Propentofylline attenuates tau hyperphosphorylation in Alzheimer's Swedish mutant model Tg2576 Fulltext Access 12 Pages 2005
Use of optically active cyclic diethyl sulfamidate 2-phosphonates as chiral synthons for the synthesis of β-substituted α-amino phosphonates Fulltext Access 12 Pages 2005
Transport of the investigational anti-cancer drug 5,6-dimethylxanthenone-4-acetic acid and its acyl glucuronide by human intestinal Caco-2 cells Fulltext Access 12 Pages 2005
Preparation and evaluation of glibenclamide-polyglycolized glycerides solid dispersions with silicon dioxide by spray drying technique Fulltext Access 12 Pages 2005
Pharmacokinetic and pharmacodynamic modeling of recombinant human erythropoietin after multiple subcutaneous doses in healthy subjects Fulltext Access 12 Pages 2005
Pluronic-g-poly(acrylic acid) copolymers as novel excipients for site specific, sustained release tablets Fulltext Access 12 Pages 2005
Differential expression of P2X receptors on neurons from different parasympathetic ganglia Fulltext Access 12 Pages 2005
Effect of acute and chronic psychostimulant drugs on redox status, AP-1 activation and pro-enkephalin mRNA in the human astrocyte-like U373 MG cells Fulltext Access 12 Pages 2005
Reversal of caffeine-induced anxiety by neurosteroid 3-alpha-hydroxy-5-alpha-pregnane-20-one in rats Fulltext Access 12 Pages 2005
Role of α7-nicotinic acetylcholine receptors in tetanic stimulation-induced γ oscillations in rat hippocampal slices Fulltext Access 12 Pages 2005
Endocannabinoid release from midbrain dopamine neurons: a potential substrate for cannabinoid receptor antagonist treatment of addiction Fulltext Access 12 Pages 2005
Phasic cardiovascular responses to mevinphos are mediated through differential activation of cGMP/PKG cascade and peroxynitrite via nitric oxide generated in the rat rostral ventrolateral medulla by NOS I and II isoforms Fulltext Access 12 Pages 2005
A study of the enantiopreference of lipase PS (Pseudomonas cepacia) towards diastereomeric dihydro-5-alkyl-4-hydroxymethyl-2(3H)-furanones Fulltext Access 12 Pages 2005
Cisplatin increases brain 2-arachidonoylglycerol (2-AG) and concomitantly reduces intestinal 2-AG and anandamide levels in the least shrew Fulltext Access 12 Pages 2005
Neuronal Kir3.1/Kir3.2a channels coupled to serotonin 1A and muscarinic m2 receptors are differentially modulated by the 'short' RGS3 isoform Fulltext Access 12 Pages 2005
Metabotropic glutamate receptor (mGluR5) antagonist MPEP attenuated cue- and schedule-induced reinstatement of nicotine self-administration behavior in rats Fulltext Access 12 Pages 2005
Group II and III mGluRs-mediated presynaptic inhibition of EPSCs recorded from hippocampal interneurons of CA1 stratum lacunosum moleculare Fulltext Access 12 Pages 2005
Group II mGluR-induced long term depression in the dentate gyrus in vivo is NMDA receptor-independent and does not require protein synthesis Fulltext Access 12 Pages 2005
Antinociceptive effects of the antidepressants amitriptyline, duloxetine, mirtazapine and citalopram in animal models of acute, persistent and neuropathic pain Fulltext Access 12 Pages 2005
The substituted aspartate analogue l-β-threo-benzyl-aspartate preferentially inhibits the neuronal excitatory amino acid transporter EAAT3 Fulltext Access 12 Pages 2005
Ncm-d-aspartate: A novel caged d-aspartate suitable for activation of glutamate transporters and N-methyl-d-aspartate (NMDA) receptors in brain tissue Fulltext Access 12 Pages 2005
Effects of cinnarizine, a calcium antagonist that produces human parkinsonism, in parkin knock out mice Fulltext Access 12 Pages 2005
Peripherally acting NMDA receptor/glycineB site receptor antagonists inhibit morphine tolerance Fulltext Access 12 Pages 2005
Synthesis and anti-viral activity of a series of d- and l-2â²-deoxy-2â²-fluororibonucleosides in the subgenomic HCV replicon system Fulltext Access 12 Pages 2005
Synthesis and characterization of EADAM: a selective radioligand for mapping the brain serotonin transporters by positron emission tomography Fulltext Access 12 Pages 2005
Backbone metal-cyclization: a novel approach for simultaneous peptide cyclization and radiolabeling. Application to the combinatorial synthesis of rhenium-cyclic somatostatin analogs Fulltext Access 12 Pages 2005
Modeling and analysis of PET studies with norepinephrine transporter ligands: the search for a reference region Fulltext Access 12 Pages 2005
Picolylamine-methylphosphonic acid esters as tridentate ligands for the labeling of alcohols with the fac-[M(CO)3]+ core (M=99mTc, Re): synthesis and biodistribution of model compounds and of a 99mTc-labeled cobinamide Fulltext Access 12 Pages 2005
MBP-annexin V radiolabeled directly with iodine-124 can be used to image apoptosis in vivo using PET Fulltext Access 12 Pages 2005
Structure-activity relationships for inhibition of human cholinesterases by alkyl amide phenothiazine derivatives Fulltext Access 12 Pages 2005
Natural and synthetic cage compounds incorporating the 2,9,10-trioxatricyclo[4.3.1.03,8]decane type moiety Fulltext Access 12 Pages 2005
Non-stochastic and stochastic linear indices of the 'molecular pseudograph's atom adjacency matrix': application to 'in silico' studies for the rational discovery of new antimalarial compounds Fulltext Access 12 Pages 2005
Synthesis and biological evaluation of nucleobase-modified analogs of the anticancer compounds 3â²-C-ethynyluridine (EUrd) and 3â²-C-ethynylcytidine (ECyd) Fulltext Access 12 Pages 2005
Modified mannose disaccharides as substrates and inhibitors of a polyprenol monophosphomannose-dependent α-(1â6)-mannosyltransferase involved in mycobacterial lipoarabinomannan biosynthesis Fulltext Access 12 Pages 2005
Non-steroidal anti-inflammatory drugs have anti-amyloidogenic effects for Alzheimer's β-amyloid fibrils in vitro Fulltext Access 12 Pages 2005
Structure-based discovery of human l-xylulose reductase inhibitors from database screening and molecular docking Fulltext Access 12 Pages 2005
Design, synthesis, and evaluation of potent and selective benzoyleneurea-based inhibitors of protein geranylgeranyltransferase-I Fulltext Access 12 Pages 2005
Chemo-enzymatic synthesis and cell-growth inhibition activity of resveratrol analogues Fulltext Access 12 Pages 2005
Circular dichroism and absorption spectroscopic data reveal binding of the natural cis-carotenoid bixin to human α1-acid glycoprotein Fulltext Access 12 Pages 2005
Formation of stacking complexes between caffeine (1,2,3-trimethylxanthine) and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine may attenuate biological effects of this neurotoxin Fulltext Access 12 Pages 2005
Dinuclear macrocyclic polyamine zinc(II) complexes linked with flexible spacers: Synthesis, characterization, and DNA cleavage Fulltext Access 12 Pages 2005
Synthesis of gold nanoparticles bearing the Thomsen-Friedenreich disaccharide: a new multivalent presentation of an important tumor antigen Fulltext Access 12 Pages 2005
Novel multivalent mannose compounds and their inhibition of the adhesion of type 1 fimbriated uropathogenic E. coli Fulltext Access 12 Pages 2005
5-Thio-d-glycopyranosylamines and their amidinium salts as potential transition-state mimics of glycosyl hydrolases: synthesis, enzyme inhibitory activities, X-ray crystallography, and molecular modeling Fulltext Access 12 Pages 2005
Synthesis and conformational analysis of novel water soluble macrocycles incorporating carbohydrates, including a β-cyclodextrin mimic Fulltext Access 12 Pages 2005
Mapping the Dose-Effect Relationship of Orbofiban from Sparse Data with an Artificial Neural Network Fulltext Access 12 Pages 2005
Dendrisomes: Vesicular Structures Derived from a Cationic Lipidic Dendron Fulltext Access 12 Pages 2005
Complexation of celecoxib with βâcyclodextrin: Characterization of the interaction in solution and in solid state Fulltext Access 12 Pages 2005
Carrier mediated transport of chlorpheniramine and chlorcyclizine across bovine olfactory mucosa: Implications on noseâtoâbrain transport Fulltext Access 12 Pages 2005
Reductaseâmediated metabolism of motexafin gadolinium (Xcytrin®) in rat and human liver subcellular fractions and purified enzyme preparations Fulltext Access 12 Pages 2005
Effects of electrophoresis and electroosmosis during alternating current iontophoresis across human epidermal membrane Fulltext Access 12 Pages 2005
Influence of the intermediate digestion phases of common formulation lipids on the absorption of a poorly waterâsoluble drug Fulltext Access 12 Pages 2005
Place actuelle des endoprothèses coronaires dans le traitement de la cardiopathie ischémique Fulltext Access 12 Pages 2005
Place de la chimiothérapie de première ligne dans le cancer de l'ovaire Fulltext Access 12 Pages 2005
Peroxide-Mediated Desulfurization of Phosphorothioate Oligonucleotides and Its Prevention Fulltext Access 12 Pages 2005
Characterization of Physico-Mechanical Properties of Indomethacin and Polymers to Assess their Suitability for Hot-Melt Extrusion Processs as a Means to Manufacture Solid Dispersion/Solution* Fulltext Access 12 Pages 2005
Evaluation of pig esophageal mucosa as a permeability barrier model for buccal tissue Fulltext Access 12 Pages 2005
Significant differences in the disposition of cyclic prodrugs of opioid peptides in rats and guinea pigs following IV administration Fulltext Access 12 Pages 2005
Dose dependency in the oral bioavailability of an organic cation model, tributylmethyl ammonium (TBuMA), in rats: Association with the saturation of efflux by the P-gp system on the apical membrane of the intestinal epithelium Fulltext Access 12 Pages 2005
Synthesis and evaluation of 3-aryl piperidine analogs as potent and efficacious dopamine D4 receptor agonists Fulltext Access 12 Pages 2005
Geldanamycin derivative inhibition of HGF/SF-mediated Met tyrosine kinase receptor-dependent urokinase-plasminogen activation Fulltext Access 12 Pages 2005
Preventive effects of soyasapogenol B derivatives on liver injury in a concanavalin A-induced hepatitis model Fulltext Access 12 Pages 2005
Exploration of orally available calpain inhibitors: Peptidyl α-ketoamides containing an amphiphile at P3 site Fulltext Access 12 Pages 2005
Dirhodium tetraacetate as an auxiliary chromophore in a circular dichroic study on vic-amino alcohols Fulltext Access 12 Pages 2005
An efficient approach to enantiomeric isoxazolidinyl analogues of tiazofurin based on nitrone cycloadditions Fulltext Access 12 Pages 2005
Pharmacokinetic Effects of 4C9, An Anti-FcRn Antibody, in Rats: Implications for the Use of FcRn Inhibitors for the Treatment of Humoral Autoimmune and Alloimmune Conditions Fulltext Access 12 Pages 2005
Down-regulation of the glial glutamate transporter GLT-1 in rat hippocampus and striatum and its modulation by a group III metabotropic glutamate receptor antagonist following transient global forebrain ischemia Fulltext Access 12 Pages 2005
Repeated exposure to Î9-tetrahydrocannabinol alters heroin-induced locomotor sensitisation and Fos-immunoreactivity Fulltext Access 12 Pages 2005
Glycinergic inhibition in thalamus revealed by synaptic receptor blockade Fulltext Access 12 Pages 2005
Excessive crying and gastro-oesophageal reflux disease in infants: misalignment of biology and culture Fulltext Access 12 Pages 2005
Calcium-mediated aponecrosis plays a central role in the pathogenesis of estrogenic chemical-induced neurotoxicity Fulltext Access 12 Pages 2005
Metabolic depression in hibernation and major depression: An explanatory theory and an animal model of depression Fulltext Access 12 Pages 2005
A possible explanation for the racial difference in distribution of large-arterial cerebrovascular disease: Ancestral European settlers evolved genetic resistance to atherosclerosis, but confined to the intracranial arteries Fulltext Access 12 Pages 2005
Intrinsic toxicity of glucose, due to non-enzymatic glycation, is controlled in-vivo by deglycation systems including: FN3K-mediated deglycation of fructosamines and transglycation of aldosamines Fulltext Access 12 Pages 2005
The impact of the transmission dynamics of the HIV/AIDS epidemic on sexual behaviour: A new hypothesis to explain recent increases in risk taking-behaviour among men who have sex with men Fulltext Access 12 Pages 2005
Multiple sclerosis and hepatitis B vaccination: Could minute contamination of the vaccine by partial Hepatitis B virus polymerase play a role through molecular mimicry? Fulltext Access 12 Pages 2005
Partially Crystalline Systems in Lyophilization: II. Withstanding Collapse at High Primary Drying Temperatures and Impact on Protein Activity Recovery Fulltext Access 12 Pages 2005
Synthesis of disparlure analogues, using resolution on microcrystalline cellulose triacetate-I Fulltext Access 12 Pages 2005
Single Crystal and Powder Diffraction Characterization of Three Polymorphic Forms of Acitretin Fulltext Access 12 Pages 2005
The Effect of Water to Ethanol Feed Ratio on Physical Properties and Aerosolization Behavior of Spray Dried Cromolyn Sodium Particles Fulltext Access 12 Pages 2005
Microdialysis evaluation of the brain distribution of stavudine following intranasal and intravenous administration to rats Fulltext Access 12 Pages 2005
Surface roughness contribution to the adhesion force distribution of salmeterol xinafoate on lactose carriers by atomic force microscopy Fulltext Access 12 Pages 2005
Effect of the covalent modification of horseradish peroxidase with poly(ethylene glycol) on the activity and stability upon encapsulation in polyester microspheres Fulltext Access 12 Pages 2005
Intracellular delivery of doxorubicin with RGD-modified sterically stabilized liposomes for an improved antitumor efficacy: In vitro and in vivo Fulltext Access 12 Pages 2005
Lipid Binding Region (2303-2332) is Involved in Aggregation of Recombinant Human FVIII (rFVIII)* Fulltext Access 12 Pages 2005
Tissue Distribution of Basic Drugs: Accounting for Enantiomeric, Compound and Regional Differences Amongst β-Blocking Drugs in Rat Fulltext Access 12 Pages 2005
Pharmacokinetic Study of Methotrexate Following Intra-Articular Injection of Methotrexate Loaded Poly(L-Lactic Acid) Microspheres in Rabbits Fulltext Access 12 Pages 2005
Pharmacokinetics and Metabolism of Metoprolol and Propranolol in the Female DA and Female Wistar Rat: The Female DA Rat Is Not Always an Animal Model for Poor Metabolizers of CYP2D6 Fulltext Access 12 Pages 2005