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Daneshyari Drug Discovery Journas Latest Articles

Drug Discovery Research Articles

Comparison of the Effects of Ionization Mechanism, Analyte Concentration, and Ion “Cool-Times” on the Internal Energies of Peptide Ions Produced by Electrospray and Atmospheric Pressure Matrix-Assisted Laser Desorption Ionization
Fulltext Access 9 Pages 2005
Increasing Peptide Identification in Tandem Mass Spectrometry Through Automatic Function Switching Optimization
Fulltext Access 9 Pages 2005
Trapping of Wide Range Mass-to-Charge Ions and Dependence on Matrix Amount in Internal Source MALDI-FTMS
Fulltext Access 9 Pages 2005
A Combination Atmospheric Pressure LC/MS:GC/MS Ion Source: Advantages of Dual AP-LC/MS:GC/MS Instrumentation
Fulltext Access 9 Pages 2005
In-Situ probing of the biotic-abiotic boundary of plants by laser desorption/ionization time-of-flight mass spectrometry
Fulltext Access 9 Pages 2005
Algorithm for accurate similarity measurements of peptide mass fingerprints and its application
Fulltext Access 9 Pages 2005
Ultrafiltration tandem mass spectrometry of estrogens for characterization of structure and affinity for human estrogen receptors
Fulltext Access 9 Pages 2005
Promotion of α-cyano-4-hydroxycinnamic acid and peptide cocrystallization within levitated droplets with net charge1
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Hydroxyl radical probe of the calmodulin-melittin complex interface by electrospray ionization mass spectrometry1
Fulltext Access 9 Pages 2005
Atmospheric pressure MALDI-FTMS of normal and chemically modified RNA
Fulltext Access 9 Pages 2005
Fragmentations and reactions of the organophosphate insecticide Diazinon and its oxygen analog Diazoxon studied by electrospray ionization ion trap mass spectrometry
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Optimization of a MALDI TOF-TOF mass spectrometer for intact protein analysis
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Facile Generation of Tripeptide Radical Cations In Vacuo via Intramolecular Electron Transfer in CuII Tripeptide Complexes Containing Sterically Encumbered Terpyridine Ligands
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Interactions Between Sodium Dodecyl Sulfate Micelles and Peptides During Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry (MALDI-MS) of Proteolytic Digests
Fulltext Access 9 Pages 2005
Low Uncertainty Reverse Isotope Dilution ICP-MS Applied to Certifying an Isotopically Enriched Cd Candidate Reference Material: A Case Study
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MALDI-TOF MS Analysis of Soluble PEG Based Multi-Step Synthetic Reaction Mixtures with Automated Detection of Reaction Failure
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Fragmentation of Negative Ions from Carbohydrates: Part 1. Use of Nitrate and Other Anionic Adducts for the Production of Negative Ion Electrospray Spectra from N-linked Carbohydrates
Fulltext Access 9 Pages 2005
Compensation Voltage (CV) Peak Shapes Using a Domed FAIMS with the Inner Electrode Translated to Various Longitudinal Positions
Fulltext Access 9 Pages 2005
Denaturation of Lysozyme and Myoglobin in Laser Spray
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Actions of Ya-hom, a herbal drug combination, on isolated rat aortic ring and atrial contractions
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Randomized trial of a fixed combination (KanJang®) of herbal extracts containing Adhatoda vasica, Echinacea purpurea and Eleutherococcus senticosus in patients with upper respiratory tract infections
Fulltext Access 9 Pages 2005
In vitro induction of endothelial cell fibrinolytic alterations by Nigella sativa
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Antiprotozoal activity of Brazilian plant extracts from isoquinoline alkaloid-producing families
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Modulatory influence of Adhatoda vasica Nees leaf extract against gamma irradiation in Swiss albino mice
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Formulation and in vitro/in vivo evaluation of combining DNA repair and immune enhancing nutritional supplements
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Development of Proton-Transfer Ion Trap-Mass Spectrometry: On-line Detection and Identification of Volatile Organic Compounds in Air
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Radioiodinated phenylalanine derivatives to image pancreatic cancer: a comparative study with [18F]fluoro-2-deoxy-d-glucose in human pancreatic carcinoma xenografts and in inflammation models
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Evidence for reduced arterial plasma input, prolonged lung retention and reduced lung monoamine oxidase in smokers
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Inhibition of carnitine-acyl transferase I by oxfenicine studied in vivo with [11C]-labeled fatty acids
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Tumor-targeting properties of 90Y- and 177Lu-labeled α-melanocyte stimulating hormone peptide analogues in a murine melanoma model
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True tracers: comparing FDG with glucose and FLT with thymidine
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Evaluation of F-18-labeled amino acid derivatives and [18F]FDG as PET probes in a brain tumor-bearing animal model
Fulltext Access 9 Pages 2005
Synthesis and in vitro examination of [124I]-, [125I]- and [131I]-2-(4-iodophenylamino) pyrido[2,3-d]pyrimidin-7-one radiolabeled Abl kinase inhibitors
Fulltext Access 9 Pages 2005
Biodistribution of 225Ra citrate in mice: retention of daughter radioisotopes in bone
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Noninvasive imaging of transplanted living functional cells transfected with a reporter estrogen receptor gene
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Imaging herpes viral thymidine kinase-1 reporter gene expression with a new 18F-labeled probe: 2′-fluoro-2′-deoxy-5-[18F]fluoroethyl-1-β-d-arabinofuranosyl uracil
Fulltext Access 9 Pages 2005
The Validation of Exact Mass Measurements for Small Molecules Using FT-ICRMS for Improved Confidence in the Selection of Elemental Formulas
Fulltext Access 9 Pages 2005
Effect of the Solvent Flow Rate on the Ionization Efficiency in Atmospheric Pressure Photoionization-Mass Spectrometry
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A 1-year follow-up after a pilot study with Doloteffin® for low back pain
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Collision induced ion ejection in an FTICR trapped-ion cell
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Structural characterization and regiochemical differentiation of α-cyanoethylindole isomers in the gas phase
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Chemometric approaches in calibration experiments of trilinolenoylglycerol by liquid chromatography ion-trap mass spectrometry
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Upper stability island of the quadrupole mass filter with amplitude modulation of the applied voltages
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Investigation of metal-oligonucleotide complexes by nanoelectrospray tandem mass spectrometry in the positive mode
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Enhanced detection of sulfated glycosylation sites in glycoproteins
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Structural characterization of sialic acid synthase by electrospray mass spectrometry-a tetrameric enzyme composed of dimeric dimers
Fulltext Access 9 Pages 2005
Ganglioside Analysis by Thin-Layer Chromatography Matrix-Assisted Laser Desorption/Ionization Orthogonal Time-of-Flight Mass Spectrometry
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Speciation of Cyclo(Pro-Gly)3 and Its Divalent Metal-Ion Complexes by Electrospray Ionization Mass Spectrometry
Fulltext Access 9 Pages 2005
Complexes of Dibromo(ethylenediamine)- Palladium(II) Observed from Aqueous Solutions by Electrospray Mass Spectrometry
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FAIMS Operation for Realistic Gas Flow Profile and Asymmetric Waveforms Including Electronic Noise and Ripple
Fulltext Access 9 Pages 2005
Biochemical and Molecular Pharmacological Aspects of Transporters as Determinants of Drug Disposition
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Pharmacokinetics and Tissue Distribution of Etoposide Delivered in Parenteral Emulsion
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Rheology and NMR Self-Diffusion Experiments as Well as Skin Permeation of Diclofenac-Sodium and Cyproterone Acetate of New Gel Preparations
Fulltext Access 9 Pages 2005
Study of the Percutaneous Penetration of Flurbiprofen by Cutaneous and Subcutaneous Microdialysis after Iontophoretic Delivery in Rat
Fulltext Access 9 Pages 2005
Study of Interaction between Ibuprofen and Nicotinamide Using Differential Scanning Calorimetry, Spectroscopy, and Microscopy and Formulation of a Fast-Acting and Possibly Better Ibuprofen Suspension for Osteoarthritis Patients
Fulltext Access 9 Pages 2005
Buccal Permeation of Buspirone: Mechanistic Studies on Transport Pathways
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Determination of fluidized bed granulation end point using near‐infrared spectroscopy and phenomenological analysis
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Phase solubility and structure of the inclusion complexes of prednisolone and 6α‐methyl prednisolone with various cyclodextrins
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Interindividual Variability in Nicotine Metabolism: C-Oxidation and Glucuronidation
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Prediction of Theophylline Clearance in CCl4-treated Rats Using in vivo CYP1A2 and CYP3A2 Contents Assessed with the PKCYP Test
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Na+/H+ Exchanger 3 Affects Transport Property of H+/Oligopeptide Transporter 1
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Role of Soybean Oil Pat Emulsion in the Prevention of Hepatic Xenobiotic Transporter mRNA Up- and Down-Regulation Induced by Overdose of Pat-free Total Parenteral Nutrition in Infant Rats
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Urinary Excretion of Phenytoin Metabolites, 5-(4′-hydroxyphenyl)-5-Phenylhydantoin and its O-glucuronide in Humans and Analysis of Genetic Polymorphisms of UDP-glucuronosyltransferases
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Nasal Drug Administration: Potential for Targeted Central Nervous System Delivery
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Développement des inhibiteurs de farnésyl transférase comme agents anticancéreux
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Relations structure, activité et mécanisme d'action des antitumoraux de série benzo[b]acronycine
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Le traitement médicamenteux de l'insuffisance cardiaque
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Stratégies thérapeutiques dans les cancers colorectaux
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Spectroscopic Analysis of Highly Concentrated Suspensions of Bovine Somatotropin in Sesame Oil
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Chitosan Oligomers as Potential and Safe Absorption Enhancers for Improving the Pulmonary Absorption of Interferon-α in Rats
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Capillary zone electrophoresis for the estimation of transdermal iontophoretic mobility
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Noninvasive Determination of Protein Conformation in the Solid State Using Near Infrared (NIR) Spectroscopy
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Stability of Oxymethyl-Modified Coumarinic Acid Cyclic Prodrugs of Diastereomeric Opioid Peptides in Biological Media from Various Animal Species Including Human
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Study on the Interactions Between Polyvinylpyrrolidone (PVP) and Acetaminophen Crystals: Partial Dissolution Pattern Change
Fulltext Access 9 Pages 2005
Double Bond Migration to Methylidene Positions During Electron Ionization Mass Spectrometry of Branched Monounsaturated Fatty Acid Derivatives
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Multiple Pathways Are Involved in the Oral Absorption of BMS-262084, a Tryptase Inhibitor, in Rats: Role of Paracellular Transport, Binding to Trypsin, and P-Glycoprotein Efflux
Fulltext Access 9 Pages 2005
Validation of a colorimetric assay for the in vitro screening of inhibitors of angiotensin-converting enzyme (ACE) from plant extracts
Fulltext Access 9 Pages 2005
Signal transduction underlying carbachol-induced PGE2 generation and cox-1 mRNA expression of rat brain
Fulltext Access 9 Pages 2005
Opioids inhibit purinergic nociceptors in the sensory neurons and fibres of rat via a G protein-dependent mechanism
Fulltext Access 9 Pages 2005
Diclofenac, a nonsteroidal anti-inflammatory drug, activates the transient outward K+ current in rat cerebellar granule cells
Fulltext Access 9 Pages 2005
Pentylenetetrazole-induced convulsions affect cellular and molecular parameters of the mechanism of action of triiodothyronine in adult rat brain
Fulltext Access 9 Pages 2005
Behavioral and convulsant effects of the (S) enantiomer of the group I metabotropic glutamate receptor agonist 3,5-DHPG in mice
Fulltext Access 9 Pages 2005
Pharmacological reactivity to cocaine in adult rats undernourished at perinatal age: behavioral and neurochemical correlates
Fulltext Access 9 Pages 2005
Comparison of the effects of anticonvulsant drugs with diverse mechanisms of action in the formalin test in rats
Fulltext Access 9 Pages 2005
Beneficial effects of vitamin C and vitamin E on reserpine-induced oral dyskinesia in rats: Critical role of striatal catalase activity
Fulltext Access 9 Pages 2005
Studies of ATP-sensitive potassium channels on 6-hydroxydopamine and haloperidol rat models of Parkinson's disease: Implications for treating Parkinson's disease?
Fulltext Access 9 Pages 2005
Bioconversion of Naltrexone and Its 3-O-Alkyl-Ester Prodrugs in a Human Skin Equivalent
Fulltext Access 9 Pages 2005
Effect of Polymer Size and Cosolutes on Phase Separation of Poly(Vinylpyrrolidone) (PVP) and Dextran in Frozen Solutions
Fulltext Access 9 Pages 2005
Investigation of the Presence of b Ions in Electron Capture Dissociation Mass Spectra
Fulltext Access 9 Pages 2005
In Vitro Percutaneous Penetration of Acyclovir from Solvent Systems and Carbopol 971-P Hydrogels: Influence of Propylene Glycol
Fulltext Access 9 Pages 2005
Effect of Particle Shape of Active Pharmaceutical Ingredients Prepared by Fluidized-Bed Jet-Milling on Cohesiveness
Fulltext Access 9 Pages 2005
Effect of Piceatannol in Human Monocyte-Derived Dendritic Cells In Vitro
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Relationship between swelling of hydroxypropylmethylcellulose and the Hansen and Karger partial solubility parameters
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Real-time near-infrared monitoring of content uniformity, moisture content, compact density, tensile strength, and young's modulus of roller compacted powder blends
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Effect of device inhalational resistance on the three-dimensional configuration of the upper airway
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Bioavailability of seocalcitol I: Relating solubility in biorelevant media with oral bioavailability in rats-effect of medium and long chain triglycerides
Fulltext Access 9 Pages 2005
Bilayer to micelle transition of DMPC and alcohol ethoxylate surfactants as studied by isoperibol calorimetry
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Increased erythrocyte distribution of valproic acid in pharmacokinetic interaction with carbapenem antibiotics in rat and human
Fulltext Access 9 Pages 2005
Postfabrication encapsulation of model protein drugs in a negatively thermosensitive hydrogel
Fulltext Access 9 Pages 2005
Biowaiver monographs for immediate release solid oral dosage forms: Ranitidine hydrochloride
Fulltext Access 9 Pages 2005
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