulltext Access 5 Pages 2005
Disparate forms of MK 886-induced programmed death in BCL-2 (+) blood and BCL-2 (-) solid cancer cells and a putative “nuclear” Ca2+ channel: “soil” trumps “seed”?
Fulltext Access 5 Pages 2005
The contribution of intrapleural pressures to the pathogenesis of emphysema
Fulltext Access 5 Pages 2005
Why revelations have occurred on mountains?
Fulltext Access 5 Pages 2005
Antiviral therapy with non-selective β-blockers: preliminary experimental and clinical corroboration
Fulltext Access 5 Pages 2005
Is hypertension an inflammatory disease?
Fulltext Access 5 Pages 2005
Are dopaminergic genes involved in a predisposition to pathological aggression?
Fulltext Access 5 Pages 2005
Deep-feeling development gives autistics abstractions: When a young person has no abstractions, his or her thoughts or behaviors frequently seem autistic
Fulltext Access 5 Pages 2005
Epilepsy and psychiatry: Automatic psychic paroxysms
Fulltext Access 5 Pages 2005
Drought, epidemic disease, and the fall of classic period cultures in Mesoamerica (AD 750-950). Hemorrhagic fevers as a cause of massive population loss
Fulltext Access 5 Pages 2005
The inevitable rise of mediocrity in academic medicine
Fulltext Access 5 Pages 2005
The multiple outcomes bias in antidepressants research
Fulltext Access 5 Pages 2005
Potential involvement of vascular endothelial growth factor in pathophysiology of Turner syndrome
Fulltext Access 5 Pages 2005
Genetic basis of common diseases: The general theory of Mendelian recessive genetics
Fulltext Access 5 Pages 2005
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