Synthesis and 5-HT1A, 5-HT2A receptor activity of new β-tetralonohydantoins Fulltext Access 10 Pages 2005
The effect of pressurized carbon dioxide as a temporary plasticizer and foaming agent on the hot stage extrusion process and extrudate properties of solid dispersions of itraconazole with PVP-VA 64 Fulltext Access 10 Pages 2005
Canine versus in vitro data for predicting input profiles of l-sulpiride after oral administration Fulltext Access 10 Pages 2005
Pathophysiology of migraine headache: Insight from pharmacology and genetics Fulltext Access 10 Pages 2005
Neurodegeneration and neuroprotective strategies after traumatic brain injury Fulltext Access 10 Pages 2005
Synthetic chalcones as potential anti-inflammatory and cancer chemopreventive agents Fulltext Access 10 Pages 2005
Atypical and typical antipsychotic drug interactions with the dopamine D2 receptor Fulltext Access 10 Pages 2005
New triorganotin(IV) derivatives of dipeptides as anti-inflammatory-antimicrobial agents Fulltext Access 10 Pages 2005
Synthesis and antimycobacterial activities of glycosylated amino alcohols and amines Fulltext Access 10 Pages 2005
A structure-activity relationship study of quinone compounds with trypanocidal activity Fulltext Access 10 Pages 2005
Discovery of pyrimidyl-5-hydroxamic acids as new potent histone deacetylase inhibitors Fulltext Access 10 Pages 2005
A three step supercritical process to improve the dissolution rate of Eflucimibe Fulltext Access 10 Pages 2005
Novel pyrazinone and pyridinone thrombin inhibitors incorporating weakly basic heterobicyclic P1-arginine mimetics Fulltext Access 10 Pages 2005
Synthesis, characterization, activities, cell uptake and DNA binding of trinuclear complex: [{trans-PtCl(NH3)}2μ-{trans-Pt(NH3)(2-hydroxypyridine)-(H2N(CH2)6NH2)2]Cl4 Fulltext Access 10 Pages 2005
Development of novel 4-aminopyridine derivatives as potential treatments for neurological injury and disease Fulltext Access 10 Pages 2005
3D-QSAR, Synthesis, and antimicrobial activity of 1-Alkylpyridinium Compounds as Potential Agents to Improve Food Safety Fulltext Access 10 Pages 2005
Regioselective synthesis and estrogenicity of (±)-8-alkyl-5,7-dihydroxy-4-(4-hydroxyphenyl)-3,4-dihydrocoumarins Fulltext Access 10 Pages 2005
Dandelion (Taraxacum officinale) flower extract suppresses both reactive oxygen species and nitric oxide and prevents lipid oxidation in vitro Fulltext Access 10 Pages 2005
Large-scale observational studies of hypericum extracts in patients with depressive disorders-a systematic review Fulltext Access 10 Pages 2005
Antinociceptive effect of Nidularium procerum: a Bromeliaceae from the Brazilian coastal rain forest Fulltext Access 10 Pages 2005
Troxerutin protects the isolated perfused rat liver from a possible lipid peroxidation by coumarin Fulltext Access 10 Pages 2005
The subunit composition and pharmacology of α-Conotoxin MII-binding nicotinic acetylcholine receptors studied by a novel membrane-binding assay Fulltext Access 10 Pages 2005
Alterations in brain Protein Kinase A activity and reversal of morphine tolerance by two fragments of native Protein Kinase A inhibitor peptide (PKI) Fulltext Access 10 Pages 2005
“Bioplutonism” and the evolutionary implications of beneficial genes from another biosphere Fulltext Access 10 Pages 2005
Keynote review: Medicinal chemistry strategies to CB1 cannabinoid receptor antagonists Fulltext Access 10 Pages 2005
Biological networks and analysis of experimental data in drug discovery Fulltext Access 10 Pages 2005
Analysis of synonymous codon usage in H5N1 virus and other influenza A viruses Fulltext Access 10 Pages 2005
The origin of the genetic code: theories and their relationships, a review Fulltext Access 10 Pages 2005
Reverse engineering of biochemical equations from time-course data by means of genetic programming Fulltext Access 10 Pages 2005
Identification of conserved regulatory RNA structures in prokaryotic metabolic pathway genes Fulltext Access 10 Pages 2005
Designing a neural network for the constraint optimization of the fitness functions devised based on the load minimization of the genetic code Fulltext Access 10 Pages 2005
Thermosynthesis as energy source for the RNA World: A model for the bioenergetics of the origin of life Fulltext Access 10 Pages 2005
The GABAA receptor agonist THIP alters the EEG in waking and sleep of mice Fulltext Access 10 Pages 2005
QSAR analysis of substituted bis[(acridine-4-carboxamide)propyl]methylamines using optimized block-wise variable combination by particle swarm optimization for partial least squares modeling Fulltext Access 10 Pages 2005
pH-Dependent passive and active transport of acidic drugs across Caco-2 cell monolayers Fulltext Access 10 Pages 2005
Solid-state characterization of falicaine hydrochloride and isomorphic dyclonine hydrochloride Fulltext Access 10 Pages 2005
The pharmacokinetics of pulmonary insulin in the in vitro isolated perfused rat lung: Implications of metabolism and regional deposition Fulltext Access 10 Pages 2005
Pharmacokinetics of theophylline in diabetes mellitus rats: Induction of CYP1A2 and CYP2E1 on 1,3-dimethyluric acid formation Fulltext Access 10 Pages 2005
The pharmacokinetics of perindoprilat in normal volunteers and patients: Influence of age and disease state Fulltext Access 10 Pages 2005
Development of a simple method for the preparation of a silica gel based controlled delivery system with a high drug content Fulltext Access 10 Pages 2005
Activation of mitogen activated protein kinase pathways and melanogenesis by novel nitro-derivatives of 7-hydroxycomarin in human malignant melanoma cells Fulltext Access 10 Pages 2005
Spray freeze drying to produce a stable Î9-tetrahydrocannabinol containing inulin-based solid dispersion powder suitable for inhalation Fulltext Access 10 Pages 2005
Neural correlates of consciousness: A definition of the dorsal and ventral streams and their relation to phenomenology Fulltext Access 10 Pages 2005
Serotonergic modulation of carbachol-induced rhythmic activity in hippocampal slices Fulltext Access 10 Pages 2005
Activation of protein kinase C reduces benzodiazepine potency at GABAA receptors in NT2-N neurons Fulltext Access 10 Pages 2005
Hippocampal dopamine receptors modulate cFos expression in the rat nucleus accumbens evoked by chemical stimulation of the ventral hippocampus Fulltext Access 10 Pages 2005
Differential effects of 7-OH-DPAT and apomorphine on hyperactivity induced by MK-801 (dizocilpine) in rats Fulltext Access 10 Pages 2005
Prolonged nicotine exposure does not alter GABAB receptor-mediated regulation of brain reward function Fulltext Access 10 Pages 2005
2-[4-(3,4-Dimethylphenyl)piperazin-1-ylmethyl]-1H benzoimidazole (A-381393), a selective dopamine D4 receptor antagonist Fulltext Access 10 Pages 2005
Selective and nonselective serotonin antagonists block the aversive stimulus properties of MK212 and m-chlorophenylpiperazine (mCPP) in mice Fulltext Access 10 Pages 2005
Effects of opioid antagonists and morphine in a hippocampal hypoxia/hypoglycemia model Fulltext Access 10 Pages 2005
Carrier-mediated release of monoamines induced by the nicotinic acetylcholine receptor agonist DMPP Fulltext Access 10 Pages 2005
Muscarinic receptor stimulation reduces NMDA responses in CA3 hippocampal pyramidal cells via Ca2+-dependent activation of tyrosine phosphatase Fulltext Access 10 Pages 2005
Involvement of cyclooxygenase-2 and EP3 prostaglandin receptor in acute herpetic but not postherpetic pain in mice Fulltext Access 10 Pages 2005
Paradoxical strategy for treating chronic diseases where the therapeutic effect is derived from compensatory response rather than drug effect Fulltext Access 10 Pages 2005
Cocaine-induced modulation of long-term potentiation in the CA1 region of rat hippocampus Fulltext Access 10 Pages 2005
The possible role of female sex hormones in milk from pregnant cows in the development of breast, ovarian and corpus uteri cancers Fulltext Access 10 Pages 2005
Unifying mechanism for toxicity and addiction by abused drugs: electron transfer and reactive oxygen species Fulltext Access 10 Pages 2005
Could obsessive-compulsive disorder have originated as a group-selected adaptive trait in traditional societies? Fulltext Access 10 Pages 2005
Nicotinamide homeostasis: A xenobiotic pathway that is key to development and degenerative diseases Fulltext Access 10 Pages 2005
High risk of schizophrenia and other mental disorders associated with chlamydial infections: Hypothesis to combine drug treatment and adoptive immunotherapy Fulltext Access 10 Pages 2005
An ezetimibe-policosanol combination has the potential to be an OTC agent that could dramatically lower LDL cholesterol without side effects Fulltext Access 10 Pages 2005
Marinobufagenin may mediate the impact of salty diets on left ventricular hypertrophy by disrupting the protective function of coronary microvascular endothelium Fulltext Access 10 Pages 2005
Making improvements in the management of patients with type 2 diabetes: a possible role for the control of variation in glycated hemoglobin Fulltext Access 10 Pages 2005
Neurotoxicity of inhaled manganese: Public health danger in the shower? Fulltext Access 10 Pages 2005
Neoplastic growth: The consequence of evolutionary malignant resistance to chronic damage for survival of cells (review of a new theory of the origin of cancer) Fulltext Access 10 Pages 2005
Regulation of 5-HT2A receptor mRNA levels and binding sites in rat frontal cortex by the agonist DOI and the antagonist mianserin Fulltext Access 10 Pages 2005
Modulatory action of metabotropic glutamate receptor (mGluR) 5 on mGluR1 function in striatal cholinergic interneurons Fulltext Access 10 Pages 2005
Comparison of responses of ventral posterolateral and posterior complex thalamic neurons in naïve rats and rats with hindpaw inflammation: μ-opioid receptor mediated inhibitions Fulltext Access 10 Pages 2005
Non-adrenergic inhibition at prejunctional sites by agmatine of purinergic vasoconstriction in rabbit saphenous artery Fulltext Access 10 Pages 2005
Protection of ischemic rat spinal cord white matter: Dual action of KB-R7943 on Na+/Ca2+ exchange and L-type Ca2+ channels Fulltext Access 10 Pages 2005
Agonistic effects of the β-carboline DMCM revealed in GABAA receptor γ2 subunit F77I point-mutated mice Fulltext Access 10 Pages 2005
Mechanisms of Na+ and Ca2+ influx into respiratory neurons during hypoxia Fulltext Access 10 Pages 2005
Determination of guinea-pig cortical γ-secretase activity ex vivo following the systemic administration of a γ-secretase inhibitor Fulltext Access 10 Pages 2005
Acute or repeated cocaine administration generates reactive oxygen species and induces antioxidant enzyme activity in dopaminergic rat brain structures Fulltext Access 10 Pages 2005
Involvement of the cannabimimetic compound, N-palmitoyl-ethanolamine, in inflammatory and neuropathic conditions: Review of the available pre-clinical data, and first human studies Fulltext Access 10 Pages 2005
Adenosine kinase inhibitor attenuates the expression of inducible nitric oxide synthase in glial cells Fulltext Access 10 Pages 2005
Effects of long-term biogenic amine transporter blockade on receptor/G-protein coupling in rat brain Fulltext Access 10 Pages 2005
Endogenous activation of mGlu5 metabotropic glutamate receptors supports self-renewal of cultured mouse embryonic stem cells Fulltext Access 10 Pages 2005
Differential roles of mGlu8 receptors in the regulation of glutamate and γ-aminobutyric acid release at periaqueductal grey level Fulltext Access 10 Pages 2005
Density-functional theory studies on standard electrode potentials of half reaction for l-adrenaline and adrenalinequinone Fulltext Access 10 Pages 2005
Grm5 expression is not required for the oncogenic role of Grm1 in melanocytes Fulltext Access 10 Pages 2005
Investigations of the protein synthesis dependency of mGluR-induced long-term depression in the dentate gyrus of freely moving rats Fulltext Access 10 Pages 2005
Neurochemical properties of ramelteon (TAK-375), a selective MT1/MT2 receptor agonist Fulltext Access 10 Pages 2005
Effects of an endothelin B receptor agonist on secretory phospholipase A2-IIA-induced apoptosis in cortical neurons Fulltext Access 10 Pages 2005
Purinergic modulation of pacemaker Ca2+ activity in interstitial cells of Cajal Fulltext Access 10 Pages 2005
Dopamine antagonist modulation of amphetamine response as detected using pharmacological MRI Fulltext Access 10 Pages 2005
The glycine transporter GLYT1 interacts with Sec3, a component of the exocyst complex Fulltext Access 10 Pages 2005
Sulfhydryl modification of cysteine mutants of a neuronal glutamate transporter reveals an inverse relationship between sodium dependent conformational changes and the glutamate-gated anion conductance Fulltext Access 10 Pages 2005
Differential effects of dopamine and psychoactive drugs on dopamine transporter phosphorylation and regulation Fulltext Access 10 Pages 2005
Fluoxetine inhibits ATP-induced [Ca2+]i increase in PC12 cells by inhibiting both extracellular Ca2+ influx and Ca2+ release from intracellular stores Fulltext Access 10 Pages 2005
In vivo labelling of α5 subunit-containing GABAA receptors using the selective radioligand [3H]L-655,708 Fulltext Access 10 Pages 2005