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Daneshyari Drug Discovery Journas Latest Articles

Drug Discovery Research Articles

ortho-Lithiation of S-tert-butyl-S-phenylsulfoximines. New route to enantiopure sulfinamides via a de-tert-butylation reaction
Fulltext Access 10 Pages 2005
Conformational behavior of dithia[n.3.3](1,3,5)cyclophanes and dithia[n.3.3](1,2,6)cyclophanes
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Total synthesis of marine bisindole alkaloids, (+)-hamacanthins A, B and (−)-antipode of cis-dihydrohamacanthin B
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Neurosteroid analogues: synthesis of 6-aza-allopregnanolone
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Synthesis of carbosilane dendrimers having peripheral mannose and mannobiose
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On-microchip multiphase chemistry-a review of microreactor design principles and reagent contacting modes
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Understanding the catalytic role of flexible chiral δ-amino alcohols: the 1-(2-aminoethyl)norbornan-2-ol model
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Synthesis of (Z)-1-bromo-1-alkenes and terminal alkynes from anti-2,3-dibromoalkanoic acids by microwave-induced reaction
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Regioselective cyclization of unsymmetrical dicyanoanilines to novel 2,3-bifunctionalised indole regioisomers and their use in the synthesis of 4,5-dihydro[1,3]oxazino[5,4-b]indole-6-carbonitriles
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Ab initio and density functional study of substituent effects in halogenated cations of alkenes
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Expanding the substitution pattern of 2(1H)-pyrazinones via Suzuki and Heck reactions
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Regio- and stereochemical aspects in synthesis of 2-allyl derivatives of glycolic, mandelic and lactic acids and their iodocyclisations to 3-hydroxy-3,4-dihydrofuran-2(5H)-ones
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4-Nitrobenzodifuroxan: a highly reactive nitroolefin in Diels-Alder reactions
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Graphical contents list
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Synthesis of 2-azaspiro[4.4]nonan-1-ones via phosphine-catalysed [3+2]-cycloadditions
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Tandem alkylation-cyclization process via an O,C-dianion
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Generation of ketone dilithio α,β-dianions and their reactions with electrophiles
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Solvent effects on the mixed aggregates of chiral 3-aminopyrrolidine lithium amides and alkyllithiums
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Structural studies of {6Li} 2-lithiopyrrolidines using NMR spectroscopy
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Synthesis and lithiation of oxazolinylaziridines: the N-substituent effect
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Copper mediated scalemic organolithium reagents in alkaloid syntheses
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A formal synthesis of (±)-physostigmine via 3,3-rearrangement of a bis-enamine
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Synthesis of n-chloroquinolines and n-ethynylquinolines (n=2, 4, 8): homo and heterocoupling reactions
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Achievement of ring inversion of myo-inositol derivatives due to silyloxy/silyloxy repulsion enhanced by the trans-substituents on both sides
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A practical synthesis of highly functionalized aryl nitriles through cyanation of aryl bromides employing heterogeneous Pd/C: in quest of an industrially viable process
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The application of vinylogous iminium salt derivatives to an efficient relay synthesis of the pyrrole containing alkaloids polycitone A and B
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A new method for adjusting neural response jitter in the STRF obtained by spike-trigger averaging
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Retino-cortical information transmission achievable with a retina implant
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Dynamics of pruning in simulated large-scale spiking neural networks
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A hybrid systems framework for cellular processes
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Indispensable role of quantum theory in the brain dynamics
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Graphical contents list
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Graphical contents list
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Expedient synthesis of β,β-disubstituted α-methylenepropionates
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New '2-phenylnaphthalene'-mediated synthesis of benzo[b]naphtho[2,3-d]furan-6,11-diones and 6-oxa-benzo[a]anthracene-5,7,12-triones: first total synthesis of 6-oxa-benzo[a]anthracen-5-ones
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Studies on the diastereoselective reductive alkylation of (R)-phenylglycinol derived phthalimide: observation of stereoelectronic effects
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Graphical contents list
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Multi-functionalization of gallic acid towards improved synthesis of α- and β-DDB
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Palladium-catalyzed trans-selective alkynylation-alkylation tandem process for the synthesis of (E)-3-alkyl-1-trialkylsilyl-3-alken-1-ynes
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Synthesis and antagonist activities of 4-aryl-substituted conformationally restricted cyclopentenyl and cyclopentanyl-glutamate analogues
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A new strategy for the stereoselective synthesis of unnatural α-amino acids
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Base- and light-assisted synthesis of anthracenes from 3-allylnaphthalene-2-carbaldehydes
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Regioselective synthesis of peptidic derivatives and glycolamidic esters of Methotrexate
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Is potential coordination of alkali metal ions to stereodefined polyoxygenated cyclohexanes an adequate driving force for fostering the adoption of axial conformers?
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Synthesis of vicinal diols from various arenes with a heterocyclic, amino or carboxyl group by using recombinant Escherichia coli cells expressing evolved biphenyl dioxygenase and dihydrodiol dehydrogenase genes
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Improvement in the synthesis of metallophthalocyanines using microwave irradiation
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Synthesis and spectroscopic properties of Schiff bases derived from 3-hydroxy-4-pyridinecarboxaldehyde
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α-Phenylselanyl imines: preparation of β-phenylselanyl amines and original synthesis of allylaziridines
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Graphical contents list
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Graphical contents list
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Unexpected valence bond isomerization of [1,2,4]triazolo[3,4-c][1,2,4]benzotriazines under flash vacuum pyrolytic (fvp) conditions
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Pd-catalyzed nucleophilic allylic alkylation of aliphatic aldehydes by the use of allyl alcohols
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Lannotinidines A-G, new alkaloids from two species of Lycopodium
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Synthesis of a caryophyllene isoprenologue, a potential diterpene natural product
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Can a consecutive double turn conformation be considered as a peptide based molecular scaffold for supramolecular helix in the solid state?
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Synthesis, structural studies and desilylation reactions of some N-2-(trimethylsilyl)ethyl-N-nitrosocarbamates
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Study of the reaction of chalcone analogs of dehydroacetic acid and o-aminothiophenol: synthesis and structure of 1,5-benzothiazepines and 1,4-benzothiazines
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Synthesis, biological activity and modelling studies of two novel anti HIV PR inhibitors with a thiophene containing hydroxyethylamino core
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SG1 based alkoxyamines as radical initiators for the synthesis of lactones and lactames
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Versatility of an intramolecularly hydrogen-bonded 4-(N,N-dimethylamino)benzoate group as a signaling subunit for anion recognition
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Stereoselective synthesis of dienylamines: from amino acids to E-alkene dipeptide isosters
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Short synthesis of hydroxylated thiolane and selenolane rings from mono-benzylated pentitols and aldoses dithioacetals bis-thionocarbonates as bis-electrophilic substrates
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Bisphosphonate prodrugs: synthesis of new aromatic and aliphatic 1-hydroxy-1,1-bisphosphonate partial esters
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Synthesis of cyclopropyl silyl ethers and their facile ring opening by photoinduced electron transfer as key step in radical/radical cationic cascade reactions
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Application of 1J(C,H) coupling constants in conformational analysis
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The first 6′-O-sulfated phenylanthraquinones: isolation from Bulbine frutescens, structural elucidation, enantiomeric purity, and partial synthesis
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Novel highly fluorescent dendritic chiral amines: synthesis and optical properties
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Preparation of both enantiomers of β2-(3,4-dihydroxybenzyl)-β-alanine, higher homologues of Dopa
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Oligosaccharide synthesis on a soluble, hyperbranched polymer support via thioglycoside activation
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Computer-aided determination of relative stereochemistry and 3D models of complex organic molecules from 2D NMR spectra
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Simple preparation of phenylpropenoid β-d-glucopyranoside congeners by Mizoroki-Heck type reaction using organoboron reagents
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Chiral β-diketonate ligands of 'pseudo planar chiral' topology: enantioselective synthesis and transition metal complexation
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One-pot sequential four-component coupling via Cp*RuCl-catalyzed cyclotrimerization and Suzuki-Miyaura coupling
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Straightforward synthesis of di-, tri- and tetracyclic lactams via catalytic Pauson-Khand and Alder-Ene reactions of MCR products
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Regiochemical control of the ring opening of 1,2-epoxides by means of chelating processes. Part 18: Regioselectivity of the opening reactions with MeOH of 1-(benzyloxy)-2,3- and -3,4-epoxyalkanes under condensed and gas phase operating conditions
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An iodoacetamide-based free radical cyclisation approach to the 7,12-dihydro-indolo[3,2-d][1]benzazepin-6(5H)-one (paullone) system
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Amygdaloidins A-L, twelve new 13 α-OH jatrophane diterpenes from Euphorbia amygdaloides L.
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Sulfonate protecting groups. Synthesis of O- and C-methylated inositols: d- and l-ononitol, d- and l-laminitol, mytilitol and scyllo-inositol methyl ether
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Enantioselective total synthesis of (−)-microcarpalide
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Reaction of magnesium alkylidene carbenoids with lithium acetylides and lithium thiolates: a novel synthesis of conjugated enynes and vinyl sulfides
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Pyrazolyl-benzoxazole derivatives as protein kinase inhibitors. Design and validation of a combinatorial library
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Synthesis and properties of azobenzocrown ethers with π-electron donor, or π-electron donor and π-electron acceptor group(s) on benzene ring(s)
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Steroid-based head-to-tail amphiphiles as effective iono- and protonophores
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Leontopodic acid-a novel highly substituted glucaric acid derivative from Edelweiss (Leontopodium alpinum Cass.) and its antioxidative and DNA protecting properties
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A bis(η5-cyclopentadienyl)cobalt complex of a bis-dithiolene: a chemical analogue of the metal centres of the DMSO reductase family of molybdenum and tungsten enzymes, in particular ferredoxin aldehyde oxidoreductase
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Neighboring effect of the lactam functionality in select reactions of 6-azaspiro[4.5]decane-1,7-dione
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Conformational preferences of the aldol adducts of oxadiazinones. 1H NMR spectroscopy and computational studies of N4-methyl and N4-isopropyloxadiazinones
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Biotransformation of 7-oxo-ent-kaur-16-ene derivatives by Gibberella fujikuroi
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An isomerization-ring-closing metathesis strategy for the synthesis of substituted benzofurans
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First synthesis of an α-d-Fucp3NAc containing oligosaccharide: a study on d-Fucp3NAc glycosylation
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Synthesis of novel C4-linked imidazole ribonucleoside phosphoramidites for probing general acid and base catalysis in ribozyme
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Fukuyama-Mitsunobu alkylation in amine synthesis on solid phase revisited: N-alkylation with secondary alcohols and synthesis of curtatoxins
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Synthesis of new iminocoumarins and their transformations into N-chloro and hydrazono compounds
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Reactions of bis(tetrazole)phenylenes. Surprising formation of vinyl compounds from alkyl halides
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A comparison of ring-chain tautomerism in heterocycles derived from 2-aminobenzenesulfonamide and anthranilamide
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The novel hydrogen bonding motifs and supramolecular patterns in 2,4-diaminopyrimidine-nitrobenzoate complexes
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Catalyst-substrate helical character matching determines enantiomeric excess
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Towards highly powerful neutral organic superacids-a DFT study of some polycyano derivatives of planar hydrocarbons
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Addition reactions to chiral aziridine-2-carboxaldimine toward various enantiopure nitrogen-containing heterocycles
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New approach to λ5-phosphinines
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