QSAR study on carbonic anhydrase inhibitors: water-soluble sulfonamides incorporating β-alanyl moieties, possessing long lasting-intra ocular pressure lowering properties-a molecular connectivity approach Fulltext Access 11 Pages 2005
Synthesis and pharmacological studies at the Gly/NMDA, AMPA and Kainate receptors of new oxazolo[4,5-c]quinolin-4-one derivatives bearing different substituents at position-2 and on the fused benzo ring Fulltext Access 11 Pages 2005
Synthesis of some novel benzoxazole derivatives as anticancer, anti-HIV-1 and antimicrobial agents Fulltext Access 11 Pages 2005
Synthesis and anticancer activities of amphiphilic 5-fluoro-2â²-deoxyuridylic acid prodrugs Fulltext Access 11 Pages 2005
Biological and physicochemical properties of gemini quaternary ammonium compounds in which the positions of a cross-linking sulfur in the spacer differ Fulltext Access 11 Pages 2005
Carbapenem-based prodrugs. Design, synthesis, and biological evaluation of carbapenems Fulltext Access 11 Pages 2005
1,8-Naphthyridines V. Novel N-substituted 5-amino-N,N-diethyl-9-isopropyl [1,2,4]triazolo[4,3-a] [1,8]naphthyridine-6-carboxamides, as potent anti-inflammatory and/or analgesic agents completely devoid of acute gastrolesivity Fulltext Access 11 Pages 2005
Synthesis, structure-activity relationship of some new anti-arrhythmic 5-arylidene imidazolidine-2,4-dione derivatives Fulltext Access 11 Pages 2005
The 2-aminoglucosamide motif improves cellular uptake and photodynamic activity of tetraphenylporphyrin Fulltext Access 12 Pages 2005
Catalytic electronic activation as a tool for the addition of stabilised nucleophiles to allylic alcohols Fulltext Access 12 Pages 2005
A novel synthesis, including asymmetric synthesis, of 2,4,4-trisubstituted 2-cyclopentenones based on the reaction of 1-chlorovinyl p-tolyl sulfoxides with acetonitrile and its homologues Fulltext Access 12 Pages 2005
Enantioselective syntheses of two 5, 9E diastereomers of 223V, an alkaloid from the poison frog Dendrobates pumilio Fulltext Access 12 Pages 2005
Regio- and stereospecific [3+2] cycloaddition of an unusual nitrone derived from a N-hydroxy-2-pyridone with medium ring enones Fulltext Access 12 Pages 2005
Synthetic studies related to diketopyrrolopyrrole (DPP) pigments. Part 2: The use of esters in place of nitriles in standard DPP syntheses: Claisen-type acylations and furopyrrole intermediates Fulltext Access 12 Pages 2005
Cyclic peptides containing a δ-sugar amino acid-synthesis and evaluation as artificial receptors Fulltext Access 12 Pages 2005
Synthesis of an external beta-turn based on the GLDV motif of cell adhesion proteins Fulltext Access 12 Pages 2005
Formation of reactive o-quinone methides from the reaction of trimethylsilyl(methyl)-substituted 1,4-benzoquinones with nucleophiles Fulltext Access 12 Pages 2005
On the application of the extended Fujita-Nishioka equation to polysubstituted systems. A kinetic study of the rearrangement of several poly-substituted Z-arylhydrazones of 3-benzoyl-5-phenyl-1,2,4-oxadiazole into 2-aryl-4-benzoylamino-5-phenyl-1,2,3-tria Fulltext Access 12 Pages 2005
Copper-mediated regio- and stereoselective 12β-hydroxylation of steroids with molecular oxygen and an unexpected 12β-chlorination Fulltext Access 12 Pages 2005
An aqueous extract of the popular Chinese nutraceutical Kwei Ling Ko (Tortoise shell-Rhizome Jelly) activates the PPARγ pathway and down-regulates the NFκB activity Fulltext Access 12 Pages 2005
Repeated Glucuronidation at One Hydroxyl Group Leads to Structurally Novel Diglucuronides of Steroid Sex Hormones Fulltext Access 12 Pages 2005
Mechanism-Based Inactivation of Human Liver Microsomal CYP3A4 by Rutaecarpine and Limonin from Evodia Fruit Extract Fulltext Access 12 Pages 2005
Keynote review: Recent advances in biomarkers for cancer diagnosis and treatment Fulltext Access 12 Pages 2005
Is optimal solution of every NP-complete or NP-hard problem determined from its characteristic for DNA-based computing Fulltext Access 12 Pages 2005
EXAMINE: A computational approach to reconstructing gene regulatory networks Fulltext Access 12 Pages 2005
On the use of multi-objective evolutionary algorithms for the induction of fuzzy classification rule systems Fulltext Access 12 Pages 2005
Generative topographic mapping applied to clustering and visualization of motor unit action potentials Fulltext Access 12 Pages 2005
λ3-Iodane-mediated arenol dearomatization. Synthesis of five-membered ring-containing analogues of the aquayamycin ABC tricyclic unit and novel access to the apoptosis inducer menadione Fulltext Access 12 Pages 2005
Synthesis, stereochemistry and biological activity of some novel long alkyl chain substituted thiazolidin-4-ones and thiazan-4-one from 10-undecenoic acid hydrazide Fulltext Access 12 Pages 2005
Synthesis and biological evaluation of new clofibrate analogues as potential PPARα agonists Fulltext Access 12 Pages 2005
Preparations of vitamin D analogs, spirostanols and furostanols from diosgenin and their cytotoxic activities Fulltext Access 12 Pages 2005
Inhibition of secretory phospholipase A2. 1-Design, synthesis and structure-activity relationship studies starting from 4-tetradecyloxybenzamidine to obtain specific inhibitors of group II sPLA2s Fulltext Access 12 Pages 2005
Unified drug-target interaction thermodynamic Markov model using stochastic entropies to predict multiple drugs side effects Fulltext Access 12 Pages 2005
An efficient construction of bridged chiral tetracyclic indolidines, a core structure of asperparaline, via stereocontrolled catalytic Pauson-Khand reaction Fulltext Access 12 Pages 2005
Synthesis of acridine-nuclear localization signal (NLS) conjugates and evaluation of their impact on lipoplex and polyplex-based transfection Fulltext Access 12 Pages 2005
Novel synthesized aminosteroidal heterocycles intervention for inhibiting iron-induced oxidative stress Fulltext Access 12 Pages 2005
A new class of readily available and conformationally rigid phosphino-oxazoline ligands for asymmetric catalysis Fulltext Access 12 Pages 2005
Synthesis, characterization and ion transportation studies of some novel cyclophane amides Fulltext Access 12 Pages 2005
Reaction of methyl (2E)-3-dimethylamino-2-(1H-indol-3-yl)-propenoate with ureas: facile entry into the polycyclic meridianin analogues with uracil structural unit Fulltext Access 12 Pages 2005
Cu-mediated Stille reactions of sterically congested fragments: towards the total synthesis of zoanthamine Fulltext Access 12 Pages 2005
Facile synthesis and optical resolution of inherently chiral fluorescent calix[4]crowns: enantioselective recognition towards chiral leucinol Fulltext Access 12 Pages 2005
New developments in the synthesis of pyrrolizidinone-based dipeptide isosteres Fulltext Access 12 Pages 2005
Conformational studies of N-carbomethoxy-2-alkoxyindolenines by dynamic NMR, crystallography, and molecular mechanics Fulltext Access 12 Pages 2005
An efficient synthesis of benzofurans and their application in the preparation of natural products of the genus Calea Fulltext Access 12 Pages 2005
Synthesis of the phthalide-containing anti-Helicobacter pylori agents CJ-13,015, CJ-13,102, CJ-13,103, CJ-13,104 and CJ-13,108 Fulltext Access 12 Pages 2005
Diastereoselective synthesis of new polyhydroxylated indolizidines from (l)-glutamic acid Fulltext Access 12 Pages 2005
Synthesis of two glycolipid antigens of the causative agent of Lyme disease Fulltext Access 12 Pages 2005
Novel photo-induced oxidative cyclization of 1,3-dimethyl-5-(1-arylmethylidene)pyrimidine-2,4,6(1,3,5H)-triones: synthesis and properties of areno[5,6]pyrano[2,3-d]pyrimidine-2,4(1,3H)-dionylium ions and their photo-induced autorecycling oxidizing reactio Fulltext Access 12 Pages 2005
The stereoselective synthesis of α-substituted β-amino secondary alcohols based on the proline-mediated, asymmetric, three-component Mannich reaction and its application to the formal total synthesis of nikkomycins B and Bx Fulltext Access 12 Pages 2005
A facile and efficient synthesis of enyne-reaction precursors by multicomponent reactions Fulltext Access 12 Pages 2005
Polyisobutylene supports-a non-polar hydrocarbon analog of PEG supports Fulltext Access 12 Pages 2005
pH-dependent functional activity of P-glycoprotein in limiting intestinal absorption of protic drugs: Kinetic analysis of quinidine efflux in situ Fulltext Access 12 Pages 2005
The Metabolic Profile of Azimilide in Man: In Vivo and in Vitro Evaluations Fulltext Access 12 Pages 2005
Particle Size and Density in Spray Drying-Effects of Carbohydrate Properties Fulltext Access 12 Pages 2005
A Study of Sulfamerazine Single Crystals Using Atomic Force Microscopy, Transmission Light Microscopy, and Raman Spectroscopy Fulltext Access 12 Pages 2005
Effect of Amino Acids on the Dispersion of Disodium Cromoglycate Powders Fulltext Access 12 Pages 2005
Folate Receptor-Mediated Drug Targeting: From Therapeutics to Diagnostics Fulltext Access 12 Pages 2005
Rh(I)-catalyzed allenic Pauson-Khand reaction: first construction of the bicyclo[6.3.0]undecadienone ring system Fulltext Access 12 Pages 2005
Hydrogen atom transfer methodology for the synthesis of C-22, C-23, and C-25 stereoisomers of cephalostatin north 1 side chain from spirostan sapogenins Fulltext Access 12 Pages 2005
Free radical synthesis of benzofused tricyclic β-lactams by intramolecular cyclization of 2-azetidinone-tethered haloarenes Fulltext Access 12 Pages 2005
Hetero Diels-Alder reaction: a novel strategy to regioselective synthesis of pyrimido[4,5-d]pyrimidine analogues from Biginelli derivative Fulltext Access 12 Pages 2005
N,N,Nâ²-Trialkyl-1,8-diaminonaphthalenes: convenient method of preparation from protonated proton sponges and the first X-ray information Fulltext Access 12 Pages 2005
Stereochemistry of the cyclization of alkoxy-substituted 5-hexenyllithiums: effect of solvent and lithium iodide on diastereoselectivity Fulltext Access 12 Pages 2005
New synthetic approaches to sugar ureas. Access to ureido-β-cyclodextrins Fulltext Access 12 Pages 2005
Halogenated-2-pyrones in Sonogashira cross-coupling: limitations, optimisation and consequences for GC analysis of Pd-mediated reactions Fulltext Access 12 Pages 2005
Synthesis and utilisation of 2,7â²-diindolylmethanes and a 2-(2-indolyl)pyrrolylmethane as macrocyclic precursors Fulltext Access 12 Pages 2005
Short synthesis of new salacinol analogues and their evaluation as glycosidase inhibitors Fulltext Access 12 Pages 2005
Lewis acid promoted reactions of γ,γ-dialkoxyallylic zirconium species with various carbonyl compounds Fulltext Access 12 Pages 2005
Ionic liquid phase technology supported the three component synthesis of Hantzsch 1,4-dihydropyridines and Biginelli 3,4-dihydropyrimidin-2(1H)-ones under microwave dielectric heating Fulltext Access 12 Pages 2005
Asymmetric synthesis of (2-carbamoyloxy-1-alkenyl)cyclopropanes by intramolecular cycloalkylation Fulltext Access 12 Pages 2005
Catalytic processes for the functionalisation and desymmetrisation of malononitrile derivatives Fulltext Access 12 Pages 2005
Cation and anion fluorescent and electrochemical sensors derived from 4,4â²-substituted biphenyl Fulltext Access 12 Pages 2005
1,9-Bis(N,N-dimethylaminomethyl)dipyrromethanes in the synthesis of porphyrins bearing one or two meso substituents Fulltext Access 12 Pages 2005
[2]Pseudorotaxanes based on the cryptand/monopyridinium recognition motif Fulltext Access 12 Pages 2005
Synthesis and gelation properties of a new class of α-amino acid-based sector block dendrons Fulltext Access 12 Pages 2005
Enantiospecific synthesis, separation and olfactory evaluation of all diastereomers of a homologue of the sandalwood odorant Polysantol® Fulltext Access 12 Pages 2005
Molecular recognition of biotin, barbital and tolbutamide with new synthetic receptors Fulltext Access 12 Pages 2005