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Daneshyari Drug Discovery Journas Latest Articles

Drug Discovery Research Articles

Carbon-sulfur bond formation from 2-halochalcogenophenes via copper catalyzed thiol cross-coupling
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A vicarious synthesis of unsymmetrical meta- and para- terphenyls from 2H-pyran-2-ones
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A water-soluble β-cyclodextrin derivative possessing a fullerene tether as an efficient photodriven DNA-cleavage reagent
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High intensity ultrasound-assisted reduction of sterically demanding nitroaromatics
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A direct method for the synthesis of nucleoside 5′-methylenebis(phosphonate)s from nucleosides
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A novel supramolecular assembly of 3,5-dinitro-4-methylbenzoic acid and trans-1,2-bis(4-pyridyl)ethene
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Mild copper-catalyzed N-arylation of azaheterocycles with aryl halides
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Synthesis of N-protected azaoligosaccharides and their cyclic derivatives
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Traceless solid-phase synthesis of 2-amino-5-alkylidene-thiazol-4-ones
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Intramolecular metathesis versus Kharasch reactions using the Grubbs metathesis catalyst: towards catalyst economy
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Asymmetric synthesis of (+)-abresoline
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Chemical capture of an unprecedented oxatetramethyleneethane radical cation with a through-space electronic coupling
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New polyfunctional dendritic linear hybrids from terminal amine polyether oligomers (Jeffamine®): synthesis and characterization
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Solid-phase synthesis development of a thymidinyl and 2′-deoxyuridinyl Ugi library for anti-bacterial agent screening
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Synthesis of arenediynes via the vinylidenecarbene-acetylene rearrangement
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Pd-catalyzed amination in a polar medium: rate enhancement, convenient product isolation, and tandem Suzuki cross-coupling
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Construction of benzene ring-layered polymers
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Spectroscopic and DFT evidence for a nonclassical radical cation derived from 7-benzhydrylidenenorbornene
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Skeletal rearrangements of bicyclo[2.2.2]lactones: a short and efficient route towards Corey's lactone
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Efficient access to functionalised medium-ring systems by radical fragmentation/radical addition to α-iodoketones
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Direct SNAr amination of fluorinated imidazo[4,5-c]pyridine nucleosides: efficient syntheses of 3-fluoro-3-deazaadenosine analogs
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Efficient and selective hydroarylation of propiolic acids and their esters with arenes catalyzed by a PtCl2/AgOTf system
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Aryl radical cyclizations of N-(2-halobenzoyl)-cyclic ketene-N,S-acetals
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A novel TFA-mediated cyclo-dimerization of 1-substituted 3-alkenylindole derivatives to cyclopent[b]indoles
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Enantioselective synthesis of 2-ethyl-2,3-dihydrobenzofuran carboxylic acid, direct precursor of (+)-efaroxan, from a Baylis-Hillman adduct
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Synthesis of streptorubin B core
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Synthesis of a photoactivatable phospholipidic probe containing tetrafluorophenylazide
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Palladium-catalyzed and organozinc-promoted synthesis of dienes from allylic esters possessing an acyloxy or alkoxy group
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Six new indole alkaloids from Gelsemium sempervirens Ait. f.
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Selective bifunctionalization of pyrido[2,3-d]pyrimidines in positions 2 and 4 by SNAr and palladium-catalyzed coupling reactions
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Deuterium kinetic isotope effects in homogeneous decatungstate catalyzed photooxygenation of 1,1-diphenylethane and 9-methyl-9H-fluorene: evidence for a hydrogen abstraction mechanism
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Synthesis of novel fluorinated 4-aminoquinoline derivatives
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One-pot synthesis of α-amino phosphonates from α-amino acids and β-amino alcohols
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Direct synthesis of new cryptates based on the N,C-pyrazolylpyridine motif
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Efficient syntheses of new chiral peptidomimetic macrocycles through a configurationally driven preorganization
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Synthesis and photoinitiated radical cyclization of allyl- and propynyloxymethyl substituted cyclopentanones to tetrahydrocyclopenta[c]furanols
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Use of p-nitrobenzyloxycarbonyl (pNZ) as a permanent protecting group in the synthesis of Kahalalide F analogs
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Selective alkylation of a 6,7-dihydroxyquinazoline
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Synthetic studies on thiostrepton family of peptide antibiotics: synthesis of the cyclic core portion containing the dehydropiperidine, dihydroquinoline, l-valine, and masked dehydroalanine segments
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Synthesis of [13]-membered macrocyclic stevastelins via a transesterification reaction as the key step: total synthesis of stevastelin C3
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Synthesis of 5-aza-analogues of angucyclines: manipulation of the 2-deoxy-C-glycoside subunit
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Cyclopropanation of 3,4-dihydro-1 H-benzo[e][1,4]diazepine-2,5-diones
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A facile preparation of N-protected indolaldehydes using a modified Hass procedure
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Calix[4]crown in dual sensing functions with FRET
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Linear C2-symmetric polycyclic benzodithiophene: efficient, highly diversified approaches and the optical properties
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Lewis acid catalyzed intramolecular halo-arylation of tethered alkenes using N-halosuccinimide (NXS) as the halogen source: a general method for the synthesis of chromanones, chromans, quinolones, tetrahydroquinolines and tetralins
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Regioselective palladium-catalyzed phenylation of ethyl 4-oxazolecarboxylate
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Preparation of enantiomerically pure 2-(1′-aminomethyl)furan derivatives and synthesis of an unnatural polyhydroxylated piperidine
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Atomarianones A and B: two cytotoxic meroditerpenes from the brown alga Taonia atomaria
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A study of epoxyolefin cyclizations catalyzed by bismuth trifluoromethanesulfonate and other metal triflates
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Selective photoswitching of a dyad with diarylethene and spiropyran units
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A hyodeoxycholic acid-based molecular tweezer: a highly selective fluoride anion receptor
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Facile access to methoxylated 2-phenylnaphthalenes and epoxydibenzocyclooctenes
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Effective reductive amination of carbonyl compounds with hydrogen catalyzed by iridium complex in organic solvent and in ionic liquid
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Graphical contents list
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An efficient Stille cross-coupling reaction catalyzed by Pd(OAc)2/DAB-Cy catalytic system
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Daminin, a bioactive pyrrole alkaloid from the Mediterranean sponge Axinella damicornis
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Microwave-assisted conversion of N-substituted oxazolidin-2,4-diones into α-hydroxyamides
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A new alkylation-elimination method for synthesis of antiviral fluoromethylenecyclopropane analogues of nucleosides
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A novel cis-chelated Pd(II)-NHC complex for catalyzing Suzuki and Heck-type cross-coupling reactions
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m-Aminobenzoic acid inserted β-turn in acyclic tripeptides: a peptidomimetic design
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Biphasic Suzuki coupling reactions of aryl or benzyl bromides employing cobalt-containing phosphine ligand coordinated palladium complex
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Syntheses, optical and electrochemical properties of 4,4′-bis-[2-(3,4-dibutyl-2-thienylethynyl)]biphenyl and its oligomers
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Graphical contents list
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2-Ethoxy-3-pyridylboronic acid: a versatile reagent for the synthesis of highly-functionalised 3-aryl/heteroaryl-pyridines via Suzuki cross-coupling reactions
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1,3-Dipolar cycloadditions of MeOPEG-bounded azides
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Synthesis and crystalline state photochromism of 3,3′-diaryl biindenylidenedione derivatives
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Regio- and stereoselective synthesis of bis-spiropyrazoline-5,3′-chroman(thiochroman)-4-one derivatives via bis-nitrilimines
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Cesium fluoride-Celite: a solid base for efficient syntheses of aromatic esters and ethers
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Efficient synthesis of orthogonally protected anti-2,3-diamino acids
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A chitosan-based chemomechanical polymer triggered by stacking effects with aromatic effectors including aminoacid derivatives
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Lissoclibadins 1-3, three new polysulfur alkaloids, from the ascidian Lissoclinum cf. badium
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Isolation and structure elucidation of a new amphidinol with a truncated polyhydroxyl chain from Amphidinium klebsii
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Pyranosylmagellanicus a novel structural class of polyhalogenated acetogenins from Ptilonia magellanica
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Straightforward enantioselective synthesis of (+)-ancistrofuran
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Lewis acid catalyzed asymmetric halohydrin reactions of chiral α,β-unsaturated carboxylic acid derivatives with N-halosuccinimide (NXS) as the halogen source
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Diastereoselective conjugate addition of 1-(α,β-unsaturated acyl)hydantoin with nucleophiles
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Benzo[1,2,5]selenadiazole bridged amines: electro-optical properties
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Substitution reactions in ionic liquids. A kinetic study
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Spectroscopic and DFT studies of nonclassical and classical radical cations of 7-benzhydrylidenenorbornene analogues: contrasting molecular geometry and electronic structures originating from the different patterns of electronic coupling
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Ring-opening reactions of diarylvinylidenecyclopropanes by iodine and bromine
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Synthesis of aromatic phosphates via cycloaddition of phosphate dienes
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Synthesis of chiral nonracemic polyimine macrocycles from cyclocondensation reactions of biaryl and terphenyl aromatic dicarboxaldehydes and 1R,2R-diaminocyclohexane
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Microwave-assisted synthesis of 1-aryl-1H-indazoles via one-pot two-step Cu-catalyzed intramolecular N-arylation of arylhydrazones
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Efficient and general method for the synthesis of benzopyrans by ethylenediamine diacetate-catalyzed reactions of resorcinols with α,β-unsaturated aldehydes. One step synthesis of biologically active (±)-confluentin and (±)-daurichromenic acid
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Solid-phase synthesis of 2-cyanoquinazolin-4(3H)-one and 2,3-dihydrooxazolo[2,3-b]quinazolin-5-one derivatives utilizing resin-bound anthranilic acid derivatives
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Solid-phase synthesis of α-substituted proline hydantoins and analogs
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General-buffer catalysis of the reaction of N-(hydroxymethyl)benzamide: a new pathway for the aqueous reaction of carbinolamides
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Palladium-catalyzed aromatization of β-bromovinyl aldehydes with alkenes
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De novo synthesis of galacto-sugar δ-lactones via a catalytic osmium/palladium/osmium reaction sequence
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Copper-catalyzed aryl amination in aqueous media with 2-dimethylaminoethanol ligand
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Synthesis of chiral N-protected 1,2-dihydro-quinoline-2-carbonitrile and 1,2-dihydro-isoquinoline-1-carbonitrile via an asymmetric Reissert reaction
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Biotechnological production of two new 8,4′-oxynorneolignans by elicitation of Echinacea purpurea cell cultures
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Amide bond formation from selenocarboxylates and aromatic azides
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Indium triflate catalyzed allylation of ketones with diallyldibutyltin
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Zinc oxide (ZnO) as a new, highly efficient, and reusable catalyst for acylation of alcohols, phenols and amines under solvent free conditions
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Syntheses of macrocyclic bisbibenzyls on solid support
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New enantioselective method for hydration of alkenes using cyclodextrins as phase transfer catalyst
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Efficient construction of novel α-keto spiro ketal and the total synthesis of (±)-terreinol
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A novel phosphoramidite for the synthesis of α-oxo aldehyde-modified oligodeoxynucleotides
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