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Daneshyari Drug Discovery Journas Latest Articles

Drug Discovery Research Articles

Chitosan-reinforced alginate microspheres obtained through the emulsification/internal gelation technique
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Techniques necessary for multiple tracer quantitative small-animal imaging studies
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Evaluation of Dodecylmaltoside as a Permeability Enhancer for Insulin Using Human Carcinoma Cells
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Mechanism of the Stationary Canalicular Excretion of Tributylmethyl Ammonium in Rats with a CCl4-Induced Acute Hepatic Injury
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Screening of Bitterness-Suppressing Agents for Quinine: The Use of Molecularly Imprinted Polymers
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Expression of PPAR, RXR Isoforms and Fatty Acid Transporting Proteins in the Rat and Human Gastrointestinal Tracts
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Multiple P450 substrates in a single run: rapid and comprehensive in vitro interaction assay
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PEGylation of Yeast Cytosine Deaminase for Pretargeting
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Synthesis and in vitro evaluation of macromolecular antitumour derivatives based on phenylenediamine mustard
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Evaluation of Buccal Methyl-β-Cyclodextrin Toxicity on Human Oral Epithelial Cell Culture Model
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Effect of self-microemulsifying drug delivery systems containing Labrasol on tight junctions in Caco-2 cells
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Pyrimidine and nucleoside γ-esters of l-Glu-Sar: Synthesis, stability and interaction with hPEPT1
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Glycoengineering: The effect of glycosylation on the properties of therapeutic proteins
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Estimation of dosing strategies aiming at maximizing utility or responder probability, using oxybutynin as an example drug
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Enhanced absorption of 3-O-methyl glucose following gastrointestinal injury induced by repeated oral administration of 5-FU in mice
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The Impact of Pharmacologic and Genetic Knockout of P-Glycoprotein on Nelfinavir Levels in the Brain and Other Tissues in Mice
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Effect of ion-exchange fiber structure on the binding and release of model salicylates
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Kinetics of iron-mediated artemisinin degradation: Effect of solvent composition and iron salt
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State of insulin self-association does not affect its absorption from the pulmonary route
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Occurrence of Pharmaceutically Acceptable Anions and Cations in the Cambridge Structural Database
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Effects of cysteine on the pharmacokinetics of oltipraz in rats with protein-calorie malnutrition
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Determination of the binding constant between alprostadil and alpha-cyclodextrin by capillary electrophoresis: Implications for a freeze-dried formulation
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Bioavailability enhancement of a COX-2 inhibitor, BMS-347070, from a nanocrystalline dispersion prepared by spray-drying
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Solid Films of Blended Poly(Vinyl Alcohol)/Poly(Vinyl Pyrrolidone) for Topical S-Nitrosoglutathione and Nitric Oxide Release
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Mass Spectral Analyses of Labile DOTA-NHS and Heterogeneity Determination of DOTA or DM1 Conjugated Anti-PSMA Antibody for Prostate Cancer Therapy
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Using Terahertz Pulsed Spectroscopy to Quantify Pharmaceutical Polymorphism and Crystallinity
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Enhanced Buccal Mucosal Retention and Reduced Buccal Permeability of Estradiol in the Presence of Padimate O and Azone®: A Mechanistic Study
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Interspecies Scaling of Biliary Excreted Drugs: A Comparison of Several Methods*
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Silicone Oil Induced Aggregation of Proteins
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Polysorbate 80 and Cremophor EL Micelles Deaggregate and Solubilize Nystatin at the Core-Corona Interface
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Optimization of labeling and metabolite analysis of copper-64-labeled azamacrocyclic chelators by radio-LC-MS
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Investigation into 64Cu-labeled Bis(selenosemicarbazone) and Bis(thiosemicarbazone) complexes as hypoxia imaging agents
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Disposition and Biotransformation of the Acetylenic Retinoid Tazarotene in Humans
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Effects of New 4-Aryl-1,4-Dihydropyridines and 4-Arylpyridines on Drug Efflux Mediated by Multidrug Resistance-Associated Protein 1
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Effect of Galactose Density on Asialoglycoprotein Receptor-Mediated Uptake of Galactosylated Liposomes
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Isothermal Crystallization Kinetics of Lidocaine in Supersaturated Lidocaine/Polyacrylate Pressure Sensitive Adhesive Systems
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Biodistribution characteristics of all-trans retinoic acid incorporated in liposomes and polymeric micelles following intravenous administration
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Synthesis and initial PET imaging of new potential NK1 receptor radioligands 1-[2-(3,5-bis-trifluoromethyl-benzyloxy)-1-phenyl-ethyl]-4-[11C]methyl-piperazine and {4-[2-(3,5-bis-trifluoromethyl-benzyloxy)-1-phenyl-ethyl]-piperazine-1-yl}-acetic acid [11C]
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177Lu-antibody conjugates for single-cell kill of B-lymphoma cells in vitro and for therapy of micrometastases in vivo
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Radiosynthesis and evaluation of two novel 123I-labeled 2-methyl-4-nitroimidazole derivatives as potential infection imaging agents
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Factors Affecting Shear Thickening Behavior of a Concentrated Injectable Suspension of Levodopa
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Preclinical and clinical evaluation of O-[11C]methyl-l-tyrosine for tumor imaging by positron emission tomography
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Methoxyphenylethynyl, methoxypyridylethynyl and phenylethynyl derivatives of pyridine: synthesis, radiolabeling and evaluation of new PET ligands for metabotropic glutamate subtype 5 receptors
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An Investigation of the Factors Controlling the Adsorption of Protein Antigens to Anionic PLG Microparticles
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Programmed Humidifying in Drug Stability Experiments
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Using a Novel Multicompartment Dissolution System to Predict the Effect of Gastric pH on the Oral Absorption of Weak Bases with Poor Intrinsic Solubility
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In Vivo Pharmacology and Antidiarrheal Efficacy of a Thiazolidinone CFTR Inhibitor in Rodents
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Physical Stability of Sonicated Arsonoliposomes: Effect of Calcium Ions
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Effects of acidic N + 1 residues on asparagine deamidation rates in solution and in the solid state
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Influence of Itraconazole Co-administration and CYP2D6 Genotype on the Pharmacokinetics of the New Antipsychotic ARIPIPRAZOLE
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Single Nucleotide Polymorphisms and Haplotypes of CYP1A2 in a Japanese Population
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Essential Role of Singlet Oxygen Species in Cytochrome P450-dependent Substrate Oxygenation by Rat Liver Microsomes
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Radiobromination of humanized anti-HER2 monoclonal antibody trastuzumab using N-succinimidyl 5-bromo-3-pyridinecarboxylate, a potential label for immunoPET
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Prodrogues glucuronylées du paclitaxel (Taxol®) activables au niveau des tumeurs
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Les médicaments radiopharmaceutiques fluorés
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Apport d'un automate centralisé de délivrance nominative dans la sécurisation du circuit du médicament Expérience du CHU de Toulouse
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Le système rénine-angiotensine : données actuelles
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Stimulatory Effects of Testosterone and Progesterone on the NADH-and NADPH-dependent Oxidation of 7β-Hydroxy-Δ8-tetrahydrocannabinol to 7-Oxo-Δ8-tetrahydrocannabinol in Monkey Liver Microsomes
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α1-Antitrypsin and fibromyalgia: new data in favour of the inflammatory hypothesis of fibromyalgia
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Cholesterol synthesis is the trigger and isoprenoid dependent interleukin-6 mediated inflammation is the common causative factor and therapeutic target for atherosclerotic vascular disease and age-related disorders including osteoporosis and type 2 diabet
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Bioavailability and pharmacokinetics of caffeoylquinic acids and flavonoids after oral administration of Artichoke leaf extracts in humans
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The origins of life - the 'protein interaction world' hypothesis: protein interactions were the first form of self-reproducing life and nucleic acids evolved later as memory molecules
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Can thromboembolism be the result, rather than the inciting cause, of acute vascular events such as stroke, pulmonary embolism, mesenteric ischemia, and venous thrombosis?: a maladaptation of the prehistoric trauma response
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Interactions between melatonin and estrogen may regulate cerebrovascular function in women: clinical implications for the effective use of HRT during menopause and aging
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Does clozapine work by blocking spikes and sparing bursts?
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Chronic Lyme borreliosis at the root of multiple sclerosis - is a cure with antibiotics attainable?
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Why we should offer routine vitamin D supplementation in pregnancy and childhood to prevent multiple sclerosis
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Effect of sorbitol and residual moisture on the stability of lyophilized antibodies: Implications for the mechanism of protein stabilization in the solid state
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A theory of marks and mind: the effect of notational systems on hominid brain evolution and child development with an emphasis on exchanges between mothers and children
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Drugs of anesthesia acting on central cholinergic system may cause post-operative cognitive dysfunction and delirium
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Direct placental effects of cigarette smoke protect women from pre-eclampsia: the specific roles of carbon monoxide and antioxidant systems in the placenta
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Development of a novel high-concentration galantamine formulation suitable for intranasal delivery
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Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Ibuprofen*
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Comparison of Pharmacokinetics of Loxoprofen and its Active Metabolites After an Intravenous, Intramuscular, and Oral Administration of Loxoprofen in Rats: Evidence for Extrahepatic Metabolism
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Application of substrate depletion assay for early prediction of nonlinear pharmacokinetics in drug discovery: Assessment of nonlinearity of metoprolol, timolol, and propranolol
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Electrostatic charge characteristics of aerosols produced from metered dose inhalers
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Pharmacokinetics of α-Naphthyl Isothiocyanate in Rats
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Rheological and Dielectric Characterization of Monoolein/Water Mesophases in the Presence of a Peptide Drug
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Application of Powder X-ray Diffraction in Studying the Compaction Behavior of Bulk Pharmaceutical Powders
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In-Line Monitoring of Hydrate Formation during Wet Granulation Using Raman Spectroscopy
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The Study of In Vitro-In Vivo Correlation: Pharmacokinetics and Pharmacodynamics of Albuterol Dry Powder Inhalers
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Low Molecular Weight Dextrans Stabilize Nonviral Vectors During Lyophilization at Low Osmolalities: Concentrating Suspensions by Rehydration to Reduced Volumes
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Interaction of Clonixin with EPC Liposomes Used as Membrane Models
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IPM/DOSS/water Microemulsions as Reactors for Silver Sulfadiazine Nanocrystal Synthesis
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Double-Coated Poly (Butylcynanoacrylate) Nanoparticulate Delivery Systems for Brain Targeting of Dalargin Via Oral Administration
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Prediction of in vivo intestinal absorption enhancement on P-glycoprotein inhibition, from rat in situ permeability
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Synergistic interaction of heterozygous deletions impairs performance and confers susceptibility to disease at all ages
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Effect of formulation factors on electroosmotic glucose transport through human skin in vivo
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Magnetic resonance profiling of human skin in vivo using GARField magnets
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Measurement of drug release from microcarriers by microdialysis
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Trends in Solubility of Polymorphs
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Physicochemical Characterization of Ricobendazole: I. Solubility, Lipophilicity, and Ionization Characteristics
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A Novel Standard Sample Powder Preparation Method for Quantitative Analysis of Polymorphs
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Physicochemical and Structural Characterization of Quercetin-β-Cyclodextrin Complexes
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Drug Molecules as Probes for Studying the Compatibility Between Gels and Mucous Tissue with Dielectric Spectroscopy
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Thermal and Fractal Analysis of Diclofenac/Gelucire 50/13 Microparticles Obtained by Ultrasound-Assisted Atomization
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Evaluation of Indomethacin Percutaneous Absorption from Nanostructured Lipid Carriers (NLC): In Vitro and In Vivo Studies
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Tuning the Polymer Release from Hydrophilic Matrix Tablets by Mixing Short and Long Matrix Polymers
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Fluconazole Distribution in Rat Dermis Following Intravenous and Topical Application: A Microdialysis Study
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Partially Crystalline Systems in Lyophilization: I. Use of Ternary State Diagrams to Determine Extent of Crystallization of Bulking Agent
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