Inhibitory effects of 2-substituted-1-naphthol derivatives on cyclooxygenase I and II Fulltext Access 9 Pages 2005
Nanotechnology, nanomedicine, and the development of new, effective therapies for cancer Fulltext Access 9 Pages 2005
Structure-activity study of thiazides by magnetic resonance methods (NQR, NMR, EPR) and DFT calculations Fulltext Access 9 Pages 2005
Predictive Bayesian neural network models of MHC class II peptide binding Fulltext Access 9 Pages 2005
An implementation of the nudged elastic band algorithm and application to the reaction mechanism of HGXPRTase from Plasmodium falciparum Fulltext Access 9 Pages 2005
Structural model of the Plasmodium CDK, Pfmrk, a novel target for malaria therapeutics Fulltext Access 9 Pages 2005
3D-QSAR comparative molecular field analysis on delta opioid receptor agonist SNC80 and its analogs Fulltext Access 9 Pages 2005
Theoretical study of stereoselective reduction controlled by NADH analogs Fulltext Access 9 Pages 2005
Computational tools for the analysis and visualization of multiple protein-ligand complexes Fulltext Access 9 Pages 2005
Structure–activity study of epi-gallocatechin gallate (EGCG) analogs as proteasome inhibitors Fulltext Access 9 Pages 2005
Synthesis and biological evaluation of 2-aminothiazoles and their amide derivatives on human adenosine receptors. Lack of effect of 2-aminothiazoles as allosteric enhancers Fulltext Access 9 Pages 2005
Synthesis, conformational analysis, and biological activity of new analogues of thiazole-4-carboxamide adenine dinucleotide (TAD) as IMP dehydrogenase inhibitors Fulltext Access 9 Pages 2005
Synthesis and biological activity of fluoroquinolone-pyrrolo[2,1-c][1,4]benzodiazepine conjugates Fulltext Access 9 Pages 2005
Chiral cyclopalladated complexes derived from N,N-dimethyl-1-phenethylamine with bridging bis(diphenylphosphine)ferrocene ligand as inhibitors of the cathepsin B activity and as antitumoral agents Fulltext Access 9 Pages 2005
Synthesis, properties, and photodynamic inactivation of Escherichia coli using a cationic and a noncharged Zn(II) pyridyloxyphthalocyanine derivatives Fulltext Access 9 Pages 2005
[11C]Glycylsarcosine: synthesis and in vivo evaluation as a PET tracer of PepT2 transporter function in kidney of PepT2 null and wild-type mice Fulltext Access 9 Pages 2005
Synthesis and biological evaluation of 3,4-diphenyl-1,2,5-oxadiazole-2-oxides and 3,4-diphenyl-1,2,5-oxadiazoles as potential hybrid COX-2 inhibitor/nitric oxide donor agents Fulltext Access 9 Pages 2005
Design, synthesis, and biological evaluation of 10-methanesulfonyl-DDACTHF, 10-methanesulfonyl-5-DACTHF, and 10-methylthio-DDACTHF as potent inhibitors of GAR Tfase and the de novo purine biosynthetic pathway Fulltext Access 9 Pages 2005
Horseradish peroxidase-mediated aerobic and anaerobic oxidations of 3-alkylindoles Fulltext Access 9 Pages 2005
Mutation of surface cysteine 374 to alanine in monoamine oxidase A alters substrate turnover and inactivation by cyclopropylamines Fulltext Access 9 Pages 2005
β-Turn peptidomimetics incorporating i + 1-i + 3 residues: solid phase syntheses and conformational properties Fulltext Access 9 Pages 2005
The identification of 5â²-fluoro-5-deoxyinosine as a shunt product in cell free extracts of Streptomyces cattleya Fulltext Access 9 Pages 2005
DFT-GIAO study of aryltetralin lignan lactones: Conformational analyses and chemical shifts calculations Fulltext Access 9 Pages 2005
Synthesis and in vitro antileishmanial activity of 5-substituted-2â²-deoxyuridine derivatives Fulltext Access 9 Pages 2005
The conformational behaviour of α,β-trehalose-like disaccharides and their C-glycosyl, imino-C-glycosyl and carbagalactose analogues depends on the chemical nature of the modification: an NMR investigation Fulltext Access 9 Pages 2005
Exploiting an aromatic aglycone as a reporter of glycosylation stereochemistry in the synthesis of 1,6-linked maltooligosaccharides Fulltext Access 9 Pages 2005
Preparation of an analogue of orbicuside A, an unusual cardiac glycoside Fulltext Access 9 Pages 2005
Cinchona alkaloid induced chiral discrimination for the determination of the enantiomeric composition of α-trifluoromethylated-hydroxyl compounds by 19F NMR spectroscopy Fulltext Access 9 Pages 2005
Enantioselective sulfoxide-directed preparation of 1,2-diols from oxalic compounds: formal synthesis of the 10-membered lactone core of ascidiatrienolides and didemnilactones Fulltext Access 9 Pages 2005
Synthesis of β-adrenergic blockers (R)-(â)-nifenalol and (S)-(+)-sotalol via a highly efficient resolution of a bromohydrin precursor Fulltext Access 9 Pages 2005
Stereocontrolled intramolecular meta-arene-alkene photocycloaddition reactions using chiral tethers: efficiency of the tether derived from 2,4-pentanediol Fulltext Access 9 Pages 2005
Asymmetric synthesis of both enantiomers of esters and γ-lactones from optically active 1-chlorovinyl p-tolyl sulfoxides and lithium ester enolates with the formation of a tertiary or a quaternary carbon stereogenic center at the β-position Fulltext Access 9 Pages 2005
Synthesis and antiprotozoan evaluation of new alkyl-linked bis(2-thioxo-[1,3,5]thiadiazinan-3-yl) carboxylic acids Fulltext Access 9 Pages 2005
Carbohydrate-derived aminoalcohol ligands for asymmetric Reformatsky reactions Fulltext Access 9 Pages 2005
Synthesis of functionalized heterocycles via a tandem Staudinger/aza-Wittig/Ugi multicomponent reaction Fulltext Access 9 Pages 2005
Preparation of enantiopure 1,4-amino alcohols derived from [3]ferrocenophanes: use in the asymmetric addition of diethylzinc to benzaldehyde Fulltext Access 9 Pages 2005
Organocatalytic kinetic resolution of racemic primary alcohols using a chiral 1,2-diamine derived from (S)-proline Fulltext Access 9 Pages 2005
Stereoselective synthesis of chiral tetrahydrofurans with potent 5-LO inhibitory activity Fulltext Access 9 Pages 2005
A concise synthetic route to optically active cis-β,γ-disubstituted-γ-butyrolactones via tandem Michael-MPV reaction: new total synthesis of (â)-cis-whisky lactone and (â)-cis-cognac lactone Fulltext Access 9 Pages 2005
Chiral 3-hydroxypyrrolidin-2-ones. Part 2: Stereodivergent synthesis of conformationally restricted analogues of β-homoserine Fulltext Access 9 Pages 2005
Efficient synthesis of multifunctional furanoid C-glycoamino acid precursors Fulltext Access 9 Pages 2005
Chemoenzymatic synthesis of chiral 4-(N,N-dimethylamino)pyridine derivatives Fulltext Access 9 Pages 2005
Synthesis, antimalarial, antileishmanial, and antimicrobial activities of some 8-quinolinamine analogues Fulltext Access 9 Pages 2005
Fancy bioisosteres: Synthesis, SAR, and pharmacological investigations of novel nonaromatic dopamine D3 receptor ligands Fulltext Access 9 Pages 2005
Phthalazine PDE IV inhibitors: Conformational study of some 6-methoxy-1,4-disubstituted derivatives Fulltext Access 9 Pages 2005
Theoretical quantitative structure–activity relationships of flavone ligands interacting with cytochrome P450 1A1 and 1A2 isozymes Fulltext Access 9 Pages 2005
Chiral oxazoline-1,3-dithianes: new effective nitrogen–sulfur donating ligands in asymmetric catalysis Fulltext Access 9 Pages 2005
Fluorous derivatives of (1R,2R)-diaminocyclohexane as chiral ligands for metal-catalyzed asymmetric reactions Fulltext Access 9 Pages 2005
N-(Chloroacetyl)- and N-(dichloroacetyl)-N-(xylyl)alanine esters: assignment of the absolute configurations and enantiodifferentiation by the dirhodium method Fulltext Access 9 Pages 2005
The Cahn, Ingold and Prelog System: eliminating ambiguity in the comparison of diastereomorphic and enantiomorphic ligands Fulltext Access 9 Pages 2005
Enantiomeric excess of 1,2-diols by formation of cyclic boronates: an improved method Fulltext Access 9 Pages 2005
Deracemisation of aromatic β-hydroxy esters using immobilised whole cells of Candida parapsilosis ATCC 7330 and determination of absolute configuration by 1H NMR Fulltext Access 9 Pages 2005
Synthesis and in vitro anti-mycobacterial activity of 5-substituted pyrimidine nucleosides Fulltext Access 9 Pages 2005
Synthesis of JOSIPHOS-type ligands via a diastereoselective three-component reaction and their application in asymmetric rhodium-catalyzed hydroborations Fulltext Access 9 Pages 2005
Asymmetric synthesis of 1,3-thiazolidine-derived spiro-β-lactams via a Staudinger reaction between chiral ketenes and imines Fulltext Access 9 Pages 2005
Stereochemistry of terpene derivatives. Part 4: Fragrant terpenoid derivatives with an unsaturated gem-dimethylbicyclo[3.1.0]hexane system Fulltext Access 9 Pages 2005
Effect of the presence of a free hydroxyl group on the enantiodiscrimination properties of cholic acid based CSPs bearing 2-naphthylcarbamate and 3,5-dinitrophenylcarbamate moieties in the HPLC resolution of racemic compounds Fulltext Access 9 Pages 2005
New enantiopure 7-azanorbornane β-substituted prolines by SN2 displacements at the Cγ of the side chain Fulltext Access 9 Pages 2005
Oxidatively generated electrophiles as initiators of epoxide cascade cyclization processes Fulltext Access 9 Pages 2005
Manganese-catalyzed enantioselective oxidation of C–H bonds of alkanes and silyl ethers to optically active ketones Fulltext Access 9 Pages 2005
Aluminum-based catalysts for the asymmetric Meerwein–Schmidt–Ponndorf–Verley–Oppenauer (MSPVO) reaction manifold Fulltext Access 9 Pages 2005
Quantitative structure–activity relationship to predict differential inhibition of aldose reductase by flavonoid compounds Fulltext Access 9 Pages 2005
Design, synthesis, and biological testing of thiosalicylamides as a novel class of calcium channel blockers Fulltext Access 9 Pages 2005
Design and synthesis of glycosidase inhibitor 5-amino-1,2,3,4-cyclohexanetetrol derivatives from (−)-vibo-quercitol Fulltext Access 9 Pages 2005
Synthesis of acridinyl-thiazolino derivatives and their evaluation for anti-inflammatory, analgesic and kinase inhibition activities Fulltext Access 9 Pages 2005
3D-QSAR study of bis-azaaromatic quaternary ammonium analogs at the blood-brain barrier choline transporter Fulltext Access 9 Pages 2005
Synthesis of a C-terminally biotinylated macrocyclic peptide mimetic exhibiting high Grb2 SH2 domain-binding affinity Fulltext Access 9 Pages 2005
Radical scavenging activity of dicaffeoyloxycyclohexanes: Contribution of an intramolecular interaction of two caffeoyl residues Fulltext Access 9 Pages 2005
A quantitative structure-activity relationship study on some series of anthranilic acid-based matrix metalloproteinase inhibitors Fulltext Access 9 Pages 2005
Hypocholesterolemic effects of phenolic-rich extracts of Chemlali olive cultivar in rats fed a cholesterol-rich diet Fulltext Access 9 Pages 2005
Bridge-linked bis-quaternary ammonium anti-microbial agents: relationship between cytotoxicity and anti-bacterial activity of 5,5′-[2,2′-(tetramethylenedicarbonyldioxy)-diethyl]bis(3-alkyl-4-methylthiazonium iodide)s Fulltext Access 9 Pages 2005
Porphyrin substituted phosphoramidites: new building blocks for porphyrin–oligonucleotide syntheses Fulltext Access 9 Pages 2005
Synthesis of four enantiomerically pure 4-(4-carbamoyl-1,2,3-triazol-1-yl)-2,3-dihydroxy-1-methoxybutylphosphonic acids Fulltext Access 9 Pages 2005
Anti-cancer ProTides: tuning the activity of BVDU phosphoramidates related to thymectacin Fulltext Access 9 Pages 2005
Synthesis and biological evaluation of novel 6-nitro-5-substituted aminoquinolines as local anesthetic and anti-arrhythmic agents: molecular modeling study Fulltext Access 9 Pages 2005
3D-QSAR studies on c-Src kinase inhibitors and docking analyses of a potent dual kinase inhibitor of c-Src and c-Abl kinases Fulltext Access 9 Pages 2005
Synthesis and C-11 labeling of three potent norepinephrine transporter selective ligands ((R)-nisoxetine, lortalamine, and oxaprotiline) for comparative PET studies in baboons Fulltext Access 9 Pages 2005
Oligonucleotides containing 2′-O-[2-(2,3-dihydroxypropyl)amino-2-oxoethyl]uridine as suitable precursors of 2′-aldehyde oligonucleotides for chemoselective ligation Fulltext Access 9 Pages 2005
Design and synthesis of low molecular weight compounds with complement inhibition activity Fulltext Access 9 Pages 2005
Design, synthesis, and biological evaluation of novel naphthoquinone derivatives with CDC25 phosphatase inhibitory activity Fulltext Access 9 Pages 2005
Synthesis of novel 5-aryl-2-thio-1,3,4-oxadiazoles and the study of their structure–anti-mycobacterial activities Fulltext Access 9 Pages 2005
Synthesis, antiproliferative, and antiplatelet activities of oxime- and methyloxime-containing flavone and isoflavone derivatives Fulltext Access 9 Pages 2005
Chalcogenoxanthylium photosensitizers for the photodynamic purging of blood-borne viral and bacterial pathogens Fulltext Access 9 Pages 2005
Dicationic near-linear biphenyl benzimidazole derivatives as DNA-targeted antiprotozoal agents Fulltext Access 9 Pages 2005