Pharmacokinetics and tissue distribution of a new heterocyclic N-phenylpiperazine derivative (LASSBio-581) in rats Fulltext Access 9 Pages 2005
Pegylated nanoparticles based on poly(methyl vinyl ether-co-maleic anhydride): preparation and evaluation of their bioadhesive properties Fulltext Access 9 Pages 2005
Permeability of pig urinary bladder wall: the effect of chitosan and the role of calcium Fulltext Access 9 Pages 2005
Atomic force microscopy and photon correlation spectroscopy: Two techniques for rapid characterization of liposomes Fulltext Access 9 Pages 2005
Vanillin suppresses in vitro invasion and in vivo metastasis of mouse breast cancer cells Fulltext Access 9 Pages 2005
Pharmacokinetic changes of DA-7867, a new oxazolidinone, after intravenous and oral administration to rats with short-term and long-term diabetes mellitus induced by streptozotocin Fulltext Access 9 Pages 2005
Hydrophilic solutes in modified carbon dioxide extraction-prediction of the extractability using molecular dynamic simulation Fulltext Access 9 Pages 2005
Modulation of drug transport by selected flavonoids: Involvement of P-gp and OCT? Fulltext Access 9 Pages 2005
Biphasic accumulation kinetics of [99mTc]-hexakis-2-methoxyisobutyl isonitrile in tumour cells and its modulation by lipophilic P-glycoprotein ligands Fulltext Access 9 Pages 2005
Enhanced oral paclitaxel absorption with vitamin E-TPGS: Effect on solubility and permeability in vitro, in situ and in vivo Fulltext Access 9 Pages 2005
A modification of the Hammett equation for predicting ionisation constants of p-vinyl phenols Fulltext Access 9 Pages 2005
Insights into structure-activity relationships from lipophilicity profiles of pyridin-2(1H)-one analogs of the cardiotonic agent milrinone Fulltext Access 9 Pages 2005
Oxidative metabolism of 5-o-caffeoylquinic acid (chlorogenic acid), a bioactive natural product, by metalloporphyrin and rat liver mitochondria Fulltext Access 9 Pages 2005
Amphiphilic amino acid copolymers as stabilizers for the preparation of nanocrystal dispersion Fulltext Access 9 Pages 2005
Effect of amino acid sequence on transdermal iontophoretic peptide delivery Fulltext Access 9 Pages 2005
Quantitative structure-activity relationships of methotrexate and methotrexate analogues transported by the rat multispecific resistance-associated protein 2 (rMrp2) Fulltext Access 9 Pages 2005
Release evaluation of drugs from ordered three-dimensional silica structures Fulltext Access 9 Pages 2005
Pharmacological and histological characterisation of nicotine-kindled seizures in mice Fulltext Access 9 Pages 2005
GABAB receptor antagonist SGS742 improves spatial memory and reduces protein binding to the cAMP response element (CRE) in the hippocampus Fulltext Access 9 Pages 2005
Comparison of the effects of diazepam, the CRF1 antagonist CP-154,526 and the group II mGlu receptor agonist LY379268 on stress-evoked extracellular norepinephrine levels Fulltext Access 9 Pages 2005
Hyperfunctionality of serotonin-2C receptor-mediated inhibition of accumbal dopamine release in an animal model of depression is reversed by antidepressant treatment Fulltext Access 9 Pages 2005
Autoradiographic characterisation of [35S]GTPγS binding stimulation mediated by 5-HT1B receptor in postmortem human brain Fulltext Access 9 Pages 2005
Influence of probenecid on the delivery of morphine-6-glucuronide to the brain Fulltext Access 9 Pages 2005
Disease models for elucidation of mechanisms and prediction of drug-induced proarrhythmia Fulltext Access 9 Pages 2005
Assessment of the combined approach of N-alkylation and salt formation to enhance aqueous solubility of tertiary amines using bupivacaine as a model drug Fulltext Access 9 Pages 2005
Development of a nanoprecipitation method intended for the entrapment of hydrophilic drugs into nanoparticles Fulltext Access 9 Pages 2005
Differential inhibitory effects of honokiol and magnolol on excitatory amino acid-evoked cation signals and NMDA-induced seizures Fulltext Access 9 Pages 2005
Thermodynamics of solubility, sublimation and solvation processes of parabens Fulltext Access 9 Pages 2005
Determination of the partition coefficients and absorption kinetic parameters of chemicals in a lipophilic membrane/water system by using a membrane-coated fiber technique Fulltext Access 9 Pages 2005
A new method to determine the partial solubility parameters of polymers from intrinsic viscosity Fulltext Access 9 Pages 2005
2,3-Diarylimidazo[1,2-a]pyridines as potential inhibitors of UV-induced keratinocytes apoptosis: synthesis, pharmacological properties and interactions with model membranes and oligonucleotides by NMR Fulltext Access 9 Pages 2005
In vivo in vitro correlations for a poorly soluble drug, danazol, using the flow-through dissolution method with biorelevant dissolution media Fulltext Access 9 Pages 2005
Antiprotozoal activities of new bicyclo[2.2.2]octan-2-imines and esters of bicyclo[2.2.2]octan-2-ols Fulltext Access 9 Pages 2005
Identification and quantitation of novel metabolites of amiodarone in plasma of treated patients Fulltext Access 9 Pages 2005
Transfer of morphine along the olfactory pathway to the central nervous system after nasal administration to rodents Fulltext Access 9 Pages 2005
The role of physicochemical properties of entacapone and tolcapone on their efficacy during local intrastriatal administration Fulltext Access 9 Pages 2005
Autoimmune disorders result from loss of epigenetic control following chromosome damage Fulltext Access 9 Pages 2005
5-HT1A receptor agonists modify epileptic seizures in three experimental models in rats Fulltext Access 9 Pages 2005
Serotonin 5-HT2A but not 5-HT2C receptor antagonism reduces hyperlocomotor activity induced in dopamine-depleted rats by striatal administration of the D1 agonist SKF 82958 Fulltext Access 9 Pages 2005
Pleomorphic mammalian tumor-derived bacteria self-organize as multicellular mammalian eukaryotic-like organisms: morphogenetic properties in vitro, possible origins, and possible roles in mammalian `tumor ecologies' Fulltext Access 9 Pages 2005
A “new-old” way of thinking about brain disorder, cerebral excitability - the fundamental property of nervous tissue Fulltext Access 9 Pages 2005
The potential importance of steroids in the treatment of autistic spectrum disorders and other disorders involving mercury toxicity Fulltext Access 9 Pages 2005
Effects on the serotoninergic system in sub-acute transmissible spongiform encephalopathies: current data, hypotheses, suggestions for experimentation Fulltext Access 9 Pages 2005
Carotid body dysfunction: The possible etiology of non-insulin dependent diabetes mellitus and essential hypertension Fulltext Access 9 Pages 2005
Up-regulation of PPARγ coactivator-1α as a strategy for preventing and reversing insulin resistance and obesity Fulltext Access 9 Pages 2005
Chronic ACTH autoantibodies are a significant pathological factor in the disruption of the hypothalamic-pituitary-adrenal axis in chronic fatigue syndrome, anorexia nervosa and major depression Fulltext Access 9 Pages 2005
Magnesium may mediate the favorable impact of whole grains on insulin sensitivity by acting as a mild calcium antagonist Fulltext Access 9 Pages 2005
Paraventricular hypothalamic CB1 cannabinoid receptors are involved in the feeding stimulatory effects of Î9-tetrahydrocannabinol Fulltext Access 9 Pages 2005
The sweet thing about Type 1 diabetes: A cryoprotective evolutionary adaptation Fulltext Access 9 Pages 2005
Serotonergic paradoxes of autism replicated in a simple mathematical model Fulltext Access 9 Pages 2005
Mitochondrial dysfunction plays a key role in progressive axonal loss in Multiple Sclerosis Fulltext Access 9 Pages 2005
PEGylated peptide-based dendritic nanoparticulate systems for delivery of artemether Fulltext Access 9 Pages 2005
Template-synthesized nanotubes for biotechnology and biomedical applications Fulltext Access 9 Pages 2005
Improvement in the variation of inhalation properties of an FK888 dry powder inhaler using an E-haler, by adding coarse lactose in spherical soft agglomerates of fine drug particles, and its absorption in healthy volunteers Fulltext Access 9 Pages 2005
Inhibitory effect of imipramine on the human corticotropin-releasing-hormone gene promoter activity operates through a PI3-K/AKT mediated pathway Fulltext Access 9 Pages 2005
Lack of stimulant and anxiolytic-like effects of ethanol and accelerated development of ethanol dependence in mu-opioid receptor knockout mice Fulltext Access 9 Pages 2005
Antiepileptogenic and antioxidant effects of Nigella sativa oil against pentylenetetrazol-induced kindling in mice Fulltext Access 9 Pages 2005
MTEP, a new selective antagonist of the metabotropic glutamate receptor subtype 5 (mGluR5), produces antiparkinsonian-like effects in rats Fulltext Access 9 Pages 2005
Repeated administration of group I mGluR antagonists prevents seizure-induced long-term aberrations in hippocampal synaptic plasticity Fulltext Access 9 Pages 2005
Group I metabotropic glutamate receptors stimulate the activity of poly(ADP-ribose) polymerase in mammalian mGlu1-transfected cells and in cortical cell cultures Fulltext Access 9 Pages 2005
Modulation of retino-collicular transmission by Group III metabotropic glutamate receptors at different ages during development Fulltext Access 9 Pages 2005
Transport of transforming growth factor-β2 across the blood-brain barrier Fulltext Access 9 Pages 2005
Neonatal toluene exposure alters N-methyl-d-aspartate receptor subunit expression in the hippocampus and cerebellum in juvenile rats Fulltext Access 9 Pages 2005
Serotonin-transporter mediated efflux: A pharmacological analysis of amphetamines and non-amphetamines Fulltext Access 9 Pages 2005
Rapid delivery of the dopamine transporter to the plasmalemmal membrane upon amphetamine stimulation Fulltext Access 9 Pages 2005
Intramolecular cross-linking in a bacterial homolog of mammalian SLC6 neurotransmitter transporters suggests an evolutionary conserved role of transmembrane segments 7 and 8 Fulltext Access 9 Pages 2005
Naltrexone in the short-term decreases antiparkinsonian response to l-Dopa and in the long-term increases dyskinesias in drug-naïve parkinsonian monkeys Fulltext Access 9 Pages 2005
Novel antipsychotic agents with 5-HT1A agonist properties: Role of 5-HT1A receptor activation in attenuation of catalepsy induction in rats Fulltext Access 9 Pages 2005
Ascorbic acid inhibits ROS production, NF-κB activation and prevents ethanol-induced growth retardation and microencephaly Fulltext Access 9 Pages 2005
In vivo behavioral effects of stable, receptor-selective neurotensin[8-13] analogues that cross the blood-brain barrier Fulltext Access 9 Pages 2005
Munc18-dependent regulation of synaptic vesicle exocytosis by syntaxin-1A in hippocampal neurons Fulltext Access 9 Pages 2005
Pro-VGF-derived peptides induce penile erection in male rats: Involvement of paraventricular nitric oxide Fulltext Access 9 Pages 2005
Effects of emodin on synaptic transmission in rat hippocampal CA1 pyramidal neurons in vitro Fulltext Access 9 Pages 2005
Time course of opioid and cannabinoid gene transcription alterations induced by repeated administration with fluoxetine in the rat brain Fulltext Access 9 Pages 2005
Postsynaptic actions of substance P on rat periaqueductal grey neurons in vitro Fulltext Access 9 Pages 2005
Inhibition of fatty-acid amide hydrolase enhances cannabinoid stress-induced analgesia: Sites of action in the dorsolateral periaqueductal gray and rostral ventromedial medulla Fulltext Access 9 Pages 2005
Activation of GABAA receptors by taurine and muscimol blocks the neurotoxicity of β-amyloid in rat hippocampal and cortical neurons Fulltext Access 9 Pages 2005