Highly enantioselective sequential Claisen-Ireland/metathesis: synthesis of cycloalkenes bearing two contiguous highly functionalized asymmetric centres Fulltext Access 15 Pages 2005
Synthetic disaccharide analogs as potential substrates and inhibitors of a mycobacterial polyprenol monophosphomannose-dependent α-(1â6)-mannosyltransferase Fulltext Access 15 Pages 2005
A novel class of sodium/calcium exchanger inhibitor: design, synthesis, and structure–activity relationships of 3,4-dihydro-2(1H)-quinazolinone derivatives Fulltext Access 15 Pages 2005
Novel 3-amino-2-hydroxy acids containing protease inhibitors. Part 1: Synthesis and kinetic characterization as aminopeptidase P inhibitors Fulltext Access 15 Pages 2005
From glycoside hydrolases to thioglycoligases: the synthesis of thioglycosides Fulltext Access 15 Pages 2005
2,9-Disubstituted-N6-(arylcarbamoyl)-8-azaadenines as new selective A3 adenosine receptor antagonists: Synthesis, biochemical and molecular modelling studies Fulltext Access 15 Pages 2005
Anomeric α-azido acid (2-azido-2-deoxy-hept-2-ulopyranosonic acid) derivatives en route to peptides incorporating sugar amino acids Fulltext Access 15 Pages 2005
Disarming, non-participating 2-O-protecting groups in manno- and rhamnopyranosylation: scope and limitations of sulfonates, vinylogous esters, phosphates, cyanates, and nitrates Fulltext Access 15 Pages 2005
Chiral catalysts in the stereoselective synthesis of pyrrolidine derivatives via metallo-azomethine ylides Fulltext Access 15 Pages 2005
Two novel series of allocolchicinoids with modified seven membered B-rings: design, synthesis, inhibition of tubulin assembly and cytotoxicity Fulltext Access 15 Pages 2005
Semiempirical MO approach to the mechanism of the NIS-mediated nucleophilic addition to glycals: multicomponent intermediates as models to tackle reactivity in organic chemistry Fulltext Access 15 Pages 2005
Structure–activity relationships and molecular modelling of 5-arylidene-2,4-thiazolidinediones active as aldose reductase inhibitors Fulltext Access 15 Pages 2005
Pathways of Peptide Ion Fragmentation Induced by Vacuum Ultraviolet Light Fulltext Access 15 Pages 2005
A physically interpretable quantum-theoretic QSAR for some carbonic anhydrase inhibitors with diverse aromatic rings, obtained by a new QSAR procedure Fulltext Access 15 Pages 2005
Formation of [b(nâ1) + OH + H]+ Ion Structural Analogs by Solution-Phase Chemistry Fulltext Access 15 Pages 2005
Ion Excitation in a Linear Quadrupole Ion Trap with an Added Octopole Field Fulltext Access 15 Pages 2005
Synthesis, solution structure, and bioactivity of six new simplified analogues of the natural cyclodepsipeptide jaspamide Fulltext Access 15 Pages 2005
C2-Symmetric nitroxides and their potential as enantioselective oxidants Fulltext Access 15 Pages 2005
Matched and mismatched pairings in B-secotaxane construction: a structure elucidation study Fulltext Access 15 Pages 2005
The aldol–annulation–fragmentation strategy toward the taxoid diterpene framework revisited. Instructive failures in the chemistry of medium ring containing systems Fulltext Access 15 Pages 2005
Synthesis and pharmacological evaluation of 4H-1,4-benzothiazine-2-carbonitrile 1,1-dioxide and N-(2-cyanomethylsulfonylphenyl)acylamide derivatives as potential activators of ATP sensitive potassium channels Fulltext Access 15 Pages 2005
Inhibitory activity of polyhydroxycarboxylate chelators against recombinant NF-κB p50 protein-DNA binding Fulltext Access 15 Pages 2005
Discovery of an N-(2-aminopyridin-4-ylmethyl)nicotinamide derivative: a potent and orally bioavailable NCX inhibitor Fulltext Access 15 Pages 2005
Synthesis of 4-(1-oxo-isoindoline) and 4-(5,6-dimethoxy-1-oxo-isoindoline)-substituted phenoxypropanolamines and their β1-, β2-adrenergic receptor binding studies Fulltext Access 15 Pages 2005
C3′-cis-Substituted carboxycyclopropyl glycines as metabotropic glutamate 2/3 receptor agonists: Synthesis and SAR studies Fulltext Access 15 Pages 2005
Molecular modeling, design, synthesis, and biological evaluation of novel 3′,4′-dicamphanoyl-(+)-cis-khellactone (DCK) analogs as potent anti-HIV agents Fulltext Access 15 Pages 2005
Structure activity studies of the serine-AIB dipeptide domain in 2,3-dihydroisothiazole based growth hormone secretagogues Fulltext Access 15 Pages 2005
Synthesis of 17β-estradiol-linked platinum(II) complexes and their cytocidal activity on estrogen-dependent and -independent breast tumor cells Fulltext Access 15 Pages 2005
Polymorphism of paracetamol: Relative stabilities of the monoclinic and orthorhombic phases inferred from topological pressureâtemperature and temperatureâvolume phase diagrams Fulltext Access 16 Pages 2005
Reactivity of substituted and unsubstituted diphenyephosphonium diylides towards carbonic anhydride derivatives. Fulltext Access 16 Pages 2005
Comparison of a Miniaturized Shake-Flask Solubility Method with Automated Potentiometric Acid/Base Titrations and Calculated Solubilities Fulltext Access 16 Pages 2005
Quantitative Structure-Pharmacokinetic Relationships for Drug Distribution Properties by Using General Regression Neural Network Fulltext Access 16 Pages 2005
Stability of 5-aminolevulinic acid in novel non-aqueous gel and patch-type systems intended for topical application Fulltext Access 16 Pages 2005
Hybrid films from blends of chitosan and egg phosphatidylcholine for localized delivery of paclitaxel Fulltext Access 16 Pages 2005
Differential binding properties of [3H]dextrorphan and [3H]MK-801 in heterologously expressed NMDA receptors Fulltext Access 16 Pages 2005
Interactions between CAP70 and actinfilin are important for integrity of actin cytoskeleton structures in neurons Fulltext Access 16 Pages 2005
Plasticity-specific phosphorylation of CaMKII, MAP-kinases and CREB during late-LTP in rat hippocampal slices in vitro Fulltext Access 16 Pages 2005
Cholinergic modulation of the spatiotemporal pattern of hippocampal activity in vitro Fulltext Access 16 Pages 2005
Morphine alters the selective association between mu-opioid receptors and specific RGS proteins in mouse periaqueductal gray matter Fulltext Access 16 Pages 2005
Fragmentation of Negative Ions from Carbohydrates: Part 2. Fragmentation of High-Mannose N-Linked Glycans Fulltext Access 16 Pages 2005
Tandem Mobility Mass Spectrometry Study of Electrosprayed Tetraheptyl Ammonium Bromide Clusters Fulltext Access 16 Pages 2005
Assigning product ions from complex MS/MS spectra: The importance of mass uncertainty and resolving power Fulltext Access 16 Pages 2005
Effects of Solvent Flow, Dopant Flow, and Lamp Current on Dopant-Assisted Atmospheric Pressure Photoionization (DA-APPI) for LC-MS. Ionizationvia Proton Transfer Fulltext Access 16 Pages 2005
An interdisciplinary approach to certain fundamental issues in the fields of physics and biology: towards a unified theory Fulltext Access 16 Pages 2005
1-Amino-1-ferrocenyl-2-methyl-2-propanol: a case study on the conformational control of asymmetric induction Fulltext Access 16 Pages 2005
Atom, atom-type and total molecular linear indices as a promising approach for bioorganic and medicinal chemistry: theoretical and experimental assessment of a novel method for virtual screening and rational design of new lead anthelmintic Fulltext Access 16 Pages 2005
Synthesis and pharmacological evaluation of glycine-modified analogues of the neuroprotective agent glycyl-l-prolyl-l-glutamic acid (GPE) Fulltext Access 16 Pages 2005
Aza-Wittig reaction of fluoroalkylated N-vinylic phosphazenes with carbonyl compounds. Usefulness of 2-azadienes for the preparation of fluoroalkyl pyridine derivatives Fulltext Access 16 Pages 2005
Novel fluoropeptidomimetics: synthesis, stability studies and protease inhibition Fulltext Access 16 Pages 2005
Effect of change in nucleoside structure on the activation and antiviral activity of phosphoramidate derivatives Fulltext Access 16 Pages 2005
Development of α-keto-based inhibitors of cruzain, a cysteine protease implicated in Chagas disease Fulltext Access 16 Pages 2005
Synthesis of novel substituted 2-phenylpyrazolopyridines with potent activity against herpesviruses Fulltext Access 16 Pages 2005
Synthetic studies on novel Syk inhibitors. Part 1: Synthesis and structure–activity relationships of pyrimidine-5-carboxamide derivatives Fulltext Access 16 Pages 2005
5-(3-Bromophenyl)-7-(6-morpholin-4-ylpyridin-3-yl)pyrido[2,3-d]pyrimidin-4-ylamine: structure–activity relationships of 7-substituted heteroaryl analogs as non-nucleoside adenosine kinase inhibitors Fulltext Access 16 Pages 2005
Design, synthesis, and evaluation of novel 2-substituted-4-aryl-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,5]oxazocin-5-ones as NK1 antagonists Fulltext Access 16 Pages 2005
Studies on the Mechanism of Aspartic Acid Cleavage and Glutamine Deamidation in the Acidic Degradation of Glucagon Fulltext Access 16 Pages 2005
Potent, selective, and orally bioavailable matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis Fulltext Access 16 Pages 2005
Tunable phosphinite, phosphite and phosphoramidite ligands for the asymmetric hydrovinylation reactions Fulltext Access 16 Pages 2005
Reactions of guaiazulene with methyl terephthalaldehydate and 2-hydroxy- and 4-hydroxybenzaldehydes in methanol in the presence of hexafluorophosphoric acid: comparative studies on molecular structures and spectroscopic, chemical and electrochemical prope Fulltext Access 16 Pages 2005
Synthesis of functionalized α-amino-phosphine oxides and -phosphonates by addition of amines and aminoesters to 4-phosphinyl- and 4-phosphonyl-1,2-diaza-1,3-butadienes Fulltext Access 16 Pages 2005
XYZH systems as potential 1,3-dipoles. Part 62:1 1,3-Dipolar cycloaddition reactions of metallo-azomethine ylides derived from α-iminophosphonates Fulltext Access 16 Pages 2005
Synthetic studies on 3-arylquinazolin-4-ones: intramolecular nucleophilic aromatic substitution reaction of 2-carboxamido-3-arylquinazolin-4-ones and its application to the synthesis of secondary aryl amines Fulltext Access 16 Pages 2005
Oxidative addition of N-halosuccinimides to palladium(0): the discovery of neutral palladium(II) imidate complexes, which enhance Stille coupling of allylic and benzylic halides Fulltext Access 16 Pages 2005
Dynamic resolution of N-alkyl-2-lithiopyrrolidines with the chiral ligand (â)-sparteine Fulltext Access 16 Pages 2005
Rigid backbone 1,8-anthracene-linked bis-oxazolines (AnBOXes): design, synthesis, application and characteristics in catalytic asymmetric aziridination Fulltext Access 17 Pages 2005
Novel semicarbazide-derived inhibitors of human dipeptidyl peptidase I (hDPPI) Fulltext Access 17 Pages 2005
Novel 5-substituted, 2,4-diaminofuro[2,3-d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors with antiangiogenic and antitumor activity Fulltext Access 17 Pages 2005
Trichosporon beigelli esterase (TBE): a versatile esterase for the resolution of economically important racemates Fulltext Access 17 Pages 2005
Synthesis of novel chiral hydrobenzoin mono-tert-butyl ethers derived from m-hydrobenzoin and their application as chiral auxiliaries in the diastereoselective reduction of α-keto esters Fulltext Access 17 Pages 2005
Development of 3,4-dihydro-2H-benzo[1,4]oxazine derivatives as dual thromboxane A2 receptor antagonists and prostacyclin receptor agonists Fulltext Access 17 Pages 2005
Novel matrix metalloproteinase inhibitors: Generation of lead compounds by the in silico fragment-based approach Fulltext Access 17 Pages 2005
Design, synthesis and characterization of a novel class of coumarin-based inhibitors of inducible nitric oxide synthase Fulltext Access 17 Pages 2005
Ion-Ion and Ion-Molecule Reactions at the Surface of Proteins Produced by Nanospray. Information on the Number of Acidic Residues and Control of the Number of Ionized Acidic and Basic Residues Fulltext Access 17 Pages 2005
Core-modified porphyrins. Part 4: Steric effects on photophysical and biological properties in vitro Fulltext Access 17 Pages 2005
Dielectric Studies of Molecular Motions in Amorphous Solid and Ultraviscous Acetaminophen Fulltext Access 17 Pages 2005
An Evaluation of the Utility of Physiologically Based Models of Pharmacokinetics in Early Drug Discovery Fulltext Access 17 Pages 2005
A Comparison of the Gas Phase Acidities of Phospholipid Headgroups: Experimental and Computational Studies Fulltext Access 17 Pages 2005
Caco-2 permeability of weakly basic drugs predicted with the Double-Sink PAMPA pKaflux method Fulltext Access 17 Pages 2005
RGS-Rz and RGS9-2 proteins control mu-opioid receptor desensitisation in CNS: the role of activated Gαz subunits Fulltext Access 17 Pages 2005
The dopamine D3 receptor and drug dependence: Effects on reward or beyond? Fulltext Access 17 Pages 2005
Role of the α subunit in the modulation of GABAA receptors by anabolic androgenic steroids Fulltext Access 17 Pages 2005
An approach to solvent screening for crystallization of polymorphic pharmaceuticals and fine chemicals Fulltext Access 17 Pages 2005
Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure Fulltext Access 17 Pages 2005