Electrospray Ionization Mass Spectrometry Studies of Noncovalent Myosin VI Complexes Reveal a New Specific Calmodulin Binding Site Fulltext Access 10 Pages 2005
Quantitative Analysis of the Low Molecular Weight Serum Proteome Using 18O Stable Isotope Labeling in a Lung Tumor Xenograft Mouse Model Fulltext Access 10 Pages 2005
Mass Spectrometric Analysis of Androstan-17β-ol-3-one and Androstadiene-17β-ol-3-one Isomers Fulltext Access 10 Pages 2005
Convenient synthesis of tryptophols and tryptophol homologues by hydroamination of alkynes Fulltext Access 10 Pages 2005
Combining enabling techniques in organic synthesis: solid-phase-assisted catalysis under microwave conditions using a stable Pd(II)-precatalyst Fulltext Access 10 Pages 2005
Polystyrene-supported amino alcohol ligands for the heterogeneous asymmetric addition of phenyl zinc reagents to aldehydes Fulltext Access 10 Pages 2005
1H NMR studies of homo and mixed ligand complexes of Tl+ ion with several polyazamacrocycles Fulltext Access 10 Pages 2005
Electrospray Ionization Mass Spectrometric Detection of Self-Assembly of a Crown Ether Complex Directed by Ï-Stacking Interactions Fulltext Access 10 Pages 2005
Properties and structure–activity studies of cyclic β-hairpin peptidomimetics based on the cationic antimicrobial peptide protegrin I Fulltext Access 10 Pages 2005
Cooperative lectin recognition of periodical glycoclusters along DNA duplexes: alternate hybridization and full hybridization Fulltext Access 10 Pages 2005
Synthesis of 9-alkyl and 9-heteroalkyl substituted 2-amino-6-guanidinopurines and their influence on the NO-production in macrophages Fulltext Access 10 Pages 2005
Synthesis and human NKT cell stimulating properties of 3-O-sulfo-α/β-galactosylceramides Fulltext Access 10 Pages 2005
Novel non-steroidal/non-anilide type androgen antagonists: discovery of 4-substituted pyrrole-2-carboxamides as a new scaffold for androgen receptor ligands Fulltext Access 10 Pages 2005
Design, synthesis, and biological evaluation of folic acid targeted tetraphenylporphyrin as novel photosensitizers for selective photodynamic therapy Fulltext Access 10 Pages 2005
3D-QSAR CoMFA studies on trypsin-like serine protease inhibitors: a comparative selectivity analysis Fulltext Access 10 Pages 2005
Design, synthesis, and structure–activity relationships of potent GPIIb/IIIa antagonists: discovery of FK419 Fulltext Access 10 Pages 2005
Combinatorial approach to identification of tyrphostin inhibitors of cytokine signaling Fulltext Access 10 Pages 2005
5-Arylidene-2-imino-4-thiazolidinones: Design and synthesis of novel anti-inflammatory agents Fulltext Access 10 Pages 2005
Synthesis of a Ley neoglycoconjugate and Ley-functionalized gold glyconanoparticles Fulltext Access 10 Pages 2005
Reactivity of Cdc25 phosphatase at low pH and with thiophosphorylated protein substrate Fulltext Access 10 Pages 2005
Phosphoryl transfer by aminoglycoside 3â²-phosphotransferases and manifestation of antibiotic resistance Fulltext Access 10 Pages 2005
Fluorinated cellobiose and maltose as stand-ins for energy surface calculations Fulltext Access 10 Pages 2005
C(1â4)-linked disaccharides through carbonylative Stille cross-coupling Fulltext Access 10 Pages 2005
Are the absolute configurations of 2-(1-hydroxyethyl)-chromen-4-one and its 6-bromo derivative determined by X-ray crystallography correct? A vibrational circular dichroism study of their acetate derivatives Fulltext Access 10 Pages 2005
Asymmetric heterogeneous carbene transfer catalyzed by optically active ruthenium spirobifluorenylporphyrin polymers Fulltext Access 10 Pages 2005
Stereocontrolled synthesis of unnatural cyclic dipeptides containing an l-valine unit Fulltext Access 10 Pages 2005
Glucosamine derived DISAL donors for stereoselective glycosylations under neutral conditions Fulltext Access 10 Pages 2005
A new asymmetric synthesis of 2,6-cis-disubstituted 4-methylenepiperidines: total synthesis of (+)-alkaloid 241D and (+)-isosolenopsin A Fulltext Access 10 Pages 2005
Synthesis of vinyl glycosides and carbohydrate vinyl ethers from mixed acetals: a hetero-Diels-Alder approach to deoxygenated disaccharides Fulltext Access 10 Pages 2005
Synthesis of gossypol atropisomers and derivatives and evaluation of their anti-proliferative and anti-oxidant activity Fulltext Access 10 Pages 2005
Chemoenzymatic synthesis of enantiopure α-substituted cyclohexanones from aromatic compounds Fulltext Access 10 Pages 2005
Synthesis of new chiral hydroxy oxazolines and their use in the catalytic asymmetric phenyl transfer to aldehydes Fulltext Access 10 Pages 2005
Stereoselective approach to uncommon tripeptides incorporating a 2,6-diaminopimelic acid framework: X-ray analysis and conformational studies. Part 4 Fulltext Access 10 Pages 2005
An enantioselective total synthesis of the stilbenolignan (â)-aiphanol and the determination of its absolute stereochemistry Fulltext Access 10 Pages 2005
Stereoselective addition of organometallic reagents to a chiral acyclic nitrone derived from l-erythrulose Fulltext Access 10 Pages 2005
Design and synthesis of iminosugar-based inhibitors of glucosylceramide synthase: the search for new therapeutic agents against Gaucher disease Fulltext Access 10 Pages 2005
New principle for palladacycle resolution: diastereoselective monomer to dimer conversion Fulltext Access 10 Pages 2005
Reaction of caesium 4-chlorophenate and chlorohydrins from threonines: synthesis of clofibrate analogues Fulltext Access 10 Pages 2005
New β-amino thiols as efficient catalysts for highly enantioselective alkenylzinc addition to aldehydes Fulltext Access 10 Pages 2005
O6-3-[125I]iodobenzyl-2′-deoxyguanosine ([125I]IBdG): synthesis and evaluation of its usefulness as an agent for quantification of alkylguanine-DNA alkyltransferase (AGT) Fulltext Access 10 Pages 2005
Structure–activity studies of uptake and phototoxicity with heavy-chalcogen analogues of tetramethylrosamine in vitro in chemosensitive and multidrug-resistant cells Fulltext Access 10 Pages 2005
9-Oxime-3-ketolides: Modification at the C-11,12-diol moiety and antibacterial activities against key respiratory pathogens Fulltext Access 10 Pages 2005
Antitumor activity and distribution of pyrroloiminoquinones in the sponge genus Zyzzya Fulltext Access 10 Pages 2005
Synthesis and cytotoxicity of epoxide and pyrazole analogs of the combretastatins Fulltext Access 10 Pages 2005
Synthesis of 5-haloethynyl- and 5-(1,2-dihalo)vinyluracil nucleosides: Antiviral activity and cellular toxicity Fulltext Access 10 Pages 2005
Preparation of highly substituted γ-lactam follicle stimulating hormone receptor agonists Fulltext Access 10 Pages 2005
An anionic inositol phosphate glycan pseudotetrasaccharide exhibits high insulin-mimetic activity in rat adipocytes Fulltext Access 10 Pages 2005
Optimized N-phenyl-N′-(2-chloroethyl)ureas as potential antineoplastic agents: Synthesis and growth inhibition activity Fulltext Access 10 Pages 2005
Aza-bicyclic amino acid carboxamides as α4β1/α4β7 integrin receptor antagonists Fulltext Access 10 Pages 2005
Donepezil–tacrine hybrid related derivatives as new dual binding site inhibitors of AChE Fulltext Access 10 Pages 2005
Synthesis of arylidene-substituted gelastatin analogues and their screening for MMP-2 inhibitory activity Fulltext Access 10 Pages 2005
Identification of carbon-centred radicals derived from linalyl hydroperoxide, a strong skin sensitizer: a possible route for protein modifications Fulltext Access 10 Pages 2005
Homology modelling and active-site-mutagenesis study of the catalytic domain of the pneumococcal phosphorylcholine esterase Fulltext Access 10 Pages 2005
Preparation of single-enantiomer semiochemicals using 2-methoxy-2-(1-naphthyl)propionic acid and 2-methoxy-2-(9-phenanthryl)propionic acid Fulltext Access 10 Pages 2005
Configurational assignment of vic-amino alcohols from their circular dichroism spectra with dirhodium tetracetate as an auxiliary chromophore Fulltext Access 10 Pages 2005
A new stereocontrolled approach to fused polycyclic compounds containing a diketopiperazine ring Fulltext Access 10 Pages 2005
Synthesis and structural characterization of diastereomeric isomers of RNA trimer adenylyl(3′-5′)adenylyl(3′-5′)adenosine Fulltext Access 10 Pages 2005
2-Chlorobicyclo[2.2.1]hept-5-ene-2-carboxamide and 2-chlorobicyclo[2.2.1]heptane-2-carboxamide as precursors of bicyclo[2.2.1]hept-5-en-2-one and bicyclo[2.2.1]heptan-2-one: resolution, absolute configuration and hydrogen-bonding properties Fulltext Access 10 Pages 2005
Asymmetric oxidation of sulfenates to sulfinates as a new route to optically active ortho-phosphorylated phenyl sulfoxides Fulltext Access 10 Pages 2005
Synthesis and conformational preferences of cyclic unnatural di- and tripeptides containing an l-valine unit: Part 2 Fulltext Access 10 Pages 2005
Enantioselective preparation and structural and conformational analysis of the chiral solvating agent α,α′-bis(trifluoromethyl)-1,8-anthracenedimethanol Fulltext Access 10 Pages 2005
Stereoselective synthesis of chiral atropisomerically stable ferrocenyldiols containing a biphenyl unit Fulltext Access 10 Pages 2005
Determination of the absolute stereochemistry and the activation barriers of thermally interconvertible heterocyclic compounds bearing a naphthyl substituent Fulltext Access 10 Pages 2005
New chiral 1,3-diphosphine ligands for Rh-catalyzed enantioselective hydrogenation: a search for electronic effects Fulltext Access 10 Pages 2005
A new structural alternative in benzo[b]furans for antimicrobial activity Fulltext Access 10 Pages 2005
Combinatorial design of nonsymmetrical cyclic urea inhibitors of aspartic protease of HIV-1 Fulltext Access 10 Pages 2005
Methyltrioxorhenium: a new catalyst for the activation of hydrogen peroxide to the oxidation of lignin and lignin model compounds Fulltext Access 10 Pages 2005
Structural modification of phenylpropanoid-derived compounds and the effects on their participation in redox processes Fulltext Access 10 Pages 2005
Design, synthesis, and biological evaluation of N-acetyl-2-carboxybenzenesulfonamides: a novel class of cyclooxygenase-2 (COX-2) inhibitors Fulltext Access 10 Pages 2005
Zidampidine, an aryl phosphate derivative of AZT: in vivo pharmacokinetics, metabolism, toxicity, and anti-viral efficacy against hemorrhagic fever caused by Lassa virus Fulltext Access 10 Pages 2005
Improved synthesis of daunomycin conjugates with triplex-forming oligonucleotides. The polypurine tract of HIV-1 as a target Fulltext Access 10 Pages 2005
Dual DNA recognition codes of a short peptide derived from the basic leucine zipper protein EmBP1 Fulltext Access 10 Pages 2005
Novel cytotoxic monotetrahydrofuranic Annonaceous acetogenins from Annona montana Fulltext Access 10 Pages 2005
Furoxan analogues of the histamine H3-receptor antagonist imoproxifan and related furazan derivatives Fulltext Access 10 Pages 2005
Design, modelling, synthesis and biological evaluation of peptidomimetic phosphinates as inhibitors of matrix metalloproteinases MMP-2 and MMP-8 Fulltext Access 10 Pages 2005
Design, synthesis, and biological evaluation of N-acetyl-2-(or 3-)carboxymethylbenzenesulfonamides as cyclooxygenase isozyme inhibitors Fulltext Access 10 Pages 2005
Determining the absolute configuration of secondary alcohols by means of a chiral auxiliary and NOESY Fulltext Access 10 Pages 2005
Density-functional theory and ab initio Hartree–Fork studies on the structural parameters and chemical activity of the free radicals generated by benzoquinone and hydroquinone Fulltext Access 10 Pages 2005
Synthesis and antitumor evaluation of novel 5-substituted-4-hydroxy-8-nitroquinazolines as EGFR signaling-targeted inhibitors Fulltext Access 10 Pages 2005
Synthesis and antitrichinellosis activity of some 2-substituted-[1,3]thiazolo[3,2-a]benzimidazol-3(2H)-ones Fulltext Access 10 Pages 2005
Design, synthesis, and biological characterization of potential antiatherogenic nitric oxide releasing tocopherol analogs Fulltext Access 10 Pages 2005
Synthesis and evaluation of bifunctional nitrocatechol inhibitors of pig liver catechol-O-methyltransferase Fulltext Access 10 Pages 2005
A cyclic PNA-based compound targeting domain IV of HCV IRES RNA inhibits in vitro IRES-dependent translation Fulltext Access 10 Pages 2005
Synthetic multifunctional pores that open and close in response to chemical stimulation Fulltext Access 10 Pages 2005
Design, synthesis, and biological evaluation of linear 1-(4-, 3- or 2-methylsulfonylphenyl)-2-phenylacetylenes: A novel class of cyclooxygenase-2 inhibitors Fulltext Access 10 Pages 2005