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Daneshyari Drug Discovery Journas Latest Articles

Drug Discovery Research Articles

Regio- and stereoselective reactions between cyclic Baylis-Hillman type adducts and N-nucleophiles and P-nucleophile
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Flexibility in starfish behavior by multi-layered mechanism of self-organization
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A complex adaptive systems approach to the kinetic folding of RNA
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Tri-nucleotide repeats and their association with genes in rice genome
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Detecting correlation between sequence and expression divergences in a comparative analysis of human serpin genes
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Disease mechanisms associated with mutations of the GNE gene
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From ligand design to therapeutic efficacy: the challenge for nicotinic receptor research
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Novel and emerging therapies for asthma
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Representativity of target families in the Protein Data Bank: impact for family-directed structure-based drug discovery
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Therapies for rheumatoid arthritis: hope springs eternal
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Incorporating anatomically realistic cellular-level connectivity in neural network models of the rat hippocampus
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Gap junctions promote synchronous activities in a network of inhibitory interneurons
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Effect of periodic stimulus on a neuronal diffusion model with signal-dependent noise
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DNA algorithm for an unbounded fan-in Boolean circuit
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Synthesis of [60]fullerene-based α-amino acid derivatives
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Photochemically catalyzed Diels-Alder reaction of arylimines with N-vinylpyrrolidinone and N-vinylcarbazole by 2,4,6-triphenylpyrylium salt: synthesis of 4-heterocycle-substituted tetrahydroquinoline derivatives
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Lewis acid mediated reactions of cyclopropyl aryl ketones with arylaldehydes, facile preparation of 2-(2-hydroxyethyl)-1,3-diarylpropenones
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Reaction of 3/2-formylindoles with TOSMIC: formation of indolyloxazoles and stable indolyl primary enamines
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Synthesis of poly(pyridylthioether) dendrimers incorporating a Fe2(CO)6 cluster core
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Tandem intramolecular carbolithiation-transmetallation: from lithium to copper or boron chemistry
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Graphical contents list
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Metalation/functionalization sequences applied to 2-bromo-3-fluoroquinolines
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Chemistry of vinyl sulfones. Approach to novel conformationally restricted analogues of glutamic acid
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Banyasin A and banyasides A and B, three novel modified peptides from a water bloom of the cyanobacterium Nostoc sp.
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Facile synthesis of regio-isomeric naphthofurans and benzodifurans
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Discovery and development of biomarkers of neurological disease
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Determination of tumour marker genes from gene expression data
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Computer prediction of drug resistance mutations in proteins
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Progress in protein and antibody microarray technology
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Aquaporins as targets for drug discovery
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Functional genomics in antibacterial drug discovery
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Dopamine D3 receptor antagonists as therapeutic agents
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Keynote review: Is declining innovation in the pharmaceutical industry a myth?
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Ototoxicity: therapeutic opportunities
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Dendrimers and dendritic polymers in drug delivery
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Target-based drug discovery: is something wrong?
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Therapeutic scope of modulation of non-voltage-gated cation channels
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Cell culture-based models for intestinal permeability: A critique
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New polychlorinated pyrrolidinones from the Red Sea marine sponge Lamellodysidea herbacea
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Formulation strategies for absorption windows
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In silico strategies for modeling membrane transporter function
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Staphylococcus aureus: the search for novel targets
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Peroxidases: a role in the metabolism and side effects of drugs
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Not all viruses are bad guys: the case for reovirus in cancer therapy
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Delivery options for contraceptives
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A simple mathematical model of cooperativity in receptor mosaics based on the “symmetry rule”
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Synonymous codon usage and gene function are strongly related in Oryza sativa
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Comparative analysis of base biases around the stop codons in six eukaryotes
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Controlled synthesis of target strings in a class of splicing systems
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Learning Petri net models of non-linear gene interactions
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Graphical contents list
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An unusual substitution reaction directed by an intramolecular re-arrangement
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New cytotoxic bufadienolides from the biotransformation of resibufogenin by Mucor polymorphosporus
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Mukaiyama aldolisation reactions of α,β-epoxyaldehydes in aqueous media
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Concept and synthetic approach for a kilogram scale synthesis of octa-d-arginine amide nonahydrochloride salt
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Solvent-free condensation of arylacetonitrile with aldehydes
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Synthesis of new crosslinkable co-polymers containing a push-pull zinc porphyrin for non-linear optical applications
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Electron transfer reactions of tris(polypyridine)ruthenium(III) complexes with organic sulfides: importance of hydrophobic interaction
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Synthesis of 3- and 5-amino-5-(3)-(pyrrol-2-yl)isoxazoles
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Fragmentation of tertiary cyclopropanol compounds catalyzed by vanadyl acetylacetonate
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A C3′ modified nucleotide. The difluorophosphonate function, a phosphate mimic, governs the conformational behaviour of the ribofuranose
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Exploring structural effects of ketone catalysts on asymmetric epoxidation of olefins
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Domino hydroformylation-Wittig olefination-hydrogenation
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Novel stereocontrolled approach to conformationally constrained analogues of l-glutamic acid and l-proline via stereoselective cyclopropanation of 3,4-didehydro-l-pyroglutamic ABO ester
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Multicomponent synthesis of epoxy-tetrahydronaphthyridine and structural diversification by subsequent fragmentation
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Nickel-catalyzed couplings and cyclizations involving allenes, aldehydes, and organozincs
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Preparation of functionalized primary chiral amines and amides via an enantioselective three-component synthesis of propargylamines
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Stereocontrolled reduction of chiral pyrrolidine and piperidine β-enamino esters: formal enantioselective synthesis of (+)-calvine
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Asymmetric total synthesis of B-ring modified (−)-epicatechin gallate analogues and their modulation of β-lactam resistance in Staphylococcus aureus
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Synthetic yeast oligomannosides as biological probes: α-d-Manp (1→3) α-d-Manp (1→2) α-d-Manp and α-d-Manp (1→3) α-d-Manp (1→2) α-d-Manp (1→2) α-d-Manp as Crohn's disease markers
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Thermal cyclization of N-[2-(2-propenyl)-1-naphthyl] ketenimines: intramolecular Diels-Alder reaction versus [1,5] hydrogen migration. Synthesis of dibenz[b,h]acridines and benzo[h]quinolines
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Polymer-micelle incarcerated ruthenium catalysts for oxidation of alcohols and sulfides
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Di(2-pyridyl)methylamine-palladium dichloride complex covalently anchored to a styrene-maleic anhydride co-polymer as recoverable catalyst for C-C cross-coupling reactions in water
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Polymer-bound aluminium salen complex as reusable catalysts for CO2 insertion into epoxides
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Polymer-supported palladium catalysed Suzuki-Miyaura reactions in batch and a mini-continuous flow reactor system
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Highly enantioselective hetero-Diels-Alder reaction between trans-1-methoxy-2-methyl-3-trimethylsiloxybuta-1,3-diene and aldehydes catalyzed by (R)-BINOL-Ti(IV) complex
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Reaction of some 4,6-dimethoxyindoles with nitric acid: nitration and oxidative dimerisation
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The total synthesis of bistratamides F-I
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Investigations into the utility of high-surface area silica pellets as potential solid-phase synthesis supports
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Graphical contents list
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Synthesis and photochromic properties of substituted 3H-naphtho[2,1-b]pyrans
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Synthesis of 9- and 10-membered macrolactones by selective ozonolysis of 1,4-diazaphenanthrene derivatives
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Rearrangement or gem-difluorination of quinine and 9-epiquinine and their acetates in superacid
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Synthesis of natural pulvinic acids based on a '[3+2] cyclization-Suzuki cross-coupling' strategy
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The study of intramolecular tandem radical cyclizations of acylsilanes with radicalphiles attached on silicon
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Preparation of highly deuterated zeaxanthin, lycopene, and β-carotene from fully deuterated mevalonate using engineered Escherichia coli
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Enzymatic synthesis and bioactivity of estradiol derivative conjugates with different amino acids
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Supramolecular parallel β-sheet and amyloid-like fibril forming peptides using δ-aminovaleric acid residue
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Facile and purification free synthesis of peptides utilizing ROMPgel- and ROMPsphere-supported coupling reagents
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Reactions of allyloxy(methoxy)carbene in solution. Carbene rearrangement and Claisen rearrangement of the carbene dimer
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Kinetics and mechanism of thermal gas-phase elimination of β-substituted carboxylic acids
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Synthesis of azide-fluoro-dehydrocoelenterazine analog as a photoaffinity-labeling probe and photolysis of azide-fluoro-coelenterazine
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Structure and conformational processes of bis(o-cumyl)sulfide, sulfoxide and sulfone
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Molecular structure and hydrolytic stability amidinium salts derived from triazatricyclo[5.2.1.04,10]decane
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Efficient metathesis route to the B-ring of eleutherobin and other medium-sized cyclic ethers
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Synthesis of phthalascidin analogs
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Palladium catalyzed Suzuki-Miyaura coupling with aryl chlorides using a bulky phenanthryl N-heterocyclic carbene ligand
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Tuning the reactivity and chemoselectivity of electron-poor pyrroles as dienophiles in cycloadditions with electron-rich dienes
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Radical hydrogen abstraction-cyclization with a 2-bromovinylsilyl group as a bifunctional tether
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Contributors to this issue
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