CCK-8 prevents the development of kindling and regulates the GABA and NPY expression in the hippocampus of pentylenetetrazole (PTZ)-treated adult rats Fulltext Access 11 Pages 2005
A comparative study of the potential of solid triglyceride nanostructures coated with chitosan or poly(ethylene glycol) as carriers for oral calcitonin delivery Fulltext Access 11 Pages 2005
Transport of nanoparticles across an in vitro model of the human intestinal follicle associated epithelium Fulltext Access 11 Pages 2005
Optimisation of the predictive ability of artificial neural network (ANN) models: A comparison of three ANN programs and four classes of training algorithm Fulltext Access 11 Pages 2005
Comparative scale-up of three methods for producing ibuprofen-loaded nanoparticles Fulltext Access 11 Pages 2005
Population pharmacokinetic modeling for enterohepatic recirculation in Rhesus monkey Fulltext Access 11 Pages 2005
Permeabilisation and solubilisation of soybean phosphatidylcholine bilayer vesicles, as membrane models, by polysorbate, Tween 80 Fulltext Access 11 Pages 2005
Uptake of lipophilic drugs by plasma derived isolated chylomicrons: Linear correlation with intestinal lymphatic bioavailability Fulltext Access 11 Pages 2005
The correlation grid: analysis of synchronous spiking in multi-dimensional spike train data and identification of feasible connection architectures Fulltext Access 11 Pages 2005
“Live memory” of the cell, the other hereditary memory of living systems Fulltext Access 11 Pages 2005
Oral administration of paclitaxel affects the distribution and metabolism of 2-aminofluorene in various tissues of Sprague-Dawley rats Fulltext Access 11 Pages 2005
Pharmacokinetic-pharmacodynamic modelling of the schedule-dependent effect of the anti-cancer agent CHS 828 in a rat hollow fibre model Fulltext Access 11 Pages 2005
Gene - environment interactions determine the individual variability in cocaine self-administration Fulltext Access 11 Pages 2005
The modulation of Ca2+ and K+ channels but not changes in cAMP signaling contribute to the inhibition of glutamate release by cannabinoid receptors in cerebrocortical nerve terminals Fulltext Access 11 Pages 2005
Genetic knockout and pharmacological blockade studies of the 5-HT7 receptor suggest therapeutic potential in depression Fulltext Access 11 Pages 2005
Cannabinoids produce neuroprotection by reducing intracellular calcium release from ryanodine-sensitive stores Fulltext Access 11 Pages 2005
Time-dependent effects of repeated cocaine administration on dopamine transmission in the medial prefrontal cortex Fulltext Access 11 Pages 2005
Anxiolytic activity of progesterone in progesterone receptor knockout mice Fulltext Access 11 Pages 2005
Acetylcholine receptor effects on accumbal shell dopamine-mediated turning behaviour in rats Fulltext Access 11 Pages 2005
Anticonvulsant action of an antagonist of metabotropic glutamate receptors mGluR5 MPEP in immature rats Fulltext Access 11 Pages 2005
Group I metabotropic glutamate receptors reduce excitotoxic injury and may facilitate neurogenesis Fulltext Access 11 Pages 2005
NMDA-induced potentiation of mGluR5 is mediated by activation of protein phosphatase 2B/calcineurin Fulltext Access 11 Pages 2005
A potassium channel blocker induces a long-lasting enhancement of corticostriatal responses Fulltext Access 11 Pages 2005
Equilibrium, observability and controllability in selection-mutation models Fulltext Access 11 Pages 2005
Imaging recognition of inhibition of multidrug resistance in human breast cancer xenografts using 99mTc-labeled sestamibi and tetrofosmin Fulltext Access 11 Pages 2005
Functional comparison of annexin V analogues labeled indirectly and directly with iodine-124 Fulltext Access 11 Pages 2005
F-18 Polyethyleneglycol stilbenes as PET imaging agents targeting Aβ aggregates in the brain Fulltext Access 11 Pages 2005
Ryanodine receptors as drug targets for heart failure and cardiac arrhythmias Fulltext Access 11 Pages 2005
Mechanisms of peptide and nonpeptide ligand binding to Class B G-protein-coupled receptors Fulltext Access 11 Pages 2005
Lipocalins in drug discovery: From natural ligand-binding proteins to 'anticalins' Fulltext Access 11 Pages 2005
Foundation Review: Transgenic animals and their impact on the drug discovery industry Fulltext Access 11 Pages 2005
Differential regulation of serotonin (5HT)2A receptor mRNA and protein levels after single and repeated stress in rat brain: role in learned helplessness behavior Fulltext Access 11 Pages 2005
Computational multiple steady states for enzymatic esterification of ethanol and oleic acid in an isothermal CSTR Fulltext Access 11 Pages 2005
Computational studies on conditions of the emergence of autopoietic protocells Fulltext Access 11 Pages 2005
Role of nutrient bound of prey on the dynamics of predator-mediated competitive-coexistence Fulltext Access 11 Pages 2005
Bio-computational model of object-recognition: Quantum Hebbian processing with neurally shaped Gabor wavelets Fulltext Access 11 Pages 2005
Coating alginate microspheres with a serum albumin-alginate membrane: application to the encapsulation of a peptide Fulltext Access 11 Pages 2005
Emulsion gel beads of calcium pectinate capable of floating on the gastric fluid: effect of some additives, hardening agent or coating on release behavior of metronidazole Fulltext Access 11 Pages 2005
Ascorbic and 6-Br-ascorbic acid conjugates as a tool to increase the therapeutic effects of potentially central active drugs Fulltext Access 11 Pages 2005
Physicochemical evaluation of PVP-thiazide diuretic interactions in co-spray-dried composites-analysis of glass transition composition relationships Fulltext Access 11 Pages 2005
Mixed-effects modelling of the interspecies pharmacokinetic scaling of pegylated human erythropoietin Fulltext Access 11 Pages 2005
Synthesis and pharmacological profile of non-peptide vasopressin antagonists Fulltext Access 11 Pages 2005
New antiproliferative 14,15-secopregnane glycosides from Solenostemma argel Fulltext Access 11 Pages 2005
The Novel Formulation Design of Self-emulsifying Drug Delivery Systems (SEDDS) Type O/W Microemulsion II: Stable Gastrointestinal Absorption of a Poorly Water Soluble New Compound, ER-1258 in Bile-fistula Rats Fulltext Access 11 Pages 2005
Receptor Occupancy-based Analysis of the Contributions of Various Receptors to Antipsychotics-induced Weight Gain and Diabetes Mellitus Fulltext Access 11 Pages 2005
Facile oxidative conversion of alcohols to esters using molecular iodine Fulltext Access 11 Pages 2005
Synthesis of polyanionic glycopolymers for the facile assembly of glycosyl arrays Fulltext Access 11 Pages 2005
Diastereoselectivity in addition of nitrile-stabilized carbanions to Schiff bases and in subsequent alkylation reactions Fulltext Access 11 Pages 2005
Inter- and intramolecular Mitsunobu reaction based approaches to 2-substituted chromans and chroman-4-ones Fulltext Access 11 Pages 2005
Molecular design and morphology of peptide nanotubes: towards the novel drug delivery materials Fulltext Access 11 Pages 2005
Asymmetric transfer hydrogenation using amino acid derivatives; further studies and a mechanistic proposal Fulltext Access 11 Pages 2005
Synthesis of mono- and di-substituted 2,4,5-trifluorobenzoic acid synthons, key precursors for biologically active 6-fluoroquinolones Fulltext Access 11 Pages 2005
On the reactivity of ascomycin at the binding domain. Part 3: Reactivity of the binding domain towards diazomethane Fulltext Access 11 Pages 2005
PtCl2-mediated cycloisomerization of unsaturated propargylic carboxylates Fulltext Access 11 Pages 2005
The study of reaction mechanism for the transformation of nitronate into nitrile by phosphorus trichloride Fulltext Access 11 Pages 2005
New reactivity patterns in activated indoles with 2-methyl substituents Fulltext Access 11 Pages 2005
The effect of pre-existing stereocenters in the intramolecular asymmetric Stetter reaction Fulltext Access 11 Pages 2005
Imidazo[1,5-a]pyridine-3-ylidenes—pyridine derived N-heterocyclic carbene ligands Fulltext Access 11 Pages 2005
Zinc templated synthesis—a route to get metal ion free tripodal ligands and lariat coronands, containing Schiff bases Fulltext Access 11 Pages 2005
The antidepressant-like effect of Hypericum caprifoliatum Cham & Schlecht (Guttiferae) on forced swimming test results from an inhibition of neuronal monoamine uptake Fulltext Access 11 Pages 2005
Developmentally regulated expression of VGLUT3 during early post-natal life Fulltext Access 11 Pages 2005
Selective cortical VGLUT1 increase as a marker for antidepressant activity Fulltext Access 11 Pages 2005
Evidence that Akt mediates platelet-derived growth factor-dependent increases in activity and surface expression of the neuronal glutamate transporter, EAAC1 Fulltext Access 11 Pages 2005
A pincer-like configuration of TM2 in the human dopamine transporter is responsible for indirect effects on cocaine binding Fulltext Access 11 Pages 2005
Differences in interactions with the dopamine transporter as revealed by diminishment of Na+ gradient and membrane potential: Dopamine versus other substrates Fulltext Access 11 Pages 2005
Regionally selective and dose-dependent effects of the ampakines Org 26576 and Org 24448 on local cerebral glucose utilisation in the mouse as assessed by 14C-2-deoxyglucose autoradiography Fulltext Access 11 Pages 2005
Ethanol differentially affects ATP-gated P2X3 and P2X4 receptor subtypes expressed in Xenopus oocytes Fulltext Access 11 Pages 2005
S-2474, a novel nonsteroidal anti-inflammatory drug, rescues cortical neurons from human group IIA secretory phospholipase A2-induced apoptosis Fulltext Access 11 Pages 2005
Characterization of the neuroprotective activity of rasagiline in cerebellar granule cells Fulltext Access 11 Pages 2005
Mechanisms of allosteric modulation at GABAB receptors by CGP7930 and GS39783: effects on affinities and efficacies of orthosteric ligands with distinct intrinsic properties Fulltext Access 11 Pages 2005
GLYX-13: A monoclonal antibody-derived peptide that acts as an N-methyl-d-aspartate receptor modulator Fulltext Access 11 Pages 2005
Synthesis of polystyrene-bound perfluoroalkyl sulfonic acids and the application of their ytterbium salts in multicomponent reactions (MCRs) Fulltext Access 11 Pages 2005
Effects of novel antipsychotics with mixed D2 antagonist/5-HT1A agonist properties on PCP-induced social interaction deficits in the rat Fulltext Access 11 Pages 2005
Combined effects of mechanical and ischemic injury to cortical cells: Secondary ischemia increases damage and decreases effects of neuroprotective agents Fulltext Access 11 Pages 2005
Identification, design, synthesis, and pharmacological activity of (4-ethyl-piperazin-1-yl)-phenylmethanone derivatives with neuroprotective properties against β-amyloid-induced toxicity Fulltext Access 11 Pages 2005
Endogenous γ-aminobutyric acid (GABA)A receptor active neurosteroids and the sedative/hypnotic action of γ-hydroxybutyric acid (GHB): A study in GHB-S (sensitive) and GHB-R (resistant) rat lines Fulltext Access 11 Pages 2005
Effects of the antibiotic gentamicin on nicotinic acetylcholine receptors Fulltext Access 11 Pages 2005
Sequential changes in BDNF mRNA expression and synaptic levels of AMPA receptor subunits in rat hippocampus after chronic antidepressant treatment Fulltext Access 11 Pages 2005
Design, synthesis, and evaluation of the antipsychotic potential of orally bioavailable neurotensin (8-13) analogues containing non-natural arginine and lysine residues Fulltext Access 11 Pages 2005
Effect of a selective GABAB receptor agonist baclofen on the μ-opioid receptor agonist-induced antinociceptive, emetic and rewarding effects Fulltext Access 11 Pages 2005
Efficacy of antiepileptic tetramethylcyclopropyl analogues of valproic acid amides in a rat model of neuropathic pain Fulltext Access 11 Pages 2005
Neurosteroid pregnenolone sulfate inhibits stimulus-evoked EPSC via presynaptic inhibition of protein kinase A in rat prelimbic cortical neurons Fulltext Access 11 Pages 2005
NMDA enhances a depolarization-activated inward current in subthalamic neurons Fulltext Access 11 Pages 2005