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Daneshyari Drug Discovery Journas Latest Articles

Drug Discovery Research Articles

Preparation of α-silyl- or α,α-bis(silyl)-substituted alkylcopper reagents and their synthetic use
Fulltext Access 9 Pages 2005
An improved Ullmann-Ukita-Buchwald-Li conditions for CuI-catalyzed coupling reaction of 2-pyridones with aryl halides
Fulltext Access 9 Pages 2005
Bellisosides A-F, six novel acylated triterpenoid saponins from Bellis perennis (compositae)
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Synthesis of new polyaza heterocycles. Part 42: Diazines
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Synthesis of 2-aryl-4-chloropyrroles via ring expansion of 2-aryl-1-chlorocyclopropanecarbaldehydes
Fulltext Access 9 Pages 2005
Synthesis of functionalized m-bistrifluoromethylbenzenes via cyclocondensation of 1,1,1,5,5,5-hexafluoroacetylacetone with enamines
Fulltext Access 9 Pages 2005
The reaction between 3-aminocrotonates and oxindole-3-ylidene derivatives: synthesis of highly substituted pyrroles
Fulltext Access 9 Pages 2005
Synthesis of isomerically pure carboxylate- and sulfonate-substituted xanthene fluorophores
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Regioselective enzymatic acylation of vicinal diols of steroids
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Oligothienylenevinylenes incorporating 3,4-ethylenedioxythiophene (EDOT) units
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Thioamides versus amides in anion binding
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A new one-pot synthesis of α-Gal epitope derivatives involved in the hyperacute rejection response in xenotransplantation
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The site-selective functionalization of halogen-bearing phenols: an exercise in diversity-oriented organometallic synthesis
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Graphical contents list
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Pyridino-directed lithiation of anisylpyridines: new access to functional pyridylphenols
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Can relief of ring-strain in a cyclopropylmethyllithium drive the Brook rearrangement?
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Synthesis of cordiaquinone J and K via B-alkyl Suzuki-Miyaura coupling as a key step and determination of the absolute configuration of natural products
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A versatile route to benzocanthinones
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Efficient electrocatalytic addition reactions of allyl phenyl sulfone to electron deficient alkenes
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Convenient synthesis of 2-alkylamino-6-carboxy-5,7-diarylcyclopenteno[1,2-b]pyridines via direct acylamination with imidoyl chlorides
Fulltext Access 9 Pages 2005
Pd/C-mediated coupling of aryl halides with terminal alkynes in water
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Aryl alkynylation versus alkyne homocoupling: unprecedented selectivity switch in Cu, phosphine and solvent-free heterogeneous Pd-catalysed couplings
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Sonogashira reaction of aryl halides with propiolaldehyde diethyl acetal catalyzed by a tetraphosphine/palladium complex
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Asymmetric styrene dimerisation using mixed palladium-indium catalysts
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8-Methylquinoline palladacycles: stable and efficient catalysts for carbon-carbon bond formation
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Structure-activity relationship of trihexyphenidyl analogs with respect to the dopamine transporter in the on going search for a cocaine inhibitor
Fulltext Access 9 Pages 2005
Non-thiol farnesyltransferase inhibitors: N-(4-aminoacylamino-3-benzoylphenyl)-3-[5-(4-nitrophenyl)-2 furyl]acrylic acid amides and their antimalarial activity
Fulltext Access 9 Pages 2005
Homology models of the cannabinoid CB1 and CB2 receptors. A docking analysis study
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Non-imidazole histamine H3 ligands. Part III. New 4-n-propylpiperazines as non-imidazole histamine H3-antagonists
Fulltext Access 9 Pages 2005
Estimation of the effect of the acidosis and alkalosis on the anesthetic potency of local anesthetics by biopartitioning micellar chromatography and micellar electrokinetic chromatography
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Novel inhibitors of acetyl- and butyrylcholinesterase derived from the alkaloids dehydroevodiamine and rutaecarpine
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Synthesis and evaluation of new tripeptide phosphonate inhibitors of MMP-8 and MMP-2
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Synthesis and in vitro cytotoxic evaluation of 1,3-bisubstituted and 1,3,9-trisubstituted β-carboline derivatives
Fulltext Access 9 Pages 2005
Benzenesulfonamide analogs of fluoroquinolones. Antibacterial activity and QSAR studies
Fulltext Access 9 Pages 2005
Construction of a virtual combinatorial library using SMILES strings to discover potential structure-diverse PPAR modulators
Fulltext Access 9 Pages 2005
Synthesis of 2-substituted β-cyclodextrin derivatives with a hydrolytic activity against the organophosphorylester paraoxon
Fulltext Access 9 Pages 2005
Synthesis and evaluation of the antitrypanosomal and antiplasmodial activities of new 4-aminobicyclo[2.2.2]octane derivatives
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Design, synthesis and bioactivities of TAR RNA targeting β-carboline derivatives based on Tat-TAR interaction
Fulltext Access 9 Pages 2005
Palladacycles bearing pendant benzamidinate ligands as catalysts for the Suzuki and Heck coupling reactions
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Design, synthesis and biological activity of acyl substituted 3-amino-5-methyl-1,4,5,7-tetrahydropyrazolo[3,4-b]pyridin-6-ones as potential hypnotic drugs
Fulltext Access 9 Pages 2005
AMBER force field implementation of the boronate function to simulate the inhibition of β-lactamases by alkyl and aryl boronic acids
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Synthesis of 2,5- and 3,5-diphenylpyridine derivatives for DNA recognition and cytotoxicity
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Novel milrinone analogs of pyridine-3-carbonitrile derivatives as promising cardiotonic agents
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A new potential cyclooxygenase-2 inhibitor, pyridinic analogue of nimesulide
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Synthesis and biological evaluation of functionalized coumarins as acetylcholinesterase inhibitors
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Cytotoxic activity of new cerium (III) complexes of bis-coumarins
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Structural changes of benzylether derivatives of vesamicol and their influence on the binding selectivity to the vesicular acetylcholine transporter
Fulltext Access 9 Pages 2005
Synthesis of α,α-disubstituted amino acids based on tandem reaction of dehydroamino acid derivatives
Fulltext Access 9 Pages 2005
Synthesis of (+)-goniothalesdiol and (+)-7-epi-goniothalesdiol
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2-Bromoethyl glycosides for synthesis of glycoconjugates on solid support
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Synthesis of a β-turn mimetic suitable for incorporation in the peptide hormone LHRH
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Galanthamine analogs: 6H-benzofuro[3a,3,2,-e,f][1]benzazepine and 6H-benzofuro[3a,3,2-e,f][3]benzazepine
Fulltext Access 9 Pages 2005
Conservation of helical asymmetry in chiral interactions
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Efficient synthesis of new 11-thiasteroids and their oxides and dioxides
Fulltext Access 9 Pages 2005
Synthesis, X-ray crystallographic, and dynamic 1H NMR studies of crown-tetrathia[3.3.3.3]metacyclophanes-conformational control by cooperative intramolecular C-H⋯π interaction both in solid state and in solution
Fulltext Access 9 Pages 2005
Efficient stereocontrolled synthesis of sphingadienine derivatives
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5-Hydroxy-3-phenyl-5-vinyl-2-isoxazoline and 3-phenyl-5-vinylisoxazole: synthesis and reactivity
Fulltext Access 9 Pages 2005
Preparation of novel 3H-trifluoromethyldiazirine-based photoactivatable potassium channel antagonists
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Arylzinc species by microwave assisted Grignard formation-transmetallation sequence: application in the Negishi coupling
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The total synthesis and reassignment of stereochemistry of dragonamide
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Nitrogen is a requirement for the photochemical induced 3-azabicyclo[3.3.1]nonane skeletal rearrangement!
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Silver acetate-catalysed asymmetric 1,3-dipolar cycloadditions of imines and chiral acrylamides
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Formal total synthesis of (+)-wortmannin using catalytic asymmetric intramolecular aldol condensation reaction
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An approach to the synthesis of α-(1-6)-C-disaccharides by tandem Tebbe methylenation and Claisen rearrangement
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Utilization of 2-ethoxymethylene-3-oxobutanenitrile in the synthesis of heterocycles possessing biological activity
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Modular synthesis of triaroylbenzene-derived crownophanes
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Substituent effects in the ring-chain tautomerism of 4-aryl-1,3,4,6,7,11b-hexahydro-2H-pyrimido[6,1-a]isoquinolines
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Two-dimensional oligoarylenes: synthesis and structure-properties relationships
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Organozinc alkoxide-promoted aldol-Tishchenko reaction of aliphatic aldehydes: an expedient entry to prepare the α-methylene ketones
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Acid-catalysed synthesis and deprotection of dimethyl acetals in a miniaturised electroosmotic flow reactor
Fulltext Access 9 Pages 2005
Efficient and versatile single pot approach to dipyrromethanes and bis(heterocyclyl)methanes
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Fluorescence modification of Gb3 oligosaccharide and rapid synthesis of oligosaccharide moieties using fluorous protective group
Fulltext Access 9 Pages 2005
X=Y-ZH systems as potential 1,3-dipoles. Part 61: Metal exchanged zeolites, silver(I) oxide, Ni(II) and Cu(I) complexes as catalysts for 1,3-dipolar cycloaddition reactions of imines generating proline derivatives
Fulltext Access 9 Pages 2005
Synthesis and properties of 5-[bis(1-heteroazulen-3-yl)methylidene]pyrimidine-2,4,6(1,3,5H)-triones
Fulltext Access 9 Pages 2005
A stereoselective route to multi-substituted tetrahydropyrans by vinyl radical cyclization
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Conformationally restricted analogues of both (S)-β-homoserine and (S)-aspartic acid from chiral 3-acylamino pyrrolidin-2-ones
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In situ formation of palladium(0) from a P,C-palladacycle
Fulltext Access 9 Pages 2005
Graphical contents list
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Organometallic alkylation of 2-chloro-4,6-dimethoxy-1,3,5-triazine: a study
Fulltext Access 9 Pages 2005
Synthesis of alkyl 4-(diethoxymethyl)-3-pyridin-3-ylisoxazole-5-carboxylates: useful scaffold for highly functionalised 3-(pyridin-3-yl)isoxazoles
Fulltext Access 9 Pages 2005
Ligand creation via linking-a rapid and convenient method for construction of novel supported PyOX-ligands
Fulltext Access 9 Pages 2005
Development of a new traceless aniline linker for solid-phase synthesis of azomethines. Application to parallel synthesis of a rod-shaped liquid crystalline library
Fulltext Access 9 Pages 2005
Micellar effect on the electron transfer reaction of chromium(V) ion with organic sulfides
Fulltext Access 9 Pages 2005
Synthesis of substituted bis(heteroaryl)maleimides
Fulltext Access 9 Pages 2005
Efficient syntheses of thiadiazoline and thiadiazole derivatives by the cyclization of 3-aryl-4-formylsydnone thiosemicarbazones with acetic anhydride and ferric chloride
Fulltext Access 9 Pages 2005
A new (R)-hydroxynitrile lyase from Prunus mume: asymmetric synthesis of cyanohydrins
Fulltext Access 9 Pages 2005
Acid-catalyzed addition of indoles to hydroxyquinones
Fulltext Access 9 Pages 2005
New reaction of enamines with aryldiazoacetates catalyzed by transition metal complexes
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Trifluoromethyl group as a pharmacophore: Effect of replacing a CF3 group on binding and agonist activity of a glucocorticoid receptor ligand
Fulltext Access 9 Pages 2005
Enantiomerically pure 4-amino-1,2,3-trihydroxybutylphosphonic acids
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Synthesis and solvent dependence of the photophysical properties of [60]fullerene-sugar conjugates
Fulltext Access 9 Pages 2005
One-pot three-component reaction of fluoroalkanesulfonyl azide, vinyl ether and aldehyde: the formation of polysubstituted fluorinated oxazolidines
Fulltext Access 9 Pages 2005
Synthesis and properties of 3-arylcyclohepta[4,5]imidazo[1,2-a]-1,3,5-triazine-2,4(3H)-diones and related compounds: photo-induced autorecycling oxidation of some amines
Fulltext Access 9 Pages 2005
One-pot enzymatic desymmetrization and Ugi MCR
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Regioselective formation of N-alkyl-3,5-pyrazole derived ligands. A synthetic and computational study
Fulltext Access 9 Pages 2005
The optimization for cyclization reaction of 2-(2-carbomethoxyethynyl)aniline derivatives and formal synthesis of pyrroloquinoline quinone and its analogue utilizing a sequential coupling-cyclization reaction
Fulltext Access 9 Pages 2005
Synthesis of dendritic oligo(aryl sulfone)s as supports for synthesis
Fulltext Access 9 Pages 2005
Structural analyses of 4-benzoylpyridine thiosemicarbazone using NMR techniques and theoretical calculations
Fulltext Access 9 Pages 2005
Studies on the stereochemistry of 1,2,6-trimethyl-4-piperidone
Fulltext Access 9 Pages 2005
Photoinduced electron transfer across linearly fused oligo-norbornyl structures
Fulltext Access 9 Pages 2005
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